Maine Medical Center

Summary

Organization: Maine Medical Center
Country: USA

Top Publications

  1. pmc Two novel human NUMB isoforms provide a potential link between development and cancer
    Aldona Karaczyn
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Neural Dev 5:31. 2010
  2. pmc Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD
    Luis F Ramos
    Division of Nephrology and Renal Transplantation and Clinical and Translational Research, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102
    J Am Soc Nephrol 19:593-9. 2008
  3. ncbi Percutaneous thrombin injection of a femoral artery pseudoaneurysm with simultaneous venous balloon occlusion of a communicating arteriovenous fistula
    Derek Mittleider
    Department of Radiology, Maine Medical Center, 22 Bramhall Street, Portland, Maine 04102, USA
    Cardiovasc Intervent Radiol 31:S115-9. 2008
  4. ncbi Continuous renal replacement therapy in the treatment of acute renal failure: critical assessment is required
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 2:385-9. 2007
  5. ncbi Chronic kidney disease and the public health: gaps in evidence from interventional trials
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    JAMA 297:2630-3. 2007
  6. ncbi Cost, quality, and value: the changing political economy of dialysis care
    Jonathan Himmelfarb
    Maine Medical Center, Division of Nephrology, Portland, ME 04102, USA
    J Am Soc Nephrol 18:2021-7. 2007
  7. ncbi Rural communities improving quality through collaboration: the MaineHealth story
    Lisa M Letourneau
    MaineHealth, USA
    J Healthc Qual 28:15-27. 2006
  8. ncbi Absent infrarenal inferior vena cava: an unusual cause of pelvic varices
    Joseph R Wax
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine, USA
    J Ultrasound Med 26:699-701. 2007
  9. ncbi Physiological effects of nonthyroidal illness syndrome in patients after cardiac surgery
    D I Spratt
    Division of Reproductive Endocrinology, Department of Ob Gyn, Maine Medical Center, Portland, ME 04102, USA
    Am J Physiol Endocrinol Metab 293:E310-5. 2007
  10. ncbi Prenatal sonographic diagnosis of meconium periorchitis
    Joseph R Wax
    Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME, USA
    J Ultrasound Med 26:415-7. 2007

Detail Information

Publications62

  1. pmc Two novel human NUMB isoforms provide a potential link between development and cancer
    Aldona Karaczyn
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Neural Dev 5:31. 2010
    ..Together, these novel isoforms may play a role in further understanding the NUMB function in development and cancer...
  2. pmc Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD
    Luis F Ramos
    Division of Nephrology and Renal Transplantation and Clinical and Translational Research, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102
    J Am Soc Nephrol 19:593-9. 2008
    ..Interventions focused on weight loss may decrease the inflammatory and oxidative burden in CKD, which may ultimately attenuate cardiovascular risk in this population...
  3. ncbi Percutaneous thrombin injection of a femoral artery pseudoaneurysm with simultaneous venous balloon occlusion of a communicating arteriovenous fistula
    Derek Mittleider
    Department of Radiology, Maine Medical Center, 22 Bramhall Street, Portland, Maine 04102, USA
    Cardiovasc Intervent Radiol 31:S115-9. 2008
    ..There was complete thrombosis of the PSA and AVF...
  4. ncbi Continuous renal replacement therapy in the treatment of acute renal failure: critical assessment is required
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 2:385-9. 2007
    ..When examining the totality of evidence from recent observational studies and clinical trials, there is no convincing evidence to support superiority of CRRT over IHD in the treatment of critically ill patients with ARF...
  5. ncbi Chronic kidney disease and the public health: gaps in evidence from interventional trials
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    JAMA 297:2630-3. 2007
  6. ncbi Cost, quality, and value: the changing political economy of dialysis care
    Jonathan Himmelfarb
    Maine Medical Center, Division of Nephrology, Portland, ME 04102, USA
    J Am Soc Nephrol 18:2021-7. 2007
  7. ncbi Rural communities improving quality through collaboration: the MaineHealth story
    Lisa M Letourneau
    MaineHealth, USA
    J Healthc Qual 28:15-27. 2006
    ..This collaborative approach provided an effective way to achieve improved outcomes across a geographically and structurally diverse system, and it can help influence improvement efforts in other small and medium-sized rural communities...
