Massachusetts Institute of Technology

Summary

Organization: Massachusetts Institute of Technology
Country: USA

Top Publications

  1. doi Synthesis of nanometre-thick MoO3 sheets
    Kourosh Kalantar-Zadeh
    Department of Chemistry, MIT, Cambridge, MA, USA
    Nanoscale 2:429-33. 2010
  2. pmc Probing the cancer genome
    Heidi Greulich
    Dana Farber Cancer Institute, Binney St, Boston, MA 02115, and Broad Institute of MIT and Harvard, Cambridge Center, Cambridge, MA 02142, USA
    Genome Biol 9:309. 2008
  3. doi Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 45:18-24. 2008
  4. ncbi Real-time development of patient-specific alarm algorithms for critical care
    Ying Zhang
    Harvard Medical School MIT Division of Health Sciences and Technology, MIT Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:4351-4. 2007
  5. ncbi YAP1 increases organ size and expands undifferentiated progenitor cells
    Fernando D Camargo
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 17:2054-60. 2007
  6. ncbi Subglottal coupling and its influence on vowel formants
    Xuemin Chi
    Speech Communication Group, RLE, MIT, Cambridge, Massachusetts 02139, USA
    J Acoust Soc Am 122:1735. 2007
  7. ncbi Focus detection from digital in-line holograms based on spectral l1 norms
    Weichang Li
    Applied Ocean Physics and Engineering Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    J Opt Soc Am A Opt Image Sci Vis 24:3054-62. 2007
  8. ncbi 2007 Elizabeth Winston Lanier Award Winner. Magnetic resonance imaging of cartilage glycosaminoglycan: basic principles, imaging technique, and clinical applications
    Martha L Gray
    Harvard MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
    J Orthop Res 26:281-91. 2008
  9. pmc Intravascular drug release kinetics dictate arterial drug deposition, retention, and distribution
    Brinda Balakrishnan
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Control Release 123:100-8. 2007
  10. pmc Estimation of the scattering coefficients of turbid media using angle-resolved optical frequency-domain imaging
    A E Desjardins
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Opt Lett 32:1560-2. 2007

