Yuchuan Wang

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Pinhole SPECT with different data acquisition geometries: usefulness of unified projection operators in homogeneous coordinates
    Yuchuan Wang
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    IEEE Trans Med Imaging 26:298-308. 2007
  2. doi request reprint [(18)F]Fluoroethyl Triazole Substituted PSMA Inhibitor Exhibiting Rapid Normal Organ Clearance
    Ying Chen
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, United States
    Bioconjug Chem 27:1655-62. 2016
  3. ncbi request reprint Quantitative rotating multisegment slant-hole SPECT mammography with attenuation and collimator-detector response compensation
    Jingyan Xu
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
    IEEE Trans Med Imaging 26:906-16. 2007
  4. pmc 18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase
    Andrew G Horti
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Nucl Med 57:1817-1822. 2016
  5. ncbi request reprint Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
    Young H Ko
    The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem Biophys Res Commun 324:269-75. 2004
  6. doi request reprint Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players
    Jennifer M Coughlin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland2Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
    JAMA Neurol . 2016
  7. pmc MR-Guided Delivery of Hydrophilic Molecular Imaging Agents Across the Blood-Brain Barrier Through Focused Ultrasound
    Raag D Airan
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mol Imaging Biol . 2016
  8. pmc A PSMA-targeted theranostic agent for photodynamic therapy
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21287, United States Electronic address
    J Photochem Photobiol B 167:111-116. 2016
  9. pmc [(18)F]Fluorobenzoyllysinepentanedioic Acid Carbamates: New Scaffolds for Positron Emission Tomography (PET) Imaging of Prostate-Specific Membrane Antigen (PSMA)
    Xing Yang
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, United States
    J Med Chem 59:206-18. 2016
  10. pmc An immunotolerant HER-2/neu transgenic mouse model of metastatic breast cancer
    Hong Song
    Division of Nuclear Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Clin Cancer Res 14:6116-24. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Pinhole SPECT with different data acquisition geometries: usefulness of unified projection operators in homogeneous coordinates
    Yuchuan Wang
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    IEEE Trans Med Imaging 26:298-308. 2007
    ..Experimental studies were performed to demonstrate the validity of our approaches, which may be extended to other pinhole SPECT and cone-beam X-ray computed tomography imaging geometries...
  2. doi request reprint [(18)F]Fluoroethyl Triazole Substituted PSMA Inhibitor Exhibiting Rapid Normal Organ Clearance
    Ying Chen
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, United States
    Bioconjug Chem 27:1655-62. 2016
    ..Because of its low uptake in the kidney, rapid clearance from nontarget organs, and relatively simple one-pot, two-step radiosynthesis, [(18)F]YC-88 is a viable new PET radiotracer for imaging PSMA-expressing lesions. ..
  3. ncbi request reprint Quantitative rotating multisegment slant-hole SPECT mammography with attenuation and collimator-detector response compensation
    Jingyan Xu
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
    IEEE Trans Med Imaging 26:906-16. 2007
    ..We conclude that attenuation and CDR compensation provide RMSSH SPECT mammography images with improved quality and quantitative accuracy...
  4. pmc 18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase
    Andrew G Horti
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Nucl Med 57:1817-1822. 2016
    ..We developed N-(3,3-diphenylpropyl)-6-18F-fluoronicotinamide (18F-FNDP), which proved highly specific for imaging of sEH in the mouse and nonhuman primate brain with PET...
  5. ncbi request reprint Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
    Young H Ko
    The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem Biophys Res Commun 324:269-75. 2004
    ..In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers...
  6. doi request reprint Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players
    Jennifer M Coughlin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland2Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
    JAMA Neurol . 2016
    ....
  7. pmc MR-Guided Delivery of Hydrophilic Molecular Imaging Agents Across the Blood-Brain Barrier Through Focused Ultrasound
    Raag D Airan
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mol Imaging Biol . 2016
    ....
