Genomes and Genes
Affiliation: Massachusetts General Hospital
- Inferring dynamic signatures of microbes in complex host ecosystemsGeorg K Gerber
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS Comput Biol 8:e1002624. 2012..Overall, our approach provides a powerful, general-purpose framework for understanding the dynamic behaviors of complex microbial ecosystems, which we believe will prove instrumental for future studies in this field...
- CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentiumLynn Bry
4226 EBRC, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Infect Immun 74:673-81. 2006..These findings have important implications for understanding the role of T-helper-cell responses during infections involving mucosal surfaces...
- Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogenLynn Bry
Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 172:433-41. 2004..These findings have implications for understanding host defense against mucosal infections, including the pathogenesis of these diseases in immunocompromised populations...
- Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulinMatthew D Brown
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Thorn 530, Boston, Massachusetts 02115, USA
J Biol Chem 283:35212-22. 2008..Furthermore, IQGAP1 specifically interacts with Tir in vitro and in cells. Together these data identify IQGAP1, Ca(2+), and calmodulin as a novel signaling complex regulating actin pedestal formation by EPEC...
- Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitisWendy S Garrett
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Cell Host Microbe 8:292-300. 2010..Cross-fostering experiments indicated a role for these organisms in maternal transmission of disease. Our findings illustrate how gut microbial communities work in concert with specific culturable colitogenic agents to cause IBD...
- Mechanism of CD1d-restricted natural killer T cell activation during microbial infectionManfred Brigl
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 4:1230-7. 2003..We propose this mechanism of activation as a major pathway responsible for the rapid activation of NKT cells in different microbial infections...
- Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteriaMasaru Yoshida
Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
J Clin Invest 116:2142-2151. 2006....
- Alterations of the human gut microbiome in multiple sclerosisSushrut Jangi
Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Commun 7:12015. 2016..Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis. ..
- Genomically Informed Surveillance for Carbapenem-Resistant Enterobacteriaceae in a Health Care SystemNicole D Pecora
Center for Clinical and Translational Metagenomics, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
MBio 6:e01030. 2015..These findings highlight the utility of genomic analyses in internal and external surveillance efforts to stem the transmission of drug-resistant strains within and across health care institutions...
- MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces CommensalismSen Wang
Division of Immunology, Boston Children s Hospital, Boston, MA 02115, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Immunity 43:289-303. 2015..These findings establish an essential role for MyD88-dependent microbial sensing by Treg cells in enforcing mucosal tolerance and maintaining commensalism by promoting intestinal Treg cell formation and anti-commensal IgA responses...
- IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42Matthew D Brown
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:30265-72. 2007..Overexpression of IQGAP1 significantly increases the ability of Salmonella to enter host cells and required interaction with both actin and Cdc42/Rac1. Together, these data identify IQGAP1 as a novel regulator of Salmonella invasion...
- Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin ReceptorSiegfried Ussar
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA
Diabetes . 2017....
- The Host Shapes the Gut Microbiota via Fecal MicroRNAShirong Liu
Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Cell Host Microbe 19:32-43. 2016..These findings identify both a physiologic role by which fecal miRNA shapes the gut microbiota and a potential strategy for manipulating the microbiome...
- Tracheal tube obstruction in mechanically ventilated patients assessed by high-resolution computed tomographyCristina Mietto
From the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts C M, R P, A P, R M K, L Berra School of Dentistry, West Virginia University, Morgantown, West Virginia J G T Center for Clinical and Translational Metagenomics, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts L Bry, M L D, A D B Center for System Biology, Massachusetts General Hospital, Boston, Massachusetts J T, G R W, M N Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts J B A and Department of Respiratory Care, Massachusetts General Hospital, Boston, Massachusetts R M K
Anesthesiology 121:1226-35. 2014..Tracheal intubation compromises mucus clearance and secretions accumulate inside the tracheal tube (TT). The aim of this study was to evaluate with a novel methodology TT luminal obstruction in critically ill patients...
- The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell inductionLanfen Chen
Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Immunity 37:930-46. 2012....
- Protective role of cross-reactive anti-enteric antibodyLynn Bry; Fiscal Year: 2005....
- Role of T cells in self-limited mucosal infectionsLynn Bry; Fiscal Year: 2006..This training provides a necessary step in the candidate's goal to become an independent researcher investigating questions in mucosal immunology and host-microbial cross-talk in intestinal environments. ..
- Crimson - i2b2 integration for high-throughput, scalable sample collectionLynn Bry; Fiscal Year: 2010....