Detail Information

Publications62

  1. doi Synthesis of nanometre-thick MoO3 sheets
    Kourosh Kalantar-Zadeh
    Department of Chemistry, MIT, Cambridge, MA, USA
    Nanoscale 2:429-33. 2010
    ..Atomic force microscopy (AFM) measurements show that the minimum resolvable thickness of these sheets is 1.4 nm which is equivalent to the thickness of two double-layers within one unit cell of the alpha-MoO(3) crystal...
  2. pmc Probing the cancer genome
    Heidi Greulich
    Dana Farber Cancer Institute, Binney St, Boston, MA 02115, and Broad Institute of MIT and Harvard, Cambridge Center, Cambridge, MA 02142, USA
    Genome Biol 9:309. 2008
  3. doi Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 45:18-24. 2008
    ..These results indicate that H. hepaticus urease activity plays a crucial role in hepatic disease but is not required for cecal colonization by H. hepaticus...
  4. ncbi Real-time development of patient-specific alarm algorithms for critical care
    Ying Zhang
    Harvard Medical School MIT Division of Health Sciences and Technology, MIT Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:4351-4. 2007
    ..99; these figures were 0.84, 0.98, 0.72, and 0.98 respectively for the classification trees. These results suggest that real-time development of patient-specific alarm algorithms is feasible using machine learning techniques...
  5. ncbi YAP1 increases organ size and expands undifferentiated progenitor cells
    Fernando D Camargo
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 17:2054-60. 2007
    ..Our data show that the Hippo signaling pathway regulates organ size in mammals and can act on stem cell compartments, indicating a potential link between stem/progenitor cells, organ size, and cancer...
  6. ncbi Subglottal coupling and its influence on vowel formants
    Xuemin Chi
    Speech Communication Group, RLE, MIT, Cambridge, Massachusetts 02139, USA
    J Acoust Soc Am 122:1735. 2007
    ..These coupling effects are found to be generally stronger for open-phase than for closed-phase measurements. The implications for a quantal relation between coupling effects near SubF2 and [back] are discussed...
  7. ncbi Focus detection from digital in-line holograms based on spectral l1 norms
    Weichang Li
    Applied Ocean Physics and Engineering Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    J Opt Soc Am A Opt Image Sci Vis 24:3054-62. 2007
    ..Focus-detection results from holograms of plankton are demonstrated that show the technique is both accurate and robust...
  8. ncbi 2007 Elizabeth Winston Lanier Award Winner. Magnetic resonance imaging of cartilage glycosaminoglycan: basic principles, imaging technique, and clinical applications
    Martha L Gray
    Harvard MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
    J Orthop Res 26:281-91. 2008
    ..This new technical capability offers the promises of speeding development of effective therapies and focusing their use in areas where they can be most successful...
  9. pmc Intravascular drug release kinetics dictate arterial drug deposition, retention, and distribution
    Brinda Balakrishnan
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Control Release 123:100-8. 2007
    ..We demonstrate the importance of drug release kinetics and administered drug dose in governing arterial drug uptake and suggest novel drug delivery strategies for controlling spatio-temporal arterial drug distribution...
  10. pmc Estimation of the scattering coefficients of turbid media using angle-resolved optical frequency-domain imaging
    A E Desjardins
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Opt Lett 32:1560-2. 2007
    ..Modeling speckle as a random phasor sum, the relationship between the measurement accuracy and the number of compounded angles is derived. The sensitivity analysis is validated with measurements from a tissue phantom...
  11. ncbi Dual modes of natural selection on upstream open reading frames
    Daniel E Neafsey
    Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Biol Evol 24:1744-51. 2007
    ..Our analysis suggests that uORFs are an important and underappreciated mechanism of post-transcriptional gene regulation in eukaryotes...
  12. pmc Multiscale 3-D shape representation and segmentation using spherical wavelets
    Delphine Nain
    College of Computing, Georgia Institute of Technology, Atlanta, GA 30332, USA
    IEEE Trans Med Imaging 26:598-618. 2007
    ..In the segmentation task, our validation shows our algorithm is computationally efficient and outperforms the Active Shape Model algorithm, by capturing finer shape details...
  13. ncbi On the structure of phoneme categories in listeners with cochlear implants
    Harlan Lane
    Massachusetts Institute of Technology, Cambridge, and Northeastern University, Boston, MA 02139, USA
    J Speech Lang Hear Res 50:2-14. 2007
    ..To describe cochlear implant users' phoneme labeling, discrimination, and prototypes for a vowel and a sibilant contrast, and to assess the effects of 1 year's experience with prosthetic hearing...
  14. ncbi A model of cerebrocerebello-spinomuscular interaction in the sagittal control of human walking
    Sungho Jo
    Department of Electrical Engineering and Computer Science, Computer Science and Artificial Intelligence Laboratory, Laboratory for Information and Decision Systems, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biol Cybern 96:279-307. 2007
    ..In particular, internal models of body dynamics are not required...
  15. pmc A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neurons
    Jason C Dugas
    Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305 5125
    J Neurosci 28:8294-305. 2008
    ....
  16. doi Transplanted neurons form both normal and ectopic projections in the adult brain
    Sanjay S P Magavi
    Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Dev Neurobiol 68:1527-37. 2008
    ..Understanding the signals regulating axonal extension in the adult brain will be necessary to harness stem cells or embryonic neurons for effective neuronal-replacement therapies...
  17. doi The many faces of tumor dormancy
    Robert A Weinberg
    Whitehead Institute for Biomedical Research, Ludwig Center for Molecular Oncology, Department of Biology, MIT, Cambridge, MA 02142, USA
    APMIS 116:548-51. 2008
  18. pmc Effects of reverberation on the directional sensitivity of auditory neurons across the tonotopic axis: influences of interaural time and level differences
    Sasha Devore
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 30:7826-37. 2010
    ..This result suggests that, at high frequencies, ILDs provide better directional information than envelope ITDs, emphasizing the importance of the ILD-processing pathway for sound localization in reverberation...
  19. doi Network diversity and economic development
    Nathan Eagle
    Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA
    Science 328:1029-31. 2010
    ..We find that the diversity of individuals' relationships is strongly correlated with the economic development of communities...
  20. doi Perspectives on carbon nanotubes and graphene Raman spectroscopy
    Mildred S Dresselhaus
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4037, USA
    Nano Lett 10:751-8. 2010
