Michael J Linke
- Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposureMichael J Linke
Research Service, Veterans Affairs Medical Center, Cincinnati, OH, USA
Respir Res 10:10. 2009..Pneumocystis colonization has also been detected in immunocompetent hosts and may exacerbate other pulmonary diseases. Surfactant protein A (SP-A) is an innate host defense molecule and plays a role in the host response to Pneumocystis...
- Sensitized splenocytes result in deleterious cytokine cascade and hyperinflammatory response in rats with Pneumocystis pneumonia despite the presence of corticosteroidsTimothy D Thullen
Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
Infect Immun 72:757-65. 2004..Thus, in this model, corticosteroids have little effect on the cytokine cascade or other adverse effects of the host immune response to Pneumocystis...
- Effects of surfactant protein-A on the interaction of Pneumocystis murina with its host at different stages of the infection in miceMichael J Linke
Research Service, Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
J Eukaryot Microbiol 56:58-65. 2009..We conclude that SP-A can correct the host immune defect in the beginning of P. murina infection, but not in the middle or late stages of the infection...
- New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodiesTimothy D Thullen
Veterans Affairs Medical Center, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45220, USA
Infect Immun 71:6292-7. 2003....
- Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumoniaMichael J Linke
Cincinnati Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA
Infect Immun 81:984-95. 2013..That these 2 life cycle stages provoked distinct host response profiles has significant implications for clearance and interpretation of the host immune responses to PcP...
- Noninvasive method for monitoring Pneumocystis carinii pneumoniaMichael J Linke
Veterans Affairs Medical Center, Cincinnati, Ohio, USA
Emerg Infect Dis 9:1613-6. 2003..carinii organisms in the rats' lungs, as enumerated by microscopic methods. This report is the first of a noninvasive, antemortem method that can be used to monitor infection in a host over time...
- Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysemaGregory T Motz
Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0056, USA
J Immunol 181:8036-43. 2008..These findings have important implications for therapeutic approaches in the treatment of COPD, and provide insight into potential mechanisms involved in disease pathogenesis...
- Biofilm formation by Pneumocystis sppMelanie T Cushion
University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 560, Cincinnati, OH 45267 0560, USA
Eukaryot Cell 8:197-206. 2009..Identification of this biofilm process provides a tractable in vitro system that should fundamentally advance the study of Pneumocystis...
- Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected personsKieran R Daly
Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
J Infect Dis 186:644-51. 2002..None of the serum samples drawn from 9 patients before they had developed PcP recognized MsgC. These data suggest that these novel recombinant proteins are useful for the analysis of antibody responses to Msg...
- Pneumocystis murina MSG gene family and the structure of the locus associated with its transcriptionScott P Keely
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA
Fungal Genet Biol 44:905-19. 2007..carinii, but the block of conserved sequence in P. murina is nearly five times longer than in P. carinii, and much shorter than in P. wakefieldiae. These data indicate that the P. murina expression-site locus has a distinct structure...
- Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasmaKenneth R Wagner
Department of Neurology, University of Cincinnati College of Medicine, Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
Dev Neurosci 24:154-60. 2002..This rapid response, possibly in microglial cells, may contribute to white matter damage not only following ICH, but also in pathophysiological states in which blood-brain-barrier permeability to plasma proteins is increased...