  8. ncbi Absent infrarenal inferior vena cava: an unusual cause of pelvic varices
    Joseph R Wax
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine, USA
    J Ultrasound Med 26:699-701. 2007
  9. ncbi Physiological effects of nonthyroidal illness syndrome in patients after cardiac surgery
    D I Spratt
    Division of Reproductive Endocrinology, Department of Ob Gyn, Maine Medical Center, Portland, ME 04102, USA
    Am J Physiol Endocrinol Metab 293:E310-5. 2007
    ....
  10. ncbi Prenatal sonographic diagnosis of meconium periorchitis
    Joseph R Wax
    Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME, USA
    J Ultrasound Med 26:415-7. 2007
  11. ncbi Continuous dialysis is not superior to intermittent dialysis in acute kidney injury of the critically ill patient
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation at Maine Medical Center, Portland, ME 04102, USA
    Nat Clin Pract Nephrol 3:120-1. 2007
  12. ncbi Picture of the month. Nutritional rickets
    Jennifer A Jewell
    The Barbara Bush Children s Hospital, Portland, Me Dartmouth Medical School, Hanover, NH, USA
    Arch Pediatr Adolesc Med 160:983-5. 2006
  13. ncbi Pain associated with transabdominal chorionic villus sampling--anticipated versus actual
    Joseph R Wax
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine 04102, USA
    J Matern Fetal Neonatal Med 19:421-3. 2006
    ..To assess anticipated and perceived pain associated with transabdominal chorionic villus sampling (TA CVS)...
  14. ncbi External peer review quality assurance testing in von Willebrand disease: the recent experience of the United States College of American Pathologists proficiency testing program
    Timothy E Hayes
    Department of Pathology and Laboratory Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Semin Thromb Hemost 32:499-504. 2006
    ..3 to 30.9%). The reference materials used in the standard curves for immunoturbidometric vWF:Ag assays appear to have accurately assigned vWF values for the majority of commercial suppliers...
  15. doi Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells
    Diana Romero
    Instituto de Investigaciones Biomedicas Alberto Sols, Arturo Duperier 4, 28029 Madrid, Spain
    Carcinogenesis 29:1070-6. 2008
    ..These findings provide evidence for a cross talk between Smad4 and the Wnt/beta-catenin pathway in pancreatic carcinoma cells, suggesting a new role for Smad4 as an attenuator of beta-catenin proteasomal degradation...
  16. doi Pregnancy following gastric bypass surgery for morbid obesity: maternal and neonatal outcomes
    Joseph R Wax
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME, USA
    Obes Surg 18:540-4. 2008
    ..The purpose of this study was to compare obstetric and neonatal outcomes after Roux-en-Y gastric bypass (RYGB) to those in women without such surgery...
  17. doi Antimicrobial stewardship: concepts and strategies in the 21st century
    Robert C Owens
    Department of Clinical Pharmacy Services, Maine Medical Center, Portland, ME 04102, USA
    Diagn Microbiol Infect Dis 61:110-28. 2008
    ..The components of an effective ASP are described in depth, drawing examples from the literature, as well as from the author's personal experience at the Maine Medical Center, Portland, ME.
  18. doi Approach to the diagnosis and treatment of vulvar pain
    Claire S Danby
    Department of Obstetrics and Gynecology, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    Dermatol Ther 23:485-504. 2010
    ..It outlines the wide range of etiologies for vulvar pain, and provides details of the most vexing in a comprehensive look at vulvodynia, including definition, theory, diagnosis, and therapy...
  19. doi Biophysical and biochemical screening for the risk of preterm labor
    Joseph R Wax
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME, USA
    Clin Lab Med 30:693-707. 2010
    ..Together, cervical length and fibronectin can be used in the triaging of women symptomatic for preterm labor...
  20. pmc The coordination of primary and oncology specialty care at the end of life
    Paul K J Han
    MA, Center for Outcomes Research and Evaluation, Maine Medical Center, 39 Forest Ave, Portland, ME 04101, USA
    J Natl Cancer Inst Monogr 2010:31-7. 2010
    ..However, more work needs to be done to corroborate these findings, and many unanswered questions remain...
