Patrick Craig Walsh

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi Immediate Adjuvant Radiation Therapy Following Radical Prostatectomy Should Not Be Advised for Men with Extraprostatic Extension Who Have Negative Surgical Margins
    Patrick C Walsh
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Electronic address
    Eur Urol 69:191-2. 2016
  2. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
  3. doi How surgical innovation reduced death and suffering from prostate cancer
    Patrick C Walsh
    From the James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Craniofac Surg 24:49-50. 2013
  4. doi How Charles Huggins made his Nobel prize winning discovery--in his own words: an historic audio recording. Interviewed by Willard Goodwin and Elmer Bell
    Charles Huggins
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Prostate 72:1718. 2012
  5. ncbi Clinical practice. Localized prostate cancer
    Patrick C Walsh
    James Buchanan Brady Urological Institute, The Sidney Kimmel Comprehensive Cancer Center, The Department of Urology, Radiation Oncology and Molecular Radiation Sciences, and Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
    N Engl J Med 357:2696-705. 2007
  6. ncbi The discovery of the cavernous nerves and development of nerve sparing radical retropubic prostatectomy
    Patrick Craig Walsh
    James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 177:1632-5. 2007
  7. ncbi Probability of biochemical recurrence by analysis of pathologic stage, Gleason score, and margin status for localized prostate cancer
    Masood A Khan
    Department of Urology, James Buchanan Brady Urological Institute and Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21287 2101, USA
    Urology 62:866-71. 2003
  8. ncbi Importance of tumor location in patients with high preoperative prostate specific antigen levels (greater than 20 ng/ml) treated with radical prostatectomy
    Ahmed Magheli
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 178:1311-5. 2007
  9. pmc Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:101-4; discussion 105. 2009
  10. ncbi A critical analysis of the interpretation of biochemical failure in surgically treated patients using the American Society for Therapeutic Radiation and Oncology criteria
    Matthew B Gretzer
    The James Buchanan Brady Urological Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA
    J Urol 168:1419-22. 2002

Collaborators

Detail Information

Publications67

  1. doi Immediate Adjuvant Radiation Therapy Following Radical Prostatectomy Should Not Be Advised for Men with Extraprostatic Extension Who Have Negative Surgical Margins
    Patrick C Walsh
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Electronic address
    Eur Urol 69:191-2. 2016
    ....
  2. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
    ..Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive...
  3. doi How surgical innovation reduced death and suffering from prostate cancer
    Patrick C Walsh
    From the James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Craniofac Surg 24:49-50. 2013
    ..Armed with the ability to cure prostate cancer more safely with surgery and with fewer side effects, radical prostatectomy was rapidly adopted and in the following decade death from prostate cancer declined by 40%...
  4. doi How Charles Huggins made his Nobel prize winning discovery--in his own words: an historic audio recording. Interviewed by Willard Goodwin and Elmer Bell
    Charles Huggins
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Prostate 72:1718. 2012
    ..In this fascinating story, he tells how he transformed the investigation of what causes a hydrocele into a Nobel Prize winning discovery...
  5. ncbi Clinical practice. Localized prostate cancer
    Patrick C Walsh
    James Buchanan Brady Urological Institute, The Sidney Kimmel Comprehensive Cancer Center, The Department of Urology, Radiation Oncology and Molecular Radiation Sciences, and Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
    N Engl J Med 357:2696-705. 2007
  6. ncbi The discovery of the cavernous nerves and development of nerve sparing radical retropubic prostatectomy
    Patrick Craig Walsh
    James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 177:1632-5. 2007
    ..This review is of the events that led up to the discovery of the cavernous nerves and the development of nerve sparing radical retropubic prostatectomy...
  7. ncbi Probability of biochemical recurrence by analysis of pathologic stage, Gleason score, and margin status for localized prostate cancer
    Masood A Khan
    Department of Urology, James Buchanan Brady Urological Institute and Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21287 2101, USA
    Urology 62:866-71. 2003
    ....
  8. ncbi Importance of tumor location in patients with high preoperative prostate specific antigen levels (greater than 20 ng/ml) treated with radical prostatectomy
    Ahmed Magheli
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 178:1311-5. 2007
    ....
  9. pmc Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:101-4; discussion 105. 2009
    ..Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels...
