Trudy M Forte

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. ncbi request reprint Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice
    Trudy M Forte
    Life Sciences Division MS 1 222, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Lipid Res 43:477-85. 2002
  2. ncbi request reprint Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1
    Pradeep Natarajan
    Lawrence Berkeley National Laboratory, Donner Laboratory MS1 224, University of California at Berkeley, California 94720, USA
    J Biol Chem 279:24044-52. 2004
  3. ncbi request reprint Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins
    Michael N Oda
    Life Sciences Division MS 1 220, Lawrence Berkeley National Laboratory, One Cylotron Road, Berkeley, California 94720, USA
    Biochem Biophys Res Commun 290:921-7. 2002
  4. ncbi request reprint Thiol-bearing synthetic peptides retain the antioxidant activity of apolipoproteinA-I(Milano)
    Zhen Jia
    Department of Genome Sciences, Division of Life Sciences, Lawrence Berkeley National Laboratory, CA 94720, USA
    Biochem Biophys Res Commun 297:206-13. 2002
  5. pmc NanoDisk containing super aggregated amphotericin B: a high therapeutic index antifungal formulation with enhanced potency
    Braydon L Burgess
    Children s Hospital Oakland Research Institute, Oakland, CA, USA Lypro Biosciences, Berkeley, CA, USA
    Int J Nanomedicine 8:4733-43. 2013
  6. ncbi request reprint Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme
    Mina Nikanjam
    Department of Bioengineering, University of California, Berkeley, CA 94609, USA
    Int J Pharm 328:86-94. 2007
  7. ncbi request reprint Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis
    Jennifer A Beckstead
    Lipid Biology in Health and Disease Research Group, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Biochemistry 42:9416-23. 2003
  8. pmc Orientation and mode of lipid-binding interaction of human apolipoprotein E C-terminal domain
    Vincent Raussens
    Structure and Function of Biological Membranes, Universite Libre de Bruxelles, CP 206 2, Bd du Triomphe, B 1050 Brussels, Belgium
    Biochem J 387:747-54. 2005
  9. ncbi request reprint Optimized bacterial expression of human apolipoprotein A-I
    Robert O Ryan
    Lipid Biology in Health and Disease Research Group, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Protein Expr Purif 27:98-103. 2003
  10. ncbi request reprint Apolipoprotein A-I and the molecular variant apoA-I(Milano): evaluation of the antiatherogenic effects in knock-in mouse model
    Cinzia Parolini
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Atherosclerosis 183:222-9. 2005

