Jonathan E Allen
Affiliation: Lawrence Livermore National Laboratory
- Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoeliiJane M Carlton
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:512-9. 2002..This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease...
- JIGSAW: integration of multiple sources of evidence for gene predictionJonathan E Allen
Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, College Park, MD 20742, USA
Bioinformatics 21:3596-603. 2005..Genome annotation pipelines collect a variety of types of evidence about gene structure and synthesize the results, which can then be refined further through manual, expert curation of gene models...
- Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced AlignmentsBrian J Haas
J Craig Venter Institute, The Institute for Genomic Research, Rockville, Maryland 20850, USA
Genome Biol 9:R7. 2008..Our experiments on both rice and human genome sequences demonstrate that EVM produces automated gene structure annotation approaching the quality of manual curation...
- Conserved amino acid markers from past influenza pandemic strainsJonathan E Allen
Lawrence Livermore National Laboratory, Livermore, CA, 94551, USA
BMC Microbiol 9:77. 2009..Influenza proteomes from distinct viral phenotype classes were searched for class specific amino acid mutations conserved in past pandemics, using reverse engineered linear classifiers...
- DNA signatures for detecting genetic engineering in bacteriaJonathan E Allen
Lawrence Livermore National Lab, Livermore, CA 94550, USA
Genome Biol 9:R56. 2008..Such DNA signatures could be important in detecting genetically engineered bacteria in environmental samples...
- Ultra-deep sequencing of intra-host rabies virus populations during cross-species transmissionMonica K Borucki
Lawrence Livermore National Laboratory, Livermore, California, United States of America
PLoS Negl Trop Dis 7:e2555. 2013..These results suggest that analysis of rare variants within a viral population may yield clues to ancestral genomes and identify rare variants that have the potential to be selected for if environment conditions change. ..
- Ultra-deep mutant spectrum profiling: improving sequencing accuracy using overlapping read pairsHaiyin Chen-Harris
Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA, USA
BMC Genomics 14:96. 2013..The challenge however, is to accurately model the errors in the sequencing data and differentiate real viral mutations, particularly those that exist at low frequencies, from sequencing errors...
- Scalable metagenomic taxonomy classification using a reference genome databaseSasha K Ames
Center for Applied Scientific Computing, Lawrence Livermore National Laboratory and Global Security Directorate, P O Box 808, Livermore, CA 94551, USA
Bioinformatics 29:2253-60. 2013..Existing metagenomic taxonomic classification algorithms, however, do not scale well to analyze large metagenomic datasets, and balancing classification accuracy with computational efficiency presents a fundamental challenge...
- The role of viral population diversity in adaptation of bovine coronavirus to new host environmentsMonica K Borucki
Lawrence Livermore National Laboratory, Livermore, CA, USA
PLoS ONE 8:e52752. 2013....
- Metagenomic analysis of the airborne environment in urban spacesNicholas A Be
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94551, USA
Microb Ecol 69:346-55. 2015..Together, these data demonstrate the temporally dependent metagenomic complexity of urban aerosols and the potential of genomic analytical techniques for biosurveillance and monitoring of threats to public health. ..
- Microbial profiling of combat wound infection through detection microarray and next-generation sequencingNicholas A Be
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA
J Clin Microbiol 52:2583-94. 2014..Future application of genomic protocols for assessing microbial content could allow application of specialized care through early and rapid identification and management of critical patterns in wound bioburden. ..
- JIGSAW, GeneZilla, and GlimmerHMM: puzzling out the features of human genes in the ENCODE regionsJonathan E Allen
Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA
Genome Biol 7:S9.1-13. 2006....
- The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformansBrendan J Loftus
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 307:1321-4. 2005..neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes...
- Computational gene prediction using multiple sources of evidenceJonathan E Allen
The Institute for Genomic Research, Rockville, Maryland 20850, USA
Genome Res 14:142-8. 2004..Our results show that combining gene prediction evidence consistently outperforms even the best individual gene finder and, in some cases, can produce dramatic improvements in sensitivity and specificity...