A K Bhan

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Lessons for human inflammatory bowel disease from experimental models
    A K Bhan
    Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Gastroenterol 15:285-90. 1999
  2. ncbi request reprint Colitis in transgenic and knockout animals as models of human inflammatory bowel disease
    A K Bhan
    Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Boston 02114, USA
    Immunol Rev 169:195-207. 1999
  3. ncbi request reprint Spontaneous chronic colitis in TCR alpha-mutant mice; an experimental model of human ulcerative colitis
    A K Bhan
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Int Rev Immunol 19:123-38. 2000
  4. ncbi request reprint An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis
    A L Woodward
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    J Allergy Clin Immunol 107:359-66. 2001
  5. ncbi request reprint Regulatory role of mature B cells in a murine model of inflammatory bowel disease
    E Mizoguchi
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street Cox 5, Boston, MA 02114, USA
    Int Immunol 12:597-605. 2000
  6. pmc Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice
    A Mizoguchi
    Immunopathology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Exp Med 184:707-15. 1996
  7. pmc Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice
    T L Freitag
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gut 58:1597-605. 2009
  8. ncbi request reprint Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine
    P G Andres
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 164:6303-12. 2000
  9. ncbi request reprint Limited CD4 T-cell diversity associated with colitis in T-cell receptor alpha mutant mice requires a T helper 2 environment
    A Mizoguchi
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Gastroenterology 119:983-95. 2000
  10. pmc Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice
    A Mizoguchi
    Immunopathology Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Exp Med 186:1749-56. 1997