  21. doi The bispectral index and suppression ratio are very early predictors of neurological outcome during therapeutic hypothermia after cardiac arrest
    David B Seder
    Neuroscience Institute, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    Intensive Care Med 36:281-8. 2010
    ..To evaluate the bispectral index (BIS) and suppression ratio (SR) as very early predictors of neurological outcome during therapeutic hypothermia after cardiac arrest...
  22. doi Benign skin lesions: lipomas, epidermal inclusion cysts, muscle and nerve biopsies
    Kartik A Pandya
    Department of Surgery, Maine Medical Center, Maine Surgical Care Group, 22 Bramhall Street, Portland, ME 04102, USA
    Surg Clin North Am 89:677-87. 2009
    ..Although the procedures are straightforward, there are important technical issues to assist in getting the best specimen to avoid confounding disease diagnosis...
  23. doi Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis
    Clifford J Rosen
    Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Am J Med 122:409-14. 2009
    ..This article explores these relationships in the context of a new paradigm with implications for obesity and osteoporosis...
  24. ncbi Therapeutic hypothermia for cardiac arrest: a practical approach
    David B Seder
    David B Seder, MD Maine Medical Center, Division of Pulmonary and Critical Care Medicine, 22 Bramhall Street, Portland, ME 04102, USA
    Curr Treat Options Neurol 11:137-49. 2009
    ....
  25. doi Performance of endotracheal intubation and rescue techniques by emergency services personnel in an air medical service
    Carl A Germann
    Department of Emergency Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Prehosp Emerg Care 13:44-9. 2009
    ..Previous researchers have reported intubation success rates of 66% to 97% in the air medical setting...
  26. pmc Diagnostic-therapeutic cascade revisited: coronary angiography, coronary artery bypass graft surgery, and percutaneous coronary intervention in the modern era
    F L Lucas
    Center for Outcomes Research and Evaluation, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    Circulation 118:2797-802. 2008
    ..We assessed the relationship between coronary angiography and coronary artery revascularization by procedure type (coronary artery bypass graft surgery or percutaneous coronary intervention)...
  27. doi Altered nonrenal drug clearance in ESRD
    Thomas D Nolin
    Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, Portland, ME 04102, USA
    Curr Opin Nephrol Hypertens 17:555-9. 2008
    ..The present review summarizes these studies and critically assesses the proposed mechanisms and clinical implications of altered nonrenal clearance in ESRD...
  28. pmc An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney
    Ulrika Blank
    Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    BMC Dev Biol 8:86. 2008
    ..In this study, we generate a transgenic reporter for organogenesis studies that we use to define BMP pathway activation in the developing kidney...
  29. doi Resistant hypertension: Core Curriculum 2008
    Mark G Parker
    Division of Nephrology, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    Am J Kidney Dis 52:796-802. 2008
  30. doi The partnership care delivery model: an examination of the core concept and the need for a new model of care
    Marjorie Splaine Wiggins
    Maine Medical Center, Portland, ME, USA
    J Nurs Manag 16:629-38. 2008
    ..This article describes the foundation of an emerging care delivery model based on partnership. It also reflects on and synthesizes the findings of earlier concept analyses of its core concept...
  31. ncbi Erythropoietin-dependent erythropoiesis: New insights and questions
    Don M Wojchowski
    Maine Medical Center Research Institute and Program in Stem Cell Biology and Regenerative Medicine, ME 04074 7205, USA
    Blood Cells Mol Dis 36:232-8. 2006
    ..Ways in which these studies advance an understanding of core Epo signal transduction events are outlined. Also introduced are two new putative negative regulators of Epo-dependent erythropoiesis, DYRK3 and DAPK2 kinases...
  32. ncbi Clostridium difficile-associated disease: an emerging threat to patient safety: insights from the Society of Infectious Diseases Pharmacists
    Robert C Owens
    Antimicrobial Stewardship Program, Departments of Pharmacy Services and Infectious Diseases, Maine Medical Center, Portland, Maine 04102, USA
    Pharmacotherapy 26:299-311. 2006
    ..difficile-associated disease. Efforts to combat BI/NAP1 should include good antimicrobial stewardship in addition to effective infection control and environmental intervention...
