David A Loewenstein

Summary

Country: USA

Publications

  1. pmc An investigation of PreMCI: subtypes and longitudinal outcomes
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 8:172-9. 2012
  2. pmc Stability of different subtypes of mild cognitive impairment among the elderly over a 2- to 3-year follow-up period
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Fla, USA
    Dement Geriatr Cogn Disord 27:418-23. 2009
  3. pmc The utility of a brief memory screen in the diagnosis of mild memory impairment in the elderly: preliminary study
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 17:437-40. 2009
  4. ncbi Vulnerability to proactive semantic interference and progression to dementia among older adults with mild cognitive impairment
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami Beach, FL 33140, USA
    Dement Geriatr Cogn Disord 24:363-8. 2007
  5. doi Severity of medial temporal atrophy and amnestic mild cognitive impairment: selecting type and number of memory tests
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 17:1050-8. 2009
  6. pmc Pre-MCI and MCI: neuropsychological, clinical, and imaging features and progression rates
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Miami Beach, Florida, USA
    Am J Geriatr Psychiatry 19:951-60. 2011
  7. doi Comparing new templates and atlas-based segmentations in the volumetric analysis of brain magnetic resonance images for diagnosing Alzheimer's disease
    Qian Shen
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 8:399-406. 2012
  8. pmc Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale: the mCDR
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Int J Geriatr Psychiatry 25:282-9. 2010
  9. pmc The cognitive change checklist (3CL): cross-validation of a measure of change in everyday cognition
    John A Schinka
    James A Haley VA Medical Center, Tampa, FL, USA
    Int J Geriatr Psychiatry 25:266-74. 2010
  10. pmc Minimal atrophy of the entorhinal cortex and hippocampus: progression of cognitive impairment
    Daniel Varon
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Dement Geriatr Cogn Disord 31:276-83. 2011

