Jay R Shapiro

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. ncbi request reprint Osteogenesis imperfecta: effecting the transition from adolescent to adult medical care
    J R Shapiro
    Bone and Osteogenesis Imperfecta Department, Kennedy Krieger Institute, Johns Hopkins School of Medicine, 707 North Broadway, Baltimore, MD 21205, United States
    J Musculoskelet Neuronal Interact 12:24-7. 2012
  2. ncbi request reprint Treatment with zoledronic acid ameliorates negative geometric changes in the proximal femur following acute spinal cord injury
    J Shapiro
    Department of Physical Medicine and Rehabilitation, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Calcif Tissue Int 80:316-22. 2007
  3. doi request reprint Bone mineral density and fracture rate in response to intravenous and oral bisphosphonates in adult osteogenesis imperfecta
    Jay R Shapiro
    Osteogenesis Imperfecta Program, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Calcif Tissue Int 87:120-9. 2010
  4. doi request reprint Osteogenesis imperfecta: questions and answers
    Jay R Shapiro
    Department Physical Medicine and Rehabilitation, Johns Hopkins University, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Curr Opin Pediatr 21:709-16. 2009
  5. ncbi request reprint Microgravity and drug effects on bone
    J R Shapiro
    National Space Biomedical Research Institute, Department of Physical Medicine and Rehabilitation, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, MD 21205, USA
    J Musculoskelet Neuronal Interact 6:322-3. 2006
  6. doi request reprint Increased fracture risk and low bone mineral density in patients with loeys-dietz syndrome
    Eric W Tan
    Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD 21224 2780, USA
    Am J Med Genet A 161:1910-4. 2013
  7. pmc Phenotypic variability of osteogenesis imperfecta type V caused by an IFITM5 mutation
    Jay R Shapiro
    Department of Bone and Osteogenesis Imperfecta, Kennedy Krieger Institution, Johns Hopkins University, Baltimore, MD, USA
    J Bone Miner Res 28:1523-30. 2013
  8. ncbi request reprint Serum and urine markers of bone metabolism during the year after hip fracture
    J A Yu-Yahiro
    Department of Orthopaedic Surgery, The Union Memorial Hospital, Baltimore, Maryland, USA
    J Am Geriatr Soc 49:877-83. 2001
  9. doi request reprint Cross-sectional and longitudinal growth patterns in osteogenesis imperfecta: implications for clinical care
    Emily L Germain-Lee
    Bone and Osteogenesis Imperfecta Department, Kennedy Krieger Institute, Baltimore, Maryland
    Pediatr Res 79:489-95. 2016
  10. doi request reprint Osteoblast function and bone histomorphometry in a murine model of Rett syndrome
    Mary E Blue
    Hugo W Moser Research Institute at Kennedy Krieger, Inc, 707 North Broadway, Baltimore, MD 21205, USA Electronic address
    Bone 76:23-30. 2015

Collaborators

  • Emily L Germain-Lee
  • Adele L Boskey
  • Paul D Sponseller
  • Toni I Pollin
  • Kim M Fox
  • JAY STEVEN MAGAZINER
  • David C Rowe
  • E F McCarthy
  • Mary E Blue
  • Eric W Tan
  • Elizabeth Martin
  • Elizabeth A Streeten
  • Mir Ahamed Hossain
  • Stephen B Doty
  • Neal S Fedarko
  • Gehua Zhen
  • Harry C Dietz
  • Ashvin K Dewan
  • Gretchen L Oswald
  • Xu Cao
  • Roosevelt U Offoha
  • Richard L Skolasky
  • J A Yu-Yahiro
  • D J McBride
  • Richa Agarwala
  • Daniel J McBride
  • Braxton D Mitchell
  • Amy L Lodge
  • David G Stinchcomb
  • Alejandro A Schäffer
  • Alan R Shuldiner
  • J R Hebel
  • W G Hawkes
  • N H Dubin
  • R H Michael
  • S I Zimmerman
  • M Sachs
  • S D Chipman
  • M G Dunn
  • A R Shuldiner
  • R J Wenstrup
  • H O Sweet
  • S C Marks
  • M T Davisson
  • P Branson
  • M B McKinstry
  • M L Stover