Research Grants

Detail Information

Publications55

  1. ncbi request reprint Lessons for human inflammatory bowel disease from experimental models
    A K Bhan
    Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Gastroenterol 15:285-90. 1999
    ..Lessons learned from these experimental models are leading to new strategies for the treatment of IBD...
  2. ncbi request reprint Colitis in transgenic and knockout animals as models of human inflammatory bowel disease
    A K Bhan
    Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Boston 02114, USA
    Immunol Rev 169:195-207. 1999
    ..A major benefit of these models is in the development of therapeutic strategies for the treatment of inflammatory bowel disease...
  3. ncbi request reprint Spontaneous chronic colitis in TCR alpha-mutant mice; an experimental model of human ulcerative colitis
    A K Bhan
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Int Rev Immunol 19:123-38. 2000
    ..The colitis in TCR alpha-/- mice resembles human ulcerative colitis and provides a useful model to study the pathogenesis of human inflammatory bowel disease...
  4. ncbi request reprint An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis
    A L Woodward
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    J Allergy Clin Immunol 107:359-66. 2001
    ..Epicutaneous sensitization induces a rise in the levels of serum total IgE and OVA-specific antibodies, further indicating that it elicits a predominantly TH2 response...
  5. ncbi request reprint Regulatory role of mature B cells in a murine model of inflammatory bowel disease
    E Mizoguchi
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street Cox 5, Boston, MA 02114, USA
    Int Immunol 12:597-605. 2000
    ..These results indicate that mature B cells play an important role in the development of chronic colitis in TCRalpha(-/-) mice by directly regulating the pathogenic T cells (CD4(+) TCRalpha(-)beta(+) T cells)...
  6. pmc Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice
    A Mizoguchi
    Immunopathology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Exp Med 184:707-15. 1996
    ..These results suggest that ALF, rather than PP, is the priming site of cells involved in the disease process and plays an important role in the development of IBD in TCR-alpha-/- mice...
  7. pmc Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice
    T L Freitag
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gut 58:1597-605. 2009
    ..We aimed to assess the pathogenic role of gluten-reactive T cells and to generate a model of gluten-induced enteropathy...
  8. ncbi request reprint Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine
    P G Andres
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 164:6303-12. 2000
    ..Our data indicate that CCR5 may be critical for the promotion of intestinal Th1-type immune responses in mice...
  9. ncbi request reprint Limited CD4 T-cell diversity associated with colitis in T-cell receptor alpha mutant mice requires a T helper 2 environment
    A Mizoguchi
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Gastroenterology 119:983-95. 2000
    ..The aim of this study was to analyze the mechanisms of expansion of these cells by characterization of the TCRbeta repertoire...
  10. pmc Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice
    A Mizoguchi
    Immunopathology Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Exp Med 186:1749-56. 1997
    ..These findings suggest that although B cells are not required for the initiation of colitis, B cells and Igs (autoAbs) can suppress colitis, presumably by affecting the clearance of apoptotic cells...
  11. pmc Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease
    A Mizoguchi
    Immunopathology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    J Exp Med 183:847-56. 1996
    ..It is possible that the unusual CD4+ TCR-alpha-/beta+ population and expanded TCR-gamma/delta+ population present in TCR-alpha-/- mice plays a central role in this abnormal immune response...
  12. ncbi request reprint Antineutrophil cytoplasmic antibodies in T-cell receptor alpha-deficient mice with chronic colitis
    E Mizoguchi
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Gastroenterology 113:1828-35. 1997
    ....
  13. ncbi request reprint Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
    S B Snapper
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 9:81-91. 1998
    ..We discuss the implications of our findings regarding WASP function in receptor signaling and cytoskeletal reorganization in T and B cells and compare the effects of WASP deficiency in mice and humans...
  14. ncbi request reprint Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration
    Y P de Jong
    Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Gastroenterology 119:715-23. 2000
    ..We investigated whether chronic experimental colitis is dependent on the CD154/CD40 pathway and whether disease can be prevented by anti-CD154 antibody treatment...
  15. ncbi request reprint Development of chronic colitis is dependent on the cytokine MIF
    Y P de Jong
    Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nat Immunol 2:1061-6. 2001
    ..Because we found increased plasma MIF concentrations in patients with Crohn's disease, these data suggested that MIF is a new target for intervention in Crohn's disease...
  16. ncbi request reprint The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice
    A Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 116:320-6. 1999
    ..The role of interleukin (IL)-4 and interferon (IFN)-gamma in the pathogenesis of colitis was examined by creating IL-4- or IFN-gamma-deficient TCRalpha-/- mice...
  17. ncbi request reprint Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation
    Ken Sugimoto
    Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Boston 02114, USA
    Gastroenterology 133:124-36. 2007
    ..However, it is unclear whether IL-10-producing B cells directly or indirectly regulate inflammation...
  18. pmc Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein
    Deanna D Nguyen
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 133:1188-97. 2007
    ..Wiskott-Aldrich syndrome protein (WASP) deficiency in mice results in similar clinical features. Herein, we characterized the colitis in WASP-deficient mice...
  19. ncbi request reprint Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection
    Y Ghendler
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Eur J Immunol 27:2279-89. 1997
