Mark A Smith

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. pmc Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
    Mark A Smith
    Neuroscience Center, LSUHSC, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 548:245-58. 2003
  2. pmc Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient mice
    Bertalan K Andrasfalvy
    Neuroscience Center, Louisiana State University Health Science Center, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 552:35-45. 2003
  3. pmc Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease
    Gjumrakch Aliev
    Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249 1664, USA
    Vasc Health Risk Manag 4:721-30. 2008
  4. ncbi request reprint Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
    Hyoung gon Lee
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Neurosci Res 84:1856-61. 2006
  5. ncbi request reprint Therapeutic options in Alzheimer's disease
    Paula I Moreira
    Case Western Reserve University, Department of Pathology, Cleveland, Ohio 44106, USA
    Expert Rev Neurother 6:897-910. 2006
  6. ncbi request reprint Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1762:447-52. 2006
  7. ncbi request reprint 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal
    De Lin
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Chem Res Toxicol 18:1219-31. 2005
  8. ncbi request reprint The cell cycle in Alzheimer disease: a unique target for neuropharmacology
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Mech Ageing Dev 126:1019-25. 2005
  9. ncbi request reprint Therapeutic opportunities in Alzheimer disease: one for all or all for one?
    Michael W Marlatt
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Curr Med Chem 12:1137-47. 2005
  10. pmc The role of insulin receptor substrate 2 in hypothalamic and beta cell function
    Agharul I Choudhury
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 115:940-50. 2005

Collaborators

  • Jeffrey C Magee
  • Graham C R Ellis-Davies
  • Rolf Sprengel
  • Quan Liu
  • Kelly L Drew
  • A Takeda
  • George Perry
  • Xiongwei Zhu
  • Hyoung gon Lee
  • Gemma Casadesus
  • Craig S Atwood
  • Paula I Moreira
  • Osamu Ogawa
  • Akihiko Nunomura
  • Kate M Webber
  • Sandra L Siedlak
  • Rudy J Castellani
  • Richard L Bowen
  • Peggy L R Harris
  • Gjumrakch Aliev
  • Arun K Raina
  • Rudolph J Castellani
  • Glenda M Bishop
  • Ralph N Martins
  • Adam D Cash
  • Andrew McShea
  • Kazuhiro Honda
  • Michael W Marlatt
  • Robert Bowser
  • Peggy L Harris
  • Miguel A Pappolla
  • Shun Shimohama
  • Robert P Friedland
  • Reena S Shah
  • Andrea C Wilson
  • Xinglong Wang
  • Akanksha Thakur
  • Carme Pelegri
  • John K Wung
  • Laura A Previll
  • Masumi Ueda
  • Mark E Obrenovich
  • Robert B Petersen
  • Jens Oliver Funk
  • Agharul I Choudhury
  • Massimo Tabaton
  • De Lin
  • Laura Morelli
  • Barbara Shukitt-Hale
  • Luke I Szweda
  • Heather M Stellwagen
  • James A Joseph
  • Jose M Pizarro
  • Hisashi Fujioka
  • Lawrence M Sayre
  • Jian Dong
  • Gerald Veurink
  • Gary J Grover
  • Bertalan K Andrasfalvy
  • Arun Raina
  • Jesus Avila
  • Hossein A Ghanbari
  • Fang Zhou
  • Jun ichi Kakimura
  • Takafumi Wataya
  • Kimberly L Clapp-Lilly
  • Johnathan M Tedesco
  • Michael G Zagorski
  • Zhu Xiongwei
  • Justin C Shenk
  • Eldar Gasimov
  • Kathryn Fischbach
  • David T Denhardt
  • Joseph C Lamanna
  • Mehul A Trivedi
  • Jaume del Valle
  • Jordi Vilaplana
  • Merce Pallas
  • Anna Maria Canudas
  • Catarina R Oliveira
  • Inez Vincent
  • Aaron Kowalski
  • Sterling C Johnson
  • Nancy J Linford
  • Meredith E Crosby
  • Robert A Shapiro
  • Maria S Santos
  • Antoni Camins
  • Yoshihiro Yoneda
  • Yoichi Miyamoto

Detail Information

Publications48

  1. pmc Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
    Mark A Smith
    Neuroscience Center, LSUHSC, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 548:245-58. 2003
    ..We conclude, therefore, that the main synaptic mechanism involved in the production of distance-dependent scaling of Schaffer collateral synapses is an elevated postsynaptic AMPA receptor density...