  33. ncbi Laparoscopic resection of large adrenal tumors
    Dougald C MacGillivray
    Department of Surgery, Division of Surgical Oncology, Maine Medical Center, Portland, ME 04104, USA
    Ann Surg Oncol 9:480-5. 2002
    ..We report our experience with laparoscopic adrenalectomy in patients with adrenal tumors of > or =6 cm compared with patients with smaller tumors...
  34. ncbi Torsades de pointes associated with fluoroquinolones
    Robert C Owens
    Department of Clinical Pharmacy, Maine Medical Center, Portland 04102, USA
    Pharmacotherapy 22:663-8; discussion 668-72. 2002
    ..For moxifloxacin, levofloxacin, and gatifloxacin, the point must be clear that these agents should not be used in patients with risk factors predisposing them to TdP...
  35. ncbi Nonbilharzial bladder carcinoma complicating pregnancy: review of the literature
    Joseph R Wax
    Maine Medical Center, Portland, Maine, USA
    Obstet Gynecol Surv 57:236-44. 2002
    ..Routine ultrasound evaluation of the bladder in these patients may improve the diagnostic yield. Pregnancy is not a contraindication to treating most forms of bladder cancer...
  36. ncbi Growth hormone stimulation testing with oral clonidine: 90 minutes is the preferred duration for the assessment of growth hormone reserve
    A H Morris
    Department of Pediatrics, Barbara Bush Children s Hospital, Portland, Maine, USA
    J Pediatr Endocrinol Metab 14:1657-60. 2001
    ..It is therefore concluded that serial GH sampling to 90 min is the preferred duration when screening for GH deficiency with clonidine...
  37. ncbi Documented arterial gas embolism after spinal epidural injection
    C A MacLean
    Department of Emergency Medicine, Maine Medical Center, Portland, ME 04102, USA
    Ann Emerg Med 38:592-5. 2001
    ..Emergency physicians should consider and rapidly diagnose this rare but potentially fatal complication of spinal epidural puncture...
  38. ncbi Interpersonal influence in family systems: a social relations model analysis
    W L Cook
    Department of Psychiatry, Maine Medical Center, Portland 04102, USA
    Child Dev 72:1179-97. 2001
    ..A pattern in which parents compensate for each other's influenceability was also found. It is recommended that these findings be replicated using observational data that have been sequentially analyzed...
  39. ncbi Herbal medicines for children: an illusion of safety?
    A J Tomassoni
    Maine Poison Center, Portland, Maine, USA
    Curr Opin Pediatr 13:162-9. 2001
    ..The authors propose a risk reduction approach in which physicians actively seek information about the use of complementary or alternative medicine while taking medical histories...
  40. ncbi Employment outcomes in family-aided assertive community treatment
    W R McFarlane
    Maine Medical Center, Portland, USA
    Am J Orthopsychiatry 70:203-14. 2000
    ..No evidence was found that competitive work presented a significant risk for relapse...
  41. ncbi Understanding attachment security in family context
    W L Cook
    Department of Psychiatry, Maine Medical Center, Portland 04102 3175, USA
    J Pers Soc Psychol 78:285-94. 2000
    ..The author concludes that internal working models of relationships may not be so "internal" after all and that greater emphasis on the interpersonal sources of adult attachment security is warranted...
  42. ncbi Variation in the use of echocardiography
    F L Lucas
    Maine Medical Center, Portland, USA
    Eff Clin Pract 2:71-5. 1999
    ..However, little is known about variation in rates of noninvasive testing for cardiovascular disease. Echocardiography is the second most common cardiac diagnostic procedure...
  43. ncbi Pancreatic stones: treat or ignore?
    D A Howell
    Portland Gastroenterology Associates, Portland, Maine 04102 3214, USA
    Can J Gastroenterol 13:461-5. 1999
    ..Finally, it must be recognized that chronic pancreatitis is an ongoing disease that does not have a simple treatment or cure, and frequently represents a process of remissions and relapses requiring interventions and problem solving...
  44. ncbi The NF-kappaB and IkappaB system in injured arteries
    V Lindner
    Center for Molecular Medicine, Maine Medical Center Research Institute, South Portland, ME 04106, USA
    Pathobiology 66:311-20. 1998
    ..These findings link the activation of NF-kappaB to the inflammatory response and to intimal lesion formation following vascular injury...
