Ruy M Ribeiro

Summary

Affiliation: Los Alamos National Laboratory
Country: USA

Publications

  1. pmc Experimental depletion of CD8+ cells in acutely SIVagm-infected African Green Monkeys results in increased viral replication
    Thaidra Gaufin
    Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
    Retrovirology 7:42. 2010
  2. pmc Response network analysis of differential gene expression in human epithelial lung cells during avian influenza infections
    Ken Tatebe
    Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
    BMC Bioinformatics 11:170. 2010
  3. ncbi request reprint Modeling deuterated glucose labeling of T-lymphocytes
    Ruy M Ribeiro
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, MS K710, Los Alamos, New Mexico 87545, USA
    Bull Math Biol 64:385-405. 2002
  4. pmc The contribution of the thymus to the recovery of peripheral naive T-cell numbers during antiretroviral treatment for HIV infection
    Ruy M Ribeiro
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    J Acquir Immune Defic Syndr 49:1-8. 2008
  5. ncbi request reprint Dynamics of CD4+ T cells in HIV-1 infection
    Ruy M Ribeiro
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Immunol Cell Biol 85:287-94. 2007
  6. pmc Hepatitis B virus kinetics under antiviral therapy sheds light on differences in hepatitis B e antigen positive and negative infections
    Ruy M Ribeiro
    Los Alamos National Laboratory, Los Alamos, New Mexico, USA
    J Infect Dis 202:1309-18. 2010
  7. pmc In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: why are CD4+ but not CD8+ T cells depleted?
    Ruy M Ribeiro
    Theoretical Division, Los Alamos National Laboratory, NM 87545, USA
    Proc Natl Acad Sci U S A 99:15572-7. 2002
  8. pmc Early ribavirin pharmacokinetics, HCV RNA and alanine aminotransferase kinetics in HIV/HCV co-infected patients during treatment with pegylated interferon and ribavirin
    Harel Dahari
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    J Hepatol 47:23-30. 2007
  9. ncbi request reprint A hepatitis C viral kinetic model that allows for time-varying drug effectiveness
    Emi Shudo
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    Antivir Ther 13:919-26. 2008
  10. doi request reprint Mathematical modeling of HCV infection and treatment
    Harel Dahari
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    Methods Mol Biol 510:439-53. 2009

Detail Information

Publications60

  1. pmc Experimental depletion of CD8+ cells in acutely SIVagm-infected African Green Monkeys results in increased viral replication
    Thaidra Gaufin
    Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
    Retrovirology 7:42. 2010
    ..To assess the role of cellular immune responses in the control of SIV replication in natural hosts, we investigated the impact of CD8+ cell depletion during acute SIV infection in AGMs...
  2. pmc Response network analysis of differential gene expression in human epithelial lung cells during avian influenza infections
    Ken Tatebe
    Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
    BMC Bioinformatics 11:170. 2010
    ..Additional analysis of the data is conducted by training support vector machines (SVM) with the data and examining the orientations of the optimal hyperplanes generated...
  3. ncbi request reprint Modeling deuterated glucose labeling of T-lymphocytes
    Ruy M Ribeiro
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, MS K710, Los Alamos, New Mexico 87545, USA
    Bull Math Biol 64:385-405. 2002
    ..The use of these models in the interpretation of the experimental data will increase our knowledge of T cell dynamics in the context of HIV infection...
  4. pmc The contribution of the thymus to the recovery of peripheral naive T-cell numbers during antiretroviral treatment for HIV infection
    Ruy M Ribeiro
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    J Acquir Immune Defic Syndr 49:1-8. 2008
    ....
  5. ncbi request reprint Dynamics of CD4+ T cells in HIV-1 infection
    Ruy M Ribeiro
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Immunol Cell Biol 85:287-94. 2007
    ..As the experimental techniques become more accurate and quantitative, modeling should play a more important part in both experimental design and data analysis...
  6. pmc Hepatitis B virus kinetics under antiviral therapy sheds light on differences in hepatitis B e antigen positive and negative infections
    Ruy M Ribeiro
    Los Alamos National Laboratory, Los Alamos, New Mexico, USA
    J Infect Dis 202:1309-18. 2010
    ..The former usually presents with lower viral levels but faster progression to liver disease. We sought to better understand the balance between replication and the immune response against hepatitis B virus (HBV)...
  7. pmc In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: why are CD4+ but not CD8+ T cells depleted?
