Xin Gu

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. pmc Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis
    Xianpeng Liu
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL 60611, USA
    BMC Cancer 14:57. 2014
  2. pmc Expression of eNOS in kidneys from hypertensive patients
    Xin Gu
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Int J Nephrol Renovasc Dis 3:11-9. 2010
  3. pmc The combination of stem cell factor and granulocyte-colony stimulating factor for chronic stroke treatment in aged animals
    Chun Shu Piao
    Department of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71130, USA
    Exp Transl Stroke Med 4:25. 2012
  4. pmc Acantholytic squamous cell carcinoma in upper aerodigestive tract: histopathology, immunohistochemical profile and epithelial mesenchymal transition phenotype change
    Xin Gu
    Department of Pathology, Louisiana State University Health Science Center Shreveport, 1501 King s Highway, Shreveport, LA 71130, USA
    Head Neck Pathol 6:438-44. 2012
  5. doi Ultrastructural changes in cerebral capillary pericytes in aged Notch3 mutant transgenic mice
    Xin Gu
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Ultrastruct Pathol 36:48-55. 2012
  6. ncbi Thrombotic microangiopathy in cocaine abuse-associated malignant hypertension: report of 2 cases with review of the literature
    Xin Gu
    Department of Pathology, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71130, USA
    Arch Pathol Lab Med 131:1817-20. 2007
  7. ncbi Expression of eukaryotic initiation factor 4E in astrocytic tumors
    Xin Gu
    Department of Pathology, Louisiana University Health Sciences Center Shreveport, Shreveport, LA 71130, USA
    Appl Immunohistochem Mol Morphol 13:178-83. 2005
  8. pmc Sphenoid sinus basaloid squamous cell carcinoma presenting as a sellar mass: report a case with review of the literature
    Xin Gu
    Department of Pathology, Louisiana State University Health Science Center Shreveport, Shreveport, LA 71130, USA
    Head Neck Pathol 5:81-5. 2011
  9. pmc The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis
    Delira Robbins
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
    PLoS ONE 5:e11902. 2010
  10. ncbi Renal pathologic spectrum in an autopsy series of patients with plasma cell dyscrasia
    Guillermo A Herrera
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Arch Pathol Lab Med 128:875-9. 2004

