Shinung Ching

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc A neurophysiological-metabolic model for burst suppression
    Shinung Ching
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:3095-100. 2012
  2. pmc Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness
    Shinung Ching
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:22665-70. 2010
  3. pmc Thalamocortical mechanisms for the anteriorization of α rhythms during propofol-induced unconsciousness
    Sujith Vijayan
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 33:11070-5. 2013
  4. pmc Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression
    Jessica Chemali
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Neural Eng 10:056017. 2013
  5. pmc Real-time closed-loop control in a rodent model of medically induced coma using burst suppression
    Shinung Ching
    Research Fellow, Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts Research Fellow, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts Research Assistant, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Instructor, Department of Neurology, Harvard Medical School Assistant in Neurology, Department of Neurology, Massachusetts General Hospital Assistant Professor, Department of Anaesthesia, Harvard Medical School Assistant Anesthetist, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology Instructor, Department of Anaesthesia, Harvard Medical School Instructor, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology Warren M Zapol Professor of Anaesthesia, Department of Anaesthesia, Harvard Medical School Anesthetist, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Professor of Computational Neuroscience
    Anesthesiology 119:848-60. 2013
  6. pmc The human burst suppression electroencephalogram of deep hypothermia
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA Department of Neurology, Harvard Medical School, Boston, MA, USA Electronic address
    Clin Neurophysiol 126:1901-14. 2015
  7. pmc Real-time segmentation of burst suppression patterns in critical care EEG monitoring
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci Methods 219:131-41. 2013
  8. pmc Electroencephalogram signatures of loss and recovery of consciousness from propofol
    Patrick L Purdon
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 110:E1142-51. 2013
  9. pmc Robust control of burst suppression for medical coma
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neural Eng 12:046004. 2015
  10. pmc A closed-loop anesthetic delivery system for real-time control of burst suppression
    Max Y Liberman
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Neural Eng 10:046004. 2013

Collaborators

Detail Information

Publications11

  1. pmc A neurophysiological-metabolic model for burst suppression
    Shinung Ching
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:3095-100. 2012
    ..Consequently, the model makes a number of specific predictions of experimental and clinical relevance...
  2. pmc Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness
    Shinung Ching
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:22665-70. 2010
    ..The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state...
  3. pmc Thalamocortical mechanisms for the anteriorization of α rhythms during propofol-induced unconsciousness
    Sujith Vijayan
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 33:11070-5. 2013
    ..Our model generalizes to other anesthetics that include GABA as a target, since the molecular targets of many such anesthetics alter the model dynamics in a manner similar to that of propofol. ..
  4. pmc Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression
    Jessica Chemali
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Neural Eng 10:056017. 2013
    ....
  5. pmc Real-time closed-loop control in a rodent model of medically induced coma using burst suppression
    Shinung Ching
    Research Fellow, Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts Research Fellow, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts Research Assistant, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Instructor, Department of Neurology, Harvard Medical School Assistant in Neurology, Department of Neurology, Massachusetts General Hospital Assistant Professor, Department of Anaesthesia, Harvard Medical School Assistant Anesthetist, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology Instructor, Department of Anaesthesia, Harvard Medical School Instructor, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology Warren M Zapol Professor of Anaesthesia, Department of Anaesthesia, Harvard Medical School Anesthetist, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Professor of Computational Neuroscience
    Anesthesiology 119:848-60. 2013
    ..The authors hypothesized that a closed-loop anesthetic delivery system could automatically and precisely control the electroencephalogram state of burst suppression and efficiently maintain a medically induced coma...
  6. pmc The human burst suppression electroencephalogram of deep hypothermia
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA Department of Neurology, Harvard Medical School, Boston, MA, USA Electronic address
    Clin Neurophysiol 126:1901-14. 2015
    ..We set out to investigate the electroencephalogram changes induced by cooling the human brain through increasing depths of BS through isoelectricity...
  7. pmc Real-time segmentation of burst suppression patterns in critical care EEG monitoring
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci Methods 219:131-41. 2013
    ..Develop a real-time algorithm to automatically discriminate suppressions from non-suppressions (bursts) in electroencephalograms of critically ill adult patients...
  8. pmc Electroencephalogram signatures of loss and recovery of consciousness from propofol
    Patrick L Purdon
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 110:E1142-51. 2013
    ....
  9. pmc Robust control of burst suppression for medical coma
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neural Eng 12:046004. 2015
    ..We sought to develop a robust closed-loop anesthesia delivery (CLAD) system to control medical coma...
  10. pmc A closed-loop anesthetic delivery system for real-time control of burst suppression
    Max Y Liberman
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Neural Eng 10:046004. 2013
    ..Our objective is to design a CLAD system for burst suppression control to automate management of medically-induced coma...
  11. doi request reprint A PK-PD model of ketamine-induced high-frequency oscillations
    Francisco J Flores
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Neural Eng 12:056006. 2015
    ..Despite the widespread use of ketamine there is no model description of the relationship between the pharmacokinetic-pharmacodynamics (PK-PDs) of ketamine and the observed HFO power...