    Ruy M Ribeiro
    Theoretical Division, Los Alamos National Laboratory, NM 87545, USA
    Proc Natl Acad Sci U S A 99:15572-7. 2002
    ..Our results also explain why telomeres shorten in CD8(+) cells, but not in CD4(+) cells of HIV-1-infected patients, compared with age-matched controls...
  8. pmc Early ribavirin pharmacokinetics, HCV RNA and alanine aminotransferase kinetics in HIV/HCV co-infected patients during treatment with pegylated interferon and ribavirin
    Harel Dahari
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    J Hepatol 47:23-30. 2007
    ..We evaluated whether early ribavirin pharmacokinetics differ comparing hepatitis C/human immunodeficiency virus coinfected sustained virological responders and nonresponders...
  9. ncbi request reprint A hepatitis C viral kinetic model that allows for time-varying drug effectiveness
    Emi Shudo
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    Antivir Ther 13:919-26. 2008
    ..However, for treatment with pegylated (PEG)-IFN-alpha2b dosed weekly, drug levels fall substantially and viral load rebounds have been observed toward the end of the weekly dosing interval, implying non-constant drug efficacy...
  10. doi request reprint Mathematical modeling of HCV infection and treatment
    Harel Dahari
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    Methods Mol Biol 510:439-53. 2009
    ..Here, we describe our current understanding of the kinetics of HCV infection and treatment...
  11. pmc Rapid emergence of protease inhibitor resistance in hepatitis C virus
    Libin Rong
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Sci Transl Med 2:30ra32. 2010
    ....
  12. pmc Modeling HCV kinetics under therapy using PK and PD information
    Emi Shudo
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, MS K710, New Mexico 87545, USA
    Expert Opin Drug Metab Toxicol 5:321-32. 2009
    ..Mathematical models have proven helpful in analyzing the virological response to antiviral therapy in hepatitis C virus (HCV) infected subjects...
  13. pmc Naïve and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human immunodeficiency virus type 1: implications for therapy
    Ruy M Ribeiro
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Virol 80:802-9. 2006
    ..We also investigate the effects of different antiviral strategies. Surprisingly, these results suggest that both conventional antiretroviral regimens and CCR5 receptor-blocking drugs will promote R5 virus over X4 virus...
  14. ncbi request reprint Triphasic decline of hepatitis C virus RNA during antiviral therapy
    Harel Dahari
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Hepatology 46:16-21. 2007
    ..Finally, the enhanced third phase in patients treated with IFN-alpha in combination with RBV versus patients treated with IFN-alpha alone can be explained by a mutagenic effect of RBV against HCV...
  15. ncbi request reprint Modeling the long-term control of viremia in HIV-1 infected patients treated with antiretroviral therapy
    Michele Di Mascio
    Theoretical Division, Los Alamos National Laboratory, 1 Los Alamos Lab, Los Alamos, NM 87545 0001, USA
    Math Biosci 188:47-62. 2004
    ....
  16. ncbi request reprint Kinetics of hepatitis C virus reinfection after liver transplantation
    Kimberly A Powers
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Liver Transpl 12:207-16. 2006
    ..In conclusion, we have quantified liver reinfection dynamics in the absence of posttransplantation antiviral therapy. Our findings support the notion that early antiviral therapy may delay or prevent reinfection...
  17. ncbi request reprint Modeling viral and drug kinetics: hepatitis C virus treatment with pegylated interferon alfa-2b
    Kimberly A Powers
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    Semin Liver Dis 23:13-8. 2003
    ..Models incorporating pharmacokinetics are needed to correctly interpret viral load changes and estimate drug effectiveness in treatment protocols using peginterferon alfa-2b...
  18. ncbi request reprint Hepatitis B virus kinetics and mathematical modeling
    Alan S Perelson
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    Semin Liver Dis 24:11-6. 2004
    ....
  19. pmc Modeling hepatitis C virus dynamics: liver regeneration and critical drug efficacy
    Harel Dahari
    Theoretical Biology and Biophysics, MS K710, Los Alamos National Laboratory, NM 87545, USA
    J Theor Biol 247:371-81. 2007
    ..Further, we define and characterize a critical drug efficacy, such that for efficacies above the critical value HCV is ultimately cleared, while for efficacies below it, a new chronically infected viral steady-state level is reached...
