Divaker Choubey

Summary

Affiliation: Loyola University Medical Center
Country: USA

Publications

  1. ncbi request reprint Interferon-inducible IFI16 protein in human cancers and autoimmune diseases
    Divaker Choubey
    Cincinnati VA Medical Center, OH, USA
    Front Biosci 13:598-608. 2008
  2. ncbi request reprint Interferon-inducible p202 in the susceptibility to systemic lupus
    Divaker Choubey
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center and Hines VA Hospital, 2160 South First Avenue, Maywood, IL 60153, USA
    Front Biosci 7:e252-62. 2002
  3. ncbi request reprint Subcellular localization and mechanisms of nucleocytoplasmic distribution of p202, an interferon-inducible candidate for lupus susceptibility
    Divaker Choubey
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 60153 Maywood, IL, USA
    FEBS Lett 553:245-9. 2003
  4. ncbi request reprint Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth
    Hong Xin
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Building No 1, Mail Code 114B, Maywood, IL 60153, USA
    Oncogene 22:4775-85. 2003
  5. ncbi request reprint Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence
    Hong Xin
    Departments of Pathology and Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Mail Code 114B, Maywood, IL 60153, USA
    Oncogene 22:4831-40. 2003
  6. ncbi request reprint Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility
    Rocky Pramanik
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 279:16121-7. 2004
  7. ncbi request reprint IFI16 in human prostate cancer
    Fatouma Alimirah
    Department of Radiation Oncology, Loyola University Chicago, Illinois, USA
    Mol Cancer Res 5:251-9. 2007
  8. ncbi request reprint Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis
    Hong Xin
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    J Immunol 176:5863-70. 2006
  9. ncbi request reprint DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation
    Fatouma Alimirah
    Department of Radiation Oncology, Loyola University Chicago and Edward Hines Jr VA Hospital, Hines, IL 60141, USA
    FEBS Lett 580:2294-300. 2006
  10. pmc Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway
    Jianming Chen
    Department of Radiation Oncology, Loyola University Medical Center, Maywood, IL 60153, USA
    Immunol Lett 118:13-20. 2008

