Ming Zhao

Summary

Affiliation: La Jolla Institute for Molecular Medicine
Country: USA

Publications

  1. ncbi Regulation of CXCR4-mediated nuclear translocation of extracellular signal-related kinases 1 and 2
    Ming Zhao
    Division of Cancer Biology, La Jolla Institute for Molecular Medicine, 4570 Executive Drive, Suite 100, San Diego, CA 92121, USA
    Mol Pharmacol 69:66-75. 2006
  2. ncbi Akt plays an important role in breast cancer cell chemotaxis to CXCL12
    Ming Zhao
    Division of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    Breast Cancer Res Treat 110:211-22. 2008
  3. ncbi Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium
    Katsuhiro Hayashi
    AntiCancer, Inc, San Diego, California, USA
    Cell Cycle 8:870-5. 2009
  4. doi Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer-cell anchorage and shape
    Aisada Uchugonova
    AntiCancer Inc, San Diego, CA, USA
    J Cell Biochem 114:99-102. 2013
  5. pmc Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer
    Ming Zhao
    AntiCancer Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 104:10170-4. 2007
  6. ncbi Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2
    Ming Zhao
    Division of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
    J Biol Chem 279:49259-67. 2004
  7. pmc Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer
    Clinton Yam
    AntiCancer, Inc, San Diego, California, USA
    J Surg Res 164:248-55. 2010
  8. pmc Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice
    Yasunori Matsumoto
    AntiCancer, Inc, San Diego, CA, USA
    Oncotarget 6:11369-77. 2015
  9. pmc Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice
    Yukihiko Hiroshima
    AntiCancer, Inc, San Diego, California, United States of America Department of Surgery, University of California San Diego, San Diego, California, United States of America Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 10:e0134324. 2015
  10. ncbi Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice
    Yong Zhang
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Anticancer Res 32:2501-8. 2012

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi Regulation of CXCR4-mediated nuclear translocation of extracellular signal-related kinases 1 and 2
    Ming Zhao
    Division of Cancer Biology, La Jolla Institute for Molecular Medicine, 4570 Executive Drive, Suite 100, San Diego, CA 92121, USA
    Mol Pharmacol 69:66-75. 2006
    ....
  2. ncbi Akt plays an important role in breast cancer cell chemotaxis to CXCL12
    Ming Zhao
    Division of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    Breast Cancer Res Treat 110:211-22. 2008
    ..Collectively, we have demonstrated that prolonged Akt activation is an important signaling pathway for breast cancer cells expressing CXCR4 and is necessary for CXCL12-dependent cell migration...
  3. ncbi Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium
    Katsuhiro Hayashi
    AntiCancer, Inc, San Diego, California, USA
    Cell Cycle 8:870-5. 2009
    ..RFP intensity of the lung metastasis was 3 +/- 1.5 x 10(6) in the untreated group and 0.42 +/- 0.33 x 10(6) in the treated group (p < 0.05). Therefore, bacterial treatment was effective for both primary bone tumor and lung metastasis...
  4. doi Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer-cell anchorage and shape
    Aisada Uchugonova
    AntiCancer Inc, San Diego, CA, USA
    J Cell Biochem 114:99-102. 2013
    ..These results suggest a new paradigm for a stromal element of tumors: their role in maintaining anchorage and shape of cancer cells that may enable them to proliferate...
  5. pmc Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer
    Ming Zhao
    AntiCancer Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 104:10170-4. 2007
    ..The approach described here, where bacterial monotherapy effectively treats metastatic prostate tumors, is a significant improvement over previous bacterial tumor-therapy strategies that require combination with toxic chemotherapy...
  6. ncbi Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2
    Ming Zhao
    Division of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
    J Biol Chem 279:49259-67. 2004
    ..These results indicate a novel function for arrestin, which is protection from an excessive oxidative burst, resulting from the sustained stimulation of G-protein-coupled receptors that cause Rac translocation...
  7. pmc Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer
    Clinton Yam
    AntiCancer, Inc, San Diego, California, USA
    J Surg Res 164:248-55. 2010
    ..Systemic treatment with intravenous A1-R also increased survival time. All results were statistically significant. This study suggests the clinical potential of bacterial treatment of a critical metastatic target of pancreatic cancer...
  8. pmc Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice
    Yasunori Matsumoto
    AntiCancer, Inc, San Diego, CA, USA
    Oncotarget 6:11369-77. 2015
    ..Both i.v. and i.p. treatments effected prolonged survival compared with the untreated control group (P=0.025 and P<0.001, respectively). However, i.p. treatment was less toxic than i.v...
