Anna Liisa Brownell
Affiliation: Massachusetts General Hospital
- Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease modelAnna Liisa Brownell
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
Neuroimage 20:1064-75. 2003..These experimental results obtained in primate studies of striato-thalamo-cortico circuitry show a similar trend as hypothetized in Parkinson's disease-type degeneration...
- 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopyAnna Liisa Brownell
Department of Radiology, Bartlett Hall 504R, Massachusetts General Hospital, Boston, MA 02114, USA
J Neurochem 89:1206-14. 2004..Animals that did not develop lesions showed reversible enhancement in cortical glucose utilization and no change in striatal glucose utilization or neurochemicals or locomotor activity...
- Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's diseaseXukui Wang
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Neurol Sci 231:57-66. 2005..Cerebral imaging and histological evidence support the use of cystamine as a neuroprotective agent for Huntington's disease (HD) pathology...
- Mapping dopamine function in primates using pharmacologic magnetic resonance imagingBruce G Jenkins
Massachusetts General Hospital MGH Nuclear Magnetic Resonance Center, Athinoula A Martinos Center for Biomedical Imaging, Boston, Massachusetts 02129, USA
J Neurosci 24:9553-60. 2004..These data indicate that phMRI is a powerful tool for assessment of dynamic changes associated with normal and dysfunctional DA brain circuitry in primates...
- Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian ratsDaniela Pellegrino
Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Nucl Med 48:1147-53. 2007..To further address this issue, we investigated the imaging profile and expression of dopamine D(2) receptors and mGluRs in a classic parkinsonian rodent model induced by the toxin 6-hydroxydopamine...
- Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptorsMeixiang Yu
Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
Nucl Med Biol 32:631-40. 2005..The feasibility of synthesizing high-affinity and high-selectivity ligands for mGluR5 receptors and their suitability as PET imaging ligands for mGluR5 receptors in vivo are demonstrated...
- Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4Kun Eek Kil
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149, 13th St, Suite 2301, Charlestown, MA 02129, USA
Bioorg Med Chem Lett 26:133-9. 2016..Therefore, [(11)C]11 will be a useful radioligand to investigate mGlu4 in different biological applications. ..
- Radiolabeling and biodistribution of methyl 2-(methoxycarbonyl)-2-(methylamino) bicyclo[2.1.1] -hexane -5-carboxylate, a potential neuroprotective drugMeixiang Yu
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Bartlett Hall 511R, Boston, MA 02114, USA
Life Sci 73:1577-85. 2003..During 20-40 min, 2.9+/-0.4% of the total activity stayed in the brain. These results showed that MMMHC could be labeled with C-11 with high yield, and it passed the brain-blood barrier and accumulated in several brain regions...
- Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPSDany Arsenault
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
PLoS ONE 10:e0142093. 2015....
- PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A geneAnna Liisa Brownell
Athinoula A Martinos Biomedical Imaging Center, Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA
J Neuroinflammation 12:217. 2015..Since therapeutic approaches for ALS are focused on glutamatergic function, we investigated modulation of glutamate transport based on its receptor function as well as excitotoxicity-induced inflammatory response...
- Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4)Kun Eek Kil
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United States
J Med Chem 57:9130-8. 2014....
- Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4)Kun Eek Kil
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, United States
Bioorg Med Chem 21:5955-62. 2013..Biodistribution studies and blood analyses support fast metabolism. Altogether this is the first PET imaging ligand for mGlu4, in which the labeled ML128 was used for imaging its in vivo distribution and pharmacokinetics in brain. ..
- Positron emission tomography of herpes simplex virus 1 oncolysisDarshini Kuruppu
Division of Surgical Oncology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 67:3295-300. 2007..These observations have important consequences with regard to strategies to use [(18)F]FHBG PET for monitoring sites of HSV-TK expression during viral oncolysis...
- Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivoJi Quan Wang
Athinoula A Martinos Biomedical Imaging Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 2129, USA
Bioorg Med Chem Lett 22:1958-62. 2012..5±3.2%. The results show [(11)C]CMGDE is the first PET tracer that is brain penetrating and can be used to image group II mGluRs in vivo...
- Co-operative binding assay for the characterization of mGlu4 allosteric modulatorsPekka Poutiainen
Athinoula A Martinos Biomedical Imaging Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neuropharmacology 97:142-8. 2015..Results suggest that mGlu4 PAMs have characteristic co-operative binding with orthosteric glutamate, which offers a notable insight to the further development of mGlu4 targeted therapies. ..
- Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stabilityZhaoda Zhang
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149, 13th Street, Suite 2301, Charlestown, MA 02129, United States
Bioorg Med Chem Lett 25:3956-60. 2015..The dideuteriumfluoromethoxy modified compound 24 is identified as a very promising mGlu4 ligand, which has demonstrated enhanced affinity, improved in vitro microsomal stability, good selectivity and good permeability. ..
- Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout miceJi Kyung Choi
Martinos Center for Biomedical Imaging, Department of Radiology, MGH and Harvard Medical School, Charlestown, MA 02129, USA
Neurosci Lett 609:159-64. 2015..These data provide additional support to demonstrate that the Shn-2 KO mouse model exhibits several behavioral and pathological markers resembling human schizophrenia making it an attractive translational model for the disease. ..
- Anatomical and functional assessment of brown adipose tissue by magnetic resonance imagingY Iris Chen
A Martino s Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Obesity (Silver Spring) 20:1519-26. 2012..In conclusion, we demonstrate the feasibility of measuring BAT volume and function in vivo using routine MRI sequences. The MRI measurement of BAT volume is consistent with quantitative measurement of the tissue ex vivo...
- Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's diseaseYolanda D Black
Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neurosci Lett 486:161-5. 2010..Our findings substantiate the key role of mGluR5 receptors in animal models of PD, strengthening the rationale for the development of mGluR5 antagonists for their neuroprotective, as well as symptomatic, benefit...
- Evaluation of (4-[18F]Fluorophenyl)triphenylphosphonium ion. A potential myocardial blood flow agent for PETTimothy M Shoup
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Imaging Biol 13:511-7. 2011..The lipophilic cationic compound, (4-[¹⁸F]fluorophenyl)triphenylphosphonium ion (¹⁸F-FTPP) was synthesized and evaluated as a potential positron emission tomography (PET) myocardial perfusion agent...
- 18F-fluorodeoxyglucose positron emission tomography/computed tomography enables the detection of recurrent same-site deep vein thrombosis by illuminating recently formed, neutrophil-rich thrombusTetsuya Hara
From the Cardiovascular Research Center T H, C W K, F A J, Center for Systems Biology J T, G R W, R W, Cardiology Division A T, W J H, M H M, M R J, F A J, and Martinos Biomedical Imaging Center A L B, K J, Massachusetts General Hospital, Harvard Medical School, Boston, MA and Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI P K H
Circulation 130:1044-52. 2014....
- Evaluation of four pyridine analogs to characterize 6-OHDA-induced modulation of mGluR5 function in rat brain using microPET studiesAijun Zhu
Department of Radiology, Experimental PET Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Cereb Blood Flow Metab 27:1623-31. 2007..These studies showed that glutamatergic neurotransmission might have a complementary role in dopaminergic degeneration, which can be evaluated by in vivo PET imaging...
- A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overloadMichael J Raher
Cardiac Ultrasound Laboratory, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
Am J Physiol Heart Circ Physiol 295:H2495-502. 2008..These metabolic changes are accompanied by increased LV remodeling and dysfunction after TAC, highlighting the impact of insulin resistance in the development of pressure-overload-induced heart failure...
- Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5Ji Quan Wang
Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Synapse 61:951-61. 2007..18)F]FPEB was prepared conveniently and showed high specificity and selectivity toward mGluR5. It possesses the potential to be used in human studies to evaluate mGluR5 functions in various neurological disorders...
- Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's diseaseKevin St P McNaught
Department of Neurology, Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
Ann Neurol 56:149-62. 2004..This animal model induced by proteasome inhibitors closely recapitulates key features of PD and may be valuable in studying etiopathogenic mechanisms and putative neuroprotective therapies for the illness...
- Dual-modality in vivo monitoring of subventricular zone stem cell migration and metabolismFrancesca Cicchetti
Centre de Recherche en Neurosciences, CHUL, RC 9800, 2705 Boulevard Laurier, Quebec, Canada G1V 4G2
Contrast Media Mol Imaging 2:130-8. 2007..Thus, combining MRI and PET enables monitoring of cell migration and metabolism non-invasively in vivo for extended periods of time...
- Insights into Parkinson's disease models and neurotoxicity using non-invasive imagingRosario Sanchez-Pernaute
McLean Hospital Harvard University, Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Toxicol Appl Pharmacol 207:251-6. 2005..Functional imaging techniques are instrumental to our understanding and modeling of disease mechanisms, which should in turn lead to development of new therapies for Parkinson's disease and other neurodegenerative disorders...
- Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat modelLars M Bjorklund
Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 99:2344-9. 2002..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...
- Development of NET-Selective Piperidine-Based PET LigandAnna Liisa Brownell; Fiscal Year: 2006..4. Promising PET imaging agents will be studied in cell toxicity and animal models during the second year. ..
- MICROPET FOR ANIMAL STUDIESAnna Liisa Brownell; Fiscal Year: 2001..Our previous experience in developing and operating PET systems will be of great benefit in the expansion of the facility. ..
- Novel Approaches for in vivo of mGluRsAnna Liisa Brownell; Fiscal Year: 2006..abstract_text> ..
- F-18 SynthesizerAnna Liisa Brownell; Fiscal Year: 2007..The synthesizer must balance a number of factors in the design to fulfill requirements for performance, accessibility and fitness to the research environment. [unreadable] [unreadable] [unreadable]..
- Olfaction as a Biomarker for Parkinson's DiseaseAnna Liisa Brownell; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..