  10. ncbi A critical analysis of the interpretation of biochemical failure in surgically treated patients using the American Society for Therapeutic Radiation and Oncology criteria
    Matthew B Gretzer
    The James Buchanan Brady Urological Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA
    J Urol 168:1419-22. 2002
    ..We evaluate how the American Society for Therapeutic Radiation and Oncology (ASTRO) criteria affect the interpretation of failure when applied to radical prostatectomy...
  11. ncbi Substratification of stage T1C prostate cancer based on the probability of biochemical recurrence
    Matthew B Gretzer
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 60:1034-9. 2002
    ....
  12. ncbi Long-term cancer control of radical prostatectomy in men younger than 50 years of age: update 2003
    Masood A Khan
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Urology 62:86-91; discussion 91-2. 2003
    ..7% to 4%). Previous studies, mostly carried out before the PSA era, reported conflicting data with respect to cancer control for these younger men treated with RRP...
  13. pmc Does prostate growth confound prostate specific antigen velocity? Data from the Baltimore longitudinal study of aging
    Stacy Loeb
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions and National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland, USA
    J Urol 180:1314-7; discussion 1317. 2008
    ..Thus, we investigated the relationship between changes in prostate size and prostate specific antigen changes in a large cohort of men without prostate cancer...
  14. ncbi Radical prostatectomy for clinical stage T3a disease
    Stephen J Freedland
    Departments of Urology and Oncology, James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, Maryland, USA
    Cancer 109:1273-8. 2007
    ..The long-term outcomes among men treated with radical prostatectomy for clinical stage T3a disease were examined...
  15. ncbi Influence of biopsy perineural invasion on long-term biochemical disease-free survival after radical prostatectomy
    Kiaran J O'Malley
    James Buchanan Brady Urological Institute and Department of Pathology, Johns Hopkins University Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 59:85-90. 2002
    ..However, the histologic identification of PNI on prostate biopsy has been associated with a decreased likelihood of pathologically organ-confined disease...
  16. ncbi Death in patients with recurrent prostate cancer after radical prostatectomy: prostate-specific antigen doubling time subgroups and their associated contributions to all-cause mortality
    Stephen J Freedland
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, MD, USA
    J Clin Oncol 25:1765-71. 2007
    ..However, given the small number of patients in the highest risk PSADT subgroup, it is unclear which PSADT subgroups contribute the greatest to prostate cancer-specific death and how this influences all-cause mortality...
  17. ncbi Quantitative alterations in nuclear structure predict prostate carcinoma distant metastasis and death in men with biochemical recurrence after radical prostatectomy
    Masood A Khan
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 98:2583-91. 2003
    ....
  18. ncbi Biochemical (prostate specific antigen) recurrence probability following radical prostatectomy for clinically localized prostate cancer
    Misop Han
    James Buchanan Brady Urological Institute, Departments of Urology, Oncology and Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 169:517-23. 2003
    ..We then used those indicators to develop multivariate models for determination of recurrence probability following radical retropubic prostatectomy...
  19. ncbi Prognostic significance of Gleason score discrepancies between needle biopsy and radical prostatectomy
    Michael Muntener
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Eur Urol 53:767-75; discussion 775-6. 2008
    ..The objective of this study was to evaluate the prognostic significance of these discrepancies with respect to outcomes following RP...
  20. ncbi Prediction of extraprostatic extension in the neurovascular bundle based on prostate needle biopsy pathology, serum prostate specific antigen and digital rectal examination
    Toyonori Tsuzuki
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    J Urol 173:450-3. 2005
    ..We investigated whether clinical information and prostate biopsy data could predict EPE of clinical localized prostate cancer...
  21. doi Prostate specific antigen at the initial diagnosis of metastasis to bone in patients after radical prostatectomy
    Stacy Loeb
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 184:157-61. 2010
    ..This information would be useful in determining when to initiate androgen deprivation therapy...
  22. ncbi Pathological outcomes and biochemical progression in men with T1c prostate cancer undergoing radical prostatectomy with prostate specific antigen 2.6 to 4.0 vs 4.1 to 6.0 ng/ml
    Danil V Makarov
    James Buchanan Brady Urological Institute, and the Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 176:554-8. 2006
    ..5 ng/ml as opposed to the more traditional greater than 4.0 ng/ml. We compared outcomes between men with clinical stage T1c disease undergoing radical prostatectomy who had a low vs slightly increased prostate specific antigen...