  9. pmc Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice
    Yukihiko Hiroshima
    AntiCancer, Inc, San Diego, California, United States of America Department of Surgery, University of California San Diego, San Diego, California, United States of America Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 10:e0134324. 2015
    ..These results suggest tumor-targeting S. typhimurium A1-R is a promising treatment for chemo-resistant soft-tissue sarcoma...
  10. ncbi Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice
    Yong Zhang
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Anticancer Res 32:2501-8. 2012
    ..The results of this study suggest that p.o. administration was the most safe to the host and the i.v. route was most effective for tumor targeting with S. typhimurium A1-R...
  11. pmc In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation
    Hiroyuki Kishimoto
    AntiCancer, Inc, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 106:14514-7. 2009
    ..The data in this report suggest that adenoviral-GFP labeling tumors in patients can enable fluorescence-guided surgical navigation...
  12. pmc High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model
    Tasuku Kiyuna
    AntiCancer Inc, San Diego, CA, USA
    Oncotarget 7:33046-54. 2016
    ..The findings of the present study are of particular importance since it demonstrates that S. typhimurium A1-R is effective in a PDOX model of FDCS established from a patient who failed DOX therapy. ..
  13. pmc Tumor-Targeting Salmonella typhimurium A1-R in Combination with Trastuzumab Eradicates HER-2-Positive Cervical Cancer Cells in Patient-Derived Mouse Models
    Yukihiko Hiroshima
    AntiCancer, Inc, San Diego, California, United States of America Department of Surgery, University of California San Diego, San Diego, California, United States of America Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 10:e0120358. 2015
    ..typhimurium A1-R + trastuzumab. The results of the present study suggest that S. typhimurium A1-R and trastuzumab in combination are highly effective against HER-2-expressing cervical cancer. ..
  14. pmc Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model
    Takashi Murakami
    AntiCancer, Inc, San Diego, California, USA
    Oncotarget 6:41856-62. 2015
    ..The results suggest the future clinical potential of adjuvant S. typhimurium A1-R treatment after liver metastasis resection. ..
  15. pmc Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R
    Shinji Miwa
    AntiCancer, Inc, San Diego, California, USA Department of Surgery, University of California, San Diego, San Diego, California, USA Department of Orthopedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    Oncotarget 5:12849-61. 2014
    ..004). S. typhimurium A1-R bacterial therapy has future potential for treating advanced soft tissue sarcoma and improving prognosis of patients with lung metastasis. ..
  16. pmc Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice
    Ming Zhao
    AntiCancer, Inc, San Diego, CA, USA
    Cell Cycle 11:187-93. 2012
    ..The results in this report, demonstrating the anti-metastatic efficacy of S. typhimurium A1-R in immunocompetent mice, indicate the clinical potential of bacterial therapy of cancer...
  17. pmc Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium
    Katsuhiro Hayashi
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    J Cell Biochem 106:992-8. 2009
    ..No adverse effects were observed. This new strategy demonstrates the clinical potential of targeting and curing cancer metastasis with engineered bacteria without the need of toxic chemotherapy...
  18. ncbi Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice
    Ming Zhao
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Cancer Res 66:7647-52. 2006
    ..These results suggest that amino acid auxotrophic virulent bacteria, which selectively infect and attack viable tumor tissue, are a promising approach to cancer therapy...
  19. doi Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug
    Takashi Murakami
    AntiCancer, Inc, San Diego, California, USA
    Oncotarget . 2016
    ..001). S. typhimurium grew in the treated tumors and caused extensive necrosis of the tumor tissue. These data show that S. typhimurium A1-R is powerful therapy for an osteosarcoma patient-derived xenograft model...
  20. doi High-efficacy targeting of colon-cancer liver metastasis with Salmonella typhimurium A1-R via intra-portal-vein injection in orthotopic nude-mouse models
    Kei Kawaguchi
    AntiCancer, Inc, San Diego, California, USA
    Oncotarget . 2016
    ..There were no significant differences in body weight between all groups. The results of this study suggest that S. typhimurium A1-R administered iPV has potential for peri-operative adjuvant treatment of colon cancer liver metastasis...
  21. pmc Therapeutic efficacy of tumor-targeting Salmonella typhimurium A1-R on human colorectal cancer liver metastasis in orthotopic nude-mouse models
    Takashi Murakami
    AntiCancer Inc, San Diego, California, USA
    Oncotarget 6:31368-77. 2015
    ..In orthotopic mouse models, S. typhimurium A1-R targeted liver metastases and significantly reduced their growth. The results of this study demonstrate the future clinical potential of S. typhimurium A1-R targeting of liver metastasis. ..
