N Kipshidze

Summary

Affiliation: Lenox Hill Hospital
Country: USA

Publications

  1. ncbi request reprint First Clinical Experience With Targeted REnal Nerve Demodulation (TREND-1) Using a Neurotropic Agent for the Treatment of Sympathetic Hypertension
    Nicholas Kipshidze
    Molecular and Endoluminal Coronary Interventions, Interventional Cardiology, 130 E 77th Street, New York, NY 10021 USA
    J Invasive Cardiol . 2017
  2. ncbi request reprint Update on sirolimus drug-eluting stents
    Nicholas Kipshidze
    Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY 10021, USA
    Curr Pharm Des 10:337-48. 2004
  3. ncbi request reprint First human experience with local delivery of novel antisense AVI-4126 with Infiltrator catheter in de novo native and restenotic coronary arteries: 6-month clinical and angiographic follow-up from AVAIL study
    Nicholas Kipshidze
    Lenox Hill Heart and Vascular Institute, New York, NY 10021, USA
    Cardiovasc Revasc Med 8:230-5. 2007
  4. ncbi request reprint Update on drug-eluting coronary stents
    Nicholas N Kipshidze
    Department of Interventional Cardiac and Vascular Services, Lenox Hill Hospital, New York, NY 10021, USA
    Expert Rev Cardiovasc Ther 3:953-68. 2005
  5. ncbi request reprint Evaluation of a novel endoluminal vascular occlusion device in a porcine model: early and late follow-up
    Nicholas Kipshidze
    Department of Interventional Cardiac and Vascular Services, Lenox Hill Hospital, New York, New York 10021, USA
    J Endovasc Ther 12:486-94. 2005
  6. ncbi request reprint Novel site-specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model
    Nicholas N Kipshidze
    Department of Interventional Cardiac and Vascular Services, Lenox Hill Hospital, New York, NY 10021, USA
    Catheter Cardiovasc Interv 64:389-94. 2005
  7. ncbi request reprint Antisense therapy for restenosis following percutaneous coronary intervention
    Nicholas Kipshidze
    Lenox Hill Hospital, Department of Interventional Cardiac and Vascular Services, 130 East 77th Street, New York, NY 10021, USA
    Expert Opin Biol Ther 5:79-89. 2005
  8. ncbi request reprint Role of the endothelium in modulating neointimal formation: vasculoprotective approaches to attenuate restenosis after percutaneous coronary interventions
    Nicholas Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, New York, New York 10021, USA
    J Am Coll Cardiol 44:733-9. 2004
  9. ncbi request reprint Advanced c-myc antisense (AVI-4126)-eluting phosphorylcholine-coated stent implantation is associated with complete vascular healing and reduced neointimal formation in the porcine coronary restenosis model
    Nicholas N Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, New York, New York 10021, USA
    Catheter Cardiovasc Interv 61:518-27. 2004
  10. ncbi request reprint Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model
    Nicholas N Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, 130 East 77th Street, Black Hall, 9th Floor, New York, NY 10021, USA
    Cardiovasc Radiat Med 4:152-9. 2003