Detail Information

Publications19

  1. ncbi request reprint Osteogenesis imperfecta: effecting the transition from adolescent to adult medical care
    J R Shapiro
    Bone and Osteogenesis Imperfecta Department, Kennedy Krieger Institute, Johns Hopkins School of Medicine, 707 North Broadway, Baltimore, MD 21205, United States
    J Musculoskelet Neuronal Interact 12:24-7. 2012
    ..In addition, as the transition is established, the patient with OI should be encouraged to be his/her own advocate and care coordinator...
  2. ncbi request reprint Treatment with zoledronic acid ameliorates negative geometric changes in the proximal femur following acute spinal cord injury
    J Shapiro
    Department of Physical Medicine and Rehabilitation, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Calcif Tissue Int 80:316-22. 2007
    ....
  3. doi request reprint Bone mineral density and fracture rate in response to intravenous and oral bisphosphonates in adult osteogenesis imperfecta
    Jay R Shapiro
    Osteogenesis Imperfecta Program, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Calcif Tissue Int 87:120-9. 2010
    ..Fracture rate decreased in type III/IV patients following pamidronate but not following oral bisphosphonate treatment. These results underscore a need to consider whether bisphosphonate treatment is appropriate for all adults with OI...
  4. doi request reprint Osteogenesis imperfecta: questions and answers
    Jay R Shapiro
    Department Physical Medicine and Rehabilitation, Johns Hopkins University, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Curr Opin Pediatr 21:709-16. 2009
    ..Orthopedic intervention occurs on several levels: including the immediate treatment of fractures, the treatment of scoliosis and the use of intramedullary rods...
  5. ncbi request reprint Microgravity and drug effects on bone
    J R Shapiro
    National Space Biomedical Research Institute, Department of Physical Medicine and Rehabilitation, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, MD 21205, USA
    J Musculoskelet Neuronal Interact 6:322-3. 2006
  6. doi request reprint Increased fracture risk and low bone mineral density in patients with loeys-dietz syndrome
    Eric W Tan
    Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD 21224 2780, USA
    Am J Med Genet A 161:1910-4. 2013
    ..The lowest Z- and T-scores were not associated with an increased number of fractures. Patients with Loeys-Dietz syndrome have a high risk of fracture and a high incidence of low bone mineral density...
  7. pmc Phenotypic variability of osteogenesis imperfecta type V caused by an IFITM5 mutation
    Jay R Shapiro
    Department of Bone and Osteogenesis Imperfecta, Kennedy Krieger Institution, Johns Hopkins University, Baltimore, MD, USA
    J Bone Miner Res 28:1523-30. 2013
    ..The bone mineral density varied greatly, even within families. Our study thus highlights the phenotypic variability of OI type V caused by the IFITM5 mutation...
  8. ncbi request reprint Serum and urine markers of bone metabolism during the year after hip fracture
    J A Yu-Yahiro
    Department of Orthopaedic Surgery, The Union Memorial Hospital, Baltimore, Maryland, USA
    J Am Geriatr Soc 49:877-83. 2001
    ....
  9. doi request reprint Cross-sectional and longitudinal growth patterns in osteogenesis imperfecta: implications for clinical care
    Emily L Germain-Lee
    Bone and Osteogenesis Imperfecta Department, Kennedy Krieger Institute, Baltimore, Maryland
    Pediatr Res 79:489-95. 2016
    ..There is strikingly limited information on linear growth and weight in the different types of osteogenesis imperfecta (OI). Here, we define growth patterns further with the intent of implementing appropriate adaptations proactively...
  10. doi request reprint Osteoblast function and bone histomorphometry in a murine model of Rett syndrome
    Mary E Blue
    Hugo W Moser Research Institute at Kennedy Krieger, Inc, 707 North Broadway, Baltimore, MD 21205, USA Electronic address
    Bone 76:23-30. 2015
