Owen M Woodward

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules
    Owen M Woodward
    Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 110:5223-8. 2013
  2. ncbi request reprint Dopamine modulation of Ca(2+) dependent Cl(-) current regulates ciliary beat frequency controlling locomotion in Tritonia diomedea
    Owen M Woodward
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    J Exp Biol 209:2749-64. 2006
  3. ncbi request reprint Nervous control of ciliary beating by Cl(-), Ca(2+) and calmodulin in Tritonia diomedea
    Owen M Woodward
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195, USA
    J Exp Biol 209:2765-73. 2006
  4. pmc Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal
    Young Kwon
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 20:1672-8. 2010
  5. pmc Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1
    Owen M Woodward
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e12305. 2010
  6. pmc A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells
    Lihua Liang
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 6:e21991. 2011
  7. pmc Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
    Owen M Woodward
    Department of Physiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:10338-42. 2009
  8. pmc ABCG transporters and disease
    Owen M Woodward
    Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    FEBS J 278:3215-25. 2011
  9. pmc Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons
    Sang Hoon Kim
    Departmentsof Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:8440-5. 2010
  10. pmc Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease
    Yun Li
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 284:36431-41. 2009

Research Grants

Collaborators

Detail Information

Publications14

  1. pmc Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules
    Owen M Woodward
    Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 110:5223-8. 2013
    ..Finally, we have demonstrated the utility of using small molecules to correct the Q141K defect in expression and function as a possible therapeutic approach for hyperuricemia and gout...
  2. ncbi request reprint Dopamine modulation of Ca(2+) dependent Cl(-) current regulates ciliary beat frequency controlling locomotion in Tritonia diomedea
    Owen M Woodward
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    J Exp Biol 209:2749-64. 2006
    ..These results suggest that dopamine and TPep-NLS act to inhibit I(Cl(Ca)), initiating and prolonging Ca(2+) influx, and activating CBF excitation...
  3. ncbi request reprint Nervous control of ciliary beating by Cl(-), Ca(2+) and calmodulin in Tritonia diomedea
    Owen M Woodward
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195, USA
    J Exp Biol 209:2765-73. 2006
    ..From these results we hypothesize dopamine and TPep-NLS induce depolarization-driven Ca(2+) influx and Ca(2+) release from internal stores that activates Ca(2+)-calmodulin, thereby increasing CBF...
  4. pmc Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal
    Young Kwon
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 20:1672-8. 2010
    ....
  5. pmc Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1
    Owen M Woodward
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e12305. 2010
    ..These data describe a novel polycystin-1 cleavage product, P100, which functions to reduce SOCE via direct inhibition of STIM1 translocation; a function with consequences for ADPKD...
  6. pmc A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells
    Lihua Liang
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 6:e21991. 2011
    ..The identification of this novel role of PYK2 reveals a new signaling pathway in human airway epithelial cells...
  7. pmc Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
    Owen M Woodward
    Department of Physiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:10338-42. 2009
    ..Our study completes the chain of evidence from association to causation and supports the common disease-common variant hypothesis in the etiology of gout...
  8. pmc ABCG transporters and disease
    Owen M Woodward
    Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    FEBS J 278:3215-25. 2011
    ..We focus on the recent discovery of mutations in ABCG2 causing hyperuricemia and gout, which has led to the identification of urate as a physiological substrate for ABCG2...
  9. pmc Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons
    Sang Hoon Kim
    Departmentsof Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:8440-5. 2010
    ..Given that mammalian TRPA1 is required for responding to noxious chemicals, many of which cause pain and injury, our analysis underscores the evolutionarily conserved role for TRPA1 channels in chemical avoidance...
  10. pmc Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease
    Yun Li
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 284:36431-41. 2009
    ..These data demonstrate that PC1 inhibits Ca(2+) release, perhaps opposing the effect of PC2, which facilitates Ca(2+) release through the IP(3)R...
  11. pmc Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Hum Mol Genet 20:4056-68. 2011
    ..Our data support the importance of multi-ethnic GWAS in the identification of novel risk loci as well as functional variants...
  12. pmc ABCG2: the molecular mechanisms of urate secretion and gout
    Owen M Woodward
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland
    Am J Physiol Renal Physiol 309:F485-8. 2015
    ..This review will highlight the recent work to identify the first important human uric acid secretory transporter, ABCG2, and the identification of a common causal ABCG2 variant, Q141K, for hyperuricemia and gout. ..
  13. pmc Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier
    Jung Soo Suk
    The Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore 21231, USA Department of Ophthalmology, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore 21231, USA Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore 21205, USA
    J Control Release 178:8-17. 2014
    ..Highly compacted mucus penetrating DNA nanoparticles hold promise for lung gene therapy. ..
  14. pmc Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion
    Kazi Mirajul Hoque
    Department of Medicine, GI Division, Johns Hopkins University, Baltimore, MD 21205, USA
    J Gen Physiol 135:43-58. 2010
    ..These results led us to conclude that the Epac-Rap-PLC-[Ca2+]i signaling pathway is involved in cAMP-stimulated Cl- secretion, which is carried by a novel, previously undescribed Cl- channel...

Research Grants1

  1. Study of Tritonia crawl circuit and ciliated motor cells
    OWEN WOODWARD; Fiscal Year: 2005
    ..This project may also contribute to the understanding and treatment of motor system disorders as well as demonstrate how the CNS may control non-muscular motor behaviors. ..