  22. pmc Tumor-targeting Salmonella typhimurium A1-R inhibits human prostate cancer experimental bone metastasis in mouse models
    Makoto Toneri
    AntiCancer Inc, San Diego, California, USA
    Oncotarget 6:31335-43. 2015
    ..The results of the present study indicate that S. typhimurium A1-R is useful to prevent and inhibit prostate cancer bone metastasis and has potential for future clinical use in the adjuvant setting. ..
  23. doi Efficacy comparison of traditional Chinese medicine LQ versus gemcitabine in a mouse model of pancreatic cancer
    Lei Zhang
    AntiCancer, Inc, San Diego, California, USA
    J Cell Biochem 114:2131-7. 2013
    ..The results indicate that TCM can have non-toxic efficacy against metastatic pancreatic cancer comparable to gemcitabine in a clinically-relevant orthotopic mouse model...
  24. ncbi Cancer-cell killing by engineered Salmonella imaged by multiphoton tomography in live mice
    Aisada Uchugonova
    AntiCancer Inc, San Diego, CA, USA
    Anticancer Res 32:4331-7. 2012
    ..The multiphoton tomographic system described here allows imaging of cancer cell killing by bacteria and can therefore be used to further understand its mechanism and optimization for clinical application...
  25. ncbi Comparative chemosensitivity of circulating human prostate cancer cells and primary cancer cells
    Rhiana Menen
    AntiCancer Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Anticancer Res 32:2881-4. 2012
    ..The future goal, based on these studies, is the culture of CTCs from cancer patients' peripheral blood for chemosensitivity testing, for improved individualized therapy...
  26. pmc Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models
    Yukihiko Hiroshima
    AntiCancer, Inc, San Diego, CA, USA Department of Surgery, University of California San Diego, San Diego, CA, USA Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Oncotarget 5:12346-57. 2014
    ..These results demonstrate that S. typhimurium A1-R following anti-angiogenic therapy is effective on pancreatic cancer including the PDOX model, suggesting its clinical potential. ..
  27. doi Salmonella promoters preferentially activated inside tumors
    Nabil Arrach
    Sidney Kimmel Cancer Center, AntiCancer, Inc, and Department of Surgery, University of California, San Diego, San Diego, California, USA
    Cancer Res 68:4827-32. 2008
    ..The expression of therapeutics in Salmonella under the regulation of one or more promoters that are activated preferentially in tumors has the potential to improve the targeting of drug delivery...
  28. ncbi Efficacy of dietary antioxidants combined with a chemotherapeutic agent on human colon cancer progression in a fluorescent orthotopic mouse model
    Huaiyu Ma
    AntiCancer, Inc, San Diego, CA, USA
    Anticancer Res 29:2421-6. 2009
    ..The results of the present study therefore indicate enhancement of cisplatin efficacy by high-dose antioxidants in combination with fish oil for colon cancer progression and suggests the design of clinical trials for this regimen...
  29. pmc Comparison of efficacy and toxicity of traditional Chinese medicine (TCM) herbal mixture LQ and conventional chemotherapy on lung cancer metastasis and survival in mouse models
    Lei Zhang
    AntiCancer, Inc, San Diego, California, United States of America Department of Surgery, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 9:e109814. 2014
    ..LQ was more potent to induce cell death on cancer cell lines than normal cell lines unlike cytotoxic chemotherapy. The results indicate that LQ has non-toxic efficacy against metastatic lung cancer. ..
  30. doi Efficacy of tumor-targeting Salmonella typhimurium A1-R on nude mouse models of metastatic and disseminated human ovarian cancer
    Yasunori Matsumoto
    AntiCancer, Inc, San Diego, California Department of Surgery, University of California San Diego, San Diego, California Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Cell Biochem 115:1996-2003. 2014
    ..005). The results of this report demonstrate that A1-R is effective for highly aggressive human ovarian cancer in metastatic and dissemination mouse models and suggest its clinical potential for this highly treatment-resistant disease...
  31. pmc Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model
    Masashi Momiyama
    AntiCancer, Inc, San Diego, CA, USA
    Cell Cycle 11:628-32. 2012
    ..The results of the present study demonstrate that bacterial therapy of brain cancer is a novel, effective and safe treatment strategy in a highly treatment-resistance cancer...
  32. pmc Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity
    Fang Liu
    AntiCancer Inc, San Diego, California, USA
    Cell Cycle 9:4518-24. 2010
    ..Therefore, tumor vascularity correlated positively with tumor efficacy of A1-R. The present study suggests that bacteria efficacy on tumors involved vessel destruction which depends on the extent of vascularity of the tumor...