  45. ncbi Elevated plasma glycocalicin levels and decreased ristocetin-induced platelet agglutination in hemodialysis patients
    J Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland 04102, USA
    Am J Kidney Dis 32:132-8. 1998
    ....
  46. ncbi Sharing of a single picture archiving and communications system among disparate institutions: barriers to success
    Matthew D Ralston
    Radiology Department, Maine Medical Center, Portland, USA
    J Digit Imaging 15:3-6. 2002
    ..In our own effort to share the Maine Medical Center PACS with other providers, we have found that the micro issues are just as important, including trust, ..
  47. ncbi Safety, tolerability, and efficacy of iontophoresis with lidocaine for dermal anesthesia in ED pediatric patients
    Alyce A Schultz
    Emergency Department, Maine Medical Center, Portland, ME 04102, USA
    J Emerg Nurs 28:289-96. 2002
    ....
  48. ncbi Underuse of analgesia in very young pediatric patients with isolated painful injuries
    John Alexander
    Department of Emergency Medicine, Maine Medical Center, Portland, ME 04102, USA
    Ann Emerg Med 41:617-22. 2003
    ..We sought to compare the use of analgesic agents in very young children with that in older children with isolated painful injuries...
  49. ncbi Customer disservice?
    James L Glazer
    Maine Medical Center, Portland, Maine 04101, USA
    Ann Intern Med 144:61-2; discussion 62. 2006
  50. ncbi Use and effectiveness of tobacco telephone counseling and nicotine therapy in Maine
    Susan H Swartz
    Center for Tobacco Independence, Maine Medical Center, Portland, Maine 04102 3175, USA
    Am J Prev Med 29:288-94. 2005
    ..This study examined the utilization of treatment services, evaluated quit outcomes, and estimated the population impact of treatment...
  51. ncbi Comparison of neutrophil CD64 expression, manual myeloid immaturity counts, and automated hematology analyzer flags as indicators of infection or sepsis
    Bruce H Davis
    Trillium Diagnostics, LLC, Scarborough, Maine, USA
    Lab Hematol 11:137-47. 2005
    ....
  52. ncbi Suspected opioid-related emergency medical services encounters in a rural state, 1997-2002
    John L Alexander
    Department of Emergency Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Prehosp Emerg Care 8:427-30. 2004
    ..News organizations and governmental agencies have reported substantial increases in the number of opioid-related overdose cases in recent years...
  53. ncbi Human monocyte CD163 expression inversely correlates with soluble CD163 plasma levels
    Bruce H Davis
    Maine Medical Center Research Institute, Scarborough, Maine, USA
    Cytometry B Clin Cytom 63:16-22. 2005
    ..CD163 is shed from the cell surface and exists as a soluble form in plasma (sCD163). Monocyte CD163 and sCD163 are potential diagnostic tools in variety of disease states...
  54. ncbi Impaired monocyte cytokine production in critically ill patients with acute renal failure
    Jonathan Himmelfarb
    Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 66:2354-60. 2004
    ..Anti-inflammatory strategies are postulated to be beneficial in treatment. However, there are few studies simultaneously examining monocyte cytokine production and plasma cytokine levels in patients with ARF...
  55. ncbi Patient choice cesarean: an evidence-based review
    Joseph R Wax
    Maine Medical Center, Portland, USA
    Obstet Gynecol Surv 59:601-16. 2004
    ..Moreover, comprehensive economic impact assessments of cesarean on request are lacking, and professional organizations do not agree on the ethics of offering patient choice cesarean...
  56. ncbi Role of research in reconstructing global healthcare for the 21st century
    Alyce A Schultz
    Department of Nursing, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    Nurs Adm Q 28:133-43. 2004
    ..Clinical nursing scholars who are the expert care providers must be involved in the conduct and application of research if any reconstruction of global healthcare is to succeed...
  57. ncbi The risks of underwater birth
    Michael G Pinette
    Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME 04102, USA
    Am J Obstet Gynecol 190:1211-5. 2004
    ..We performed a retrospective review of the literature on the complications that could be associated potentially with water birth...
  58. pmc Using claims data to examine patients using practice-based Internet communication: is there a clinical digital divide?
