Affiliation: Keck Graduate Institute
- Gene, stem cell, and future therapies for orphan diseasesM Ian Phillips
Center for Rare Disease Therapies, Keck Graduate Institute, Claremont, California, USA
Clin Pharmacol Ther 92:182-92. 2012..Stem cells secrete paracrine factors that could become new therapeutic tools in the treatment of orphan diseases. Gene therapy and stem cell therapy with DNA repair are promising approaches to the treatment of rare, intractable diseases...
- Stem cell therapy for heart failure: the science and current progressM Ian Phillips
Keck Graduate Institute, Stem Cell Labs, 535 Watson Drive, Claremont, CA 91711, USA
Future Cardiol 4:285-98. 2008..As we await results from larger and more prolonged clinical trials, the science of stem cell therapy in cardiac disease keeps progressing...
- Antisense Therapy for Cardiovascular DiseasesM Ian Phillips
Keck Graduate Institute, Claremont, CA, USA
Curr Pharm Des 21:4417-26. 2015..These antisense techniques also could be applied as antisense therapies to overcome gene defects in hypertension, heart disease, muscular defects and metabolic syndrome...
- Brain renin angiotensin in diseaseM Ian Phillips
Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711, USA
J Mol Med (Berl) 86:715-22. 2008..There is growing evidence to consider developing treatment strategies for a variety of neurological disease states based on brain RAS...
- Genetic modification of stem cells for transplantationM Ian Phillips
Keck Graduate Institute, Claremont, CA 91711, USA
Adv Drug Deliv Rev 60:160-72. 2008..We review the current uses of gene-modified stem cells in cardiovascular disease, diabetes, neurological diseases, (including Parkinson's, Alzheimer's and spinal cord injury repair), bone defects, hemophilia, and cancer...
- A novel two-step procedure to expand cardiac Sca-1+ cells clonallyYao Liang Tang
Stem Cell Biology, Keck Graduate Institute, 535 Watson Dr, Claremont, CA 91711, USA
Biochem Biophys Res Commun 359:877-83. 2007..To avoid these problems, we developed a two-step procedure by growing the cells before selecting the Sca-1+ cells and culturing in cardiac fibroblast conditioned medium, they avoid fibroblast overgrowth...
- Antisense therapeutics for hypertension: targeting the renin-angiotensin systemM Ian Phillips
Office of Research, University of South Florida, Tampa, FL, USA
Methods Mol Med 106:51-68. 2005
- Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardiumYao Liang Tang
Department of Pediatrics, College of Medicine and All Children s Hospital Research Institute, University of South Florida, 140 7th Avenue S, CRI 2007, St Petersburg, FL 33701, USA
Regul Pept 117:3-10. 2004..Hence, autologous MSCs transplantation may represent a promising therapeutic strategy free of ethical concerns and immune rejection, for neovascularization in ischemic heart diseases...
- Hypoxia inducible double plasmid system for myocardial ischemia gene therapyYi Tang
Department of Physiology and Functional Genomics, University of Florida, Gainesville 32610, USA
Hypertension 39:695-8. 2002..From these results, we concluded that this hypoxia inducible double plasmid system could be used therapeutically to switch on genes that have proven beneficial effects in myocardial ischemia...
- Gene therapy for hypertension: the preclinical dataM Ian Phillips
Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
Methods Enzymol 346:3-13. 2002..We conclude that there is sufficient preclinical data to give serious consideration to Phase I trials for testing the antisense ODNs, first and later the AAV...
- Angiotensin II as a pro-inflammatory mediatorM Ian Phillips
Department of Physiology, College of Medicine, University of Florida, Gainesville 32610, USA
Curr Opin Investig Drugs 3:569-77. 2002..ACE inhibitors and AT1R inhibitors could therefore be appropriate therapeutic agents in the treatment of atherosclerosis...
- Vigilant vectors: adeno-associated virus with a biosensor to switch on amplified therapeutic genes in specific tissues in life-threatening diseasesYi Tang
Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Box 100274, Gainesville, FL 32610 0274, USA
Methods 28:259-66. 2002....
- Presenilins in the heart: presenilin-2 expression is increased by low glucose and by hypoxia in cardiac cellsDagmara Mohuczy
Department of Physiology, College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
Regul Pept 110:1-7. 2002..The finding of presenilin-2 in the heart and the responsiveness to low glucose and hypoxia suggests that PS2 may be regulated by conditions of ischemia, a condition which both the heart and brain may experience...