  33. doi C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation
    Ingrid U Schraufstatter
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    J Immunol 182:3827-36. 2009
    ..These results suggest that the anaphylatoxins C3a and C5a present in injured tissues contribute to the recruitment of MSCs and regulation of their behavior...
  34. pmc Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model
    Takashi Murakami
    AntiCancer, Inc, San Diego, California, USA
    Oncotarget 7:12783-90. 2016
    ..typhimurium A1-R followed by DOX. Our present study indicates future clinical potential of combining S. typhimurium A1-R with chemotherapy such as DOX for soft tissue sarcoma patients. ..
  35. pmc Tumor-targeting Salmonella typhimurium A1-R arrests growth of breast-cancer brain metastasis
    Yong Zhang
    AntiCancer, Inc, San Diego, CA, USA
    Oncotarget 6:2615-22. 2015
    ..05). The results of the present study suggest the clinical potential of bacterial therapy of breast cancer brain metastasis. ..
  36. pmc The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum
    Ingrid U Schraufstatter
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    Immunology 135:287-98. 2012
    ..In summary, CCL18 induces an M2 spectrum macrophage phenotype in the absence of IL-4...
  37. ncbi The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla
    Fang Liu
    AntiCancer Inc, San Diego, CA, USA
    Cell Cycle 10:830-9. 2011
    ..Nestin-expressing pluripotent stem cells from both the BA and DP have potential for spinal cord regeneration, with the BA being the greater and more constant source...
  38. pmc Comparison of the selective targeting efficacy of Salmonella typhimurium A1-R and VNP20009 on the Lewis lung carcinoma in nude mice
    Yong Zhang
    AntiCancer, Inc, San Diego, California, USA
    Oncotarget 6:14625-31. 2015
    ..typhimurium A1-R to at a least 2-fold higher dose than VNP20009 when the bacteria were administered iv. The results of the present study suggest that S. typhimurium A1-R has greater clinical potential than VNP20009. ..
  39. ncbi Whole-body imaging of bacterial infection and antibiotic response
    Robert M Hoffman
    AntiCancer Incorporated, 7917 Ostrow Street, San Diego, California, 92111, USA
    Nat Protoc 1:2988-94. 2006
    ..This imaging technology affords a powerful approach to visualizing the infection process, determining the tissue specificity of infection, the spatial migration of the infectious agents and the response to antimicrobial agents...
  40. doi Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model
    Kei Kawaguchi
    AntiCancer, Inc, San Diego, CA, USA
    Oncotarget . 2016
    ..typhimurium A1-R (p = 0.0004) alone or TEM alone (p = 0.0017). TEM combined with S. typhimurium A1-R could regress the melanoma in the PDOX model and has important future clinical potential for melanoma patients...
  41. doi Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX)
    Yukihiko Hiroshima
    AntiCancer, Inc, San Diego, California Department of Surgery, University of California, San Diego, California Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Cell Biochem 115:1254-61. 2014
    ..The data of the present report suggest A1-1 will have clinical activity in pancreatic cancer, a highly lethal and treatment-resistant disease and may be most effectively used in combination with other agents...
  42. ncbi IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptor
    Ingrid U Schraufstatter
    Department of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    J Immunol 171:6714-22. 2003
    ..These results indicate that IL-8-induced transactivation of the EGFR is mediated by the CXCR2 and involves cathepsin B, and that this pathway is important for the migratory and tumorigenic effects of IL-8...
  43. pmc Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium
    Ming Zhao
    AntiCancer, 7917 Ostrow Street, San Diego, CA 92111 3604, USA
    Proc Natl Acad Sci U S A 102:755-60. 2005
    ..This result is in marked contrast to bacteria previously tried for cancer therapy that were confined to necrotic areas of the tumor, which may account, in part, for the strain's unique antitumor efficacy...
  44. doi Methods for Tumor Targeting with Salmonella typhimurium A1-R
    Robert M Hoffman
    AntiCancer Inc and Department of Surgery, University of California San Diego, San Diego, CA, USA
    Methods Mol Biol 1409:143-64. 2016
    ..The testing of S. typhimurium A1-R on patient tumors in patient-derived orthotopic xenograft (PDOX) mouse models is also described. The major methodologies described in this chapter should be translatable for clinical studies. ..
  45. doi Methods for the development of tumor-targeting bacteria
    Robert M Hoffman
    AntiCancer, Inc, San Diego, CA, USA
    Expert Opin Drug Discov 9:741-50. 2014
    ..There is also controversy about which bacteria are optimum for cancer treatment and whether bacteria should be used as tumor-targeting vectors, immune stimulators, or for direct tumor killing...