  8. pmc A PSMA-targeted theranostic agent for photodynamic therapy
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21287, United States Electronic address
    J Photochem Photobiol B 167:111-116. 2016
    ..This study proves in principle that YC-9 is a promising therapeutic agent for targeted PDT of PSMA-expressing tissues, such as prostate tumors, and may also be useful against non-prostate tumors by virtue of neovascular PSMA expression...
  9. pmc [(18)F]Fluorobenzoyllysinepentanedioic Acid Carbamates: New Scaffolds for Positron Emission Tomography (PET) Imaging of Prostate-Specific Membrane Antigen (PSMA)
    Xing Yang
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, United States
    J Med Chem 59:206-18. 2016
    ..Prolonged tumor-specific uptake demonstrated by [(18)F]24, which did not reach equilibrium during the 4 h study period, suggests carbamates as alternative scaffolds for mitigating dose to nontarget tissues. ..
  10. pmc An immunotolerant HER-2/neu transgenic mouse model of metastatic breast cancer
    Hong Song
    Division of Nuclear Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Clin Cancer Res 14:6116-24. 2008
    ..We have developed and characterized a preclinical model for the evaluation of immune-mediated metastatic breast cancer therapies...
  11. ncbi request reprint Performance evaluation of the GE healthcare eXplore VISTA dual-ring small-animal PET scanner
    Yuchuan Wang
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nucl Med 47:1891-900. 2006
    ....
  12. ncbi request reprint Radiolabeled small-molecule ligands for prostate-specific membrane antigen: in vivo imaging in experimental models of prostate cancer
    Catherine A Foss
    Johns Hopkins University, Baltimore, Maryland 21287 2182, USA
    Clin Cancer Res 11:4022-8. 2005
    ..Our goal in this study was to develop a series of PSMA-based imaging agents for clinical use...
  13. pmc Neuroimaging of translocator protein in patients with systemic lupus erythematosus: a pilot study using [11C]DPA-713 positron emission tomography
    Yuchuan Wang
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Lupus . 2016
    ....
  14. pmc [64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma
    Il Minn
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget . 2016
    ..These results indicate pharmacokinetics superior to those of previously reported imaging agents binding to CAIX. [64Cu]XYIMSR-06 is a new low-molecular-weight PET ligand targeting CAIX, which can image localized and metastatic ccRCC...
  15. pmc Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation
    Alena V Savonenko
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America
    PLoS ONE 10:e0129618. 2015
    ..Thus this study in mouse models of AD indicates that a CB2-specific radiotracer can be used as a biomarker of neuroinflammation in the early preclinical stages of AD, when no significant neuronal loss has yet developed. ..
  16. doi request reprint Evaluation of a PSMA-targeted BNF nanoparticle construct
    Babak Behnam Azad
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Nanoscale 7:4432-42. 2015
    ..The BNF nano-formulation described is promising for PSMA-targeted imaging applications in vivo. ..
  17. pmc 18F-ASEM, a radiolabeled antagonist for imaging the α7-nicotinic acetylcholine receptor with PET
    Andrew G Horti
    Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Maryland
    J Nucl Med 55:672-7. 2014
    ..The goal of this study was to evaluate the potential of (18)F-ASEM ((18)F-JHU82132) as an α7-nAChR radioligand for PET...
  18. pmc Detection of dose response in chronic doxorubicin-mediated cell death with cardiac technetium 99m annexin V single-photon emission computed tomography
    Kathleen L Gabrielson
    Department of Molecular and Comparative Pathobiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Imaging 7:132-8. 2008
    ..99mTc-HYNIC-annexin V SPECT-based molecular imaging may provide an attractive new technique for assessing early changes in myocardial function in patients undergoing DOX therapy...
  19. pmc Integration of SimSET photon history generator in GATE for efficient Monte Carlo simulations of pinhole SPECT
    Chia Lin Chen
    Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei 102, Taiwan
    Med Phys 35:3278-84. 2008
    ..This integrated simulation tool can also be adapted for studying other preclinical and clinical SPECT techniques...
  20. ncbi request reprint High-resolution molecular imaging techniques for cardiovascular research
    Benjamin M W Tsui
    J Nucl Cardiol 12:261-7. 2005