Affiliation: Loyola University Medical Center
- Cholesterol and Alzheimer's diseaseB Wolozin
Department of Pharmacology, Loyola University Medical Center, Bldg 102, Rm 3634, 2160 South First Avenue, Maywood, IL 60153, USA
Biochem Soc Trans 30:525-9. 2002..70% lower risk of developing AD. Since statins are widely used by doctors, their ability to reduce A beta offers a putative therapeutic strategy for treating AD by using medicines that have already been proved safe to use in humans...
- The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's diseaseBenjamin Wolozin
Department of Pharmacology, Loyola University Medical Center, Bldg 102, Rm 3634, 2160 South First Ave, Maywood, IL 60153, USA
CNS Drug Rev 10:127-46. 2004..These lines of evidence raise the possibility that genetic abnormalities in cholesterol metabolism might contribute to the pathophysiology of AD...
- Cholesterol and the biology of Alzheimer's diseaseBenjamin Wolozin
Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA
Neuron 41:7-10. 2004..The ability of cholesterol to modulate Abeta production suggests opportunities for therapeutic intervention, although the functional significance underlying the connection between cholesterol and Abeta remains to be investigated...
- Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitorsB Wolozin
Department of Pharmacology, Loyola University Medical Center, Bldg 102, Room 3634, 2160 S First Ave, Maywood, IL 60153
Arch Neurol 57:1439-43. 2000..Increasing evidence suggests that cholesterol plays a role in the pathophysiology of Alzheimer disease (AD). For instance, an elevated serum cholesterol level has been shown to be a risk factor for AD...
- Re-assessing the relationship between cholesterol, statins and Alzheimer's diseaseB Wolozin
Department of Pharmacology, Boston University School of Medicine, MA 02118, USA
Acta Neurol Scand Suppl 185:63-70. 2006..These results suggest that the primary action of statins in humans with AD might be to reduce inflammation rather than decrease Abeta load...
- Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashionJ J Palacino
Department of Pharmacology and Neuroscience Program, Loyola University Medical Center, Maywood, Illinois 60153, USA
J Biol Chem 276:38563-9. 2001..These data show that PS1 interacts with multiple components of the beta-catenin signaling cascade and suggest that PS1 regulates beta-catenin in a manner independent of GSK 3beta activity...
- Cholesterol, statins and dementiaBenjamin Wolozin
Department of Pharmacology, Boston University School of Medicine, L 603, Boston, MA 02118 2526, USA
Curr Opin Lipidol 15:667-72. 2004..Although the genetics and cell biology continue to support the link between cholesterol and Alzheimer's disease, recent clinical studies suggest that the animal studies might not directly translate to clinical studies in humans...
- The players on the gamma-secretase teamAkihiko Takashima
Nat Med 12:766-7; discussion 767. 2006
- Interventions for heart disease and their effects on Alzheimer's diseaseBenjamin Wolozin
Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118 2526, USA
Neurol Res 28:630-6. 2006..To review the contributions of cardiovascular disease to Alzheimer's disease and vascular dementia...
- Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplastyTodd A Lee
Midwest Center for Health Services and Policy Research, Hines VA Hospital, Hines, IL, USA
J Alzheimers Dis 7:319-24. 2005..These data support the hypothesis that CABG surgery is associated with a reduced neuronal reserve in an aging population...
- Apolipoprotein E receptor LR11: intersections between neurodegeneration and cholesterol metabolismBenjamin Wolozin
Arch Neurol 61:1178-80. 2004
- Differential expression of cholesterol hydroxylases in Alzheimer's diseaseJames Brown
Departments of Pharmacology and Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
J Biol Chem 279:34674-81. 2004....
- Oxidative damage in the olfactory system in Alzheimer's diseaseGeorge Perry
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Acta Neuropathol 106:552-6. 2003....
- Cyp46 (24S-cholesterol hydroxylase): a genetic risk factor for Alzheimer diseaseBenjamin Wolozin
Arch Neurol 60:16-8. 2003
- Hypoxia enhances beta-amyloid-induced apoptosis in rat cultured hippocampal neuronsNobuaki Egashira
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
Jpn J Pharmacol 90:321-7. 2002....
- Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neuronsLeonard Petrucelli
Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
Neuron 36:1007-19. 2002..Therefore, parkin and alpha-synuclein are linked by common effects on a pathway associated with selective cell death in catecholaminergic neurons...
- alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cellsBong Hyun Ahn
Department of Physiology, Research Institute of Molecular Genetics, and Anatomy, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
J Biol Chem 277:12334-42. 2002..These results suggest that the association of alpha-synuclein with PLD, and modulation of PLD activity, is biologically important, but PLD does not appear to play an essential role in the pathophysiology of alpha-synuclein...
- Simvastatin is associated with a reduced incidence of dementia and Parkinson's diseaseBenjamin Wolozin
Boston University School of Medicine, Boston, MA, USA
BMC Med 5:20. 2007..We used a large database to compare the action of several different statins to investigate whether some statins might be differentially associated with a reduction in the incidence of dementia and Parkinson's disease...