Zabrina L Brumme
Affiliation: Massachusetts General Hospital
- HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteinsZabrina L Brumme
Ragon Institute of MGH, MIT and Harvard, Charlestown, MA, USA
PLoS ONE 4:e6687. 2009..Results are organized into protein-wide escape maps illustrating the sites and pathways of HLA-driven viral evolution...
- Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infectionZabrina L Brumme
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Virol 82:9216-27. 2008..Dramatic differences in escape and reversion rates across codons, genes, and HLA restrictions are observed, highlighting the complexity of viral adaptation to the host immune response...
- Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative studySantiago Avila-Ríos
Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico
Retrovirology 6:72. 2009..However, it is not known whether characteristic HLA frequency distributions in different populations have resulted in additional unique footprints...
- Impaired replication capacity of acute/early viruses in persons who become HIV controllersToshiyuki Miura
Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
J Virol 84:7581-91. 2010..These data suggest that viral dynamics during acute infection have a major impact on HIV disease outcome...
- HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1Toshiyuki Miura
Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
J Virol 83:140-9. 2009....
- HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllersToshiyuki Miura
Ragon Institute formerly Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Virol 83:3407-12. 2009..These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HIV-1 infection...
- Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infectionZabrina L Brumme
Partners AIDS Research Center, Massachusetts General Hospital, Boston, Harvard Medical School, Massachusetts 02129, USA
AIDS 22:1277-86. 2008..Here we undertake a population-based identification of HLA-associated polymorphisms in Gag and investigate their relationship with plasma viral load...
- HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognitionToshiyuki Miura
Ragon Institute, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
J Virol 83:2743-55. 2009..These data suggest a dual mechanism for durable control of HIV replication, consisting of viral fitness loss resulting from CTL escape mutations together with strong CD8 T-cell immune responses to the arising variant epitopes...
- Characteristics and outcomes of initial virologic suppressors during analytic treatment interruption in a therapeutic HIV-1 gag vaccine trialJonathan Z Li
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 7:e34134. 2012..In the placebo-controlled trial ACTG A5197, a trend favoring viral suppression was seen in the HIV-1-infected subjects who received a recombinant Ad5 HIV-1 gag vaccine...
- Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changesToshiyuki Miura
Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Virol 82:8422-30. 2008..These results indicate that the spontaneous control of HIV replication is not attributable to shared viral genetic defects or shared viral polymorphisms...
- Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequencesChristoph T Berger
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, Boston, MA 02129, USA
J Exp Med 207:61-75. 2010..These data indicate that responses to ARF-encoded HIV epitopes are induced during natural infection, can contribute to viral control in vivo, and drive viral evolution on a population level...
- Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1Christoph T Berger
Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA Translational Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
J Virol 89:4015-9. 2015..Results suggest that antisense-derived sequences are commonly transcribed and translated and could encode functional proteins that contain important targets of anti-HIV cellular immunity. ..
- Frequent and variable cytotoxic-T-lymphocyte escape-associated fitness costs in the human immunodeficiency virus type 1 subtype B Gag proteinsChristian L Boutwell
Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA
J Virol 87:3952-65. 2013....
- TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infectionHuabiao Chen
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, USA
Nat Immunol 13:691-700. 2012..Thus, the efficacy of such so-called 'protective alleles' is modulated by specific TCR clonotypes selected during natural infection, which provides a functional explanation for divergent HIV-1 outcomes...
- Transmission and long-term stability of compensated CD8 escape mutationsArne Schneidewind
Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
J Virol 83:3993-7. 2009..Herein, we illustrate the long-term stability of stereotypic escape mutations in the immunodominant HLA-B27-restricted epitope KK10 in p24/Gag following transmission when accompanied by a specific compensatory mutation...
- Factors associated with viral rebound in HIV-1-infected individuals enrolled in a therapeutic HIV-1 gag vaccine trialJonathan Z Li
Section of Retroviral Therapeutics, Brigham and Women s Hospital, Boston, Massachusetts 02139, USA
J Infect Dis 203:976-83. 2011..Human immunodeficiency virus type 1 (HIV-1) vaccines directed to the cell-mediated immune system could have a role in lowering the plasma HIV-1 RNA set point, which may reduce infectivity and delay disease progression...
- Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1Zabrina L Brumme
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Pathog 3:e94. 2007..The design of preventative and therapeutic CTL-based vaccine approaches could incorporate information on predictable escape pathways...
- Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individualsShao Chong Zhang
Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
J Immunol 188:5924-34. 2012..These results underscore an important and widespread role of Ag processing mutations in HIV immune escape and identify molecular mechanisms underlying impaired epitope presentation...
- Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplificationZabrina L Brumme
Ragon Institute of MGH, MIT and Harvard, Charlestown MA 02129, USA
J Exp Med 206:1215-8. 2009..Studies using single-genome amplification now reveal new details about the kinetics and specificity of the CD8(+) T cell response and the evolution of the virus during early HIV infection...
- Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cellsHendrik Streeck
Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Med 5:e100. 2008....
- Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infectionMatthew R Henn
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
PLoS Pathog 8:e1002529. 2012....