Anping Chen

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. pmc The antioxidant (-)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression
    Anping Chen
    Department of Pathology, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, USA
    Biochem J 368:695-704. 2002
  2. pmc Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells
    Anping Chen
    Department of Pathology, Louisiana State University Health Sciences Center in Shreveport, 1501 Kings Hwy, Shreveport, LA 71130, USA
    Biochem J 368:683-93. 2002
  3. ncbi Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR
    Anping Chen
    Department of Pathology, Louisiana State University, Health Sciences Center in Shreveport, 1501 Kings Hwy, Shreveport, LA 71130, USA
    Am J Physiol Gastrointest Liver Physiol 288:G447-56. 2005
  4. ncbi The antioxidant (-)-epigallocatechin-3-gallate inhibits rat hepatic stellate cell proliferation in vitro by blocking the tyrosine phosphorylation and reducing the gene expression of platelet-derived growth factor-beta receptor
    Anping Chen
    Department of Pathology, Louisiana State University Health Sciences Center in Shreveport, Shreveport, Louisiana 71130, USA
    J Biol Chem 278:23381-9. 2003
  5. pmc Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells
    Jianguo Lin
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO 63104, USA
    Lab Invest 88:529-40. 2008
  6. pmc Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress
    Jianguo Lin
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO 63104, USA
    Br J Pharmacol 166:2212-27. 2012
  7. ncbi The antifibrogenic effect of (-)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells
    Fu Yumei
    Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, USA
    Lab Invest 86:697-709. 2006
  8. ncbi Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells
    Shizhong Zheng
    Department of Pathology, School of Medicine, St Louis University, St Louis, MO 63104, USA
    Am J Physiol Gastrointest Liver Physiol 292:G113-23. 2007
  9. pmc Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress
    Jianguo Lin
    Department of Pathology, Saint Louis University, MO 63104, USA
    Lab Invest 89:1397-409. 2009
  10. pmc Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1
    Qiaohua Kang
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, Missouri 63104, USA
    Endocrinology 150:5384-94. 2009