  2. pmc Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient mice
    Bertalan K Andrasfalvy
    Neuroscience Center, Louisiana State University Health Science Center, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 552:35-45. 2003
    ....
  3. pmc Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease
    Gjumrakch Aliev
    Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249 1664, USA
    Vasc Health Risk Manag 4:721-30. 2008
    ..Therefore, pharmacological interventions, directed at correcting the chronic hypoperfusion state, may change the natural course of the development of dementing neurodegeneration...
  4. ncbi request reprint Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
    Hyoung gon Lee
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Neurosci Res 84:1856-61. 2006
    ....
  5. ncbi request reprint Therapeutic options in Alzheimer's disease
    Paula I Moreira
    Case Western Reserve University, Department of Pathology, Cleveland, Ohio 44106, USA
    Expert Rev Neurother 6:897-910. 2006
    ..The possibility that oxidative stress is a primary event in AD indicates that antioxidant-based therapies are perhaps the most promising weapons against this devastating neurodegenerative disorder...
  6. ncbi request reprint Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1762:447-52. 2006
    ..Since both cognitive loss and amyloid-beta deposition are features of Alzheimer disease, leuprolide acetate treatment may prove to be a useful therapeutic strategy for this disease...
  7. ncbi request reprint 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal
    De Lin
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Chem Res Toxicol 18:1219-31. 2005
    ..The greater neurotoxicity of ONE could reflect in part the different reactivity characteristics of ONE as compared to HNE...
  8. ncbi request reprint The cell cycle in Alzheimer disease: a unique target for neuropharmacology
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Mech Ageing Dev 126:1019-25. 2005
    ..Therefore, therapeutic interventions targeted toward ameliorating mitotic changes would be predicted to have a profound and positive impact on Alzheimer disease progression...
  9. ncbi request reprint Therapeutic opportunities in Alzheimer disease: one for all or all for one?
    Michael W Marlatt
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Curr Med Chem 12:1137-47. 2005
    ..In this review, the scientific basis for common AD therapeutics as well as the efficacy of these treatments will be discussed...
  10. pmc The role of insulin receptor substrate 2 in hypothalamic and beta cell function
    Agharul I Choudhury
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 115:940-50. 2005
    ..Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis...
  11. ncbi request reprint Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron
    Kazuhiro Honda
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 280:20978-86. 2005
    ....
  12. ncbi request reprint Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats
    Gemma Casadesus
    VSDA, HNRC on Aging, Tufts University, Boston, MA, USA
    Exp Gerontol 40:249-54. 2005
    ..Additionally, irradiated subjects show decreased levels of PSA-NCAM expression. These changes are consistent with those found in aged subjects indicating that heavy-particle irradiation is an adequate model for the study of aging...
  13. ncbi request reprint Increased expression of p130 in Alzheimer disease
    Laura A Previll
    Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA
    Neurochem Res 32:639-44. 2007
    ..Our data suggest that, despite its upregulation, the aberrant localization of p130 to the neuronal cytoplasm facilitates neuronal cell cycle re-entry in AD...
  14. pmc Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances
    Mark A Smith
    Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    J Physiol 578:425-38. 2007
    ....
  15. pmc Antibodies to potato virus Y bind the amyloid beta peptide: immunohistochemical and NMR studies
    Robert P Friedland
    Department of Neurology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 283:22550-6. 2008
    ..Immune responses generated from dietary exposure to proteins homologous to Abeta may induce antibodies that could influence the normal physiological processing of the protein and the development or progression of AD...
  16. doi request reprint Current approaches in the treatment of Alzheimer's disease
    Reena S Shah
    Department of Neurology, University of Maryland, Baltimore, MD 21201, USA
    Biomed Pharmacother 62:199-207. 2008
    ..Drugs directly targeting amyloid-beta, particularly the amyloid-beta vaccine, continue to be investigated and their forthcoming results are eagerly anticipated...
  17. ncbi request reprint Iron homeostasis is maintained in the brain, but not the liver, following mild hypoxia
    Glenda M Bishop
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Redox Rep 12:257-66. 2007
    ..Together, these results indicate that there is a tighter regulation of iron metabolism in the brain than the liver, which limits the redistribution of Fe3+ following hypoxia...
