Genomes and Genes
Owen M Woodward
Affiliation: Johns Hopkins University
- Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small moleculesOwen M Woodward
Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 110:5223-8. 2013..Finally, we have demonstrated the utility of using small molecules to correct the Q141K defect in expression and function as a possible therapeutic approach for hyperuricemia and gout...
- Dopamine modulation of Ca(2+) dependent Cl(-) current regulates ciliary beat frequency controlling locomotion in Tritonia diomedeaOwen M Woodward
Department of Biology, University of Washington, Seattle, WA 98195, USA
J Exp Biol 209:2749-64. 2006..These results suggest that dopamine and TPep-NLS act to inhibit I(Cl(Ca)), initiating and prolonging Ca(2+) influx, and activating CBF excitation...
- Nervous control of ciliary beating by Cl(-), Ca(2+) and calmodulin in Tritonia diomedeaOwen M Woodward
Department of Biology, University of Washington, Box 351800, Seattle, WA 98195, USA
J Exp Biol 209:2765-73. 2006..From these results we hypothesize dopamine and TPep-NLS induce depolarization-driven Ca(2+) influx and Ca(2+) release from internal stores that activates Ca(2+)-calmodulin, thereby increasing CBF...
- Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellalYoung Kwon
Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Curr Biol 20:1672-8. 2010....
- Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1Owen M Woodward
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e12305. 2010..These data describe a novel polycystin-1 cleavage product, P100, which functions to reduce SOCE via direct inhibition of STIM1 translocation; a function with consequences for ADPKD...
- A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cellsLihua Liang
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
PLoS ONE 6:e21991. 2011..The identification of this novel role of PYK2 reveals a new signaling pathway in human airway epithelial cells...
- Identification of a urate transporter, ABCG2, with a common functional polymorphism causing goutOwen M Woodward
Department of Physiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 106:10338-42. 2009..Our study completes the chain of evidence from association to causation and supports the common disease-common variant hypothesis in the etiology of gout...
- ABCG transporters and diseaseOwen M Woodward
Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
FEBS J 278:3215-25. 2011..We focus on the recent discovery of mutations in ABCG2 causing hyperuricemia and gout, which has led to the identification of urate as a physiological substrate for ABCG2...
- Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neuronsSang Hoon Kim
Departmentsof Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 107:8440-5. 2010..Given that mammalian TRPA1 is required for responding to noxious chemicals, many of which cause pain and injury, our analysis underscores the evolutionarily conserved role for TRPA1 channels in chemical avoidance...
- Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney diseaseYun Li
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 284:36431-41. 2009..These data demonstrate that PC1 inhibits Ca(2+) release, perhaps opposing the effect of PC2, which facilitates Ca(2+) release through the IP(3)R...
- Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function alleleAdrienne Tin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Hum Mol Genet 20:4056-68. 2011..Our data support the importance of multi-ethnic GWAS in the identification of novel risk loci as well as functional variants...
- ABCG2: the molecular mechanisms of urate secretion and goutOwen M Woodward
Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland
Am J Physiol Renal Physiol 309:F485-8. 2015..This review will highlight the recent work to identify the first important human uric acid secretory transporter, ABCG2, and the identification of a common causal ABCG2 variant, Q141K, for hyperuricemia and gout. ..
- Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrierJung Soo Suk
The Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore 21231, USA Department of Ophthalmology, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore 21231, USA Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore 21205, USA
J Control Release 178:8-17. 2014..Highly compacted mucus penetrating DNA nanoparticles hold promise for lung gene therapy. ..
- Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretionKazi Mirajul Hoque
Department of Medicine, GI Division, Johns Hopkins University, Baltimore, MD 21205, USA
J Gen Physiol 135:43-58. 2010..These results led us to conclude that the Epac-Rap-PLC-[Ca2+]i signaling pathway is involved in cAMP-stimulated Cl- secretion, which is carried by a novel, previously undescribed Cl- channel...
- Study of Tritonia crawl circuit and ciliated motor cellsOWEN WOODWARD; Fiscal Year: 2005..This project may also contribute to the understanding and treatment of motor system disorders as well as demonstrate how the CNS may control non-muscular motor behaviors. ..