  46. pmc High efficiency genetic modification of hair follicles and growing hair shafts
    Norimitsu Saito
    AntiCancer, Inc, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 99:13120-4. 2002
    ..Most follicles produced GFP-fluorescent growing hair shafts. This technique has produced efficient genetic modification of the hair shaft...
  47. pmc Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase
    Arlixer M Coleman
    Microbiology and Immunology Program, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Immunol 181:2330-7. 2008
    ..This is the first demonstration of a biological role for D-DT, and its synergism with MIF suggests that the combined therapeutic targeting of both family members may enhance current anti-MIF-based therapies...
  48. ncbi Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype
    Ming Zhao
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    J Bone Miner Res 17:1441-51. 2002
    ..These results suggest that BMP-2 triggers follicle cells to differentiate toward a cementoblast/osteoblast phenotype and that the MAPK pathway is involved...
  49. ncbi Suppression of bcl-2 gene by RNA interference increases chemosensitivity to cisplatin in nasopharyngeal carcinoma cell line CNE1
    Zhi hua Yin
    Cancer Research Institute, Central South University, Changsha 410078, China
    Acta Biochim Biophys Sin (Shanghai) 36:749-53. 2004
    ..This will help physicians to make some clinical trials of gene therapy on nasopharyngeal carcinoma by RNAi...
  50. ncbi Establishment of human embryonic stem cell line stably expressing Epstein-Barr virus-encoded nuclear antigen 1
    Cai ping Ren
    Cancer Research Institute, Central South University, Changsha 410078, China
    Acta Biochim Biophys Sin (Shanghai) 37:68-73. 2005
    ..All the results show that we have successfully created stable EBNA1-hES cells, thus laying a good foundation for further research...
  51. pmc Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo
    Ming Zhao
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Biol Chem 279:12854-9. 2004
    ..In these transgenic mice, bone formation was significantly reduced during postnatal life. Our results demonstrate for the first time that Smurf1 plays a specific role in osteoblast differentiation and bone formation in vivo...
  52. doi Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells
    Guozhu Chen
    Department of Pathology, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China
    J Proteome Res 7:2733-42. 2008
    ..Thus, proteomic analysis provides new information about target proteins important for FK228-induced cytotoxicity in cancer cells...
  53. doi Head and neck cancer cell lines are resistant to mitochondrial-depolarization-induced apoptosis
    Ming Zhao
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins Medical Institution, Baltimore, MD 21287 0910, USA
    ORL J Otorhinolaryngol Relat Spec 70:257-63. 2008
    ....
  54. doi Polyaspartoyl.l-arginine inhibits platelet aggregation through stimulation of NO release from endothelial cells
    Zhiyu Tang
    Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Eur J Pharmacol 588:41-6. 2008
    ..Therefore the effect of PDR on platelet aggregation is primarily attributed to its stimulation of NO synthesis in endothelial cells; PDR may be a better cardiovascular protective agent than l-arginine...
  55. pmc Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Dis 30:312-22. 2008
    ..Additionally, the effective levels of sertraline are comparable to the safe levels achievable in humans. The findings suggest that sertraline is a potential candidate for treatment of HD patients...
  56. doi Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines
    Sin Ting Lau
    School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Phytother Res 22:477-86. 2008
    ....
  57. doi Imaging paclitaxel (chemotherapy)-induced tumor apoptosis with 99mTc C2A, a domain of synaptotagmin I: a preliminary study
    Feng Wang
    Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China
    Nucl Med Biol 35:359-64. 2008
    ..To evaluate the dynamics and feasibility of imaging non-small cell lung cancer (NSCLC) apoptosis induced by paclitaxel treatment using 99mTc-labeled C2A domain of synaptotagmin I in a mouse model...
  58. pmc Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice
    Ming Zhao
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 8028, USA
    Mol Cell Biol 22:3111-20. 2002
    ..These results indicate that the zona matrix accrues from the inside out and, unexpectedly, suggest that cleavage at the furin site is not required for formation of the extracellular zona pellucida surrounding mouse eggs...
  59. ncbi Using 99mTc-sestamibi to evaluate the effects of a chemosensitizer on P-glycoprotein in multidrug-resistant carcinoma cells
    Zhenwei Zhang
    Department of Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Methods Enzymol 386:212-6. 2004
  60. ncbi Nucleoprotein transitions during spermiogenesis in mice with transition nuclear protein Tnp1 and Tnp2 mutations
    Ming Zhao
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biol Reprod 71:1016-25. 2004
    ..Thus the absence of one of the TPs did not significantly affect transcription or translation of the other basic proteins, but it did affect posttranslational events...