    ..These results indicate that MeCP2 deficiency leads to altered bone growth. Osteoblast dysfunction was more marked in Mecp2-null male than in HET female mice, suggesting that expression of MeCP2 plays a critical role in bone development...
  11. ncbi request reprint Osteogenesis imperfecta:epidemiology and pathophysiology
    Elizabeth Martin
    The Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Curr Osteoporos Rep 5:91-7. 2007
    ..Other treatment options, such as recombinant human parathyroid hormone (1-34), Rank ligand inhibitors, and stem cell technology, are being evaluated or are of future investigative interest...
  12. ncbi request reprint Reduced incidence of hip fracture in the Old Order Amish
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bone Miner Res 19:308-13. 2004
    ..The incidence of hip fracture was estimated in a community of Old Order Amish and compared with available data from non-Amish whites. Hip fracture rates were 40% lower in the Amish, and the Amish also experienced higher BMD...
  13. pmc Bone mass in Rett syndrome: association with clinical parameters and MECP2 mutations
    Jay R Shapiro
    Department of Bone and Osteogenesis Imperfecta, Kennedy Krieger Institution, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Pediatr Res 68:446-51. 2010
    ..Studies in a murine model of RTT confirmed low bone mass as an inherent component of this syndrome. MECP2 mutations and clinical parameters impact bone mass in RTT, but an association with a specific mutation was not demonstrable...
  14. ncbi request reprint The effect of intravenous pamidronate on bone mineral density, bone histomorphometry, and parameters of bone turnover in adults with type IA osteogenesis imperfecta
    J R Shapiro
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Calcif Tissue Int 72:103-12. 2003
    ..These results indicate that intravenous pamidronate, 30 mg every 3 months, may have significant effects on bone density and histomorphometry in adults with type IA OI. Responses at higher doses remain to be evaluated...
  15. ncbi request reprint OIM and related animal models of osteogenesis imperfecta
    J R Shapiro
    Bone Metabolism Research Laboratory, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Hopkins Bayview Research Campus, Baltimore, Maryland 21224, USA
    Connect Tissue Res 31:265-8. 1995
    ..OIM duplicates the phenotype and biochemistry of human disease and has a normal life span...
  16. pmc An osteopenic nonfracture syndrome with features of mild osteogenesis imperfecta associated with the substitution of a cysteine for glycine at triple helix position 43 in the pro alpha 1(I) chain of type I collagen
    J R Shapiro
    Bone Metabolism Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224
    J Clin Invest 89:567-73. 1992
    ..The prevalence of similar NH2-terminal mutations in subjects with this phenotype which clinically overlaps idiopathic osteoporosis remains to be determined...
  17. pmc Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta
    S D Chipman
    Bone Metabolism Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21224
    Proc Natl Acad Sci U S A 90:1701-5. 1993
    ..The oim mouse will facilitate the study of type I collagen-related skeletal disease...
  18. ncbi request reprint Bone geometry and strength measurements in aging mice with the oim mutation
    D J McBride
    Bone Metabolism Research Laboratory, Division of Geriatric Medicine and Gerontology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    Calcif Tissue Int 62:172-6. 1998
    ..However, no statistical difference in body mass was detected between +/oim and +/+ mice. The absence of a gross phenotypic difference between +/oim and +/+ mice demonstrates a milder phenotype in +/oim mice...
  19. ncbi request reprint Expression of mutant alpha (I)-procollagen in osteoblast and fibroblast cultures from a proband with osteogenesis imperfecta type IV
    S D Chipman
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Bone Miner Res 7:793-805. 1992
    ..Therefore, in this patient with osteogenesis imperfecta there was no qualitative alteration in the osteoblast-specific expression of this mutant alpha 2(I)-collagen allele compared to dermal fibroblasts...