  23. pmc Does perineural invasion on prostate biopsy predict adverse prostatectomy outcomes?
    Stacy Loeb
    James Buchanan Brady Urological Institute and the Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 105:1510-3. 2010
    ....
  24. pmc Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000 to 2005
    Danil V Makarov
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Urology 69:1095-101. 2007
    ..To update the 2001 "Partin tables" with a contemporary patient cohort and revised variable categorization, correcting for the effects of stage migration...
  25. doi The case for open radical prostatectomy
    Edward M Schaeffer
    Johns Hopkins Medical Institution, Brady Urological Institute, 600 North Wolfe Street, Marburg 145, Baltimore, MD 21287, USA
    Urol Clin North Am 37:49-55, Table of Contents. 2010
    ..Although there are many differences between the 2 approaches, the common goal is to optimize oncologic and functional outcomes. This article highlights the background, techniques, and outcomes of open and robotic prostatectomy...
  26. pmc Expectant management of prostate cancer with curative intent: an update of the Johns Hopkins experience
    H Ballentine Carter
    Department of Urology, The Johns Hopkins University School of Medicine and The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2101, UAS
    J Urol 178:2359-64; discussion 2364-5. 2007
    ..We updated our experience with a strategy of expectant treatment for men with stage T1c prostate cancer and evaluated predictors of disease intervention...
  27. pmc The natural history of men treated with deferred androgen deprivation therapy in whom metastatic prostate cancer developed following radical prostatectomy
    Danil V Makarov
    James Buchanan Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 179:156-61; discussion 161-2. 2008
    ....
  28. doi Is it possible to compare PSA recurrence-free survival after surgery and radiotherapy using revised ASTRO criterion--"nadir + 2"?
    Matthew E Nielsen
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 72:389-93; discussion 394-5. 2008
    ..Because this definition inevitably will be used to compare cancer control rates after radiotherapy to those after surgery, this study examined the effect of this comparison...
  29. pmc Natural history of pathologically organ-confined (pT2), Gleason score 6 or less, prostate cancer after radical prostatectomy
    David J Hernandez
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 72:172-6. 2008
    ..We determined the incidence of biochemical recurrence (BR), local recurrence (LR), distant metastasis (DM), and prostate cancer-specific mortality (PCSM) among this low-risk cohort...
  30. doi The significance of a positive bladder neck margin after radical prostatectomy: the American Joint Committee on Cancer Pathological Stage T4 designation is not warranted
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 183:151-7. 2010
    ..We examined biochemical recurrence-free survival and cancer specific survival in men with a positive bladder neck margin...
  31. pmc Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy
    Bruce J Trock
    Brady Urological Institute, Johns Hopkins School of Medicine, 600 N Wolfe St, 546 Phipps Bldg, Baltimore, MD 21287, USA
    JAMA 299:2760-9. 2008
    ....
  32. doi High anterior release of the levator fascia improves sexual function following open radical retropubic prostatectomy
    Matthew E Nielsen
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    J Urol 180:2557-64; discussion 2564. 2008
    ..We prospectively evaluated the effect of high anterior release on oncological and sexual function outcomes following open radical retropubic prostatectomy...
  33. ncbi Correlation of postoperative pain to quality of recovery in the immediate postoperative period
    Christopher L Wu
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Reg Anesth Pain Med 30:516-22. 2005
    ..It is unclear whether the severity of postoperative pain may affect patients' quality of recovery in the immediate postoperative period (within 2 weeks of surgery)...
  34. ncbi Family history of prostate cancer and obesity in relation to high-grade disease and extraprostatic extension in young men with prostate cancer
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Prostate 55:140-6. 2003
    ..Little is known about predictors of prostate cancer severity in young men. Therefore, we examined whether family history and obesity influence risk of high-grade disease and extraprostatic extension in men < 55-years old...
  35. doi Skeletal muscle involvement by limited Gleason score 6 adenocarcinoma of the prostate on needle biopsy is not associated with adverse findings at radical prostatectomy
    Huihui Ye
    Department of Pathology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    J Urol 184:2308-12. 2010
    ..We investigated the significance of skeletal muscle involvement by cancer in needle biopsies in predicting adverse outcomes at radical prostatectomy...
