Frank O Bastian
Affiliation: Louisiana State University
- Spiroplasma spp. biofilm formation is instrumental for their role in the pathogenesis of plant, insect and animal diseasesFrank O Bastian
Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge, LA 70803, USA
Exp Mol Pathol 93:116-28. 2012..The discovery of biofilm formation by spiroplasma addresses questions regarding environmental persistence of these organisms in nature and suggests novel mechanisms of intercellular communication and transmission...
- Spiroplasma spp. from transmissible spongiform encephalopathy brains or ticks induce spongiform encephalopathy in ruminantsFrank O Bastian
Department of Veterinary Science, Louisiana State University Agricultural Center, 111 Dalrymple Building, Baton Rouge, LA 70803, USA
J Med Microbiol 56:1235-42. 2007..The spiroplasma infection models reported here will be important for investigating factors involved in the pathogenesis of TSE since ruminants are the natural hosts...
- Spiroplasma found in the eyes of scrapie affected sheepFrank O Bastian
Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge, LA, USA
Vet Ophthalmol 14:10-7. 2011..In this study, we set out to demonstrate similar retinal changes in our ruminant spiroplasmosis TSE model...
- The case for involvement of spiroplasma in the pathogenesis of transmissible spongiform encephalopathiesFrank O Bastian
From the Department of Animal Science, Louisiana State University Agricultural Center, Baton Rouge, Louisiana
J Neuropathol Exp Neurol 73:104-14. 2014..Research efforts should focus on this bacterium for development of therapeutic regimens for Creutzfeldt-Jakob disease. ..
- Linking chronic wasting disease to scrapie by comparison of Spiroplasma mirum ribosomal DNA sequencesFrank O Bastian
Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Exp Mol Pathol 77:49-56. 2004..The presence of Spiroplasma DNA in TSE-infected tissues supports our hypothesis that Spiroplasma may be involved in the pathogenesis of these diseases...
- Spiroplasma as a candidate agent for the transmissible spongiform encephalopathiesFrank O Bastian
Department of Pathology, Tulane Health Science Center, New Orleans, Louisiana 70112, USA
J Neuropathol Exp Neurol 64:833-8. 2005..These data support our hypothesis that a Spiroplasma sp. is the causal agent of TSE, although Koch's postulates must be fulfilled to definitively answer that question...
- Slow virus disease: deciphering conflicting data on the transmissible spongiform encephalopathies (TSE) also called prion diseasesFrank O Bastian
Tulane University Health Sciences Center, Department of Pathology and Lab Medicine, New Orleans, Louisian 70112, USA
Microsc Res Tech 68:239-46. 2005..Data from the bacterial-prion-receptor model will aid in the development diagnostic tests and/or treatment protocols for TSE...
- Spiroplasma 16S rDNA in TSE Brain TissuesFrank Bastian; Fiscal Year: 2006..involved. Although the role of Spiroplasma in TSE cannot be determined from these experiments, the presence of this microbe in all cases of TSE and not in controls would provide the basis for developing a test for TSE ..