David J Leehey

Summary

Country: USA

Publications

  1. pmc BP and Renal Outcomes in Diabetic Kidney Disease: The Veterans Affairs Nephropathy in Diabetes Trial
    David J Leehey
    Department of Medicine, Veterans Affairs Hospital, Hines Illinois Loyola University Medical Center, Maywood, Illinois
    Clin J Am Soc Nephrol 10:2159-69. 2015
  2. pmc Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot study
    David J Leehey
    Veterans Affairs Hospital, Hines, IL, USA
    Cardiovasc Diabetol 8:62. 2009
  3. doi request reprint Glomerular renin angiotensin system in streptozotocin diabetic and Zucker diabetic fatty rats
    David J Leehey
    Department of Medicine, Veterans Affairs Hospital, Hines, IL 60141, USA
    Transl Res 151:208-16. 2008
  4. ncbi request reprint A novel mechanism for angiotensin II formation in streptozotocin-diabetic rat glomeruli
    Rekha Singh
    Department of Medicine, Veterans Affairs Hospital, 111 L, Hines, IL 60141, USA
    Am J Physiol Renal Physiol 288:F1183-90. 2005
  5. ncbi request reprint A comparison of aerobic exercise and resistance training in patients with and without chronic kidney disease
    Irfan Moinuddin
    Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
    Adv Chronic Kidney Dis 15:83-96. 2008
  6. pmc Proteinuria induced by parenteral iron in chronic kidney disease--a comparative randomized controlled trial
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 6:114-21. 2011
  7. pmc Progression of kidney disease in type 2 diabetes - beyond blood pressure control: an observational study
    David J Leehey
    Department of Medicine Veterans Affairs Hospital Hines, IL and Loyola University Medical Center Maywood, IL, USA
    BMC Nephrol 6:8. 2005
  8. ncbi request reprint Effect of high glucose on superoxide in human mesangial cells: role of angiotensin II
    David J Leehey
    Veterans Affairs Hospital, Hines, IL 60141, USA
    Nephron Exp Nephrol 100:e46-53. 2005
  9. doi request reprint Inhibition of intracellular angiotensin II formation blocks high glucose effect on mesangial matrix
    Rekha Singh
    Hines VA Hospital, Hines, IL 60141, USA
    Regul Pept 158:103-9. 2009
  10. ncbi request reprint Effect of ACE inhibitors on angiotensin II in rat mesangial cells cultured in high glucose
    Rekha Singh
    Veterans Affairs Hospital, Hines, IL 60141, USA
    Biochem Biophys Res Commun 357:1040-5. 2007