Collaborators

Detail Information

Publications33

  1. pmc Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis
    Xianpeng Liu
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL 60611, USA
    BMC Cancer 14:57. 2014
    ..Here we demonstrate that Smurf2 expression is downregulated in human breast cancer tissues, especially of the triple-negative subtype, and address the mechanism of Smurf2 downregulation in triple-negative breast cancer cells...
  2. pmc Expression of eNOS in kidneys from hypertensive patients
    Xin Gu
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Int J Nephrol Renovasc Dis 3:11-9. 2010
    ..Loss of the compensatory mechanism via continued release of NO to prevent vascular injury may be responsible for morphological changes typically seen in the renal vasculature in patients with accelerated hypertension...
  3. pmc The combination of stem cell factor and granulocyte-colony stimulating factor for chronic stroke treatment in aged animals
    Chun Shu Piao
    Department of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71130, USA
    Exp Transl Stroke Med 4:25. 2012
    ..However, whether this treatment is effective and safe to the aged population remains to be determined...
  4. pmc Acantholytic squamous cell carcinoma in upper aerodigestive tract: histopathology, immunohistochemical profile and epithelial mesenchymal transition phenotype change
    Xin Gu
    Department of Pathology, Louisiana State University Health Science Center Shreveport, 1501 King s Highway, Shreveport, LA 71130, USA
    Head Neck Pathol 6:438-44. 2012
    ..In addition, because cytokeratin 19 staining is attenuated, this would be an insensitive marker for following up and/or in detecting disseminated tumor cells in cases of acantholytic squamous cell carcinoma in upper aerodigestive tract...
  5. doi Ultrastructural changes in cerebral capillary pericytes in aged Notch3 mutant transgenic mice
    Xin Gu
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Ultrastruct Pathol 36:48-55. 2012
    ..These findings provide new insight into understanding the role of pericyte degeneration in the phathogenesis of CADASIL disease...
  6. ncbi Thrombotic microangiopathy in cocaine abuse-associated malignant hypertension: report of 2 cases with review of the literature
    Xin Gu
    Department of Pathology, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71130, USA
    Arch Pathol Lab Med 131:1817-20. 2007
    ..Cocaine-mediated endothelial injury and platelet activation may play important pathogenetic roles in cocaine abusers who develop acute renal failure and malignant hypertension...
  7. ncbi Expression of eukaryotic initiation factor 4E in astrocytic tumors
    Xin Gu
    Department of Pathology, Louisiana University Health Sciences Center Shreveport, Shreveport, LA 71130, USA
    Appl Immunohistochem Mol Morphol 13:178-83. 2005
    ..Because eIF4E is crucial in regulation of tumor growth, eIF4E could be a potential target for inhibitors as an adjuvant therapy for brain tumors...
  8. pmc Sphenoid sinus basaloid squamous cell carcinoma presenting as a sellar mass: report a case with review of the literature
    Xin Gu
    Department of Pathology, Louisiana State University Health Science Center Shreveport, Shreveport, LA 71130, USA
    Head Neck Pathol 5:81-5. 2011
    ....
  9. pmc The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis
    Delira Robbins
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
    PLoS ONE 5:e11902. 2010
    ..We found that the introduction of wild-type p53 promoted transformation in JB6 P- cells. Our results suggest that suppression of p53 and induction of MnSOD may play an important role in the tumor suppressive activity of Protandim...
  10. ncbi Renal pathologic spectrum in an autopsy series of patients with plasma cell dyscrasia
    Guillermo A Herrera
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Arch Pathol Lab Med 128:875-9. 2004
    ..Renal dysfunction in plasma cell dyscrasias is common. It is the second most common cause of death in patients with myeloma...
  11. ncbi Plasma cell dyscrasia with kappa light-chain crystals in proximal tubular cells: a histological, immunofluorescent, and ultrastructural study
    Guoping Cai
    Department of Pathology, New York University Medical Center, New York, New York, USA
    Ultrastruct Pathol 30:315-9. 2006
    ..Ultrastructurally, the crystals appear to be located within lysosomes. No deposits of light-chains were seen elsewhere in the kidney biopsy...
  12. ncbi Light-chain-mediated acute tubular interstitial nephritis: a poorly recognized pattern of renal disease in patients with plasma cell dyscrasia
    Xin Gu
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
    Arch Pathol Lab Med 130:165-9. 2006
    ....
  13. pmc Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model
    Jianfeng Liu
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
    PLoS ONE 4:e5284. 2009
    ..Overall, induction of antioxidant enzymes by Protandim may serve as a practical and potent approach for cancer prevention...
  14. ncbi Light chain crystal deposition as a manifestation of plasma cell dyscrasias: the role of immunoelectron microscopy
    Xin Gu
    Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Hum Pathol 34:270-7. 2003
    ..It must be emphasized that in some patients the plasma cell dyscrasia does not become clinically manifested until years after the diagnosis of light chain crystal deposition...
  15. ncbi Anaplastic thyroid cancer and hyperthyroidism
    Vijay Kumar
    Section of Endocrinology, VAMC LSUHSC, Shreveport, LA 71101 4295, USA
    Endocr Pathol 16:245-50. 2005
    ..The tumor had an extremely aggressive course and the patient died of asphyxiation from severe airway compromise 11 d after his initial presentation...
  16. ncbi Atypical amyloidosis: diagnostic challenges and the role of immunoelectron microscopy in diagnosis
    Ravindra Veeramachaneni
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    Ultrastruct Pathol 28:75-82. 2004
    ....
  17. ncbi Organized deposits in the kidney and look-alikes
    David N Howell
    Department of Pathology, Duke University and Veterans Affairs Medical Centers, Durham, North Carolina 27710, USA