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Interferon-inducible IFI16 protein in human cancers and autoimmune diseases
    Divaker Choubey
    Cincinnati VA Medical Center, OH, USA
    Front Biosci 13:598-608. 2008
    ..In this review, we discuss how our understanding of the regulation of IFI16 expression and its role in cell growth regulation will help elucidate the molecular mechanisms that contribute to the development of various human diseases...
  2. ncbi request reprint Interferon-inducible p202 in the susceptibility to systemic lupus
    Divaker Choubey
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center and Hines VA Hospital, 2160 South First Avenue, Maywood, IL 60153, USA
    Front Biosci 7:e252-62. 2002
    ..Moreover, we discuss how an understanding of the role of p202 in cell growth regulation, particularly in cells of the immune system, will help elucidate the molecular mechanisms contributing to the development of lupus...
  3. ncbi request reprint Subcellular localization and mechanisms of nucleocytoplasmic distribution of p202, an interferon-inducible candidate for lupus susceptibility
    Divaker Choubey
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 60153 Maywood, IL, USA
    FEBS Lett 553:245-9. 2003
    ..These observations will serve as a basis to elucidate the molecular mechanisms by which p202 contributes to lupus susceptibility...
  4. ncbi request reprint Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth
    Hong Xin
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Building No 1, Mail Code 114B, Maywood, IL 60153, USA
    Oncogene 22:4775-85. 2003
    ..Together, our observations support the idea that the transcriptional activation of Ifi202 gene by Rb/JunD may be important for the regulation of cell growth and survival...
  5. ncbi request reprint Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence
    Hong Xin
    Departments of Pathology and Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Mail Code 114B, Maywood, IL 60153, USA
    Oncogene 22:4831-40. 2003
    ..Collectively, our observations support the idea that increased levels of IFI 16 in PrECs contribute to senescence-associated irreversible cell growth arrest...
  6. ncbi request reprint Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility
    Rocky Pramanik
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 279:16121-7. 2004
    ..Together, our observations support the idea that IL-6 stimulates transcription of the Ifi202 gene through STAT3 activation and predict that increased levels of IL-6 in lupus contribute to up-regulation of p202...
  7. ncbi request reprint IFI16 in human prostate cancer
    Fatouma Alimirah
    Department of Radiation Oncology, Loyola University Chicago, Illinois, USA
    Mol Cancer Res 5:251-9. 2007
    ..Together, our observations provide support for the idea that histone deacetylase-dependent transcriptional silencing of the IFI16 gene in prostate epithelial cells contributes to the development of prostate cancer...
  8. ncbi request reprint Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis
    Hong Xin
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    J Immunol 176:5863-70. 2006
    ..Taken together, our observations support the idea that increased expression of p202 in B6.Nba2 mice increases the susceptibility to develop lupus, in part, by inhibiting p53-mediated apoptosis...
  9. ncbi request reprint DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation
    Fatouma Alimirah
    Department of Radiation Oncology, Loyola University Chicago and Edward Hines Jr VA Hospital, Hines, IL 60141, USA
    FEBS Lett 580:2294-300. 2006
    ..Our observations demonstrate the expression of AR protein in DU-145 and PC-3 prostate cancer cell lines...
  10. pmc Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway
    Jianming Chen
    Department of Radiation Oncology, Loyola University Medical Center, Maywood, IL 60153, USA
    Immunol Lett 118:13-20. 2008
    ..Together, our observations demonstrate that stimulation of T cells up-regulates the Ifi202 expression in part through the JNK/c-Jun pathway...
  11. ncbi request reprint Role of IFI 16 in cellular senescence of human fibroblasts
    Hong Xin
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Mail Code 114B, Maywood, IL 60153, USA
    Oncogene 23:6209-17. 2004
    ..Our observations support the idea that increased levels of IFI 16 in older populations of human fibroblasts contribute to cellular senescence...
  12. ncbi request reprint Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein
    Fatouma Alimirah
    Department of Radiation Oncology, Loyola University Chicago and Edward Hines Jr VA Hospital, 5th Avenue and Roosevelt Road, Building 1, Mail Code 114B, Hines, IL 60141, USA
    FEBS Lett 580:1659-64. 2006
    ..Our observations identify a role for IFI16 protein in AR-mediated functions...
  13. ncbi request reprint Induction of p202, a modulator of apoptosis, during oncogenic transformation of NIH 3T3 cells by activated H-Ras (Q61L) contributes to cell survival
    Hong Xin
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Building No 1, Mail Code 114B, Maywood, IL 60153, USA
    J Cell Biochem 88:191-204. 2003
    ..Collectively, our observations support the idea that the transcriptional increases in the levels of p202 by oncogenic H-Ras in NIH 3T3 cells are needed for cell survival...
  14. pmc Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes
    Vijaya Chaturvedi
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Am J Pathol 162:161-70. 2003
    ....
  15. ncbi request reprint p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity
    Rocky Pramanik
    Department of Radiation Oncology, Neurobiology and Anatomy, Loyola University of Chicago, Maywood, Illinois 60153, USA
    J Biol Chem 278:4831-9. 2003
    ....
  16. ncbi request reprint Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes
    Jian Zhong Qin
    Department of Pathology, Loyola University Medical Center, Illinois, USA
    Oncogene 21:2991-3002. 2002
    ..In conclusion, the sensitivity and resistance of KCs to apoptosis depends not only on the location within various layers of epidermis and levels of p53, but may also involve p53 activation via post-translational modifications...
  17. pmc A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16
    Marianne K H Kim
    Division of Hematology Oncology, Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
    Neoplasia 10:69-78. 2008
    ..These data suggest that IFI16 and WT1, in certain cellular context including sporadic Wilms tumors, may support cell survival...
  18. pmc Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone mice
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, Cincinnati, OH 45267, USA
    J Immunol 180:5927-34. 2008
    ..Our observations support the idea that increased Ifi202 expression in certain strains of mice contributes to lupus susceptibility in part by inhibiting E2F1-mediated functions...
  19. pmc Expression of androgen receptor is negatively regulated by p53
    Fatouma Alimirah
    Edward Hines Jr VA Hospital, Hines, IL 60141, USA
    Neoplasia 9:1152-9. 2007
    ..Together, our observations provide support for the idea that the loss of p53 function in prostate cancer cells contributes to increased expression of AR...
  20. ncbi request reprint IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway
    Yassine Amrani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1063-71. 2003
    ....
  21. ncbi request reprint The HIN domain of IFI-200 proteins consists of two OB folds
    Mario Albrecht
    Max Planck Institute for Informatics, Stuhlsatzenhausweg 85, 66123 Saarbrucken, Germany
    Biochem Biophys Res Commun 327:679-87. 2005
    ..Our results also raise the possibility of as yet unexplored functional roles of IFI-200 proteins as transcriptional regulators and as interaction partners of proteins involved in immunomodulatory and apoptotic processes...
  22. pmc Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
    Marie Laure Santiago-Raber
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 197:777-88. 2003
    ..The data indicate that type-I IFNs are important mediators in the pathogenesis of murine lupus, and that reducing their activity in the human counterpart may be beneficial...