  61. ncbi Bone morphogenetic proteins
    Di Chen
    School of Medicine and Dentistry, Department of Orthopaedics, University of Rochester, Rochester, NY 14642, USA
    Growth Factors 22:233-41. 2004
    ..A significant advancement about the understanding of in vivo functions of BMP ligands, receptors and signaling molecules has been achieved in recent years...
  62. ncbi DeltaNp63alpha up-regulates the Hsp70 gene in human cancer
    Guojun Wu
    Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Cancer Res 65:758-66. 2005
    ..Our study provides strong evidence for the physiologic association between DeltaNp63alpha and hsp70 in human cancer, thus further supporting the oncogenic potential of DeltaNp63alpha...
  63. ncbi Critical role of Cys168 in noggin protein's biological function
    Wei Dong Liu
    Cancer Research Institute, Central South University, Changsha, China
    Acta Biochim Biophys Sin (Shanghai) 37:181-5. 2005
    ..These studies highlight the critical role played by Cys168 in noggin's biological activities. It probably participates in the formation of an intermolecular disulfide bridge...
  64. ncbi Specific method for determination of gefitinib in human plasma, mouse plasma and tissues using high performance liquid chromatography coupled to tandem mass spectrometry
    Ming Zhao
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Bunting Blaustein Cancer Research Building, Room 1M86, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 819:73-80. 2005
    ..This method was subsequently used to measure concentrations of gefitinib in mice following administration of a single dose of 150 mg/kg intraperitoneally and in cancer patients receiving an oral daily dose of 250 mg...
  65. ncbi Stage-specific expression of dynein light chain-1 and its interacting kinase, p21-activated kinase-1, in rodent testes: implications in spermiogenesis
    Rui An Wang
    Department of Molecular and Cellular Oncology UT MD Anderson Cancer Center, Houston, TX 77030, USA
    J Histochem Cytochem 53:1235-43. 2005
    ..Further, Pak1 may also play a role in spermiogenesis by regulating DLC1 phosphorylation and, consequently, its function...
  66. ncbi Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells
    Julie A Hong
    Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1201, USA
    Cancer Res 65:7763-74. 2005
    ....
  67. ncbi Novel cytotoxic seco-abietane rearranged diterpenoids from Salvia prionitis
    Jun Chang
    Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P R China
    Planta Med 71:861-6. 2005
    ..Moreover, it was found that 4 (IC50 = 0.41 microM) and 5 (IC50 = 0.72 microM) showed significant cytotoxic activity against P-388 and A-549 cell lines, respectively...
  68. ncbi Transition nuclear proteins are required for normal chromatin condensation and functional sperm development
    Ming Zhao
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 38:200-13. 2004
    ..Thus, in mammals TPs are required for normal chromatin condensation, for reducing the number of DNA breaks, and for preventing the formation of secondary defects in spermatozoa, eventual loss of genomic integrity, and sterility...
  69. ncbi Synthesis and antitumor evaluation of benzoylphenylurea analogs
    Hallur Gurulingappa
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Bioorg Med Chem Lett 14:2213-6. 2004
    ..A very interesting inhibition profile against BxPC3, Mia-Paca, and Hep2 cells with compound 10 has been observed. Compounds 8 and 9 showed the significant cytotoxicity in Hep2 cells. All cell lines were resistant to compound 7...
  70. ncbi Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinases
    Ming Zhao
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping SE 581 85, Sweden
    Arch Biochem Biophys 400:199-207. 2002
    ..These results may have implications for the future design of pharmacologic agents for inhibition of VSMC growth...
  71. ncbi Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL
    Ming Zhao
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    APMIS 110:458-68. 2002
    ..Our results for the first time demonstrate a regulation of CD36 by p38, and the importance of the p38 pathway in regulation of foam cell formation...
  72. ncbi Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytes
    Ling Yu Chen
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla 92037, California 92121, USA
    Am J Physiol Lung Cell Mol Physiol 284:L607-13. 2003
    ..These findings provide evidence that LPS-induced NF-kappaB activation and IL-8 gene expression use a signaling pathway requiring protein tyrosine kinase and that such regulation may occur through tyrosine phosphorylation of TLR4...
  73. ncbi E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    Ming Zhao
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:27939-44. 2003
    ..Smurf1 therefore appears to be an important regulatory factor in osteoblast differentiation and a potential molecular target for identification of bone anabolic agents...