- Efficient and persistent transduction of exocrine and endocrine pancreas by adeno-associated virus type 8Henrique Cheng
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
J Biomed Sci 14:585-94. 2007..Leukocyte infiltration was not observed in pancreas and blood glucose levels were not altered. Thus, AAV8 represents a safe and effective vehicle for therapeutic gene transfer to pancreas in vivo...
- A vigilant, hypoxia-regulated heme oxygenase-1 gene vector in the heart limits cardiac injury after ischemia-reperfusion in vivoYao Liang Tang
Department of Physiology and Biophysics, College of Medicine, University of South Florida, St Petersburg, FL, USA
J Cardiovasc Pharmacol Ther 10:251-63. 2005..The effect of a cardiac specific, hypoxia-regulated, human heme oxygenase-1 (hHO-1) vector to provide cardioprotection from ischemia-reperfusion injury was assessed...
- Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vectorYao Liang Tang
Department of Physiology and Biophysics, University of South Florida, St Petersburg, Florida, USA
J Am Coll Cardiol 46:1339-50. 2005..The goal of this study was to modify mesenchymal stem cells (MSCs) cells with a hypoxia-regulated heme oxygenase-1 (HO-1) plasmid to enhance the survival of MSCs in acute myocardial infarction (MI) heart...
- Gene therapy for hypertension: antisense inhibition of the renin-angiotensin systemM Ian Phillips
Department of Physiology and Internal Medicine, University of South Florida, Tampa, USA
Methods Mol Med 108:363-79. 2005..No toxic effects of repeated antisense treatment were found. The results indicate that antisense therapy could be used for human hypertension and provide long-term protection that would increase compliance of patients...
- Mobilizing of haematopoietic stem cells to ischemic myocardium by plasmid mediated stromal-cell-derived factor-1alpha (SDF-1alpha) treatmentYao Liang Tang
Department of Pediatrics, College of Medicine and All Children s Hospital Research Institute, University of South Florida, 140 7th Ave South, CRI 2015, St Petersburg, Florida, 33701, USA
Regul Pept 125:1-8. 2005..The gene therapy with an SDF-1alpha vector offers a promising therapeutic strategy for mobilizing stem cells to the ischemic myocardium...
- Antisense to epidermal growth factor receptor prevents the development of left ventricular hypertrophyShuntaro Kagiyama
Department of Physiology and Functional Genomics, University of Florida, Gainesville 32610 0274, USA
Hypertension 41:824-9. 2003..This may be related to the high levels of EGFR and phosphorylated ERK in young SHR, suggesting a critical role of the EGFR-activated ERK pathway in cardiovascular development but not in the maintenance of established LVH in adult SHR...
- Antisense inhibition: oligonucleotides, ribozymes, and siRNAsY Clare Zhang
Department of Pediatrics, University of South Florida, St Petersburg, FL, USA
Methods Mol Med 106:11-34. 2005
- Antisense therapeutics: a promise waiting to be fulfilledM Ian Phillips
Office of Research University of South Florida, Tampa, FL, USA
Methods Mol Med 106:3-10. 2005
- A Cre-loxP solution for defining the brain renin-angiotensin system. Focus on "Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain"M Ian Phillips
Physiol Genomics 18:1-3. 2004
- Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid systemYao Liang Tang
Department of Pediatrics, College of Medicine and All Children s Hospital Research Institute, University of South Florida, St Petersburg, Fla, USA
Hypertension 43:746-51. 2004..This novel gene transfer strategy can provide cardiac-specific protection from future repeated bouts of ischemic injury...
- Vigilant vector: heart-specific promoter in an adeno-associated virus vector for cardioprotectionM Ian Phillips
Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610 0274, USA
Hypertension 39:651-5. 2002..Further amplification of the gene to 400-fold in 1% O(2) can be achieved with a double plasmid. The construct may serve as a prototype "vigilant vector" to switch on therapeutic genes in specific tissue with physiological signals...
- UNIVERSITY OF SOUTH FLORIDA MOUSE BARRIER FACILITYM Phillips; Fiscal Year: 2004..6 to 1. The net benefit of the movable equipment requested would accrue to nationally recognized life science research directed by scientists from eight neighboring institutions that will use this new regional resource. ..
- Enhancing Subject Protections through EducationMichael Phillips; Fiscal Year: 2003..Using state-of-the-art technology, USF will share its educational programs with UCF, UCH, and community-based institutions conducting human subject research within the Tampa Bay area. ..
- Regulated gene and stem cell induced cardioprotectionMichael Phillips; Fiscal Year: 2007..We will engineer bone marrow-derived stem cells to express HO-1 via ex vivo rAAV infection and evaluate their capacity to survive in ischemic myocardium and to improve cardiac function. ..