Nicola P Klein

Summary

Affiliation: Kaiser Permanente
Country: USA

Publications

  1. doi request reprint Rates of autoimmune diseases in Kaiser Permanente for use in vaccine adverse event safety studies
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Vaccine 28:1062-8. 2010
  2. doi request reprint Waning Tdap Effectiveness in Adolescents
    Nicola P Klein
    Northern California Kaiser Permanente Vaccine Study Center, Oakland, California
    Pediatrics 137:e20153326. 2016
  3. doi request reprint Safety of measles-containing vaccines in 1-year-old children
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, California
    Pediatrics 135:e321-9. 2015
  4. doi request reprint One or two doses of quadrivalent meningococcal serogroups A, C, W-135 and Y tetanus toxoid conjugate vaccine is immunogenic in 9- to 12-month-old children
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 32:760-7. 2013
  5. doi request reprint Comparative effectiveness of acellular versus whole-cell pertussis vaccines in teenagers
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatrics 131:e1716-22. 2013
  6. doi request reprint Safety of quadrivalent human papillomavirus vaccine administered routinely to females
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Arch Pediatr Adolesc Med 166:1140-8. 2012
  7. doi request reprint Waning protection after fifth dose of acellular pertussis vaccine in children
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    N Engl J Med 367:1012-9. 2012
  8. doi request reprint Immunogenicity and safety of a quadrivalent meningococcal conjugate vaccine administered concomitantly with measles, mumps, rubella, varicella vaccine in healthy toddlers
    Nicola P Klein
    Kaiser Permanente Vaccine Center, Oakland, CA 94612, USA
    Vaccine 30:3929-36. 2012
  9. doi request reprint Measles-containing vaccines and febrile seizures in children age 4 to 6 years
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatrics 129:809-14. 2012
  10. doi request reprint Safety and immunogenicity of a novel quadrivalent meningococcal CRM-conjugate vaccine given concomitantly with routine vaccinations in infants
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 31:64-71. 2012