Collaborators

Detail Information

Publications29

  1. pmc The antioxidant (-)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression
    Anping Chen
    Department of Pathology, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, USA
    Biochem J 368:695-704. 2002
    ..Further studies are necessary to evaluate the effect of this polyphenol in prevention of quiescent HSC activation in vivo, and to further elucidate the underlying mechanisms...
  2. pmc Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells
    Anping Chen
    Department of Pathology, Louisiana State University Health Sciences Center in Shreveport, 1501 Kings Hwy, Shreveport, LA 71130, USA
    Biochem J 368:683-93. 2002
    ..Results from this report provided a novel insight into mechanisms by which acetaldehyde stimulated the expression of alpha1(I) collagen in HSC and a better understanding of effects of alcohol (or acetaldehyde) on hepatic fibrogenesis...
  3. ncbi Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR
    Anping Chen
    Department of Pathology, Louisiana State University, Health Sciences Center in Shreveport, 1501 Kings Hwy, Shreveport, LA 71130, USA
    Am J Physiol Gastrointest Liver Physiol 288:G447-56. 2005
    ..These results provided a novel insight into the roles and mechanisms of curcumin in inhibition of colon cancer cell growth and potential therapeutic strategies for treatment of colon cancer...
  4. ncbi The antioxidant (-)-epigallocatechin-3-gallate inhibits rat hepatic stellate cell proliferation in vitro by blocking the tyrosine phosphorylation and reducing the gene expression of platelet-derived growth factor-beta receptor
    Anping Chen
    Department of Pathology, Louisiana State University Health Sciences Center in Shreveport, Shreveport, Louisiana 71130, USA
    J Biol Chem 278:23381-9. 2003
    ....
  5. pmc Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells
    Jianguo Lin
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO 63104, USA
    Lab Invest 88:529-40. 2008
    ..These results provide novel insights into the mechanisms of curcumin in the inhibition of HSC activation and the suppression of hepatic fibrogenesis...
  6. pmc Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress
    Jianguo Lin
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO 63104, USA
    Br J Pharmacol 166:2212-27. 2012
    ..We hypothesize that curcumin eliminates the effects of AGEs by suppressing gene expression of RAGE...
  7. ncbi The antifibrogenic effect of (-)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells
    Fu Yumei
    Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, USA
    Lab Invest 86:697-709. 2006
    ..These results provide novel insights into the mechanisms of EGCG as an antifibrogenic candidate in the prevention and treatment of liver fibrosis...
  8. ncbi Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells
    Shizhong Zheng
    Department of Pathology, School of Medicine, St Louis University, St Louis, MO 63104, USA
    Am J Physiol Gastrointest Liver Physiol 292:G113-23. 2007
    ..Our studies provide novel insights into the molecular mechanisms of curcumin in the induction of PPAR-gamma gene expression and in the inhibition of HSC activation...
  9. pmc Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress
    Jianguo Lin
    Department of Pathology, Saint Louis University, MO 63104, USA
    Lab Invest 89:1397-409. 2009
    ..Our results provide novel insights into the mechanisms by which curcumin inhibits the insulin-induced HSC activation...
  10. pmc Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1
    Qiaohua Kang
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, Missouri 63104, USA
    Endocrinology 150:5384-94. 2009
    ..These results provide novel insights into molecular mechanisms by which curcumin inhibits LDL-induced HSC activation...
  11. pmc Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro
    Shizhong Zheng
    Department of Pathology, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, USA
    Biochem J 384:149-57. 2004
    ..The characteristics of curcumin, which has no adverse health effects, make it a potential candidate for prevention and treatment of hepatic fibrosis...
  12. ncbi Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor
    Shizhong Zheng
    Department of Pathology, Louisiana State University Health Sciences Center Shreveport, 1501 Kings Hwy, Shreveport, LA 71130, USA
    Am J Physiol Gastrointest Liver Physiol 290:G883-93. 2006
    ..These results provide novel insights into the mechanisms underlying inhibition of HSC activation by curcumin...
  13. pmc Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling
    Youcai Tang
    Department of Pathology, School of Medicine, Saint Louis University, 1100 S Grand Boulevard, St Louis, Missouri 63104, USA
    Endocrinology 150:3011-20. 2009
    ..These results provide novel insights into therapeutic mechanisms of curcumin in inhibiting HSC activation and intervening liver fibrogenesis associated with hyperleptinemia in NASH patients...
  14. pmc Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids
    Youcai Tang
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, Missouri 63104, USA
    Endocrinology 151:4168-77. 2010
    ..These results provide novel insights into mechanisms of curcumin in inhibiting leptin-induced HSC activation...
  15. ncbi Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth
    Jianye Xu
    Dept of Pathology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Am J Physiol Gastrointest Liver Physiol 285:G20-30. 2003
    ..The characteristics of curcumin, including antioxidant potential, reduction of activated HSC growth, and no adverse health effects, make it a potential antifibrotic candidate for prevention and treatment of hepatic fibrosis...