  18. ncbi request reprint Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage
    Quan Liu
    Hamilton Glaucoma Center and the Department of Ophthalmology, University of California San Diego, La Jolla, California 92037 0946, USA
    Invest Ophthalmol Vis Sci 48:4580-9. 2007
    ..To determine whether oxidative adduct formation or heme oxygenase-1 (HO-1) expression are altered in retinal ganglion cell (RGC) cultures exposed to elevated hydrostatic pressure and in a mouse model of glaucoma...
  19. ncbi request reprint Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence
    Carme Pelegri
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Mech Ageing Dev 128:522-8. 2007
    ..We have found significantly higher levels of IgG extravasation in the hippocampus of 12-month-old SAMP8 mice compared to SAMR1 mice, indicating an increased permeability of BBB in aged senescence-accelerated mice...
  20. ncbi request reprint Autophagocytosis of mitochondria is prominent in Alzheimer disease
    Paula I Moreira
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    J Neuropathol Exp Neurol 66:525-32. 2007
    ..Whether increased autophagocytosis is a consequence of an increased turnover of mitochondria or whether the mitochondria in Alzheimer disease are more susceptible to autophagy remains to be resolved...
  21. ncbi request reprint c-Jun phosphorylation in Alzheimer disease
    Akanksha Thakur
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci Res 85:1668-73. 2007
    ..Overall, this study demonstrated specific alterations in c-Jun phosphorylation and distribution in AD which is not necessarily linked to apoptosis but rather may represent an adaptation process in the face of oxidative stress...
  22. ncbi request reprint Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain
    John K Wung
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Curr Alzheimer Res 4:67-72. 2007
    ....
  23. ncbi request reprint Neuronal cell cycle re-entry mediates Alzheimer disease-type changes
    Andrew McShea
    Department of Biology, CombiMatrix Corp, Mukilteo, WA 98275, USA
    Biochim Biophys Acta 1772:467-72. 2007
    ..As such, our neuronal cell model may be extremely valuable for the development of novel therapeutic strategies...
  24. ncbi request reprint Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease
    Hyoung gon Lee
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Brain Res 1124:1-4. 2006
    ..These data suggest a hindrance in importin-mediated cytoplasmic-nuclear transport in AD...
  25. ncbi request reprint Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats
    Gemma Casadesus
    USDA, HNRC on Aging at Tufts University, Boston, MA, USA
    Nutr Neurosci 7:309-16. 2004
    ..Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity...
  26. ncbi request reprint Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci Res 79:554-60. 2005
    ....
  27. ncbi request reprint Differential regulation of glutamate receptors in Alzheimer's disease
    Hyoung gon Lee
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Neurosignals 11:282-92. 2002
    ..Additionally, we assess the potential therapeutic value of glutamate receptors as a target for drug intervention in Alzheimer's disease...
  28. ncbi request reprint Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies
    Akihiko Nunomura
    Department of Psychiatry and Neurology, Asahikawa Medical College, Higashi 2 1 1 1, Midorigaoka, Asahikawa 078 8510, Japan
    Neuroreport 13:2035-9. 2002
    ....
  29. ncbi request reprint Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, North Carolina, USA
    J Neurosci Res 70:514-8. 2002
    ..Elevated serum and cortical neuron levels of LH, coupled with the decline in sex steroid production, could play important roles in the pathogenesis of AD...
  30. ncbi request reprint Is Alzheimer's disease a mitochondrial disorder?
    Adam D Cash
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Neuroscientist 8:489-96. 2002
    ..Supporting this, the authors have considerable in vivo and in vitro evidence for mitotic disturbances in AD...
  31. ncbi request reprint Microbial origin of glutamate, hibernation and tissue trauma: an in vivo microdialysis study
    Fang Zhou
    Department of Chemistry and Biochemistry, Institute of Arctic Biology, University of Alaska Fairbanks, PO Box 757000, Fairbanks, AK 99775, USA
    J Neurosci Methods 119:121-8. 2002
    ..Growth of these isolates as well as glutamate release was enhanced when glutamine rather than NH(4)NO(3) was added to the medium suggesting the bacteria utilize glutamine preferentially over ammonium as a nitrogen source...
