David R Powell

Summary

Affiliation: Lexicon Genetics
Country: USA

Publications

  1. ncbi Rapid development of glomerular injury and renal failure in mice lacking p53R2
    David R Powell
    Lexicon Genetics Incorporated, The Woodlands, TX 77381, USA
    Pediatr Nephrol 20:432-40. 2005
  2. ncbi Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivo
    D R Powell
    Department of Endocrinology, Pharmaceutical Biology, Lexicon Genetics Incorporated, 8800 Technology Forest Place, The Woodlands, TX 77381 1160, USA
    Obes Rev 7:89-108. 2006
  3. pmc GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4
    William K Sonnenburg
    Department of Biotherapeutics, Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX 77381, USA
    J Lipid Res 50:2421-9. 2009
  4. pmc Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice
    David R Powell
    Lexicon Pharmaceuticals, Inc, The Woodlands, TX, USA
    Front Endocrinol (Lausanne) 6:86. 2015
  5. doi LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose
    David R Powell
    Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX 77381, USA
    J Pharmacol Exp Ther 345:250-9. 2013
  6. pmc Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL)
    E Chiang Lee
    Department of Biotherapeutics, Lexicon Pharmaceuticals, Inc, The Woodlands, Texas 77381, USA
    J Biol Chem 284:13735-45. 2009
  7. doi Profound obesity secondary to hyperphagia in mice lacking kinase suppressor of ras 2
    Jean Pierre Revelli
    Lexicon Pharmaceuticals, The Woodlands, Texas, USA
    Obesity (Silver Spring) 19:1010-8. 2011
  8. pmc Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque
    David R Powell
    Metabolism Research, Lexicon Pharmaceuticals, Inc, The Woodlands, TX, USA
    Diabetes Metab Syndr Obes 9:185-99. 2016
  9. pmc Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice
    Urvi Desai
    Department of Pharmaceutical Biology, Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX, 77381, USA
    Proc Natl Acad Sci U S A 104:11766-71. 2007
  10. doi High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes
    Robert Brommage
    Lexicon Pharmaceuticals, Inc, The Woodlands, Texas, USA
    Obesity (Silver Spring) 16:2362-7. 2008

Collaborators

Detail Information

Publications14

  1. ncbi Rapid development of glomerular injury and renal failure in mice lacking p53R2
    David R Powell
    Lexicon Genetics Incorporated, The Woodlands, TX 77381, USA
    Pediatr Nephrol 20:432-40. 2005
    ..These findings suggest that lack of p53R2, the protein encoded by Rrm2b, has early and relatively selective detrimental effects on the kidney glomerulus that lead to rapid death from progressive renal failure...
  2. ncbi Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivo
    D R Powell
    Department of Endocrinology, Pharmaceutical Biology, Lexicon Genetics Incorporated, 8800 Technology Forest Place, The Woodlands, TX 77381 1160, USA
    Obes Rev 7:89-108. 2006
    ..Ultimately, the value of using this approach to identify novel targets for human anti-obesity therapies will be judged by future studies examining the anti-obesity effect, in humans, of the therapeutics that result from this approach...
  3. pmc GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4
    William K Sonnenburg
    Department of Biotherapeutics, Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX 77381, USA
    J Lipid Res 50:2421-9. 2009
    ..Moreover, therapeutic agents that prevent LPL inhibition by ANGPTL4 or, to a lesser extent, ANGPTL3, may benefit individuals with hyperlipidemia caused by gene mutations associated with decreased LPL stability...
  4. pmc Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice
    David R Powell
    Lexicon Pharmaceuticals, Inc, The Woodlands, TX, USA
    Front Endocrinol (Lausanne) 6:86. 2015
    ....
  5. doi LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose
    David R Powell
    Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX 77381, USA
    J Pharmacol Exp Ther 345:250-9. 2013
    ..The ability to inhibit both intestinal SGLT1 and renal SGLT2 provides LX4211 with a novel dual mechanism of action for improving glycemic control in patients with T2DM...
  6. pmc Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL)
    E Chiang Lee
    Department of Biotherapeutics, Lexicon Pharmaceuticals, Inc, The Woodlands, Texas 77381, USA
    J Biol Chem 284:13735-45. 2009
    ..Moreover, these results demonstrate that therapeutic antibodies that neutralize ANGPTL4 and ANGPTL3 may be useful for treatment of some forms of hyperlipidemia...
  7. doi Profound obesity secondary to hyperphagia in mice lacking kinase suppressor of ras 2
    Jean Pierre Revelli
    Lexicon Pharmaceuticals, The Woodlands, Texas, USA
    Obesity (Silver Spring) 19:1010-8. 2011
    ..The metabolic phenotype of KSR2 heterozygous (KSR2(+/minus;)) and KSR2(-/-) mice suggests that human KSR2 variants may contribute to a similar phenotype linked to human chromosome 12q24...
  8. pmc Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque
    David R Powell
    Metabolism Research, Lexicon Pharmaceuticals, Inc, The Woodlands, TX, USA
    Diabetes Metab Syndr Obes 9:185-99. 2016
    ..The beneficial metabolic phenotype demonstrated in Fads1 KO mice suggests that selective D5D inhibitors may be useful in the treatment of human obesity, diabetes, and atherosclerotic cardiovascular disease. ..
  9. pmc Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice
    Urvi Desai
    Department of Pharmaceutical Biology, Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX, 77381, USA
    Proc Natl Acad Sci U S A 104:11766-71. 2007
    ....
  10. doi High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes
    Robert Brommage
    Lexicon Pharmaceuticals, Inc, The Woodlands, Texas, USA
    Obesity (Silver Spring) 16:2362-7. 2008
    ..This simple and cost-effective screen appears capable of identifying genes with a role in regulating mammalian body fat...
  11. doi Improved glycemic control in mice lacking Sglt1 and Sglt2
    David R Powell
    Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Pl, The Woodlands, TX 77381, USA
    Am J Physiol Endocrinol Metab 304:E117-30. 2013
    ....
  12. pmc Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function
    David P Harris
    Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX 77381, USA
    Mol Cell Biol 31:63-80. 2011
    ..Thus, PI3KC2α is critical for maintenance of normal glomerular structure and function by supporting normal podocyte function...
  13. ncbi Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon
    Yingda Wang
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 281:39982-9. 2006
    ..As such, the phenotype of UGRP(-/-) mice is mild, indicating that G6Pase is the major glucose-6-phosphatase of physiological importance for glucose homeostasis in vivo...
  14. ncbi Perturbations in bone formation and resorption in insulin-like growth factor binding protein-3 transgenic mice
    Josef V Silha
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 18:1834-41. 2003
    ....