    Susan H Swartz
    Center for Outcomes Research and Evaluation, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    J Med Internet Res 6:e1. 2004
    ..While such online tools also bring great promise for educating patients with the goal of fostering behavior change, it is important to examine how individuals currently using such services differ from those who do not...
  59. ncbi Combined sonographic and biochemical markers for Down syndrome screening
    Michael G Pinette
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine, USA
    J Ultrasound Med 22:1185-90. 2003
    ..To evaluate the efficacy of fetal nuchal fold thickness and proximal long bone biometric measurements in modifying Down syndrome serum screening risk in a population of women referred for second-trimester sonography...
  60. ncbi Culture-based group B streptococcal screening. Adherence to current guidelines
    Michael G Pinette
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME 04102, USA
    J Reprod Med 48:309-12. 2003
    ..To examine the ability of a universal screening strategy to identify and treat group B Streptococcus-positive women with intrapartum antibiotics...
  61. ncbi Trauma system evaluation using the fatality analysis reporting system
    David E Clark
    Department of Surgery, Maine Medical Center, Portland, USA
    J Trauma 54:1199-204; discussion 1204. 2003
    ..At least three prior studies have used declining mortality rates derived from FARS as evidence of regional trauma system effectiveness...
  62. pmc Altered wound healing in mice lacking a functional osteopontin gene (spp1)
    L Liaw
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 101:1468-78. 1998
    ..These data indicate a role for OPN in tissue remodeling in vivo, and suggest physiological functions during matrix reorganization after injury...

Research Grants62

  1. Continuation of Dialysis Access Consortium Clinical Trials
    Jonathan Himmelfarb; Fiscal Year: 2007
    ..The health care cost o maintaining adequate vascular access should also decrease from its current rate of over one billion dollars per year. ..
  2. Evaluating Hospital Outcomes for Injured Patients
    David Clark; Fiscal Year: 2007
    ..This project is designed to produce a credible and verifiable data management structure and analytic methodology that can be used for the continuing evaluation of trauma care by the ACS, AHRQ, and others. ..
  3. Trauma System Evaluation with Survival Time Models
    David E Clark; Fiscal Year: 2010
    ..This will enable us to distinguish between the impact of level of trauma system development and other factors affecting the disparity in rural and urban trauma mortality. ..
  4. Trauma System Evaluation with Survival Time Models
    David Clark; Fiscal Year: 2009
    ..This will enable us to distinguish between the impact of level of trauma system development and other factors affecting the disparity in rural and urban trauma mortality. ..
  5. New Cardiac Surgery Programs: Patients, Outcomes, Access
    FRANCES LUCAS; Fiscal Year: 2007
    ..of existing procedures or result in an overall increase in the population-based rates of care, including CABG and total revascularization (either CABG or percutaneous coronary interventions) as additional capacity is brought online? ..
  6. MOUSE MODELS TO DELINEATE A UNIQUE METABOLIC AND SKELETAL NETWORK
    CLIFFORD JAMES ROSEN; Fiscal Year: 2010
    ..More importantly, this work could lead to a sea change in our general approach to identifying osteoporosis genes in mice and humans. ..
  7. Neutrophil CD64 Assay for Human Sepsis and Infection
    Bruce Davis; Fiscal Year: 2005
    ..abstract_text> ..
  8. Psychosis: Early Detection, Intervention and Prevention
    William McFarlane; Fiscal Year: 2007
    ..It will allow the analysis of key social factors contributing to psychosis and their interaction with the treatment conditions and each other. ..
  9. GENETIC REGULATION OF IGF-I IN PEAK BONE DENSITY OF MICE
    Clifford Rosen; Fiscal Year: 2007
    ..abstract_text> ..
  10. A Chromosome 10 QTL Associated with IGF-1 and Bone Mass
    Clifford Rosen; Fiscal Year: 2009
    ..These studies will also determine how specific alleles in the Igfl gene affect critical post-transcriptional events that ultimately determine circulating levels of IGF-I. ..
  11. A Chromosome 10 QTL Associated with IGF-1 and Bone Mass
    CLIFFORD JAMES ROSEN; Fiscal Year: 2010
    ..These studies will also determine how specific alleles in the Igfl gene affect critical post-transcriptional events that ultimately determine circulating levels of IGF-I. ..