    Ultrastruct Pathol 27:295-312. 2003
    ..Correlative light microscopic studies are often useful, however, and will be described as well...
  18. doi Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness
    Alok R Khandelwal
    Department of Otolaryngology Head and Neck Surgery, LSU Health Shreveport, Shreveport, Louisiana, USA
    Otolaryngol Head Neck Surg 155:281-8. 2016
    ..Our objective is to determine if pS6 and pERK can predict cSCC aggressiveness and to identify primary tumor characteristics that may predict parotid metastasis...
  19. pmc Laser-capture microdissection of oropharyngeal epithelium indicates restriction of Epstein-Barr virus receptor/CD21 mRNA to tonsil epithelial cells
    Ru Jiang
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
    J Oral Pathol Med 37:626-33. 2008
    ..However, its potential contribution to infection in vivo has been difficult to evaluate as discrepant results with antibodies have made it difficult to determine which, if any, epithelial cells in the oropharynx express CD21...
  20. pmc Oral dysplasia and squamous cell carcinoma: correlation between increased expression of CD21, Epstein-Barr virus and CK19
    Ru Jiang
    Center for Molecular and Tumor Virology and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Oral Oncol 48:836-41. 2012
    ..As cells become dysplastic they are reported to express higher levels of CK19. We sought to evaluate whether CD21 and CK19 expression change as oral epithelial cells outside Waldeyer's ring become dysplastic...
  21. ncbi Different types of glomerulopathic light chains interact with mesangial cells using a common receptor but exhibit different intracellular trafficking patterns
    Jiamin Teng
    Department of Pathology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Lab Invest 84:440-51. 2004
    ..The data also demonstrated that cubilin and megalin were absent on MCs, so the receptor involved is different from the one already characterized in the proximal tubules...
  22. doi Dendritic cells in renal biopsies of patients with acute tubulointerstitial nephritis
    Mingyu Cheng
    Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103
    Hum Pathol 54:113-20. 2016
    ..All these findings suggest that DC subsets may be differentially involved in the pathogenesis of ATIN. Their potential role in intrarenal regulation of immune responses in ATIN is proposed. ..
  23. doi Neuroendocrine tumors in the ovary: histogenesis, pathologic differentiation, and clinical presentation
    Moiz Vora
    Department of Pathology, Louisiana State University Health Sciences Center, 1501 King s Highway, Shreveport, LA, 71103, USA
    Arch Gynecol Obstet 293:659-65. 2016
    ..We present four primary ovarian neuroendocrine tumors and compare clinicopathologic findings based on tumor histogenesis and site of origin...
  24. pmc Association between human papilloma virus/Epstein-Barr virus coinfection and oral carcinogenesis
    Ru Jiang
    Department of Microbiology and Immunology, LSUHSC, Shreveport, LA, USA Department of Clinical Teaching and Training, Tianjin University of Traditional Chinese Medicine, Tianjin, China
    J Oral Pathol Med 44:28-36. 2015
    ....
  25. doi The many faces of cryoglobulinemic nephropathy: a clinico-pathologic study of 47 cases with emphasis on the value of electron microscopy
    Kunle Ojemakinde
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, USA
    Ultrastruct Pathol 38:367-76. 2014
    ..Even in cases where the light and immunofluorescence findings in suspicious clinical situations were quite consistent with CN, electron microscopy provided the final proof to substantiate the diagnosis in the great majority of the cases...
  26. ncbi Sebaceous carcinoma of the right arm
    Abigail Piazza
    Louisiana State University Health Sciences Center, Shreveport, USA
    J La State Med Soc 164:81-2. 2012
    ..In this paper, we describe a case of sebaceous carcinoma in the right arm of a 67-year-old woman. The relevant histopathology and appropriate diagnostic and treatment approach is discussed...
  27. ncbi Pathology case of the month. Case of heme-positive stools. Gastrointestinal stromal tumor
    Michael Constantinescu
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, USA
    J La State Med Soc 155:17-20. 2003
  28. ncbi Immunoglobulin heavy chain can be amyloidogenic: morphologic characterization including immunoelectron microscopy
    Hoa L Mai
    Department of Pathology, Ben Taub General Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Am J Surg Pathol 27:541-5. 2003
    ..Furthermore, this type of amyloidosis shares the same morphologic features with other types of amyloidosis and can involve the kidney to produce nephrotic syndrome...
  29. pmc Decreased nephrin and GLEPP-1, but increased VEGF, Flt-1, and nitrotyrosine, expressions in kidney tissue sections from women with preeclampsia
    Shuang Zhao
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Reprod Sci 16:970-9. 2009
    ....
  30. ncbi Clear cells and thyroid transcription factor I reactivity in sclerosing mucoepidermoid carcinoma of the thyroid gland
    Jorge Albores-Saavedra
    Department of Pathology, Louisiana State University Health Sciences Center School of Medicine, Shreveport, LA 71130, USA
    Ann Diagn Pathol 7:348-53. 2003
    ....
  31. pmc Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion
    Jianfeng Liu
    Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA 71130, USA
    FEBS Lett 582:1319-24. 2008
    ..Thus, our results suggest that mitochondrial permeability transition is required for p53 mitochondrial translocation...
  32. ncbi The value of electron microscopy in the diagnosis of IgA nephropathy
    Xin Gu
    Department of Pathology, Louisiana State University Health Sciences Center Shreveport, Shreveport Louisiana 71130, USA
    Ultrastruct Pathol 26:203-10. 2002
    ..Electron microscopy can be crucial in providing information either to support a diagnosis of IgA nephropathy or to aid in the diagnosis of one of its mimics...
  33. ncbi The design, construction and function of a new chimeric anti-CD20 antibody
    Yugang Wang
    Institute of Basic Medical Sciences, Beijing, PR China
    J Biotechnol 129:726-31. 2007
    ....