Collaborators

Detail Information

Publications43

  1. pmc An investigation of PreMCI: subtypes and longitudinal outcomes
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 8:172-9. 2012
    ..To investigate the clinical features and rates of progression of conditions that are not considered to be normal, but do not fulfill criteria for mild cognitive impairment (MCI)...
  2. pmc Stability of different subtypes of mild cognitive impairment among the elderly over a 2- to 3-year follow-up period
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Fla, USA
    Dement Geriatr Cogn Disord 27:418-23. 2009
    ..To investigate the longitudinal stability and progression of different subtypes of mild cognitive impairment (MCI) in older adults...
  3. pmc The utility of a brief memory screen in the diagnosis of mild memory impairment in the elderly: preliminary study
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 17:437-40. 2009
    ..This study evaluated the utility of the Florida Brief Memory Screen (FBMS), a new memory screening measure developed for Spanish-speaking and English-speaking subjects, which takes only 3-4 minutes to administer...
  4. ncbi Vulnerability to proactive semantic interference and progression to dementia among older adults with mild cognitive impairment
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami Beach, FL 33140, USA
    Dement Geriatr Cogn Disord 24:363-8. 2007
    ..Vulnerability to proactive interference may be an early manifestation of an early dementing process and may have utility in predicting future progression to dementia...
  5. doi Severity of medial temporal atrophy and amnestic mild cognitive impairment: selecting type and number of memory tests
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 17:1050-8. 2009
    ..The authors compared the strength of this biomarker with performance on four memory measures and examined the influence of demographic factors including age, level of education, and primary language (English or Spanish)...
  6. pmc Pre-MCI and MCI: neuropsychological, clinical, and imaging features and progression rates
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Miami Beach, Florida, USA
    Am J Geriatr Psychiatry 19:951-60. 2011
    ....
  7. doi Comparing new templates and atlas-based segmentations in the volumetric analysis of brain magnetic resonance images for diagnosing Alzheimer's disease
    Qian Shen
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 8:399-406. 2012
    ....
  8. pmc Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale: the mCDR
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Int J Geriatr Psychiatry 25:282-9. 2010
    ..To examine the reliability and validity of the mCDR, a modified version of the clinical dementia rating (CDR) scale...
  9. pmc The cognitive change checklist (3CL): cross-validation of a measure of change in everyday cognition
    John A Schinka
    James A Haley VA Medical Center, Tampa, FL, USA
    Int J Geriatr Psychiatry 25:266-74. 2010
    ....
  10. pmc Minimal atrophy of the entorhinal cortex and hippocampus: progression of cognitive impairment
    Daniel Varon
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Dement Geriatr Cogn Disord 31:276-83. 2011
    ..The significance of very mild atrophy of the ERC and HP on MRI scans among elderly subjects is unknown...
  11. ncbi Using different memory cutoffs to assess mild cognitive impairment
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 14:911-9. 2006
    ....
  12. pmc Reliability and validity of an algorithm for the diagnosis of normal cognition, mild cognitive impairment, and dementia: implications for multicenter research studies
    Ranjan Duara
    Mount Sinai Medical Center, Wien Center for Alzheimer s Disease and Memory Disorders, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 18:363-70. 2010
    ..As this procedure may be labor intensive and influenced by the philosophy and biases of a clinician, the diagnostic algorithm (AlgDx) was developed to identify individuals as cognitively normal, with MCI, or dementia...
  13. pmc Volumetric and visual rating of magnetic resonance imaging scans in the diagnosis of amnestic mild cognitive impairment and Alzheimer's disease
    Qian Shen
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 7:e101-8. 2011
    ....
  14. ncbi The use of amnestic and nonamnestic composite measures at different thresholds in the neuropsychological diagnosis of MCI
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    J Clin Exp Neuropsychol 29:300-7. 2007
    ..3%) and the composite measure of both impaired memory and nonmemory measures (sensitivity of 85.0%/specificity of 100%) had high levels of discrimination and may have utility as indices of early impairment as well as severity of MCI...
  15. ncbi Influence of sociodemographic variables on neuropsychological test performance in Spanish-speaking older adults
    Amarilis Acevedo
    Center on Aging and Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33140, USA
    J Clin Exp Neuropsychol 29:530-44. 2007
    ..These results underscore the impact of educational attainment on neuropsychological test performance among the cognitively normal Spanish-speaking older adult...
  16. ncbi Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Fla, USA
    Dement Geriatr Cogn Disord 21:309-15. 2006
    ..MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed...
  17. ncbi Nonpharmacological cognitive interventions in aging and dementia
    Amarilis Acevedo
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, and Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
    J Geriatr Psychiatry Neurol 20:239-49. 2007
