Genomes and Genes
Jonathan G Zaroff
Affiliation: Kaiser Permanente
- Nonutilization of Statins in a Community-based Population with a History of Coronary RevascularizationJonathan A Peng
Kaiser Permanente San Francisco Medical Center, San Francisco, California Electronic address
Clin Ther 38:288-296.e2. 2016....
- Cardiovascular predictors of long-term outcomes after non-traumatic subarachnoid hemorrhageJonathan G Zaroff
Kaiser Northern California Division of Research, San Francisco, CA, USA
Neurocrit Care 17:374-81. 2012..The second aim was to quantify the effects of cardiac injury on the outcome rates...
- Independent associations between electrocardiographic abnormalities and outcomes in patients with aneurysmal subarachnoid hemorrhage: findings from the intraoperative hypothermia aneurysm surgery trialLandis A Coghlan
University of California, Los Angeles, California, USA
Stroke 40:412-8. 2009..The aim of this study was to determine whether any specific electrocardiographic abnormalities are independently associated with adverse neurological outcomes...
- Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAHLandis A Fisher
Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
Neurocrit Care 5:180-5. 2006..This study analyzed whether abnormal serum sodium levels are associated with cardiac outcomes and mortality after subarachnoid hemorrhage (SAH)...
- Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatmentAchal S Achrol
Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
Neurosurgery 61:731-9; discussion 740. 2007..We hypothesized that the risk of posttreatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes...
- Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformationsBahar Mikhak
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
Cerebrovasc Dis 31:338-45. 2011..We investigated whether common single nucleotide polymorphisms (SNPs) in ANGPTL4 were associated with risk of BAVM or ICH...
- Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhageJonathan G Zaroff
Department of Medicine, University of California, San Francisco, USA
Stroke 37:1680-5. 2006..We hypothesized that adrenoceptor polymorphisms resulting in greater catecholamine sensitivity would be associated with an increased risk of cardiac injury...
- Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhageNerissa U Ko
Department of Neurology, University of California, San Francisco, USA
Stroke 39:1103-8. 2008..Decreased availability of nitric oxide (NO) may be crucial in its pathogenesis. We hypothesized that endothelial NO synthase (eNOS) polymorphisms may determine susceptibility to vasospasm in SAH patients...
- Predictors of left ventricular regional wall motion abnormalities after subarachnoid hemorrhageAvinash Kothavale
Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
Neurocrit Care 4:199-205. 2006..The aim of this study was to determine the prevalence of LV regional wall motion abnormalities (RWMA) after SAH and to quantify the independent effects of specific demographic and clinical variables in predicting the development of RWMA...
- Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformationHelen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Cerebrovasc Dis 27:176-82. 2009..The aim of this study was to investigate associations between single nucleotide polymorphisms (SNPs) in IL-1beta and intracranial hemorrhage (ICH) in the natural course of brain arteriovenous malformation (BAVM) patients...
- Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhageSirisha Yarlagadda
Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0124, USA
Neurocrit Care 5:102-7. 2006..The objective of this study was to test the hypothesis that cardiovascular abnormalities are independently related to in-patient mortality after SAH...
- Acute neurocardiogenic injury after subarachnoid hemorrhageNader M Banki
Division of Cardiology, Department of Radiology, UCSF Medical Center, San Francisco, California, USA
Circulation 112:3314-9. 2005..Possible mechanisms include myocardial ischemia versus excessive catecholamine release from sympathetic nerve terminals...
- Elevated BNP is associated with vasospasm-independent cerebral infarction following aneurysmal subarachnoid hemorrhagePam R Taub
Department of Medicine, Cardiology Division, University of California, San Diego, CA 94114, USA
Neurocrit Care 15:13-8. 2011..We sought to determine whether elevated levels of BNP are independently associated with radiographic cerebral infarction after SAH...
- Plasma B-type natriuretic peptide levels are associated with early cardiac dysfunction after subarachnoid hemorrhagePoyee P Tung
Division of Cardiology, University of California, San Francisco, CA, USA
Stroke 36:1567-9. 2005..The aim of this study was to prospectively quantify the relationship between BNP levels and cardiac outcomes after SAH...
- Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined populationRodney A Gabriel
UCSF Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Room 3C 38, San Francisco, CA 94110, USA
Stroke 41:21-6. 2010....
- Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformationsLudmila Pawlikowska
The Cardiovascular Research Institute, University of California, San Francisco 94110, USA
Neurosurgery 58:838-43; discussion 838-43. 2006..Identification of genetic variants associated with increased new ICH risk would facilitate risk stratification and guide therapeutic intervention...
- A genome-wide investigation of copy number variation in patients with sporadic brain arteriovenous malformationNasrine Bendjilali
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 8:e71434. 2013..Most BAVMs are sporadic, but also occur in patients with Hereditary Hemorrhagic Telangiectasia, a Mendelian disorder caused by mutations in genes in the transforming growth factor beta (TGFβ) signaling pathway...