Detail Information

Publications22

  1. ncbi request reprint First Clinical Experience With Targeted REnal Nerve Demodulation (TREND-1) Using a Neurotropic Agent for the Treatment of Sympathetic Hypertension
    Nicholas Kipshidze
    Molecular and Endoluminal Coronary Interventions, Interventional Cardiology, 130 E 77th Street, New York, NY 10021 USA
    J Invasive Cardiol . 2017
    ..To evaluate the feasibility and safety of a novel targeted neuromodulatory treatment for sympathetic hypertension involving a one-time local injection of neurotropic agents near renal nerves...
  2. ncbi request reprint Update on sirolimus drug-eluting stents
    Nicholas Kipshidze
    Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY 10021, USA
    Curr Pharm Des 10:337-48. 2004
    ..Cost-benefit issues also need to be addressed, especially because multivessel stenting and multistent usage is likely to increase...
  3. ncbi request reprint First human experience with local delivery of novel antisense AVI-4126 with Infiltrator catheter in de novo native and restenotic coronary arteries: 6-month clinical and angiographic follow-up from AVAIL study
    Nicholas Kipshidze
    Lenox Hill Heart and Vascular Institute, New York, NY 10021, USA
    Cardiovasc Revasc Med 8:230-5. 2007
    ..The purpose of the AVAIL study was to investigate both the safety and the efficacy of AVI-4126 delivered locally via Infiltrator catheter after percutaneous coronary intervention in humans...
  4. ncbi request reprint Update on drug-eluting coronary stents
    Nicholas N Kipshidze
    Department of Interventional Cardiac and Vascular Services, Lenox Hill Hospital, New York, NY 10021, USA
    Expert Rev Cardiovasc Ther 3:953-68. 2005
    ..Recent advances in vascular gene transfer have also demonstrated potential new treatment modalities for cardiovascular disease, particularly in the treatment of vascular restenosis...
  5. ncbi request reprint Evaluation of a novel endoluminal vascular occlusion device in a porcine model: early and late follow-up
    Nicholas Kipshidze
    Department of Interventional Cardiac and Vascular Services, Lenox Hill Hospital, New York, New York 10021, USA
    J Endovasc Ther 12:486-94. 2005
    ..To evaluate the efficacy of a new vascular occlusion device (VOD) in a preclinical controlled study versus embolization coils...
  6. ncbi request reprint Novel site-specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model
    Nicholas N Kipshidze
    Department of Interventional Cardiac and Vascular Services, Lenox Hill Hospital, New York, NY 10021, USA
    Catheter Cardiovasc Interv 64:389-94. 2005
    ..001). In the porcine coronary model, site-specific systemic delivery of Rapamycin utilizing PGMC resulted in overexpression of p27 and a significant reduction of neointimal formation within the stented segments...
  7. ncbi request reprint Antisense therapy for restenosis following percutaneous coronary intervention
    Nicholas Kipshidze
    Lenox Hill Hospital, Department of Interventional Cardiac and Vascular Services, 130 East 77th Street, New York, NY 10021, USA
    Expert Opin Biol Ther 5:79-89. 2005
    ..These preliminary findings from the small cohort of patients require confirmation in a larger trial utilising more sophisticated drug-eluting technologies...
  8. ncbi request reprint Role of the endothelium in modulating neointimal formation: vasculoprotective approaches to attenuate restenosis after percutaneous coronary interventions
    Nicholas Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, New York, New York 10021, USA
    J Am Coll Cardiol 44:733-9. 2004
    ....
  9. ncbi request reprint Advanced c-myc antisense (AVI-4126)-eluting phosphorylcholine-coated stent implantation is associated with complete vascular healing and reduced neointimal formation in the porcine coronary restenosis model
    Nicholas N Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, New York, New York 10021, USA
    Catheter Cardiovasc Interv 61:518-27. 2004
    ..In the porcine coronary model, an advanced c-myc-eluting PC stent blocked c-myc expression and significantly inhibited myointimal hyperplasia and allowed complete reendothelialization and healing response...
  10. ncbi request reprint Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model
    Nicholas N Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, 130 East 77th Street, Black Hall, 9th Floor, New York, NY 10021, USA
    Cardiovasc Radiat Med 4:152-9. 2003
    ..The purpose of this study was to investigate the effects of perfluorocarbon gas microbubble carrier (PGMC)-based systemic delivery of AVI-4126 on expression of the c-myc in vascular tissue and restenosis after stent implantation...
  11. ncbi request reprint Endoluminal reconstruction of the arterial wall with endothelial cell/glue matrix reduces restenosis in an atherosclerotic rabbit
    N Kipshidze
    Lenox Hill Heart and Vascular Institute of New York, and Cardiovascular Research Foundation, Lenox Hill Hospital, New York 10020, USA
    J Am Coll Cardiol 36:1396-403. 2000
    ..The objectives of this study were 1) to improve the attachment of reimplanted endothelial cells (EC) using a fibrin glue, and 2) to assess the impact of endothelial reseeding on restenosis eight weeks after balloon angioplasty...