    ..It is concluded that cognitive interventions in the elderly show considerable promise and deserve further study...
  18. doi Amyloid positron emission tomography with (18)F-flutemetamol and structural magnetic resonance imaging in the classification of mild cognitive impairment and Alzheimer's disease
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 9:295-301. 2013
    ..To evaluate the contributions of amyloid-positive (Am+) and medial temporal atrophy-positive (MTA+) scans to the diagnostic classification of prodromal and probable Alzheimer's disease (AD)...
  19. ncbi Semantic interference in mild Alzheimer disease: preliminary findings
    David A Loewenstein
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 11:252-5. 2003
    ..The authors evaluated the usefulness and psychometric properties of the Semantic Interference Test (SIT) in patients with mild Alzheimer disease (AD)...
  20. ncbi Conversion to dementia among two groups with cognitive impairment. A preliminary report
    Cheryl A Luis
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Fla 33140, USA
    Dement Geriatr Cogn Disord 18:307-13. 2004
    ..To determine the conversion rates to dementia in patients diagnosed with mild cognitive impairment (MCI) thought to be caused by incipient Alzheimer's disease (MCI-AD) or with MCI with features of vascular disease (MCI-Vas)...
  21. ncbi Cognitive rehabilitation of mildly impaired Alzheimer disease patients on cholinesterase inhibitors
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 12:395-402. 2004
    ..The authors evaluated the efficacy of a new cognitive rehabilitation program on memory and functional performance of mildly impaired Alzheimer disease (AD) patients receiving a cholinesterase inhibitor...
  22. ncbi Semantic interference deficits and the detection of mild Alzheimer's disease and mild cognitive impairment without dementia
    David A Loewenstein
    Department of Psychiatry, Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
    J Int Neuropsychol Soc 10:91-100. 2004
    ..6% and specificity of 96.2% in differentiating mild AD patients from normal older adults. Susceptibility to proactive semantic interference may be an early cognitive feature of MCI and AD patients presenting for clinical evaluation...
  23. doi Age-associated differences in cognitive performance in older patients with schizophrenia: a comparison with healthy older adults
    David A Loewenstein
    Department of Psychiatry and Behavioral Science and the Center on Aging, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Am J Geriatr Psychiatry 20:29-40. 2012
    ..Previous studies have been limited by restricted age ranges among schizophrenia and psychiatrically healthy control samples as well as small numbers of control participants...
  24. ncbi Stability of neurocognitive impairment in different subtypes of mild cognitive impairment
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Dement Geriatr Cogn Disord 23:82-6. 2007
    ....
  25. doi A Brief Computerized Paired Associate Test for the Detection of Mild Cognitive Impairment in Community-Dwelling Older Adults
    Rosie E Curiel
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA
    J Alzheimers Dis 54:793-9. 2016
    ..This is relevant given that developing assessment paradigms to identify subtle cognitive and functional deficits is a priority in preclinical Alzheimer's disease research...
  26. pmc Hospitalization and psychosis: influences on the course of cognition and everyday functioning in people with schizophrenia
    Philip D Harvey
    Center on Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Neurobiol Dis 53:18-25. 2013
    ..Prevention of relapse and discovering treatments to assist patients with resistant symptoms may reduce the risk of cognitive and functional declines across the lifespan in people with schizophrenia...
  27. pmc A Novel Cognitive Stress Test for the Detection of Preclinical Alzheimer Disease: Discriminative Properties and Relation to Amyloid Load
    David A Loewenstein
    Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center of Aging, Miami, FL Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Gainesville, FL Electronic address
    Am J Geriatr Psychiatry 24:804-13. 2016
    ..To examine the utility of a novel "cognitive stress test" to detect subtle cognitive impairments and amyloid load within the brains of neuropsychologically normal community-dwelling elders...
  28. doi Visual rating system for assessing magnetic resonance images: a tool in the diagnosis of mild cognitive impairment and Alzheimer disease
    Raksha Urs
    Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA
    J Comput Assist Tomogr 33:73-8. 2009
    ....
  29. ncbi Performance on the Boston Naming Test in English-Spanish bilingual older adults: some considerations
    Amarilis Acevedo
    Center on Aging and Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami Beach, FL 33140, USA
    J Int Neuropsychol Soc 13:212-4; discussion 215-8. 2007
    ..In light of the methodology employed, we weigh different potential interpretations of the findings and make recommendations for future studies...
  30. doi How late-life depression affects cognition: neural mechanisms
    Elizabeth A Crocco
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1695 Northwest 9th Avenue, Suite 3308, Miami, FL 33136, USA
    Curr Psychiatry Rep 12:34-8. 2010
    ..This article discusses cognitive impairment in geriatric depression and how developing a better understanding of its neural correlates may lead to improved understanding and outcome of this specific disorder...
  31. ncbi Psychiatric aspects of mild cognitive impairment
    Elizabeth A Crocco
    Department of Psychiatry, Mount Sinai Medical Center, 4300 Alton Road, MRI Building, 2nd Floor, Miami Beach, FL 33140, USA
