Sylvain V Costes

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. doi request reprint Targeted and nontargeted effects of ionizing radiation that impact genomic instability
    Christopher A Maxwell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 68:8304-11. 2008
  2. ncbi request reprint Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 165:505-15. 2006
  3. doi request reprint Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor β
    Kumari L Andarawewa
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Int J Radiat Oncol Biol Phys 79:1523-31. 2011
  4. pmc Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling
    Jonathan Tang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Integr Biol (Camb) 3:408-21. 2011
  5. pmc Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Comput Biol 3:e155. 2007
  6. pmc The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C
    Elaine M Dunleavy
    Department of Genome Dynamics, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    PLoS Biol 10:e1001460. 2012
  7. pmc Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
    Rituparna Mukhopadhyay
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Breast Cancer Res 12:R11. 2010
  8. doi request reprint Persistence of γ-H2AX and 53BP1 foci in proliferating and non-proliferating human mammary epithelial cells after exposure to γ-rays or iron ions
    Torsten Groesser
    Lawrence Berkeley National Laboratory, Life Sciences Division, Department of Cancer and DNA Damage Responses, Berkeley, CA 94720, USA
    Int J Radiat Biol 87:696-710. 2011
  9. pmc Automatic and quantitative measurement of protein-protein colocalization in live cells
    Sylvain V Costes
    Image Analysis Laboratory, National Cancer Institute, Frederick, Maryland, USA
    Biophys J 86:3993-4003. 2004
  10. doi request reprint Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors
    Jonathan Tang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley California, USA
    Stem Cells 32:649-61. 2014

Collaborators

Detail Information

Publications21

  1. doi request reprint Targeted and nontargeted effects of ionizing radiation that impact genomic instability
    Christopher A Maxwell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 68:8304-11. 2008
    ..Together, these studies show that radiation deregulates centrosome stability, which underlies genomic instability in normal human epithelial cells, and that this can be opposed by radiation-induced TGFbeta signaling...
  2. ncbi request reprint Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 165:505-15. 2006
    ..Thus, even though double-strand breaks and radiation-induced foci are correlated, the dynamic nature of both contradicts their accepted equivalence for low doses of different radiation qualities...
  3. doi request reprint Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor β
    Kumari L Andarawewa
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Int J Radiat Oncol Biol Phys 79:1523-31. 2011
    ..In this study we determined whether radiation dose or quality affected TGF-β-mediated EMT...
  4. pmc Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling
    Jonathan Tang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Integr Biol (Camb) 3:408-21. 2011
    ..Our simulations suggest that overexpression of AKT-1 must also perturb cell-cell and cell-ECM communication, reminding us that extracellular context can dictate cellular behavior...
  5. pmc Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Comput Biol 3:e155. 2007
    ..These data suggest that DNA damage-induced foci are restricted to certain regions of the nucleus of human epithelial cells. It is possible that DNA lesions are collected in these nuclear sub-domains for more efficient repair...
  6. pmc The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C
    Elaine M Dunleavy
    Department of Genome Dynamics, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    PLoS Biol 10:e1001460. 2012
    ....
  7. pmc Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
    Rituparna Mukhopadhyay
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Breast Cancer Res 12:R11. 2010
    ..We investigated whether ionizing radiation, which increases breast cancer risk in women, affects the rate of vHMEC outgrowth...
  8. doi request reprint Persistence of γ-H2AX and 53BP1 foci in proliferating and non-proliferating human mammary epithelial cells after exposure to γ-rays or iron ions
    Torsten Groesser
    Lawrence Berkeley National Laboratory, Life Sciences Division, Department of Cancer and DNA Damage Responses, Berkeley, CA 94720, USA
    Int J Radiat Biol 87:696-710. 2011
    ..1) foci formation and removal in proliferating and non-proliferating human mammary epithelial cells (HMEC) after exposure to sparsely and densely ionising radiation under different cell culture conditions...
  9. pmc Automatic and quantitative measurement of protein-protein colocalization in live cells
    Sylvain V Costes
    Image Analysis Laboratory, National Cancer Institute, Frederick, Maryland, USA
    Biophys J 86:3993-4003. 2004
    ..25 x 10(-3) s(-1). More generally, this algorithm can be used to answer a variety of biological questions involving protein-protein interactions or co-compartmentalization and can be generalized to colocalization of more than two colors...
  10. doi request reprint Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors
    Jonathan Tang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley California, USA
    Stem Cells 32:649-61. 2014
    ..These studies suggest that irradiation during puberty transiently increases stem cell self-renewal, which increases susceptibility to developing ER-negative breast cancer...
  11. pmc Rapid and automated multidimensional fluorescence microscopy profiling of 3D human breast cultures
    Catherine C Park
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Integr Biol (Camb) 5:681-91. 2013
    ..Such tools have therefore the potential to further characterize cell culture populations after cancer treatment and identify novel phenotypes of resistance...
  12. ncbi request reprint Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition
    Kumari L Andarawewa
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Cancer Res 67:8662-70. 2007
    ..Together, these data show that the interactions between radiation-induced signaling pathways elicit heritable phenotypes that could contribute to neoplastic progression...
  13. pmc Characterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse Analysis
    Walter Georgescu
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA, United States of America
    PLoS ONE 10:e0129438. 2015
    ..Such finding may therefore be critical to explain the supralinear dose dependence for chromosomal rearrangement and cell death measured after exposure to ionizing radiation. ..
  14. pmc The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic
    Joel M Swenson
    Division of Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, United States
    elife 5:. 2016
    ..We conclude that heterochromatin composition and architecture is more spatially complex and dynamic than previously suggested, and propose that a network of subdomains regulates diverse heterochromatin functions...
  15. pmc Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair
    Irene Chiolo
    Department of Genome Dynamics, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cell 144:732-44. 2011
    ..We propose that the spatial and temporal control of DSB repair in heterochromatin safeguards genome stability by preventing aberrant exchanges between repeats...
  16. ncbi request reprint A systems biology approach to multicellular and multi-generational radiation responses
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Building 74 355, Berkeley, CA 94705, USA
    Mutat Res 597:32-8. 2006
    ....
  17. ncbi request reprint Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections
    Markus C Fleisch
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Microsc Res Tech 69:964-72. 2006
    ..This was done by taking into account baseline centrosome amplification and proliferation rates measured in the tissue. Using this technique, the authors showed that 20-30% of cells have amplified centrosomes in Tp53 null mammary tumors...
  18. pmc Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo
    Dirk Daelemans
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    Mol Cell Biol 25:728-39. 2005
    ..CRM1 is able to bind Rev cargo in the nucleolus, and upon RanGTP binding a functional export complex is produced that is exported to the cytoplasm...
  19. pmc Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton
    Dalit Barkan
    Laboratory of Cell Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:6241-50. 2008
    ..Targeting this process may provide therapeutic strategies for inhibition of the dormant-to-proliferative metastatic switch...
  20. ncbi request reprint In vivo HIV-1 Rev multimerization in the nucleolus and cytoplasm identified by fluorescence resonance energy transfer
    Dirk Daelemans
    Human Retrovirus Section, Basic Research Laboratory and Image Analysis Laboratory, Science Application International Corporation, NCI Frederick, Frederick, Maryland 21702 1201, USA
    J Biol Chem 279:50167-75. 2004
    ..Our results show that Rev multimerizes in the nucleolus of living cells, suggesting an important role of the nucleolus in nucleocytoplasmic transport...
  21. ncbi request reprint Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 20:219-30. 2004
    ..These results show that CD8+ T cells have two distinct TcR-regulated secretory compartments characterized by different mobilization kinetics, effector molecules, and biological function...