Collaborators

Detail Information

Publications20

  1. pmc BP and Renal Outcomes in Diabetic Kidney Disease: The Veterans Affairs Nephropathy in Diabetes Trial
    David J Leehey
    Department of Medicine, Veterans Affairs Hospital, Hines Illinois Loyola University Medical Center, Maywood, Illinois
    Clin J Am Soc Nephrol 10:2159-69. 2015
    ..Control of BP delays progression, but the optimal BP to improve outcomes remains unclear. The objective of this analysis was to evaluate the relationship between BP and renal outcomes in proteinuric diabetic kidney disease...
  2. pmc Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot study
    David J Leehey
    Veterans Affairs Hospital, Hines, IL, USA
    Cardiovasc Diabetol 8:62. 2009
    ..Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program...
  3. doi request reprint Glomerular renin angiotensin system in streptozotocin diabetic and Zucker diabetic fatty rats
    David J Leehey
    Department of Medicine, Veterans Affairs Hospital, Hines, IL 60141, USA
    Transl Res 151:208-16. 2008
    ..The mechanism of nephropathy in the ZDF rat may involve factors other than hyperglycemia and RAS activation, such as hypertension and hyperlipidemia...
  4. ncbi request reprint A novel mechanism for angiotensin II formation in streptozotocin-diabetic rat glomeruli
    Rekha Singh
    Department of Medicine, Veterans Affairs Hospital, 111 L, Hines, IL 60141, USA
    Am J Physiol Renal Physiol 288:F1183-90. 2005
    ..Thus this study demonstrates that in diabetic rats, glomerular ANG II levels are increased due to an increase in angiotensinogen and an increase in the formation of ANG II...
  5. ncbi request reprint A comparison of aerobic exercise and resistance training in patients with and without chronic kidney disease
    Irfan Moinuddin
    Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
    Adv Chronic Kidney Dis 15:83-96. 2008
    ....
  6. pmc Proteinuria induced by parenteral iron in chronic kidney disease--a comparative randomized controlled trial
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 6:114-21. 2011
    ..This study examined differences in proteinuria between two intravenous iron preparations after multiple doses...
  7. pmc Progression of kidney disease in type 2 diabetes - beyond blood pressure control: an observational study
    David J Leehey
    Department of Medicine Veterans Affairs Hospital Hines, IL and Loyola University Medical Center Maywood, IL, USA
    BMC Nephrol 6:8. 2005
    ..Although uncontrolled blood pressure (BP) is known to be deleterious, other factors may become more important once BP is treated...
  8. ncbi request reprint Effect of high glucose on superoxide in human mesangial cells: role of angiotensin II
    David J Leehey
    Veterans Affairs Hospital, Hines, IL 60141, USA
    Nephron Exp Nephrol 100:e46-53. 2005
    ..This study was designed to investigate the effects of high glucose (HG) on O2* accumulation and SOD activity in human mesangial cells (HMC) and to determine if these effects are mediated by angiotensin II (Ang II)...
  9. doi request reprint Inhibition of intracellular angiotensin II formation blocks high glucose effect on mesangial matrix
    Rekha Singh
    Hines VA Hospital, Hines, IL 60141, USA
    Regul Pept 158:103-9. 2009
    ..These data suggest that intracellular Ang II may play an important role in the mediation of the high glucose effect on matrix and that ACE inhibitors may not be effective in blocking intracellular Ang II formation in mesangial cells...
  10. ncbi request reprint Effect of ACE inhibitors on angiotensin II in rat mesangial cells cultured in high glucose
    Rekha Singh
    Veterans Affairs Hospital, Hines, IL 60141, USA
    Biochem Biophys Res Commun 357:1040-5. 2007
    ..Addition of captopril to cell lysates was indeed able to inhibit Ang I conversion to Ang II but only partially. These findings suggest the involvement of non-ACE mechanisms in Ang II formation from Ang I in mesangial cells...
  11. ncbi request reprint Albuminuria in acute tubular necrosis
    Bradford Lee West
    Department of Medicine, Loyola University Medical Center, 2160 S 1st Avenue, Maywood, IL 60153, USA
    Nephrol Dial Transplant 21:2953-6. 2006
  12. ncbi request reprint Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus
    Mohammed S Ahmed
    Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Kidney Dis 50:1028-32. 2007
    ..The clinical course of this patient suggests that Astragalus may have beneficial effects in patients with idiopathic membranous nephropathy...
  13. doi request reprint Urinary incontinence and diuretic avoidance among adults with chronic kidney disease
    Mitul Patel
    Division of Nephrology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA
    Int Urol Nephrol 48:1321-6. 2016
    ..This single-center pilot study examined the prevalence of UI among adults age ≥60 years with CKD using diuretics and assessed diuretic avoidance due to urinary symptoms...
  14. doi request reprint Structured Exercise in Obese Diabetic Patients with Chronic Kidney Disease: A Randomized Controlled Trial
    David J Leehey
    Veterans Affairs Medical Center, Hines, Ill, USA
    Am J Nephrol 44:54-62. 2016
    ..Our objective was to determine the effects of structured exercise on physical fitness, kidney function, endothelial function, inflammation, and body composition in such patients...
  15. ncbi request reprint Sodium ferric gluconate causes oxidative stress but not acute renal injury in patients with chronic kidney disease: a pilot study
    David J Leehey
    Division of Nephrology, Department of Medicine, Loyola University School of Medicine and Edward Hines Jr VA Medical Center, Hines, IL 60141, USA
    Nephrol Dial Transplant 20:135-40. 2005
    ..Intravenous (i.v) iron is widely used to treat anaemia in patients with chronic kidney disease (CKD). Although beneficial and usually well tolerated, concerns have been raised about its ability to cause oxidative stress and renal injury...
  16. pmc Non-dialysis dependent chronic kidney disease is associated with high total and out-of-pocket healthcare expenditures
    Christina Small
    Department of Public Health Sciences, Loyola University Chicago, 2160 S First Ave, Maywood, IL, 60153, USA
    BMC Nephrol 18:3. 2017
    ..This study described total direct and out-of-pocket expenditures for adults with non-dialysis dependent CKD and compared expenditures with those for cancer or stroke...
  17. ncbi request reprint Expanding the pathologic spectrum of immunoglobulin light chain proximal tubulopathy
    Umesh Kapur
    Department of Pathology, Loyola University Medical Center, Maywood, Ill, USA
    Arch Pathol Lab Med 131:1368-72. 2007
    ..In plasma cell dyscrasias, involvement of the distal tubules is frequent and well characterized. In contrast, proximal tubules have only rarely been reported to show diagnostic pathology such as intracytoplasmic crystals...
  18. doi request reprint Life-threatening hypokalemia following rapid correction of respiratory acidosis
    Kendra Hammond
    Edward Hines, Jr Veterans Affairs Hospital, Hines, IL 60141, USA
    Heart Lung 42:287-9. 2013
    ..Serum potassium levels must be monitored closely in these patients, as failure to do so can lead to potentially lethal consequences. ..
  19. ncbi request reprint Simultaneous transjugular renal biopsy and hemodialysis catheter placement in patients with ARF
    Mohammed S Ahmed
    Department of Medicine, Loyola University Stritch School of Medicine, Maywood, IL, USA
    Am J Kidney Dis 44:429-36. 2004
    ..We sought to evaluate transjugular renal biopsy in patients with acute renal failure (ARF) or ARF in the presence of chronic renal insufficiency (CRI) who required venous catheter placement for hemodialysis (HD)...
  20. ncbi request reprint Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucose
    Rekha Singh
    Department of Medicine, Veterans Affairs Hospital, Hines, Illinois, and Loyola University Stritch School of Medicine, Maywood, Illinois 60141, USA
    J Am Soc Nephrol 14:873-80. 2003
    ..In addition, this study provides new information that Ang(1-9) is produced by mesangial cells, can be converted to AngII, and that this conversion is also stimulated under high-glucose conditions...