    ..Emphasis is given to the richness of both carbon nanostructures as prototype examples of nanostructured materials. A glimpse toward future developments in this field is presented...
  21. pmc A statistical model for multiphoton calcium imaging of the brain
    Wasim Q Malik
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:7002-5. 2009
    ..We apply this model to in vivo characterization of cells from the ferret visual cortex. The results demonstrate substantially improved tuning curve fitting and image contrast...
  22. pmc A high-throughput screening approach to discovering good forms of biologically inspired visual representation
    Nicolas Pinto
    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachussetts, USA
    PLoS Comput Biol 5:e1000579. 2009
    ....
  23. pmc Attention as inference: selection is probabilistic; responses are all-or-none samples
    Edward Vul
    Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Exp Psychol Gen 138:546-60. 2009
    ..The authors concluded that although people represent probability distributions, their discrete responses and conscious states are products of a process that samples from these probabilistic representations...
  24. doi The cross-cultural evidence on "extreme behaviors": what can it tell us?
    Jean E Jackson
    Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Ann N Y Acad Sci 1172:270-7. 2009
    ....
  25. doi From iron oxides to infections
    Dianne K Newman
    Departments of Biology and Earth and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Ave 68 380, Cambridge, MA 02139 4307, USA
    ChemSusChem 2:380-2. 2009
    ..Cellular electron transfer under diverse anaerobic conditions is a primary topic of research conducted by the Newman group. In this Viewpoint, a summary is given of how a geobiological approach has been used to investigate these processes...
  26. pmc Accurate sound localization in reverberant environments is mediated by robust encoding of spatial cues in the auditory midbrain
    Sasha Devore
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Neuron 62:123-34. 2009
    ....
  27. ncbi A comparison of gap-detection thresholds through audition and touch in listeners with real and simulated hearing impairment
    Charlotte M Reed
    Res Lab of Electron, Massachusetts Inst of Technol, 77 Massachusetts Ave, Cambridge, MA 02139
    J Acoust Soc Am 125:2722. 2009
    ..Work supported by NIH-NIDCD R01 DC00117.]...
  28. doi Validation of a novel catheter guiding method for the ablative therapy of ventricular tachycardia in a phantom model
    Maya E Barley
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    IEEE Trans Biomed Eng 56:907-10. 2009
    ..These results suggest that ISGA has potential to provide accurate and efficient guidance for RFA procedures in the patient population with hemodynamically unstable arrhythmias...
  29. doi Where is it heading? Single-particle tracking of single-walled carbon nanotubes
    Michael S Strano
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    ACS Nano 2:1749-52. 2008
    ..The ability to track and to analyze single molecules in this way may lead to new technologies that utilize as their platform a single, freely diffusing nanotube...
  30. pmc Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice
    S E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1027-32. 2009
    ..Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis...
  31. pmc The persistence of American Indian health disparities
    David S Jones
    Center for the Study of Diversity in Science, Technology, and Medicine, Massachusetts Institute of Technology 02139, USA
    Am J Public Health 96:2122-34. 2006
    ..Understanding how these economic and political forces have operated historically can explain both the persistence of the health disparities and the controversies that surround them...
  32. ncbi Enterohepatic Helicobacter species isolated from the ileum, liver and colon of a baboon with pancreatic islet amyloidosis
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Med Microbiol 55:1591-5. 2006
    ..To the best of the authors' knowledge, this is the first report describing the isolation of enterohepatic Helicobacter species from a baboon...
  33. ncbi Leukocyte recruitment and expression of chemokines following different forms of vascular injury
    Frederick G P Welt
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Vasc Med 8:1-7. 2003
    ..Conclusions: In contrast to balloon injury, stent-induced injury results in sustained chemokine expression and leukocyte recruitment. These data may have important implications for antirestenotic strategies...
  34. ncbi Source motion mitigation for adaptive matched field processing
    Lisa M Zurk
    MIT Lincoln Laboratory, 244 Wood Street, Lexington, Massachusetts 02420, USA
    J Acoust Soc Am 113:2719-31. 2003
    ..Application of the techniques in some cases proves to be the difference between detecting and not detecting the target...
  35. ncbi Thinking about John T. Edsall
    Alexander Rich
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Biophys Chem 100:99-103. 2003
  36. pmc Multiple routes to memory: distinct medial temporal lobe processes build item and source memories
    Lila Davachi
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:2157-62. 2003
    ..These outcomes suggest that the subregions within the medial temporal lobe subserve distinct, but complementary, learning mechanisms...
  37. ncbi Characterizing arterial plaque with optical coherence tomography
    Mark Brezinski
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Curr Opin Cardiol 17:648-55. 2002
    ..014 inches. Fourth, OCT systems are compact and portable. Finally, it can be combined with a range of spectroscopic techniques. This article reviews the application of OCT to intracoronary imaging...
  38. ncbi Postsynaptic signaling and plasticity mechanisms
    Morgan Sheng
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 298:776-80. 2002
    ..The complex molecular mechanisms that underlie postsynaptic signaling and plasticity are beginning to emerge...
  39. pmc Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
    R S Wildin
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Mailcode MP350, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    J Med Genet 39:537-45. 2002
    ..Remission has been observed with bone marrow transplantation despite incomplete engraftment, but the long term outcome is uncertain...
  40. ncbi Modified cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone therapy for posttransplantation lymphoproliferative disease in pediatric patients undergoing solid organ transplantation
    K Suryanarayan
    Department of Pediatrics, Stanford University School of Medicine, California, USA
    J Pediatr Hematol Oncol 23:452-5. 2001
    ....
  41. ncbi Mechanisms of viral membrane fusion and its inhibition
    D M Eckert
    Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, M I T, Cambridge, Massachusetts 02142, USA
    Annu Rev Biochem 70:777-810. 2001
    ..This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible...
  42. ncbi Infants' knowledge about occlusion and containment events: a surprising discrepancy
    S J Hespos
    Department of Brain and Cognitive Sciences, M I T NE20 423, Cambridge, MA 02139, USA