Detail Information

Publications41

  1. doi request reprint Rates of autoimmune diseases in Kaiser Permanente for use in vaccine adverse event safety studies
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Vaccine 28:1062-8. 2010
    ..These background incidence rates should prove useful for future observational vaccine safety studies and will help guide evaluation of potential vaccine AID events following introduction of new vaccines...
  2. doi request reprint Waning Tdap Effectiveness in Adolescents
    Nicola P Klein
    Northern California Kaiser Permanente Vaccine Study Center, Oakland, California
    Pediatrics 137:e20153326. 2016
    ..We investigated Tdap vaccine effectiveness (VE) and waning within Kaiser Permanente Northern California among adolescents exclusively vaccinated with DTaP vaccines...
  3. doi request reprint Safety of measles-containing vaccines in 1-year-old children
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, California
    Pediatrics 135:e321-9. 2015
    ....
  4. doi request reprint One or two doses of quadrivalent meningococcal serogroups A, C, W-135 and Y tetanus toxoid conjugate vaccine is immunogenic in 9- to 12-month-old children
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 32:760-7. 2013
    ..The incidence of invasive meningococcal disease is highest in infants. A quadrivalent meningococcal serogroups A, C, W-135 and Y tetanus toxoid conjugate vaccine (MenACWY-TT) was evaluated in children 9-12 months of age...
  5. doi request reprint Comparative effectiveness of acellular versus whole-cell pertussis vaccines in teenagers
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatrics 131:e1716-22. 2013
    ..After a 2010-2011 pertussis outbreak, we sought to evaluate whether disease risk in 10 to 17 year olds differed between those who previously received DTwP from those who received DTaP...
  6. doi request reprint Safety of quadrivalent human papillomavirus vaccine administered routinely to females
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Arch Pediatr Adolesc Med 166:1140-8. 2012
    ..To assess the safety of the quadrivalent human papillomavirus vaccine (HPV4) in females following routine administration...
  7. doi request reprint Waning protection after fifth dose of acellular pertussis vaccine in children
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    N Engl J Med 367:1012-9. 2012
    ..In the United States, children receive five doses of diphtheria, tetanus, and acellular pertussis (DTaP) vaccine before 7 years of age. The duration of protection after five doses of DTaP is unknown...
  8. doi request reprint Immunogenicity and safety of a quadrivalent meningococcal conjugate vaccine administered concomitantly with measles, mumps, rubella, varicella vaccine in healthy toddlers
    Nicola P Klein
    Kaiser Permanente Vaccine Center, Oakland, CA 94612, USA
    Vaccine 30:3929-36. 2012
    ....
  9. doi request reprint Measles-containing vaccines and febrile seizures in children age 4 to 6 years
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatrics 129:809-14. 2012
    ..Among 1- to 2-year-olds, the risk of febrile seizures 7 to 10 days after MMRV is double that after separate MMR + V. Whether MMRV or MMR + V affects risk for febrile seizure risk among 4- to 6-year-olds has not been reported...
  10. doi request reprint Safety and immunogenicity of a novel quadrivalent meningococcal CRM-conjugate vaccine given concomitantly with routine vaccinations in infants
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 31:64-71. 2012
    ..In phase II studies, MenACWY-CRM elicited robust immunologic responses in young infants. We now present results from our pivotal phase III infant immunogenicity/safety study...
  11. doi request reprint An open-label, randomized, multi-center study of the immunogenicity and safety of DTaP-IPV (Kinrix™) co-administered with MMR vaccine with or without varicella vaccine in healthy pre-school age children
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA, USA
    Vaccine 30:668-74. 2012
    ..This study was undertaken to evaluate the immunogenicity and reactogenicity of Kinrix™ when co-administered with MMR (M-M-RII(®), Merck & Co.) and Varivax™ (Merck & Co.) in 4-6 year old children...
  12. doi request reprint Differential maternal responses to a newly developed vaccine information pamphlet
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, United States
    Vaccine 28:323-8. 2009
    ..These data suggest that early provision of tailored immunization material along with the VIS to new mothers may enhance their overall confidence in vaccines and that additional strategies targeted toward certain mothers may be needed...
  13. doi request reprint Evaluation of immunization rates and safety among children with inborn errors of metabolism
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, 1 Kaiser Plaza, 16th Floor, Oakland, CA 94612, USA
    Pediatrics 127:e1139-46. 2011
    ..Children with inherited metabolic disorders are a potential high-risk group for vaccine-preventable diseases, yet information regarding immunization rates and vaccine safety within this population is limited...
  14. doi request reprint Risk factors for developing apnea after immunization in the neonatal intensive care unit