  12. Genetics of IGF1 and Bone Density: The Role of Nocturnin
    CLIFFORD JAMES ROSEN; Fiscal Year: 2010
    ..The exploration of its nature as a light-dark cycle gene regulating the production of insulin-like growth factor 1 should clarify the importance of this pathway in normal bone maintenance, as well as age- related osteoporosis. ..
  13. MOUSE MODELS TO DELINEATE A UNIQUE METABOLIC AND SKELETAL NETWORK
    Clifford Rosen; Fiscal Year: 2009
    ....
  14. A Chromosome 10 QTL Associated with IGF-1 and Bone Mass
    Clifford Rosen; Fiscal Year: 2009
    ..These studies will also determine how specific alleles in the Igfl gene affect critical post-transcriptional events that ultimately determine circulating levels of IGF-I. ..
  15. MOUSE MODELS TO DELINEATE A UNIQUE METABOLIC AND SKELETAL NETWORK
    Clifford Rosen; Fiscal Year: 2009
    ..More importantly, this work could lead to a sea change in our general approach to identifying osteoporosis genes in mice and humans. ..
  16. GENETIC REGULATION OF IGF I IN PEAK ONE DENSITY OF MICE
    Clifford Rosen; Fiscal Year: 2000
    ..In addition, we will define specific foci in addition to GH that regulate the IGF-I phenotype. These results should have wide spread implications for both understanding and treating disorders of low bone mass. ..
  17. GENETIC REGULATION OF IGF-I IN PEAK BONE DENSITY OF MICE
    Clifford Rosen; Fiscal Year: 2004
    ..abstract_text> ..
  18. COBRE in Stem Cell Biology and Regenerative Medicine
    Don Wojchowski; Fiscal Year: 2010
    ..Overall efforts will forge a nationally competitive Center in this exciting discipline. ..
  19. Epo regulated erythropoiesis
    Don Wojchowski; Fiscal Year: 2009
    ....
  20. COBRE in Stem Cell Biology and Regenerative Medicine
    Don Wojchowski; Fiscal Year: 2009
    ..Overall efforts will forge a nationally competitive Center in this exciting discipline. ..
  21. Cthrc1 function as a novel TGF-beta antagonist in the vasculature
    Volkhard Lindner; Fiscal Year: 2010
    ..With its ability to inhibit collagen production, Cthrc1 could be very suitable for the development of future antifibrotic therapies. ..
  22. Epo regulated erythropoiesis
    Don Wojchowski; Fiscal Year: 2010
    ....
  23. DYRK3: A Novel Regulator for Erythropoiesis
    Don Wojchowski; Fiscal Year: 2006
    ..DYRK3 also may emerge as an important target for small molecule inhibitors aimed at treating anemias associated with chemotherapy and chronic disease. ..
  24. Remodelin, a Novel Vascular Injury and Bone Related Gene
    Volkhard Lindner; Fiscal Year: 2006
    ..As a potential inhibitor of calcification in the vessel wall this proposal will examine the role of remodelin in vascular calcification and remodeling using both in vitro and in vivo approaches. ..
  25. Epo regulated erythropoiesis
    Don Wojchowski; Fiscal Year: 2007
    ..Insight also will be gained into the erythropoietic actions of Lyn and Kit PTK proto-oncogenes. ..
  26. DYRK3: A Novel Regulator for Erythropoiesis
    Don Wojchowski; Fiscal Year: 2003
    ..DYRK3 also may emerge as an important target for small molecule inhibitors aimed at treating anemias associated with chemotherapy and chronic disease. ..
  27. COBRE in Stem Cell Biology and Regenerative Medicine
    Don Wojchowski; Fiscal Year: 2007
    ..investigator in the field of Stem Cell Biology within the Center for Regenerative Medicine at the Maine Medical Center. The intent of including The Jackson Laboratory is to establish and bridge long-term collaborative research ..
  28. PRIMARY EPO SIGNALS FOR PROERYTHROID CELL EXPANSION
    Don Wojchowski; Fiscal Year: 2002
    ..Insight into regulation of PCD gained from studies of Epo signaling should extend to related clinically important cytokine systems. ..