  12. ncbi request reprint Influence of Class I interferons on performance of vascular cells on stent material in vitro
    Nicholas Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, New York, NY 10021, USA
    Cardiovasc Radiat Med 3:82-90. 2002
    ..The objective of the present study was to determine the effect of Class I IFNs on viability and growth characteristics of human aortic endothelial cells (ECs), smooth muscle cells (SMC) and fibroblasts (FBs) in vitro...
  13. ncbi request reprint Complete vascular healing and sustained suppression of neointimal thickening after local delivery of advanced c-myc antisense at six months follow-up in a rabbit balloon injury model
    Nicholas Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, New York, NY 10021, USA
    Cardiovasc Radiat Med 3:26-30. 2002
    ..We evaluated the long-term impact of local delivery of c-myc neutrally charged antisense oligonucleotides (Resten-NG) upon neointimal formation following PTCA in a rabbit model...
  14. ncbi request reprint Intramural coronary delivery of advanced antisense oligonucleotides reduces neointimal formation in the porcine stent restenosis model
    Nicholas N Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, New York, New York 10021, USA
    J Am Coll Cardiol 39:1686-91. 2002
    ..We evaluated the long-term influence of intramural delivery of advanced c-myc neutrally charged antisense oligonucleotides (Resten-NG) on neointimal hyperplasia after stenting in a pig model...
  15. ncbi request reprint Effect of short pulsed nonablative infrared laser irradiation on vascular cells in vitro and neointimal hyperplasia in a rabbit balloon injury model
    N Kipshidze
    Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY, USA
    Circulation 104:1850-5. 2001
    ..Neointimal hyperplasia after PTCA is an important component of restenosis...
  16. ncbi request reprint Local delivery of c-myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in the rabbit balloon injury model
    N Kipshidze
    Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, New York 10021, USA
    Catheter Cardiovasc Interv 54:247-56. 2001
    ..82 +/- 0.32 mm(2) in the control and antisense delivery groups, respectively (P < 0.05). We conclude that local delivery of Resten-NG inhibited myointimal hyperplasia after PTCA in cholesterol-fed rabbits for up to 60 days...
  17. ncbi request reprint Low-power laser irradiation increases cyclic GMP synthesis in penile smooth muscle cells in vitro
    N Kipshidze
    Lenox Hill Heart and Vascular Institute of New York, Cardiovascular Research Foundation, New York, New York 10021, USA
    J Clin Laser Med Surg 18:291-4. 2000
    ..The objective of the present study was to determine the effect of low-power laser irradiation (LPLI) on cyclic guanosine monophosphate (cGMP) produced by human corpus cavernosum smooth muscle cells (HCC SMC) in vitro...
  18. ncbi request reprint Perspectives on antisense therapy for the prevention of restenosis
    N Kipshidze
    Lenox Hill Heart and Vascular Institute of New York, NY 10022, USA
    Curr Opin Mol Ther 3:265-77. 2001
    ..Clinical studies are underway to investigate safety and efficacy of local delivery of this latest generation of antisense to reduce restenosis after coronary stenting...
  19. ncbi request reprint Photoactivation of vascular iNOS and elevation of cGMP in vivo: possible mechanism for photovasorelaxation and inhibition of restenosis in an atherosclerotic rabbit models
    N Kipshidze
    Lenox Hill Heart and Vascular Institute, New York, NY, USA
    Photochem Photobiol 72:579-82. 2000
    ..Balloon + laser treatment, however, tended to restore the expression of iNOS. Our study demonstrated that intravascular low dose laser irradiation induces iNOS and elevates vascular cGMP in an in vivo atherosclerotic rabbit model...
  20. ncbi request reprint Low-power helium: neon laser irradiation enhances production of vascular endothelial growth factor and promotes growth of endothelial cells in vitro
    N Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, New York, New York 10021, USA
    Lasers Surg Med 28:355-64. 2001
    ..These data may have significant importance leading to the establishment of new methods for endoluminal postangioplasty vascular repair and myocardial photoangiogenesis...
  21. ncbi request reprint Therapeutic angiogenesis for patients with limb ischemia by utilization of fibrin meshwork. Pilot randomized controlled study
    N Kipshidze
    Lenox Hill Heart and Vascular Institute, Cardiovascular Research Foundation, New York, NY 10021, USA
    Int Angiol 22:349-55. 2003
    ..The aim of this paper is to assess the feasibility and efficacy of fibrin in inducing neovascularization as an angiogenic substance and/or carrier for vascular endothelial growth factor (VEGF) in patients with limb ischemia...
  22. ncbi request reprint Transplantation of autologous endothelial cells induces angiogenesis
    Valeri Chekanov
    Heart Care Associates and Milwaukee Heart Institute, Milwaukee, Wisconsin, USA
    Pacing Clin Electrophysiol 26:496-9. 2003
    ..Heterotopic transplantation of EC within a fibrin matrix enhances neovascularization, increases myocardial blood flow, and improves left ventricular function...