    Nicola P Klein
    Kaiser Permanente Vaccine Studies Center, 1 Kaiser Plaza, 16th Floor, Oakland, CA 94612, USA
    Pediatrics 121:463-9. 2008
    ..Among hospitalized NICU infants, preimmunization apnea is a well-recognized predictor of postimmunization apnea. However, predictors for postimmunization apnea among NICU infants without preimmunization apnea have not been investigated...
  15. doi request reprint Preterm infants' T cell responses to inactivated poliovirus vaccine
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, California 94612, USA
    J Infect Dis 201:214-22. 2010
    ..The aim of the present study was to compare the T cell responses of preterm infants after inactivated poliovirus vaccination with those of term infants...
  16. doi request reprint Post-marketing safety evaluation of a tetanus toxoid, reduced diphtheria toxoid and 3-component acellular pertussis vaccine administered to a cohort of adolescents in a United States health maintenance organization
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA, USA
    Pediatr Infect Dis J 29:613-7. 2010
    ....
  17. doi request reprint Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatrics 126:e1-8. 2010
    ..Now with data on twice as many vaccine recipients, our goal was to reexamine seizure risk after MMRV vaccine...
  18. ncbi request reprint A role for genetics in the immune response to the varicella vaccine
    Nicola P Klein
    Kaiser Permanente Vaccine Study Center and Division of Research, Oakland, CA 94612, USA
    Pediatr Infect Dis J 26:300-5. 2007
    ..A wide range in antibody titers has been found after immunization with the varicella vaccine, although the basis for these differences has not been described...
  19. doi request reprint Effect of age on the risk of Fever and seizures following immunization with measles-containing vaccines in children
    Ali Rowhani-Rahbar
    Kaiser Permanente Vaccine Study Center, Oakland, California
    JAMA Pediatr 167:1111-7. 2013
    ..Findings of this study that focused on safety outcomes highlight the importance of timely immunization of children with the first dose of measles-containing vaccines...
  20. doi request reprint Biologically plausible and evidence-based risk intervals in immunization safety research
    Ali Rowhani-Rahbar
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, United States
    Vaccine 31:271-7. 2012
    ..In addition, we review methodologic issues related to the determination of risk intervals for consideration in future studies of immunization safety...
  21. doi request reprint Epidemiologic and clinical features of Bell's palsy among children in Northern California
    Ali Rowhani-Rahbar
    Kaiser Permanente Vaccine Study Center, Oakland, Calif 94612, USA
    Neuroepidemiology 38:252-8. 2012
    ..Large population-based studies of BP among children are lacking. We determined epidemiologic and clinical features of BP among children enrolled in a large integrated health care delivery system...
  22. doi request reprint Effectiveness of pertussis vaccines for adolescents and adults: case-control study
    Roger Baxter
    Kaiser Permanente Vaccine Study Center, 1 Kaiser Plaza, Oakland, CA 94612, USA
    BMJ 347:f4249. 2013
    ..To assess the effectiveness of reduced acellular pertussis (Tdap) vaccines in adolescents and adults...
  23. doi request reprint Immunization and Bell's palsy in children: a case-centered analysis
    Ali Rowhani-Rahbar
    Kaiser Permanente Vaccine Study Center, Oakland, California, USA
    Am J Epidemiol 175:878-85. 2012
    ..Similarly, no association was found between vaccines and BP during the periods 1-14 and 29-56 days following immunization. Results of this study suggest that there is no association between immunization and BP in children...
  24. doi request reprint Lack of association of Guillain-Barré syndrome with vaccinations
    Roger Baxter
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Clin Infect Dis 57:197-204. 2013
    ..Although cases of GBS have been reported following a wide range of vaccines, a clear association has only been established with the 1976 H1N1 inactivated influenza vaccine...
  25. ncbi request reprint Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine
    Steven Black
    Division of Pediatric Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA
    Pediatr Infect Dis J 26:771-7. 2007
    ....
  26. doi request reprint Risk of rheumatoid arthritis following vaccination with tetanus, influenza and hepatitis B vaccines among persons 15-59 years of age
    Paula Ray
    Kaiser Permanente Vaccine Study Center, Oakland, CA, USA
    Vaccine 29:6592-7. 2011
    ..Associations between vaccinations, particularly hepatitis B, and onset of rheumatoid arthritis (RA) have been reported, but examined in few large-scale studies...
  27. doi request reprint Diphtheria-tetanus-acellular pertussis and inactivated poliovirus vaccines given separately or combined for booster dosing at 4-6 years of age
    Steven Black
    Stanford University, Palo Alto, CA, USA
    Pediatr Infect Dis J 27:341-6. 2008
    ..A combined DTaP-IPV vaccine is being developed, which would reduce by one the number of injections in this age group...
  28. ncbi request reprint Acute Demyelinating Events Following Vaccines: A Case-Centered Analysis
