Affiliation: Lawrence Livermore National Laboratory
- Biological impacts and context of network theoryEivind Almaas
Microbial Systems Biology, Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, 7000 East Avenue, PO Box 808, L 452, Livermore, CA 94550, USA
J Exp Biol 210:1548-58. 2007....
- Optimal flux patterns in cellular metabolic networksEivind Almaas
Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
Chaos 17:026107. 2007..Finally, I briefly discuss the predicted activity patterns of the central carbon metabolic pathways for the sample of random environments...
- Genome-level transcription data of Yersinia pestis analyzed with a new metabolic constraint-based approachAli Navid
Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550 0808, USA
BMC Syst Biol 6:150. 2012..The method uses mRNA expression data to guide hierarchical regulation of cellular metabolism subject to the interconnectivity of the metabolic network...
- The activity reaction core and plasticity of metabolic networksEivind Almaas
Microbial Systems Division, Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA
PLoS Comput Biol 1:e68. 2005..Finally, we find that most current antibiotics interfering with bacterial metabolism target the core enzymes, indicating that our findings may have important implications for antimicrobial drug-target discovery...
- Genetic noise control via protein oligomerizationCheol Min Ghim
Microbial Systems Biology Group, Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, 7000 East Avenue Livermore, CA 94550, USA
BMC Syst Biol 2:94. 2008..While there have been numerous studies correlating the architecture of cellular reaction networks with noise tolerance, only a limited effort has been made to understand the dynamic role of protein-protein interactions...
- Systems biology of microbial communitiesAli Navid
Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, CA, USA
Methods Mol Biol 500:469-94. 2009..Thus, this set of approaches is able to address the operation and function of microbial communities on a wide range of organizational levels...
- Peeling the yeast protein networkStefan Wuchty
Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA
Proteomics 5:444-9. 2005..Even though protein interaction data are extensively flawed, we find that our results are very robust against inaccurately determined protein interactions...
- Evolutionary cores of domain co-occurrence networksStefan Wuchty
Northwestern Institute of Complexity, Northwestern University, Evanston, IL, USA
BMC Evol Biol 5:24. 2005..Here, we take the next step by studying link based properties of the protein domain co-occurrence networks of the eukaryotes S. cerevisiae, C. elegans, D. melanogaster, M. musculus and H. sapiens...
- Predicting synthetic rescues in metabolic networksAdilson E Motter
Department of Physics and Astronomy and Northwestern Institute on Complex Systems, Northwestern University, Evanston, IL 60208, USA
Mol Syst Biol 4:168. 2008..The systematic network-based identification of compensatory rescue effects may open new avenues for genetic interventions...