  20. pmc Estimation of the initial viral growth rate and basic reproductive number during acute HIV-1 infection
    Ruy M Ribeiro
    Theoretical Biology and Biophysics Group, MS K710, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Virol 84:6096-102. 2010
    ..They also better define the challenge that the immune response (or therapeutic intervention) has to overcome to defeat HIV at this early stage...
  21. pmc Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics
    Amber M Smith
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
    PLoS Comput Biol 7:e1001081. 2011
    ..We discuss the implications these mechanisms have during an infection with a virus expressing a virulent PB1-F2 on the possibility of a pandemic and on the importance of antiviral treatments...
  22. pmc Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate
    Ruy M Ribeiro
    Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
    PLoS Pathog 8:e1002881. 2012
    ..Our model identifies the relevant processes (long-lived cells and slow turnover of replication complexes) and parameters involved in determining the rate of HCV diversification...
  23. pmc Agent-based and phylogenetic analyses reveal how HIV-1 moves between risk groups: injecting drug users sustain the heterosexual epidemic in Latvia
    Frederik Graw
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, NM 87545, USA
    Epidemics 4:104-16. 2012
    ..Increases in susceptibles, through social or geographic movement of IDU, could lead to a boost in HIV-1 infections in this risk group. Targeting individuals that bridge social groups would help prevent further spread of the epidemic...
  24. ncbi request reprint Estimating drug efficacy and viral dynamic parameters: HIV and HCV
    Alan S Perelson
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Stat Med 27:4647-57. 2008
    ..Published in 2007 by John Wiley & Sons, Ltd...
  25. pmc Viral dynamics during primary simian immunodeficiency virus infection: effect of time-dependent virus infectivity
    Naveen K Vaidya
    Theoretical Biology and Biophysics Group, MS K710, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Virol 84:4302-10. 2010
    ..These results show that the infectivity depends upon the source of viral infection...
  26. ncbi request reprint Determining thymic output quantitatively: using models to interpret experimental T-cell receptor excision circle (TREC) data
    Ruy M Ribeiro
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Immunol Rev 216:21-34. 2007
    ..We show that mathematical models are not only useful but absolutely necessary for these analyses. As such, they should be taken as just another tool in the immunologist's arsenal...
  27. pmc Mathematical modeling of subgenomic hepatitis C virus replication in Huh-7 cells
    Harel Dahari
    Theoretical Biology and Biophysics, MS K710, Los Alamos National Laboratory, NM 87545, USA
    J Virol 81:750-60. 2007
    ..Moreover, the model can serve as an important tool in understanding HCV replication mechanisms and should prove useful in designing and evaluating new antivirals against HCV...
  28. ncbi request reprint Dynamics of alanine aminotransferase during hepatitis C virus treatment
    Ruy M Ribeiro
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Hepatology 38:509-17. 2003
    ..02). The week-4 ALT decline correlated with the HCV log drop (P =.006) and the efficacy of therapy (P =.025). In conclusion, our results suggest the use of ALT as a surrogate marker for treatment effect in patients with elevated ALT...
  29. pmc Real time bayesian estimation of the epidemic potential of emerging infectious diseases
    Luis M A Bettencourt
    Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
    PLoS ONE 3:e2185. 2008
    ....
  30. ncbi request reprint Dynamics of hepatitis B virus infection
    Ruy M Ribeiro
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Microbes Infect 4:829-35. 2002
    ..Here, we review the state of the art in modeling and interpreting data obtained from hepatitis B virus infected patients treated with antiviral agents...
  31. pmc The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection
    Leslie L Chavez
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Virology 381:75-80. 2008
    ..45, p=0.029), suggesting that the kinetics of early viral load may have a role in virus specific CD8+ T cell generation, although these early differences did not lead to different clinical outcomes within the vaccinated animals...
  32. pmc Estimating biologically relevant parameters under uncertainty for experimental within-host murine West Nile virus infection
    Soumya Banerjee
    Department of Computer Science, University of New Mexico, Albuquerque, NM, USA Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    J R Soc Interface 13:. 2016
    ..These models are a first step towards a quantitative understanding of the timing and effectiveness of the humoral immune response in reducing host viremia and consequently the epidemic spread of WNV. ..
  33. pmc Early HIV RNA decay during raltegravir-containing regimens exhibits two distinct subphases (1a and 1b)
    Adriana Andrade
    aThe Johns Hopkins University, Baltimore, Maryland, USA bINSERM, IAME, UMR 1137, and Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France cCenter for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts dUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania eBrigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts fTheoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
    AIDS 29:2419-26. 2015
    ..We analyzed the early kinetics with integrase inhibitor treatment to gain new insights into viral dynamics...