    Roger Baxter
    Northern California Kaiser Permanente Vaccine Study Center, Oakland
    Clin Infect Dis 63:1456-1462. 2016
    ..We analyzed the association of immunization and subsequent development of TM or ADEM...
  29. doi request reprint Case-centered Analysis of Optic Neuritis After Vaccines
    Roger Baxter
    Northern California Kaiser Permanente Vaccine Study Center, Oakland
    Clin Infect Dis 63:79-81. 2016
    ..We did not detect any association between ON and receipt of any type of vaccine. ..
  30. doi request reprint Recurrent Guillain-Barre syndrome following vaccination
    Roger Baxter
    Kaiser Permanente Vaccine Study Center, Oakland, California 94612, USA
    Clin Infect Dis 54:800-4. 2012
    ....
  31. doi request reprint Clinical assessment of serious adverse events in children receiving 2009 H1N1 vaccination
    Barbara A Pahud
    Division of Pediatric Infectious Diseases, Stanford University Medical Center, Stanford, CA, USA
    Pediatr Infect Dis J 32:163-8. 2013
    ..Monovalent 2009 H1N1 influenza vaccines were licensed and administered in the United States during the H1N1 influenza pandemic between 2009 and 2013...
  32. ncbi request reprint Assessing the safety of influenza vaccination in specific populations: children and the elderly
    Ali Rowhani-Rahbar
    Kaiser Permanente Vaccine Study Center, One Kaiser Plaza, Floor 16, Oakland, CA 94612, USA
    Expert Rev Vaccines 11:973-84. 2012
    ..The authors discuss the current status of the field, particularly the use of new technologies for influenza vaccines and their potential safety profile...
  33. doi request reprint Safety of trivalent inactivated influenza vaccine in children aged 24 to 59 months in the vaccine safety datalink
    Jason M Glanz
    Institute for Health Research, Kaiser Permanente Colorado, Denver, CO 80237 8066, USA
    Arch Pediatr Adolesc Med 165:749-55. 2011
    ....
  34. doi request reprint Risk of underlying chronic medical conditions for invasive pneumococcal disease in adults
    Roger Baxter
    Northern California Kaiser Permanente Vaccine Study Center, Oakland, CA, USA Electronic address
    Vaccine 34:4293-7. 2016
    ..We also examined IPD incidence by number of conditions diagnosed in each calendar year, using a risk-stacking model...
  35. doi request reprint Sudden-Onset Sensorineural Hearing Loss after Immunization: A Case-Centered Analysis
    Roger Baxter
    Northern California Kaiser Permanente Vaccine Study Center, Oakland, California, USA
    Otolaryngol Head Neck Surg 155:81-6. 2016
    ..Case reports of sudden sensorineural hearing loss (SSHL) following vaccines have led to concerns that vaccines may rarely cause hearing loss. Because of this concern, we analyzed for an association between SSHL and vaccinations...
  36. doi request reprint Vaccine effectiveness against laboratory-confirmed influenza in infants: A matched case control study
    Lauren W Cochran
    Stanford University School of Medicine, Stanford, CA, USA
    Hum Vaccin 6:. 2010
    ..There was no statistically significant effect of vaccination, however, for the 2003-2004 or 2004-2005 seasons. Our results highlight the need for further study of influenza vaccine effectiveness in this age group. ..
  37. doi request reprint Safety of DTaP-IPV/Hib vaccine administered routinely to infants and toddlers
    John Hansen
    Kaiser Permanente Vaccine Study Center, 1 Kaiser Plaza 16B, Oakland, CA 94612, USA Electronic address
    Vaccine 34:4172-9. 2016
    ..The aim of this study was to assess the safety of DTaP-IPV/Hib vaccine routinely administered as part of clinical care to infants at Kaiser Permanente Northern California...
  38. doi request reprint Kaiser Permanente Northern California pregnancy database: Description and proof of concept study
    Ousseny Zerbo
    Kaiser Permanente Vaccine Study Center, 1 Kaiser Plaza, 16b, Oakland, CA 94612, USA Electronic address
    Vaccine 34:5519-5523. 2016
    ..We describe the establishment of a dynamic database linking mothers to newborns with the goal of studying vaccine safety in both pregnant women and their children and provide results of a study utilizing this database as a proof of concept...
  39. pmc Kaiser Permanente Vaccine Study Center: Highlights of 2009-2012
    Roger Baxter
    Kaiser Permanente Vaccine Study Center, 1 Kaiser Plaza, 16b, Oakland, CA 94612, USA
    Vaccines (Basel) 1:139-53. 2013
    ..They have been an active vaccine research group for many years, and have participated in and led a multitude of vaccine studies. This article will review the last three years of research activities. ..
  40. doi request reprint Geographic clusters in underimmunization and vaccine refusal
    Tracy A Lieu
    Division of Research, Kaiser Permanente Northern California, Oakland, California
    Pediatrics 135:280-9. 2015
    ....
  41. ncbi request reprint Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults
    Nicola P Klein
    Division of Pediatric Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305 520, USA
    Vaccine 24:5913-8. 2006
    ..Taken together, results suggest that further studies regarding immunization of younger adults and females with the modified, high-potency live attenuated VZV vaccine may be warranted...