- Common variants on 9p21.3 are associated with brain arteriovenous malformations with accompanying arterial aneurysmsNasrine Bendjilali
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California, USA Kaiser Permanente of Northern California, Division of Research, Oakland, California, USA
J Neurol Neurosurg Psychiatry 85:1280-3. 2014..Common variants in the 9p21.3 locus have been reported to be associated with multiple cardiovascular phenotypes, including coronary artery disease and intracranial aneurysms (rs10757278 and rs1333040)...
- Donor predictors of allograft use and recipient outcomes after heart transplantationKiran K Khush
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA
Circ Heart Fail 6:300-9. 2013..We sought to identify donor predictors of allograft nonuse, and to determine whether these predictors are in fact associated with adverse recipient post-transplant outcomes...
- Perioperative hypothermia (33 degrees C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery TrialHoang P Nguyen
Department of Medicine, Kaiser San Francisco Medical Center, San Francisco, California, USA
Anesthesiology 113:327-42. 2010..By increasing the activity of sympathetic nervous system, perioperative hypothermia also has the potential to increase cardiac injury and dysfunction associated with subarachnoid hemorrhage...
- G Protein-Coupled Receptor 124 (GPR124) Gene Polymorphisms and Risk of Brain Arteriovenous MalformationShantel Weinsheimer
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA
Transl Stroke Res 3:418-27. 2012..SNP rs7015566 mapping to intron 1 of GPR124 was associated with BAVM susceptibility among Caucasians. Future work is focused on investigating this gene region. ..
- Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulationWhittemore G Tingley
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:8461-6. 2007..Our stem cell-based screen may provide a means of identifying other genes that control heart rhythm...
- Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul StudyGregory M Marcus
Electrophysiology Section, Division of Cardiology, University of California, San Francisco, CA 94143 1354, USA
Am Heart J 155:303-9. 2008..We therefore examined several biomarkers of inflammation and ultimately genotyped IL-6 polymorphisms in patients with AF in a cohort of subjects with known CAD...
- Cardiac injury after subarachnoid hemorrhage is independent of the type of aneurysm therapyJacob C Miss
Department of Medicine, University of California, San Francisco, California 94143 0124, USA
Neurosurgery 55:1244-50; discussion 1250-1. 2004..It is hypothesized that aneurysm treatment does not affect the risk of developing cardiac injury and dysfunction...
- Validation of a population-based method to assess drug-induced alterations in the QT interval: a self-controlled crossover studyCarlos Iribarren
Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA, USA
Pharmacoepidemiol Drug Saf 22:1222-32. 2013..The purpose of this study was to ascertain, in the context of an integrated health care delivery system, the association between a comprehensive list of drugs known to have potential QT liability and QT prolongation or shortening...
- Donor cardiac troponin I levels do not predict recipient survival after cardiac transplantationKiran K Khush
Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, San Francisco, California, USA
J Heart Lung Transplant 26:1048-53. 2007..This study was performed to determine whether donor cardiac cTnI levels exceeding 1.0 microg/liter are associated with adverse recipient outcomes...
- Surgical candidacy and selection biases in nonemergent left main stenting: implications for observational studiesEdward J McNulty
Division of Cardiology, Kaiser Permanente Medical Center, San Francisco, California 94115, USA
JACC Cardiovasc Interv 4:1020-7. 2011....
- Permanent Pacemaker Implantation Early After Cardiac Surgery: A Descriptive Study of Pacemaker Utility After One Year of Follow-UpAjay M Patel
Department of Cardiology, Kaiser San Francisco Medical Center, San Francisco, California
J Card Surg 31:132-8. 2016..The optimal number of days to wait for resolution of CHB prior to proceeding with a permanent pacemaker (PPM) and the long-term utility of PPMs placed in this setting remain uncertain...
- Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformationsAchal S Achrol
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California, USA
Stroke 37:231-4. 2006....
- Neurocardiogenic injury in neurovascular disordersAlexander Kopelnik
Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Crit Care Clin 22:733-52; abstract ix-x. 2006..For patients who develop brain death, cardiac evaluation under optimal conditions may help increase the organ donor pool...
- Neurogenic Cardiac InjuryNader M Banki
UCSF Medical Center, Division of Cardiology, 505 Parnassus Avenue, M1177, San Francisco, CA 94143, USA
Curr Treat Options Cardiovasc Med 5:451-458. 2003..Cardiac injury that occurs following an SAH appears to be reversible. For patients that develop brain death cardiac evaluation under optimal conditions may help increase the donor pool...
- Neurogenic stunned myocardiumHoang Nguyen
Cardiology Department, Kaiser San Francisco Medical Center, San Francisco, CA 94115, USA
Curr Neurol Neurosci Rep 9:486-91. 2009..These are reversible abnormalities, and although management should include careful cardiac monitoring, treatments should generally focus on the underlying neurologic process to maximize neurologic recovery...
- Electrocardiographic repolarization abnormalities in subarachnoid hemorrhageClaire E Sommargren
Department of Physiological Nursing, University of California, San Francisco, USA
J Electrocardiol 35:257-62. 2002..Prolonged QTc interval after SAH is significantly related to myocardial injury, but unrelated to mortality, and there is no association between ST-T wave abnormalities and either myocardial injury or mortality...