Research Grants

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice
    Trudy M Forte
    Life Sciences Division MS 1 222, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Lipid Res 43:477-85. 2002
    ..We conclude that impairment of LCAT activity and accumulation of oxidized phospholipids are part of an early atherogenic phenotype in these models...
  2. ncbi request reprint Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1
    Pradeep Natarajan
    Lawrence Berkeley National Laboratory, Donner Laboratory MS1 224, University of California at Berkeley, California 94720, USA
    J Biol Chem 279:24044-52. 2004
    ..These results suggest that a specific structural element possessing a linear array of acidic residues spanning two apoA-I amphipathic alpha-helices is required to mediate cholesterol efflux and stabilize ABCA1...
  3. ncbi request reprint Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins
    Michael N Oda
    Life Sciences Division MS 1 220, Lawrence Berkeley National Laboratory, One Cylotron Road, Berkeley, California 94720, USA
    Biochem Biophys Res Commun 290:921-7. 2002
    ..Excess mPON1 also inhibited lipid hydroperoxide formation on HDL. These data strongly suggest that overexpression of mPON1 protects HDL integrity and function...
  4. ncbi request reprint Thiol-bearing synthetic peptides retain the antioxidant activity of apolipoproteinA-I(Milano)
    Zhen Jia
    Department of Genome Sciences, Division of Life Sciences, Lawrence Berkeley National Laboratory, CA 94720, USA
    Biochem Biophys Res Commun 297:206-13. 2002
    ..Cysteine-free peptides were weak inhibitors of lipid peroxidation. These results suggest that thiol-bearing helical peptides based on apoA-I(Milano) may be useful to combat inflammatory related diseases...
  5. pmc NanoDisk containing super aggregated amphotericin B: a high therapeutic index antifungal formulation with enhanced potency
    Braydon L Burgess
    Children s Hospital Oakland Research Institute, Oakland, CA, USA Lypro Biosciences, Berkeley, CA, USA
    Int J Nanomedicine 8:4733-43. 2013
    ..We have developed an AMB-based therapy that is both well tolerated and fully efficacious...
  6. ncbi request reprint Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme
    Mina Nikanjam
    Department of Bioengineering, University of California, Berkeley, CA 94609, USA
    Int J Pharm 328:86-94. 2007
    ..Collectively these data strongly suggest that the synthetic nano-LDLs described here are taken up by LDLR and can serve as a drug delivery vehicle for targeting GBM tumors via the LDLR...
  7. ncbi request reprint Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis
    Jennifer A Beckstead
    Lipid Biology in Health and Disease Research Group, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Biochemistry 42:9416-23. 2003
    ..Taken together, the results demonstrate recombinant apoA-V possesses unique structural and functional characteristics, in keeping with its proposed role in the modulation of plasma lipid levels...
  8. pmc Orientation and mode of lipid-binding interaction of human apolipoprotein E C-terminal domain
    Vincent Raussens
    Structure and Function of Biological Membranes, Universite Libre de Bruxelles, CP 206 2, Bd du Triomphe, B 1050 Brussels, Belgium
    Biochem J 387:747-54. 2005
    ..Taken together, we propose that apoE CT domain interacts with phospholipid vesicles, forming a long extended helix that circumscribes the discoidal bilayer lipoprotein complex...
  9. ncbi request reprint Optimized bacterial expression of human apolipoprotein A-I
    Robert O Ryan
    Lipid Biology in Health and Disease Research Group, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Protein Expr Purif 27:98-103. 2003
    ..Together, these changes in apoA-I cDNA and bacterial expression protocol significantly improve the yield of apoA-I protein without compromising the relative ease of purification...
  10. ncbi request reprint Apolipoprotein A-I and the molecular variant apoA-I(Milano): evaluation of the antiatherogenic effects in knock-in mouse model
    Cinzia Parolini
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Atherosclerosis 183:222-9. 2005
    ..685). Our data suggest that, in the atherosclerosis-susceptible human apoB/A-II mouse model, expression of the human apoA-I(M) gene does not have protective advantage over that of the apoA-I gene...
  11. ncbi request reprint The C-terminal domain of apolipoprotein A-I contains a lipid-sensitive conformational trigger
    Michael N Oda
    Children s Hospital Oakland Research Institute, Oakland, California 94609 1673, USA
    Nat Struct Biol 10:455-60. 2003
    ..This conformational switch is analogous to triggered events in viral fusion proteins and may serve as a means to overcome the energy barriers of lipid sequestration, a critical step in cholesterol efflux and HDL assembly...
  12. ncbi request reprint The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins
    Charulatha Vedhachalam
    GI Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Biochemistry 46:2583-93. 2007
    ..Collectively, the data suggest that the CT lipid-binding domain of apoE encompassing amino acids 222-299 is necessary and sufficient for mediating ABCA1 lipid efflux and HDL particle assembly...
  13. ncbi request reprint Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme
    Mina Nikanjam
    Department of Bioengineering, University of California, Berkeley, California, United States
    J Control Release 124:163-71. 2007
    ..nLDL-PO has the potential to serve as a selective drug delivery vehicle for targeting GBM tumors via the LDL receptor...
  14. ncbi request reprint Effect of apolipoprotein A-V on plasma triglyceride, lipoprotein size, and composition in genetically engineered mice
    Lisa Nelbach
    Center for Prevention of Obesity, Diabetes, and Cardiovascular Disease, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Lipid Res 49:572-80. 2008
    ..It is conceivable that, in a situation in which apoA-V is chronically overexpressed, complex interactions among factors regulating TG homeostasis may result in a positive correlation of apoA-V with TG concentrations...
  15. pmc Intracellular lipid droplet targeting by apolipoprotein A-V requires the carboxyl-terminal segment
    Xiao Shu
    Center for Prevention of Obesity, Diabetes, and Cardiovascular Disease, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Lipid Res 49:1670-6. 2008
    ....
  16. ncbi request reprint Synthesis, characterization, and plasma lipoprotein association of a nucleus-targeted boronated porphyrin
    Paola Dozzo
    Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, USA
    J Med Chem 48:357-9. 2005
    ..The porphyrin-NLS conjugate associates in vitro predominantly with low density lipoproteins. Such association provides a potentially selective entry pathway into malignant cells that overexpress the LDL receptor...

Research Grants1

  1. CONFERENCE ON ARTERIOSCLEROSIS AND VASCULAR BIOLOGY
    Trudy Forte; Fiscal Year: 2004
    ..abstract_text> ..