    Psychol Sci 12:141-7. 2001
    ..5 months of age. The marked discrepancy in infants' reasoning about height in occlusion and containment events suggests that infants sort events into distinct categories, and acquire separate rules for each category...
  43. pmc Functional requirement for class I MHC in CNS development and plasticity
    G S Huh
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Science 290:2155-9. 2000
    ..These results demonstrate an important role for these molecules in the activity-dependent remodeling and plasticity of connections in the developing and mature mammalian central nervous system (CNS)...
  44. ncbi Odorant receptors: axon contact-mediated diversity
    A Chess
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 10:R152-4. 2000
    ..An intriguing recent example is the axon contact-mediated asymmetry in expression of the str-2 odorant receptor gene...
  45. ncbi A 47-amino-acid fragment of SV40 T antigen represses transcription from human GSTalpha promoters
    L Sompayrac
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, 80309, USA
    Virology 249:275-85. 1998
    ..We show, however, that this fragment does bind to three cellular proteins with approximate molecular weights of 54, 59, and 94 kDa...
  46. ncbi Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice
    Haim D Danenberg
    Harvard MIT Division of Health Sciences and Technology, Cambridge, Mass 02139, USA
    Circulation 108:512-5. 2003
    ..To determine whether CRP directly modulates vascular cell function in vivo, we subjected wild-type mice, which do not express CRP, and human CRP-transgenic (CRPtg) mice to 2 models of arterial injury...
  47. ncbi Quantitative assessment strategies and issues for mood and other psychiatric serial study data
    Steven M Pincus
    990 Moose Hill Road, Guilford, CT 06437, USA
    Bipolar Disord 5:287-94. 2003
  48. ncbi Asymmetric enzymatic oxidoreductions in organic solvents
    Alexander M Klibanov
    Department of Chemistry and Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Biotechnol 14:427-31. 2003
    ..Consequently, novel synthetic and biotechnological opportunities ensue, as illustrated herein by those based on enzymatic oxidoreductions such as the asymmetric peroxidase-catalyzed sulfoxidation of organic sulfides...
  49. pmc Modeling somatic evolution in tumorigenesis
    Sabrina L Spencer
    Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Comput Biol 2:e108. 2006
    ..The model offers insight into how the sequence of acquired mutations affects the timing and cellular makeup of the resulting tumor and how the cellular-level population dynamics drive neoplastic evolution...
  50. ncbi Comparing white matter lesions on T2 and FLAIR MRI in the Sydney Older Persons Study
    O Piguet
    Centre for Education and Research on Ageing at Concord Hospital, Department of Medicine, The University of Sydney, Sydney, NSW, Australia
    Eur J Neurol 12:399-402. 2005
    ..Absence of FLAIR does not preclude the identification of WML in this population. These findings have clinical and epidemiological relevance where the acquisition of supplementary MRI data may not always be possible...
  51. ncbi Envelope-onset asynchrony as a cue to voicing in initial english consonants
    Hanfeng Yuan
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Acoust Soc Am 116:3156-67. 2004
    ..This cue, which is simply derived in real-time, has applications to the design of sensory aids for persons with profound hearing impairments (e.g., as a supplement to lipreading), as well as to automatic speech recognition...
  52. pmc A fast global fitting algorithm for fluorescence lifetime imaging microscopy based on image segmentation
    S Pelet
    Department of Mechanical Engineering and Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 87:2807-17. 2004
    ..On our experimental measurement, this algorithm increased convergence speed by over two orders of magnitude and achieved significantly better fits...
  53. ncbi Analysis of compartmental models of ligand-induced endocytosis
    Abraham R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA, USA
    J Theor Biol 229:127-38. 2004
    ..This analysis also provides insight on the fast endocytosis and recycling limit of protocol III...
  54. pmc Master of all things phosphorylated
    Michael B Yaffe
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18 580, Cambridge, MA 02139, USA
    Biochem J 379:e1-2. 2004
    ..This study paves the way for future work on these important 14-3-3-interacting proteins...
  55. ncbi Designing materials for biology and medicine
    Robert Langer
    Department of Chemical Engineering, Massachusetts Institute of Technology, Building E25 342, Cambridge, Massachusetts 02139, USA
    Nature 428:487-92. 2004
    ..These include synthetic replacements for biological tissues, designing materials for specific medical applications, and materials for new applications such as diagnostics and array technologies...
  56. ncbi Local structural balance and functional interaction of excitatory and inhibitory synapses in hippocampal dendrites
    Guosong Liu
    Picower Centre for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 7:373-9. 2004
    ..These fundamental relationships among E/I synapses provide organizational principles relevant to deciphering the structural and functional basis for neural computation within dendritic branches...
  57. ncbi Cortical inhibitory circuits in eye-movement generation
    Peter H Schiller
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Eur J Neurosci 18:3127-33. 2003
    ..Inhibitory circuits in the LIP do not appear to play a central role in target selection and in visual discrimination...
  58. ncbi Michaelis-Menten kinetics at high enzyme concentrations
    A R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA 02139, USA
    Bull Math Biol 65:1111-29. 2003
    ..These approximations overlap and extend the domains of validity of the standard and reverse quasi-steady state approximations...
  59. pmc Dynamic structures in Escherichia coli: spontaneous formation of MinE rings and MinD polar zones
    Kerwyn Casey Huang
    Department of Physics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 12 111, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:12724-8. 2003
    ..Recent discoveries suggest that protein oscillations may play a general role in proper chromosome and plasmid partitioning...
  60. ncbi MicroRNAs and cancer
    Michael T McManus
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, Cambridge, MA 02139, USA
    Semin Cancer Biol 13:253-8. 2003
    ..Recent data suggests that a special class of ncRNAs called microRNAs might be involved in human disease. This review proposes a role for microRNAs in oncogenesis...
  61. ncbi Who can be an expert in anesthesia malpractice suits? A case of general anesthesia, cardiopulmonary risk, and patient death
    Bryan A Liang
    Health Law and Policy Institute, University of Houston Law Center, Houston, TX 77204 6060, USA
    J Clin Anesth 15:395-7. 2003
  62. ncbi Facing death in the fly: genetic analysis of apoptosis in Drosophila
    K McCall
    Howard Hughes Medical Institute, Cambridge, MA, USA
    Trends Genet 13:222-6. 1997
    ....