    Curr Psychiatry Rep 7:32-6. 2005
    ..This article presents current information on psychiatric symptoms in mild cognitive impairment, their suggested role in the pathophysiology of AD and future research considerations on the subject...
  32. doi Towards an earlier diagnosis of Alzheimer disease (Proceedings of the 5th MCI Symposium, 2007)
    Lisa J Bain
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA
    Alzheimer Dis Assoc Disord 22:99-110. 2008
    ..As was intended, the symposium delivered no consensus; however, there was substantial support for the idea that AD can and probably should be diagnosed before the onset of dementia, particularly as new interventions become available...
  33. pmc Proactive Semantic Interference is Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders: A Preliminary Study
    David A Loewenstein
    Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center on Aging, Miami, FL Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL Electronic address
    Am J Geriatr Psychiatry 23:1276-9. 2015
    ..To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders...
  34. pmc An evaluation of deficits in semantic cueing and proactive and retroactive interference as early features of Alzheimer's disease
    Elizabeth Crocco
    Center on Aging and Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL
    Am J Geriatr Psychiatry 22:889-97. 2014
    ..To determine the degree to which susceptibility to different types of semantic interference may reflect the initial manifestations of early Alzheimer's disease (AD) beyond the effects of global memory impairment...
  35. pmc Assessing functional performance using computer-based simulations of everyday activities
    Sara J Czaja
    Department of Psychiatry and Behavioral Sciences, Miami, FL, Center on Aging, University of Miami Miller School of Medicine, 1695 N W 9th Avenue, Miami, FL 33133, USA Electronic address
    Schizophr Res . 2016
    ..The battery overcomes logistic constraints associated with current FC assessment protocols as the battery is computer-based, can be delivered remotely and does not require a healthcare professional for administration...
  36. doi Recovery from Proactive Semantic Interference in Mild Cognitive Impairment and Normal Aging: Relationship to Atrophy in Brain Regions Vulnerable to Alzheimer's Disease
    David A Loewenstein
    Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA
    J Alzheimers Dis . 2017
    ..There is growing evidence that proactive semantic interference (PSI) and failure to recover from PSI may represent early features of Alzheimer's disease (AD)...
  37. pmc Inclusion of Neuropsychological Scores in Atrophy Models Improves Diagnostic Classification of Alzheimer's Disease and Mild Cognitive Impairment
    Mohammed Goryawala
    Center for Advanced Technology and Education, Department of Electrical and Computer Engineering, Florida International University, Miami, FL, USA
    Comput Intell Neurosci 2015:865265. 2015
    ..The accuracy for groups that are difficult to differentiate like EMCI versus LMCI was 73.6%. With the inclusion of the neuropsychological scores, a significant improvement (24.59%) was obtained over using MRI measures alone. ..
  38. doi Verbal fluency patterns in mild cognitive impairment and Alzheimer's disease
    Eric Rinehardt
    Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, Fla, USA
    Dement Geriatr Cogn Disord 38:1-9. 2014
    ..While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cognitive impairment (MCI) is less well known...
  39. doi The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease
    John E Lewis
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Alzheimers Dis 33:393-406. 2013
    ..Participants tolerated the APMC supplement with few, temporary adverse reactions. Our results showed improvements in both clinical and physiological outcomes for a disease that otherwise has no standard ameliorative remedy...
  40. doi High Blood caffeine levels in MCI linked to lack of progression to dementia
    Chuanhai Cao
    Department of Pharmaceutical Science, University of South Florida College of Pharmacy, Tampa, FL 33620, USA
    J Alzheimers Dis 30:559-72. 2012
    ..This case-control study provides the first direct evidence that caffeine/coffee intake is associated with a reduced risk of dementia or delayed onset, particularly for those who already have MCI...
  41. pmc The effect of a family therapy and technology-based intervention on caregiver depression
    Carl Eisdorfer
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1695 N W 9th Avenue, Suite 3204, Miami, FL 33136, USA
    Gerontologist 43:521-31. 2003
    ....
  42. pmc Caregiver appraisals of functional dependence in individuals with dementia and associated caregiver upset: psychometric properties of a new scale and response patterns by caregiver and care recipient characteristics
    Laura N Gitlin
    Thomas Jefferson University, USA
    J Aging Health 17:148-71. 2005
    ..To evaluate psychometric properties and response patterns of the Care-giver Assessment of Function and Upset (CAFU), a 15-item multidimensional measure of dependence in dementia patients and caregiver reaction...
  43. ncbi Assessing the cognitive abilities that differentiate patients with Alzheimer's disease from normals: single and multiple factor models
    Raymond L Ownby
    Center on Aging and the Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33140, USA
    Int J Geriatr Psychiatry 19:232-42. 2004
    ..As deficits in cognitive abilities may reflect the pathological process or processes occurring in AD, determination of the structure of abilities in AD is important...