  16. pmc Curcumin eliminates the inhibitory effect of advanced glycation end-products (AGEs) on gene expression of AGE receptor-1 in hepatic stellate cells in vitro
    Jianguo Lin
    Department of Pathology, School of Medicine, Saint Louis University, Saint Louis, MO, USA
    Lab Invest 92:827-41. 2012
    ..Curcumin eliminated the AGE effects at least partially by inducing the AGE-R1 gene expression. The process was mediated by inhibiting ERK activity, inducing gene expression of PPARγ and stimulating its transactivity...
  17. pmc Epigallocatechin-3-gallate inhibits growth of activated hepatic stellate cells by enhancing the capacity of glutathione synthesis
    Yumei Fu
    Department of Pathology, School of Medicine, Saint Louis University, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Mol Pharmacol 73:1465-73. 2008
    ..These results support our hypothesis and collectively demonstrate that EGCG increases the level of cellular GSH in HSC by stimulating gene expression of GCLc, leading to the inhibition of cell proliferation of activated HSC in vitro...
  18. pmc Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling
    Youcai Tang
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO, USA
    Lab Invest 94:503-16. 2014
    ..In conclusions, curcumin eliminated the effects of AGEs on the divergent regulation of gene expression of RAGE and AGE-R1 in HSC by interrupting the AGE-caused activation of leptin signaling, leading to the inhibition of HSC activation. ..
  19. pmc Liver fatty acid binding protein (L-Fabp) modulates murine stellate cell activation and diet-induced nonalcoholic fatty liver disease
    Anping Chen
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO, USA
    Hepatology 57:2202-12. 2013
    ..In addition, TFF-fed L-FABP(-/-) mice exhibited decreased hepatic fibrosis, with reduced expression of fibrogenic genes, compared to WT mice...
  20. pmc Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase
    Youcai Tang
    Department of Pathology, School of Medicine, Saint Louis University, 1100 S Grand Boulevard, St Louis, MO 63104, USA
    Br J Pharmacol 161:1137-49. 2010
    ....
  21. pmc Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1
    Qiaohua Kang
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO 63104, USA
    Lab Invest 89:1275-90. 2009
    ....
  22. ncbi Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation
    Yumei Fu
    Department of Pathology, School of Medicine, Saint Louis University, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Mol Pharmacol 73:399-409. 2008
    ..Our results suggest that curcumin might be a therapeutic antifibrotic agent for the treatment of hepatic fibrosis...
  23. ncbi Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells
    Rodney E Shackelford
    Department of Pathology, Louisiana State University Health Sciences Center in Shreveport, 1501 Kings Hwy Shreveport, LA 71130, United States
    DNA Repair (Amst) 5:1327-36. 2006
    ..ATM therefore functions in iron responses and the maintenance of genomic stability following labile iron exposure...
  24. ncbi The phyto-chemical (-)-epigallocatechin gallate suppresses gene expression of epidermal growth factor receptor in rat hepatic stellate cells in vitro by reducing the activity of Egr-1
    Yumei Fu
    Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, United States
    Biochem Pharmacol 72:227-38. 2006
    ..Taken together, our results demonstrate that EGCG suppresses gene expression of EGFR in rat activated HSC in vitro mediated by reducing the trans-activation activity of Egr-1...
  25. pmc Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells
    Qiaohua Kang
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO 63104, USA
    Br J Pharmacol 157:1354-67. 2009
    ..This study aims to clarify effects of LDL on activation of HSC, to evaluate roles of curcumin in suppressing these effects and to further elucidate the underlying molecular mechanisms...
  26. doi Perilipin 5 restores the formation of lipid droplets in activated hepatic stellate cells and inhibits their activation
    Jianguo Lin
    Department of Pathology, School of Medicine, Saint Louis University, St Louis MO, USA
    Lab Invest 96:791-806. 2016
    ..Taken together, our results indicate that expression of Plin5 plays a critical role in the formation of LDs, the elevation of lipid content in HSC, and the inhibition of the activation of HSC. ..
  27. pmc De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation
    Shizhong Zheng
    Department of Pharmacology, Nanjing Medical University, China
    Free Radic Biol Med 43:444-53. 2007
    ..De novo synthesis of GSH is a prerequisite for curcumin to inhibit HSC activation. These results provide novel insights into the mechanisms of curcumin as an antifibrogenic candidate in the prevention and treatment of hepatic fibrosis...
  28. ncbi The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro
    Yajun Zhou
    Department of Biochemistry, Nantong University, Nantong, China
    Lab Invest 87:488-98. 2007
    ..These results provide novel insights into the mechanisms of curcumin in the induction of PPARgamma gene expression in activated HSC...
  29. ncbi Transforming growth factor-beta 1 signaling contributes to Caco-2 cell growth inhibition induced by 1,25(OH)(2)D(3)
    Anping Chen
    Gastroenterology Section, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Gastrointest Liver Physiol 283:G864-74. 2002
    ..Also, 1,25(OH)(2)D(3) sensitized Caco-2 cells to growth inhibitory effects of TGF-beta 1, contributing to the inhibition of Caco-2 cell growth by this secosteroid...