Research Grants62

  1. THERMODYNAMICS OF BIOCHEMICAL SYSTEMS
    ROBERT ALBERTY; Fiscal Year: 2005
    ..This quantitative treatment of the literature data on biochemical reactions will uncover errors because deltafG'0 values can be determined by use of two or more biochemical reactions, which should give the same answer. ..
  2. THERMODYNAMICS OF BIOCHEMICAL SYSTEMS
    ROBERT ALBERTY; Fiscal Year: 2001
    ..Another objective is to use new concepts in biochemical thermodynamics to investigate coupling of reactions by enzymes, missing reactions in systems like glycolysis, muscle, and chemosmotic theory. ..
  3. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  4. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  5. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2004
    ....
  6. HELIOBACTER INDUCED HEPATITIS AND TUMORIGENESIS
    James Fox; Fiscal Year: 2003
    ..hepaticus at different stages of infection. ..
  7. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2007
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  8. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  9. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2007
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. ..
  10. BIOMEDICAL RESEARCH TRAINING FOR VETERINARY SCIENTISTS
    James Fox; Fiscal Year: 2007
    b>Massachusetts Institute of Technology provides a superb intellectual environment for the comparative veterinary scientist embarking on a career in biomedical research...
  11. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  12. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 1999
    ..Thirdly, the choice of virulence factors ot be tested in vivo will in part be determined by in vitro assays as well as screening H. pylori isogenic mutants in a mouse model, recently developed in our laboratory. ..
  13. NEURAL CONTROL OF VISUALLY GUIDED EYE MOVEMENTS
    Peter Schiller; Fiscal Year: 2007
    ..abstract_text> ..
  14. STUDIES OF INTERACTION BETWEEN EYE MOVEMENT AND VISION
    Peter Schiller; Fiscal Year: 1980
    ....