James T Macgregor

Summary

Country: USA

Publications

  1. doi request reprint IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk
    James T Macgregor
    Toxicology Consulting Services, Bonita Springs, FL, USA Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 783:66-78. 2015
  2. doi request reprint IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs)
    James T Macgregor
    Toxicology Consulting Services, Bonita Springs, FL, USA Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 783:55-65. 2015
  3. ncbi request reprint Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat
    James T Macgregor
    FDA National Center for Toxicological Research, Rockville, Maryland 21012, USA
    Toxicol Sci 94:92-107. 2006
  4. doi request reprint Flow cytometric analysis of micronuclei in peripheral blood reticulocytes IV: an index of chromosomal damage in the rhesus monkey (Macaca mulatta)
    Charlotte E Hotchkiss
    The Bionetics Corporation, Jefferson, Arkansas 72079, USA
    Toxicol Sci 102:352-8. 2008
  5. ncbi request reprint Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog
    Susan B Harper
    Department of Veterans Affairs, Washington, DC 20422, USA
    Toxicol Sci 100:406-14. 2007
  6. pmc Sensitivity of the erythrocyte micronucleus assay: dependence on number of cells scored and inter-animal variability
    Grace E Kissling
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mutat Res 634:235-40. 2007
  7. ncbi request reprint Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring
    Stephen D Dertinger
    Litron Laboratories, Rochester, New York 14623, USA
    Toxicol Sci 94:83-91. 2006
  8. ncbi request reprint Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood
    Stephen D Dertinger
    Litron Laboratories, Rochester, New York 14620, USA
    Environ Mol Mutagen 44:427-35. 2004
  9. ncbi request reprint In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test
    Makoto Hayashi
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga Setagaya ku, Tokyo 158 8501, Japan
    Mutat Res 627:10-30. 2007
  10. ncbi request reprint Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells
    Gregory S Akerman
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 45:188-205. 2005

Collaborators

Detail Information

Publications10

  1. doi request reprint IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk
    James T Macgregor
    Toxicology Consulting Services, Bonita Springs, FL, USA Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 783:66-78. 2015
    ....
  2. doi request reprint IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs)
    James T Macgregor
    Toxicology Consulting Services, Bonita Springs, FL, USA Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 783:55-65. 2015
    ..A companion report discusses the use of these metrics in genotoxicity risk assessment, including scaling and uncertainty factors to be considered when extrapolating below the PoD and/or across test systems and to the human...
  3. ncbi request reprint Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat
    James T Macgregor
    FDA National Center for Toxicological Research, Rockville, Maryland 21012, USA
    Toxicol Sci 94:92-107. 2006
    ..The data suggest that flow cytometric assessment of micronucleus induction can be integrated into routine toxicity testing, eliminating the need for a separate bioassay...
  4. doi request reprint Flow cytometric analysis of micronuclei in peripheral blood reticulocytes IV: an index of chromosomal damage in the rhesus monkey (Macaca mulatta)
    Charlotte E Hotchkiss
    The Bionetics Corporation, Jefferson, Arkansas 72079, USA
    Toxicol Sci 102:352-8. 2008
    ..Microscopy-based scoring is challenging due to the low frequency of RETs and MN-RET in monkeys, but sufficient numbers of cells are easily scored with the flow cytometric procedure...
  5. ncbi request reprint Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog
    Susan B Harper
    Department of Veterans Affairs, Washington, DC 20422, USA
    Toxicol Sci 100:406-14. 2007
    ..Responses in bone marrow and peripheral blood were highly correlated and similar to or greater than those reported in mice and rats at equitoxic doses...
  6. pmc Sensitivity of the erythrocyte micronucleus assay: dependence on number of cells scored and inter-animal variability
    Grace E Kissling
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mutat Res 634:235-40. 2007
    ....
  7. ncbi request reprint Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring
    Stephen D Dertinger
    Litron Laboratories, Rochester, New York 14623, USA
    Toxicol Sci 94:83-91. 2006
    ..Furthermore, data presented herein demonstrate a clear advantage of flow cytometry-based scoring over microscopy-significantly lower inter- and intralaboratory variation and higher statistical sensitivity...
  8. ncbi request reprint Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood
    Stephen D Dertinger
    Litron Laboratories, Rochester, New York 14620, USA
    Environ Mol Mutagen 44:427-35. 2004
    ....
  9. ncbi request reprint In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test
    Makoto Hayashi
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga Setagaya ku, Tokyo 158 8501, Japan
    Mutat Res 627:10-30. 2007
    ..A limit test at a single dose level is currently accepted when toxicity is not dose-limiting...
  10. ncbi request reprint Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells
    Gregory S Akerman
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 45:188-205. 2005
    ....