  32. ncbi request reprint Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins
    Craig S Atwood
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Peptides 23:1343-50. 2002
    ....
  33. ncbi request reprint The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors
    Miguel A Pappolla
    Department of Pathology, University of South Alabama, Mobile 36617, USA
    J Pineal Res 32:135-42. 2002
    ....
  34. ncbi request reprint Melatonin exhibits antioxidant properties in a mouse brain slice model of excitotoxicity
    Kimberly L Clapp-Lilly
    Institute of Arctic Biology and Department of Chemistry and Biochemistry, University of Alaska Fairbanks, 99775, USA
    Int J Circumpolar Health 61:32-40. 2002
    ..Our objective was to inhibit the effects of oxidative stress induced by NMDA in mouse brain slices, using melatonin...
  35. ncbi request reprint Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins
    Jun ichi Kakimura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    FASEB J 16:601-3. 2002
    ..These observations suggest that HSP-induced microglial activation may serve a neuroprotective role by facilitating Abeta clearance and cytokine production..
  36. ncbi request reprint Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence
    Jian Dong
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Biochemistry 42:2768-73. 2003
    ..The results also reveal a direct chemical basis for oxidative damage caused by amyloid-beta protein in AD...
  37. ncbi request reprint JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease
    Xiongwei Zhu
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurochem 85:87-93. 2003
    ..Together, these findings lend further credence to the notion that the JNK/SAPK pathway is dysregulated in AD and also indicate an active role for this pathway in disease pathogenesis...
  38. ncbi request reprint Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?
    Osamu Ogawa
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Acta Neuropathol 105:524-8. 2003
    ..Therefore, the aberrant cytoplasmic localization of phosphorylated histone H3 indicates a mitotic catastrophe that leads to neuronal dysfunction and neurodegeneration in AD...
  39. pmc Staying connected: synapses in Alzheimer disease
    Hyoung gon Lee
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Am J Pathol 165:1461-4. 2004
  40. ncbi request reprint Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice
    Jose M Pizarro
    Division of Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Brain Res 1025:10-20. 2004
    ..05). These findings support our hypothesis that BDNF mRNA levels are reduced by social stress, and may have implications for brain plasticity and behavioral changes following social stress...
  41. ncbi request reprint Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease
    Xiongwei Zhu
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Neurosci Res 75:698-703. 2004
    ..Therefore, therapeutics targeted toward initiators of the cell cycle are likely to prove of great efficacy for the treatment of AD...
  42. ncbi request reprint Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease
    Hyoung gon Lee
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Acta Neuropathol 107:365-71. 2004
    ..Immunocytochemical examination revealed considerable overlap between mGluR2 and neurofibrillary alterations. Thus, it is likely that mGluR2 represents a novel therapeutic target for AD...
  43. ncbi request reprint Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA
    J Biol Chem 279:20539-45. 2004
    ..Suppression of the age-related increase in serum gonadotropins using anti-gonadotropin agents may represent a novel therapeutic strategy for AD...
  44. pmc Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability
    Gary J Grover
    Metabolic and Cardiovascular Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Pennington, NJ 08534, USA
    Proc Natl Acad Sci U S A 100:10067-72. 2003
    ..TR beta-selective agonists may constitute a previously uncharacterized class of drugs to treat obesity, hypercholesterolemia, and elevated lipoprotein (a)...
  45. ncbi request reprint Increased p27, an essential component of cell cycle control, in Alzheimer's disease
    Osamu Ogawa
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Aging Cell 2:105-10. 2003
    ..The findings presented here suggest that dysregulation of the cell cycle plays a crucial role in the pathogenesis of Alzheimer's disease that may provide a novel mechanistic basis for therapeutic intervention...
  46. pmc Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation
    Adam D Cash
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Pathol 162:1623-7. 2003
    ..016). These findings suggest that reduction in microtubule assembly is not dependent on tau abnormalities of AD and aging...
  47. ncbi request reprint Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants
    Gerald Veurink
    Department of Surgery, University of Western Australia, Perth, Western Australia, Australia
    Free Radic Biol Med 34:1070-7. 2003
    ....
  48. ncbi request reprint High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal
    Takafumi Wataya
    Institute of Pathology and Departments of Physiology and Biophysics, and Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 277:4644-8. 2002
    ....