    ..Hence, negative selection processes involving MHC-bound peptide ligands are operative only prior to the late DP thymocyte stage in this MHC class I-restricted TCR transgene system...
  20. pmc Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis
    J M Spergel
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 103:1103-11. 1999
    ..These results suggest that both the TH2 cytokines IL-4 and IL-5 and the TH1 cytokine IFN-gamma play important roles in the inflammation and hypertrophy of the skin in AD...
  21. ncbi request reprint Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells
    F Young
    Howard Hughes Medical Institute and the Department of Genetics and Pediatrics, The Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 6:23-33. 1997
    ..These experiments demonstrate that the pro-B to pre-B transition in vivo cannot be effected by the expression of Bcl-2 alone, and that nontransformed immature B-lineage cells are competent to receive signals through a surface mu complex...
  22. ncbi request reprint Pegylated interferon alpha-2b plus ribavirin in the treatment of post-liver transplant recurrent hepatitis C
    Andrew S Ross
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Clin Transplant 18:166-73. 2004
    ..Hematologic toxicity and dose modifications were frequent. Our experience with antiviral therapy for HCV post-OLT remains disappointing but PEG-IFN + RBV appears to produce VR in a sizable portion of IFN + RBV non-responders...
  23. ncbi request reprint Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice
    M A Meijssen
    Department of Pathology, Massachusetts General Hospital, Boston, USA
    Am J Physiol 274:G472-9. 1998
    ..Enhanced expression of TGF-beta 1, IL-15, and CD14 by colonic epithelial cells may play a role in the subsequent development of colitis in IL-2(-/-) mice...
  24. ncbi request reprint Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40
    W N Khan
    Howard Hughes Medical Institute, Boston, MA, USA
    Int Immunol 9:395-405. 1997
    ..These data suggest that signals through Btk and CD40 are necessary for the production and maintenance of the mature B cell...
  25. doi request reprint Regulatory role of B-1 B cells in chronic colitis
    Yasuyo Shimomura
    Experimental Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int Immunol 20:729-37. 2008
    ..We conclude that B-1 cells play a regulatory role in T(h)2-mediated colitis under non-hygienic conditions, possibly by generating natural antibodies in response to microbial flora...
  26. pmc Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice
    Kabir S Matharu
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastroenterology 137:1380-90.e1-3. 2009
    ..We investigated the role of the anti-inflammatory cytokine interleukin (IL)-10 in this signaling pathway using a mouse model of colitis...
  27. pmc Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection
    Kyung Ah Kim
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Hepatol 50:705-11. 2009
    ..The response rates of HCV infection to interferon therapy vary depending on viral and host factors. We hypothesized that key regulators of the IFN signaling pathway are predictive of treatment outcome...
  28. ncbi request reprint Immune networks in animal models of inflammatory bowel disease
    Atsushi Mizoguchi
    Department of Pathology, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, U S A
    Inflamm Bowel Dis 9:246-59. 2003
    ..The study of these complicated immune networks provides the rationale for the development of new therapeutic interventions in inflammatory bowel disease...
  29. pmc Dependence of intestinal granuloma formation on unique myeloid DC-like cells
    Atsushi Mizoguchi
    Department of Pathology Service, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Invest 117:605-15. 2007
    ....
  30. ncbi request reprint A case for regulatory B cells
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:705-10. 2006
    ..In this review, we make a case for the existence of regulatory B cells and discuss the possible developmental pathways and functional mechanisms of these B cells...
  31. pmc Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons
    Raymond T Chung
    Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 351:451-9. 2004
    ..We conducted a multicenter, randomized trial comparing peginterferon plus ribavirin with interferon plus ribavirin for the treatment of chronic hepatitis C in persons coinfected with HIV...
  32. ncbi request reprint Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation
    Atsushi Mizoguchi
    Department of Pathology and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA
    Int Immunol 15:97-108. 2003
    ..The CD4(+) TCRgammadelta T cells possess immune functions similar to CD4(+) TCRalphabeta T cells...
  33. ncbi request reprint Colonic epithelial functional phenotype varies with type and phase of experimental colitis
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Diseases and Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Gastroenterology 125:148-61. 2003
    ..Colonic crypt elongation occurs during both chronic colitis and in the recovery phase of acute colitis. The impact of these alterations on epithelial cell functions is not fully defined...
  34. ncbi request reprint Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  35. pmc A unique B2 B cell subset in the intestine
    Yasuyo Shimomura
    Experimental Pathology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 205:1343-55. 2008
    ..These results describe the existence of an alternative pathway of B cell maturation in the periphery that gives rise to a tissue-specific B cell subset...
  36. ncbi request reprint Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis
    S J Simpson
    Division of Immunology Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA
    Eur J Immunol 25:2618-25. 1995
    ..In light of these findings, we propose that infiltrating CD4+, but not CD8+ T cells are central to the inflammation observed in the intestinal mucosa in IL-2null colitis...
  37. pmc The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
    Michel H Maillard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 204:381-91. 2007
    ..Overall, our data reveal a critical role for WASP in nTreg cell function and implicate nTreg cell dysfunction in the autoimmunity associated with WASP deficiency...
  38. pmc IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    Ken Sugimoto