  34. pmc Inferring viral dynamics in chronically HCV infected patients from the spatial distribution of infected hepatocytes
    Frederik Graw
    Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, United States of America Center for Modeling and Simulation in the Biosciences, Heidelberg University, Heidelberg, Germany
    PLoS Comput Biol 10:e1003934. 2014
    ..Further, we do not find a relationship between the cluster size and the estimated cluster expansion time. Our method represents a novel approach to make inferences about infection dynamics in solid tissues from static spatial data...
  35. pmc Modeling the within-host dynamics of HIV infection
    Alan S Perelson
    MS K710, Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    BMC Biol 11:96. 2013
    ..We show how modeling has revealed many dynamical features of HIV infection and how it may provide insight into the ultimate cure for this infection. ..
  36. pmc The evolutionary rate dynamically tracks changes in HIV-1 epidemics: application of a simple method for optimizing the evolutionary rate in phylogenetic trees with longitudinal data
    Irina Maljkovic Berry
    Theoretical Biology and Biophysics, MS K710, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Epidemics 1:230-9. 2009
    ..Subtype C in Ethiopia showed an increase in the evolutionary rate when the prevalence increase markedly slowed down in 1995. Thus, we show that the evolutionary rate of HIV-1 on the population level dynamically tracks epidemic events...
  37. pmc Effects of antibody on viral kinetics in simian/human immunodeficiency virus infection: implications for vaccination
    Lei Zhang
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales 2052, Australia
    J Virol 78:5520-2. 2004
    ..By contrast, reduction in peak viral load later in infection prevents CD4 depletion and contributes to long-term viral control...
  38. pmc Kinetics of virus-specific CD8+ T cells and the control of human immunodeficiency virus infection
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital, Kensington, New South Wales, Australia
    J Virol 78:10096-103. 2004
    ..However, this response is too little too late to prevent establishment of persistent infection...
  39. pmc The role of cells refractory to productive infection in acute hepatitis B viral dynamics
    Stanca M Ciupe
    Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87507, USA
    Proc Natl Acad Sci U S A 104:5050-5. 2007
    ..Without this assumption, viral resurgence is observed as uninfected cells are regenerated. Such protection, possibly mediated by cytokines, may also be important in resolving other acute viral infections...
  40. ncbi request reprint Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infection
    Sharon R Lewin
    Department of Microbiology and Immunology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Immunol 169:4657-66. 2002
    ....
  41. ncbi request reprint Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) dynamics during HCV treatment in HCV/HIV coinfection
    Francesca J Torriani
    Department of Medicine, Division of Infectious Diseases, University of California, San Diego, California 92103, USA
    J Infect Dis 188:1498-507. 2003
    ..Although the early viral kinetics of coinfected subjects treated with PEG-IFN or IFN differ from those of singly infected subjects, the treatment response seems unaffected...
  42. pmc Modeling the mechanisms of acute hepatitis B virus infection
    Stanca M Ciupe
    Santa Fe Institute, 1399 Hyde Park Rd, Santa Fe, NM 87507, USA
    J Theor Biol 247:23-35. 2007
    ..In particular, we find that a cell-mediated immune response plays an important role in controlling the virus after the peak in viral load...
  43. pmc High-potency human immunodeficiency virus vaccination leads to delayed and reduced CD8+ T-cell expansion but improved virus control
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, Australia
    J Virol 79:10059-62. 2005
    ..Nevertheless, higher initial CD8(+) T-cell numbers were associated with reduced peak and chronic viral loads and reduced CD4(+) T-cell depletion...
  44. ncbi request reprint Influence of peak viral load on the extent of CD4+ T-cell depletion in simian HIV infection
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales, Australia
    J Acquir Immune Defic Syndr 41:259-65. 2006
    ..Whether such a simple relation also holds for HIV or simian immunodeficiency virus infections remains to be determined, particularly in the gut and other anatomic sites in which most early T-cell depletion occurs...
  45. ncbi request reprint Understanding the mechanisms and limitations of immune control of HIV
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, NSW, Australia
    Immunol Rev 216:164-75. 2007
    ..However, important questions remain as to whether differences in pathogenesis in HIV will lead to different 'rules of engagement' for immune control of virus...
