Sean X Zhang
Affiliation: Johns Hopkins University
- Enhancing molecular approaches for diagnosis of fungal infectionsSean X Zhang
Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, 600 Wolfe Street, Meyer B1 193, Baltimore 21287, MD, USA
Future Microbiol 8:1599-611. 2013..Advances of developing quantitative assays and RNA detection platforms may provide another avenue to further improve fungal diagnostics. ..
- Actinomucor elegans as an emerging cause of MucormycosisAneela Mahmud
Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School ofMedicine, Baltimore, Maryland, USA
J Clin Microbiol 50:1092-5. 2012..This report, along with the three previously reported cases, is convincing evidence that A. elegans is an emerging fungal pathogen capable of causing invasive mucormycosis in humans...
- Evaluation of CLSI agar dilution method and Trek Sensititre broth microdilution panel for determining antimicrobial susceptibility of Streptococcus pneumoniaeSean X Zhang
Public Health Laboratories, Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada
J Clin Microbiol 49:704-6. 2011..While agar dilution was not an optimal method, the commercial panel appeared to be an acceptable method, with minor errors encountered for ceftriaxone, penicillin, and meropenem...
- Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimensNuntra Suwantarat
Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD
Diagn Microbiol Infect Dis 82:54-6. 2015..Overall, the LFA had sensitivity of 100% and specificity of 99.6% for the diagnosis of cryptococcosis. The LFA is rapid, accurate, and easy to perform, and it is suitable for routine patient care testing. ..
- Rapid identification of Cryptococcus neoformans var. grubii, C. neoformans var. neoformans, and C. gattii by use of rapid biochemical tests, differential media, and DNA sequencingLisa McTaggart
Medical Mycology, Ontario Public Health Laboratories, Ontario Agency for Health Protection and Promotion, Department ofLaboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
J Clin Microbiol 49:2522-7. 2011..neoformans var. grubii, C. neoformans var. neoformans, and C. gattii. Based on these results, we describe a rapid identification algorithm for use in a microbiology laboratory to distinguish clinically relevant Cryptococcus spp...
- Cerebrospinal fluid (1,3)-β-D-glucan detection as an aid for diagnosis of iatrogenic fungal meningitisJennifer L Lyons
Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Clin Microbiol 51:1285-7. 2013..S. outbreak of fungal meningitis related to contaminated methylprednisolone acetate. This test may prove a useful adjunct in diagnosis and management of exposed patients...
- Epidemiology of Candida kefyr in patients with hematologic malignanciesSimon F Dufresne
Division of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
J Clin Microbiol 52:1830-7. 2014..C. kefyr appears to be increasing in HM patients, with prominent summer seasonality. These findings raise questions about the effect of antifungal agents and health care exposures (e.g., yogurt) on the epidemiology of this yeast. ..
- Cunninghamella echinulata causing fatally invasive fungal sinusitisRobert E LeBlanc
Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Diagn Microbiol Infect Dis 76:506-9. 2013..Human infection caused by this organism has not been well documented; however, this report alerts us to its life-threatening potential. ..
- Phylogenetic analysis reveals a cryptic species Blastomyces gilchristii, sp. nov. within the human pathogenic fungus Blastomyces dermatitidisElizabeth M Brown
Public Health Laboratories Toronto, Public Health Ontario, Toronto, Ontario, Canada
PLoS ONE 8:e59237. 2013..Here, we examined the population genetic structure and geographic differentiation of the sexual, dimorphic fungus Blastomyces dermatitidis, the causative agent of blastomycosis...
- Iatrogenic Exserohilum infection of the central nervous system: mycological identification and histopathological findingsW Robert Bell
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7093, USA
Mod Pathol 26:166-70. 2013..This report describes the microbiological procedures and histopathological features for the identification of E. rostratum (a pigmented vascularly invasive fungi), the cause of a current nationwide outbreak of fatal fungal meningitis...
- Ochroconis gallopava infection in a patient with chronic granulomatous disease: case report and review of the literatureZina Meriden
Department of Pathology, Division of Infectious Disease, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Med Mycol 50:883-9. 2012..We also review the literature of human infections with Ochroconis to date, and discuss its microbiology to apprise both clinicians and laboratory personnel of this infrequently encountered but potentially aggressive pathogen...
- Candida bracarensis bloodstream infection in an immunocompromised patientThomas A Warren
Department of Laboratory Medicine and Pathobiology, University of Toronto, and Division of Microbiology, Hospital for Sick Children, Toronto, Ontario, Canada
J Clin Microbiol 48:4677-9. 2010..The organism can be distinguished from C. glabrata by its white color on CHROMagar and by DNA sequence analysis using D1/D2 and internal transcribed spacer (ITS) primers...
- Phylogeny and identification of Nocardia species on the basis of multilocus sequence analysisL R McTaggart
Medical Mycology, Public Health Laboratories, Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada
J Clin Microbiol 48:4525-33. 2010..5% and 99.5% of isolates, respectively, and would be more feasible for routine use in a clinical reference microbiology laboratory...