    Experimental Pathology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 118:534-44. 2008
    ..These data demonstrate what we believe to be a novel function for IL-22 in the intestine and suggest the potency of a local IL-22 gene-delivery system for treating UC...
  39. ncbi request reprint Recurrent allograft HCV presenting as acute cellular rejection: successful management with interferon and ribavirin alone
    Jessica Y Leung
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Transplant 17:275-83. 2003
    ..We conclude that in cases suggestive of ACR, careful consideration should be given to treatment for recurrent HCV in lieu of or in concert with intensive immunosuppression...
  40. ncbi request reprint Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis
    Joel R Pekow
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 109:2490-6. 2007
    ..The authors sought to determine whether hepatic steatosis is associated with hepatocellular carcinoma (HCC) in a cohort of patients with hepatitis C-related cirrhosis...
  41. pmc Relationships between cellular immune responses and treatment outcomes with interferon and ribavirin in HIV/hepatitis C virus co-infection
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    AIDS 20:345-51. 2006
    ..To test the hypothesis that hepatitis C virus (HCV)-specific interferon (IFN)gamma immune responses are correlated with HCV virological response following treatment in subjects with HIV-1 and HCV co-infection...
  42. ncbi request reprint Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery
    William A Faubion
    Division of Immunology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue RE 204, Boston, MA 02215, USA
    Gastroenterology 126:1759-70. 2004
    ..The aim of this study is to test the hypothesis that treatment of colitis restores thymic capability to generate regulatory T cells (CD4+25+ T(R) cells)...
  43. ncbi request reprint Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 122:134-44. 2002
    ..Tumor necrosis factor (TNF) induces multiple effects including cell proliferation and death by ligation with TNF receptor type II (TNFR2). We studied the role of TNFR2 in chronic inflammation-induced colonic epithelial alteration...
  44. ncbi request reprint I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion
    Marc Schmidt-Supprian
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 173:1612-9. 2004
    ..Finally, IKK2 is essential for homeostatic expansion of naive T cells, reflected by the inability of IKK2-deficient T cells to induce colitis in lymphopenic hosts...
  45. ncbi request reprint Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice
    Christoph Klein
    Division of Molecular Medicine and Pediatric Hematology Oncology, Howard Hughes Medical Institute, The Children s Hospital, Boston, MA, USA
    Blood 101:2159-66. 2003
    ..Our results provide proof of principle that the WAS-associated T-cell signaling defects can be improved upon transplantation of retrovirally transduced HSCs without overt toxicity and may encourage clinical gene therapy trials...
  46. doi request reprint Exacerbating role of gammadelta T cells in chronic colitis of T-cell receptor alpha mutant mice
    Masanobu Nanno
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    Gastroenterology 134:481-90. 2008
    ..Interestingly, there is a significant increase in gammadelta T cells in the inflamed mucosa of patients with ulcerative colitis (UC). However, the role of gammadelta T cells in chronic colitis has not been fully identified...
  47. ncbi request reprint Control freaks: immune regulatory cells
    Cathryn Nagler-Anderson
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 5:119-22. 2004
  48. ncbi request reprint Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C
    Alan Lee Rothman
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 41:617-25. 2005
    ....
  49. ncbi request reprint Essential role for Vav1 in activation, but not development, of gammadelta T cells
    Wojciech Swat
    The Center for Blood Research, Department of Pediatrics, The Children s Hospital, Boston, MA 02115, USA
    Int Immunol 15:215-21. 2003
    ..We propose that Vav1 has a unique and non-redundant role in the initiation of signaling downstream of the gammadelta TCR in lymphocytes...
  50. pmc CCR4-dependent regulatory T cell function in inflammatory bowel disease
    Qian Yuan
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 204:1327-34. 2007
    ..Our study demonstrates that CCR4 plays an important role in T reg cell trafficking in LNs and that this is critical for T reg cell suppressive function in vivo...
  51. pmc Antigen-specific immune responses and liver histology in HIV and hepatitis C coinfection
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    AIDS 19:767-73. 2005
    ..To test the hypothesis that antigen-specific interferon (IFN)gamma responses are correlated with milder liver disease in subjects coinfected with HIV-1 and hepatitis C virus (HCV)...
  52. ncbi request reprint Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis
    Ype P De Jong
    Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Int Immunol 16:205-13. 2004
    ....
  53. ncbi request reprint CD48 controls T-cell and antigen-presenting cell functions in experimental colitis
    Ana C Abadia-Molina
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 130:424-34. 2006
    ..Here we examine the effect of CD48 in the development of chronic experimental colitis and how CD48 affects adaptive and innate immune functions...
  54. pmc Impaired IgA class switching in APRIL-deficient mice
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:3903-8. 2004
    ..APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM(+)IgD(+) sorted B cells. These results suggest that APRIL down-regulates T cell-dependent antibody responses and promotes IgA class switching...
  55. ncbi request reprint In vivo generation of oligoclonal colitic CD4+ T-cell lines expressing a distinct T-cell receptor Vbeta
    Ana C Abadia-Molina
    Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Gastroenterology 128:1268-77. 2005
    ..Here we determined whether pathogenic T-cell clones could be derived by serial adoptive transfers into healthy tg epsilon26 recipients, starting with the population of CD4+ cells in the mesenteric lymph nodes of BM-->tg epsilon26 mice...

Research Grants1

  1. Inflammatory Bowel Disease in TCR-Mutant Mice
    Atul Bhan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] ..