  46. ncbi request reprint Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis B
    George K K Lau
    Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China
    Antivir Ther 12:705-18. 2007
    ..The patterns of hepatitis B viral dynamics during different antiviral therapies and the associated changes in HBV-specific T-cell reactivity are not well defined...
  47. pmc Th-1-type cytotoxic CD8+ T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeys
    Zichun Wang
    Division of Immunology, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, Massachusetts 01772, USA
    J Virol 80:2771-83. 2006
    ....
  48. pmc Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virus
    Amitinder Kaur
    Division of Immunology, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    J Virol 82:1084-93. 2008
    ....
  49. pmc Simian immunodeficiency virus SIVagm dynamics in African green monkeys
    Ivona Pandrea
    Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Virol 82:3713-24. 2008
    ....
  50. ncbi request reprint Pharmacodynamics of PEG-IFN alpha differentiate HIV/HCV coinfected sustained virological responders from nonresponders
    Andrew H Talal
    Department of Medicine and the Center for the Study of Hepatitis C, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hepatology 43:943-53. 2006
    ..In contrast, pharmacodynamic measurements-namely EC50, the therapeutic quotient, and C(7)/EC50--are different in coinfected SVRs and NRs. These parameters might be useful predictors of treatment outcome during the first month of therapy...
  51. ncbi request reprint Hepatitis B virus viral dynamics: effects of drug dose and baseline alanine aminotransferase
    Ruy M Ribeiro
    J Hepatol 37:277-9. 2002
  52. ncbi request reprint Hepatitis C virus genotype 1a NS5A pretreatment sequence variation and viral kinetics in African American and white patients
    Jennifer E Layden-Almer
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    J Infect Dis 192:1078-87. 2005
    ..The results of this study, in conjunction with those of a previous study illustrating the impaired IFN effectiveness in African Americans, suggest a role for host-related factors...
  53. ncbi request reprint Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus
    Sarah Tuttleton Arron
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    Eur J Immunol 35:46-55. 2005
    ..We therefore conclude that peripheral destructive processes, rather than a loss of thymic output, appear to be the main causes of T cell depletion in SIV infection...
  54. ncbi request reprint Mutagenic effects of ribavirin in vivo
    Alan S Perelson
    J Hepatol 43:553-5. 2005
  55. ncbi request reprint Mathematical modeling of viral kinetics: a tool to understand and optimize therapy
    Thomas J Layden
    Department of Medicine, College of Medicine, University of Illinois at Chicago, 840 South Wood Mail Code 787, Chicago, IL 60612, USA
    Clin Liver Dis 7:163-78. 2003
    ..Pawlotsky and Rosen). If the past is any indication of the usefulness of mathematical modeling and kinetics in the study of viruses, continued employment of these tools will only prove beneficial...
  56. ncbi request reprint Viral dynamics and response differences in HCV-infected African American and white patients treated with IFN and ribavirin
    Jennifer E Layden-Almer
    University of Illinois at Chicago, Chicago, IL, USA
    Hepatology 37:1343-50. 2003
    ..In conclusion, the failure of IFN response in African American patients infected with genotype 1 HCV is in part due to an impaired ability to inhibit viral production...
  57. ncbi request reprint Virus dynamics and immune responses during treatment in patients coinfected with hepatitis C and HIV
    Andrew H Talal
    Department of Medicine, Weill Medical College of Cornell University, New York City, NY, USA
    J Acquir Immune Defic Syndr 35:103-13. 2004
    ....
  58. ncbi request reprint The life span of ganglionic glia in murine sensory ganglia estimated by uptake of bromodeoxyuridine
    Karen Elson
    Herpes Research Laboratory, Institute of Medical and Veterinary Science, Adelaide, Australia
    Exp Neurol 186:99-103. 2004
    ..2 x 10(-3) cells/day, which implies a half-life for ganglionic glia of about 600 days. Thus murine ganglionic glia in the untraumatized state appear to behave as a homogenous, slowly replicating population...
  59. pmc Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence
    Ivona V Pandrea
    Divisions of Comparative Pathology and Microbiology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Immunol 179:3035-46. 2007
    ....
  60. pmc Predicting the impact of a nonsterilizing vaccine against human immunodeficiency virus
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital, and Centre for Vascular Research, University of New South Wales, Kensington, NSW, Australia
    J Virol 78:11340-51. 2004
    ....