  74. pmc Evidence for neurogenesis in the adult mammalian substantia nigra
    Ming Zhao
    Departments of Neuroscience, Cell and Molecular Biology, Medical Nobel Institute, and Woman and Child Health, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:7925-30. 2003
    ....
  75. ncbi Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis
    Ming Zhao
    Faculty of Health Sciences, Linkoping University, Sweden
    Eur J Biochem 270:3778-86. 2003
    ..Nonoxidant agonists of apoptosis may, thus, act through oxidant mechanisms...
  76. ncbi Exploring the origins of cementoblasts and their trigger factors
    Janice E Berry
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Connect Tissue Res 44:97-102. 2003
    ..Such dissimilarities in responsiveness associated with cell type may need to be considered when designing regenerative therapies...
  77. ncbi Intracellular cargo delivery using tat peptide and derivatives
    Ming Zhao
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Rm 5404, Bldg 149, 13th St Charlestown, Massachusetts 02129, USA
    Med Res Rev 24:1-12. 2004
    ..This review summarizes the current knowledge of tat-derived cell permeating peptides in the transduction of exogenous molecules/complexes...
  78. pmc Gene therapy approaches for bone regeneration
    Renny T Franceschi
    The Center for Craniofacial Regeneration, University of Michigan School of Dentistry, Ann Arbor, Mich, USA
    Cells Tissues Organs 176:95-108. 2004
    ..Using these types of approaches, it should be possible to mimic natural processes of bone development and fracture repair and, in so doing, be able to precisely control both the amount and type of bone regenerated...
  79. ncbi Establishment and applications of epstein-barr virus-based episomal vectors in human embryonic stem cells
    Caiping Ren
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha 410078, Hunan, People s Republic of China
    Stem Cells 24:1338-47. 2006
    ..Thus, the EBV vector system that allows a large DNA insert and sustained expression of transgene or small hairpin RNA will enhance basic and translational research using hES cells...
  80. ncbi Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome
    NaEun Cheong
    Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6068, USA
    J Biol Chem 281:9791-800. 2006
    ..We conclude that ABCA3 is required for lysosomal loading of phosphatidylcholine and conversion of lysosomes to lamellar body-like structures...
  81. ncbi Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol
    Jen Liang Su
    Graduate Institute of Cancer Biology, College of Medicine, China Medical University, Taichung 404, Taiwan
    J Biol Chem 282:19385-98. 2007
    ..Resveratrol is therefore anticipated to be highly effective in management of postmenopausal osteoporosis without an increased risk of breast cancer...
  82. pmc Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models
    Yoshinori Kato
    Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 6:891-7. 2007
    ..The absence of these molecular responses to TMZ treatment in MCF-7 tumors in vivo supports the possibility that the onset of cancer drug resistance is associated with reduced PS, which can decrease delivery of the drug to cancer cells...
  83. ncbi Downregulation of RAD17 in head and neck cancer
    Ming Zhao
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Head Neck 30:35-42. 2008
    ..Head and neck squamous cell carcinoma (HNSCC) often shows chromosomal instability. We examined the expression of human RAD17, a DNA damage cell cycle checkpoint gene, in primary head and neck cancer tissue...
  84. ncbi Regulation of human lung adenocarcinoma cell migration and invasion by macrophage migration inhibitory factor
    Beatriz E Rendon
    Molecular Targets Program, J G Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 282:29910-8. 2007
    ....
  85. ncbi Transcriptional profiling of human embryonic stem cells and embryoid bodies identifies HESRG, a novel stem cell gene
    Ming Zhao
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, 110 Xiangya Road, Changsha 410078, Hunan, and Department of Neurosurgery, Xiangya Hospital, China
    Biochem Biophys Res Commun 362:916-22. 2007
    ..The above suggested an important role for the novel HESRG gene in supporting the undifferentiated state or self-renewal of hES cells...
  86. ncbi Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indol-2-substitutedacetates
    Jiawang Liu
    College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China
    Bioorg Med Chem 15:7773-88. 2007
    ..The SAR analysis revealed that the benzylester form and the tetracyclic structure of 4a-n were critical for both sensitizing doxorubicin and the cellular anti-proliferative effect...
  87. ncbi Induction of apoptosis underlies the Radix Rubiae-mediated anti-proliferative action on human epidermal keratinocytes: implications for psoriasis treatment
    Wai Pui Tse
    School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, P R China
    Int J Mol Med 20:663-72. 2007
    ..Our experimental results suggest that Radix Rubiae is a promising source from which a herb-based topical agent could be developed for psoriasis treatment...
  88. ncbi Novel N-(3-carboxyl-9-benzyl-carboline-1-yl)ethylamino acids: synthesis, anti-proliferation activity and two-step-course of intercalation with calf thymus DNA
    Jianhui Wu
    College of Pharmaceutical Sciences, Peking University, Beijing 100083, P R China
    Mol Biosyst 3:855-61. 2007
    ..The intercalation itself goes very fast and only has limited contribution to their anticancer activities...
  89. ncbi Minimally invasive treatment combined with cytokine-induced killer cells therapy lower the short-term recurrence rates of hepatocellular carcinomas
    De sheng Weng
    State Key Laboratory of Oncology in Southern China, Biotherapy Center, Department of Imaging and Interventional Radiology, Sun Yat Sen University, Guangzhou, Guangdong, P R China
    J Immunother 31:63-71. 2008
    ..05). The data suggest that CIK cell transfusion is an effective treatment. It can boost the immunologic function in HCC patients and plays an important role in reducing the recurrence rate of HCC...
  90. ncbi Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma
    Hong Mei Yi
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, P R China
    Oncol Res 16:261-72. 2006
    ..In conclusion, our data indicate that two-hit silencing of LTF through genetic and epigenetic changes may be a common and important event in the carcinogenesis of NPC...
  91. ncbi Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells
    Xiao Dan Yu
    Department of Pathology, Institute of Basic Medical Sciences, Beijing, China
    Cancer J 13:105-13. 2007
    ..In the present study we sought to further define the mechanisms by which FK228 modulates oncoprotein signaling and to ascertain whether altered signal transduction contributes to FK228-mediated apoptosis in lung cancer cells...
  92. ncbi Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells
    Edmund S Kassis
    Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Thorac Cardiovasc Surg 131:298-306. 2006
    ..The present study was undertaken to examine the effects of antisense-mediated inhibition of DNMT expression in cultured thoracic malignancies...
  93. pmc Alterations in the rat serum proteome during liver injury from acetaminophen exposure
    B Alex Merrick
    Proteomics Group, National Institute of Environmental Health Sciences, D2 04, P O Box 12233, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 318:792-802. 2006
    ..This study demonstrates that serum proteome alterations probably reflect both liver damage and a concerted, complex response of the body for organ repair and recovery during acute hepatic injury...
  94. ncbi [Effects of hemin and thermal stress exposure on JWA expression]
    Ming Zhao
    Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24:209-13. 2006
    ..To investigate the expression of JWA after hemin and (or) thermal stress exposure...
  95. ncbi Synthesis and cytotoxic activities of beta-carboline amino acid ester conjugates
    Ming Zhao
    College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, 100054, PR China
    Bioorg Med Chem 14:6998-7010. 2006
    ....
  96. ncbi The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells
    Julie A Sterling
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Cancer Res 66:7548-53. 2006
    ..Together, these data suggest that PTHrP expression and osteolysis in vivo in human breast cancer cells is driven at least in part by Gli2...
  97. ncbi Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma
    Andre Lopes Carvalho
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287 0910, USA
    Cancer Res 66:9401-7. 2006
    ..These results suggest that DCC is a putative conditional tumor-suppressor gene that is epigenetically inactivated by promoter hypermethylation in a majority of HNSCC...
  98. ncbi Identification of label-retaining cells in nasopharyngeal epithelia and nasopharyngeal carcinoma tissues
    Hong Bo Zhang
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan 410078, China
    Histochem Cell Biol 127:347-54. 2007
    ..More importantly, our data showed that NPC also contained stem cells, which are most likely the cause for NPC spread, metastasis and recurrence...
  99. ncbi CYP3A phenotyping approach to predict systemic exposure to EGFR tyrosine kinase inhibitors
    Jing Li
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    J Natl Cancer Inst 98:1714-23. 2006
    ..We prospectively assessed the influence of CYP3A activity on gefitinib disposition and toxicity...
  100. ncbi Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cells
    Xiao Hua Guo
    Department of Pathophysiology, Southern Medical University, Guangzhou, PR China
    APMIS 114:874-83. 2006
    ..The results indicate that ERK and p38 MAPK play important roles in the mediation of AGE-induced EC barrier dysfunction associated with morphological changes of the F-actin...
  101. doi Lipofectamine RNAiMAX: an efficient siRNA transfection reagent in human embryonic stem cells
    Ming Zhao
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, 410078, Hunan, China
    Mol Biotechnol 40:19-26. 2008
    ..These results demonstrated that Lipofectamine RNAiMAX is an efficient and excellent transfection reagent for delivering siRNA into hES cells...