  36. doi Critical appraisal of management of rectal injury during radical prostatectomy
    Wilmer B Roberts
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    Urology 76:1088-91. 2010
    ..To critically evaluate the perioperative management of rectal injury during radical prostatectomy...
  37. ncbi Biochemical failure after radical prostatectomy in men with pathologic organ-confined disease: pT2a versus pT2b
    Stephen J Freedland
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Cancer 100:1646-9. 2004
    ..Whether this distinction provides prognostic significance is unclear. The authors evaluated biochemical outcomes between men with pT2aN0 and pT2bN0 disease...
  38. ncbi Amyloidosis of the seminal vesicle and hematospermia
    Edward M Schaeffer
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    J Urol 171:2382. 2004
  39. ncbi Ability to predict metastasis based on pathology findings and alterations in nuclear structure of normal-appearing and cancer peripheral zone epithelium in the prostate
    Robert W Veltri
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Clin Cancer Res 10:3465-73. 2004
    ..The nuclear structure information was combined with routine pathological findings to predict metastatic PCa progression and/or death...
  40. ncbi Preservation of accessory pudendal arteries during radical retropubic prostatectomy: surgical technique and results
    Craig G Rogers
    James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Urology 64:148-51. 2004
    ..We now report our refinements in the surgical technique, illustrated with video, and the influence of accessory artery preservation on the recovery of sexual function after radical retropubic prostatectomy (RRP)...
  41. pmc The impact of preoperative erectile dysfunction on survival after radical prostatectomy
    Misop Han
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 106:1612-7. 2010
    ..The underlying pathology for preoperative ED may adversely affect survival following radical prostatectomy (RP). We examined the association between preoperative ED and survival following RP...
  42. doi Prostate-specific antigen kinetics during follow-up are an unreliable trigger for intervention in a prostate cancer surveillance program
    Ashley E Ross
    Departments of Urology and Pathology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 28:2810-6. 2010
    ....
  43. ncbi Anatomical extent of lymph node dissection: impact on men with clinically localized prostate cancer
    Mohamad E Allaf
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 172:1840-4. 2004
    ..This study evaluates the influence of the anatomical extent of pelvic lymph node dissection performed at radical prostatectomy on lymph node yield, staging accuracy and time to prostate specific antigen progression...
  44. ncbi Prostate specific antigen progression in men with lymph node metastases following radical prostatectomy: results of long-term followup
    Ganesh S Palapattu
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 1201, USA
    J Urol 172:1860-4. 2004
    ..We examined the clinical outcome of patients with lymph node metastases found at prostatectomy with the goal to identify factors that predict freedom from prostate specific antigen (PSA) progression...
  45. doi Radical prostatectomy in older men: survival outcomes in septuagenarians and octogenarians
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Baltimore, MD, USA
    BJU Int 106:791-5. 2010
    ....
  46. ncbi Stronger association between obesity and biochemical progression after radical prostatectomy among men treated in the last 10 years
    Stephen J Freedland
    Departments of Urology, and Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 11:2883-8. 2005
    ..Whether the association between obesity and aggressive disease has changed as a result of these temporal changes is unclear...
  47. ncbi Efficacy of continuous local anesthetic infusion for postoperative pain after radical retropubic prostatectomy
    Christopher L Wu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Urology 66:366-70. 2005
    ..To determine whether a subfascial continuous infusion of local anesthetic in patients undergoing radical retropubic prostatectomy would result in a reduction in postoperative opioid requirements and an improvement in pain scores...
  48. ncbi Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    JAMA 294:433-9. 2005
    ....
  49. ncbi The prostatic specific antigen era is alive and well: prostatic specific antigen and biochemical progression following radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    J Urol 174:1276-81; discussion 1281; author reply 1281. 2005
    ..We examined the association between PSA and clinical progression in men undergoing RP...
  50. ncbi Systematic detection and repair of subclinical inguinal hernias at radical retropubic prostatectomy
    Matthew E Nielsen
    James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287 2101, USA
    Urology 66:1034-7. 2005
    ..In this study we define the frequency of inguinal hernias detected at RRP and the durability of repair...
  51. ncbi Relationship between primary Gleason pattern on needle biopsy and clinicopathologic outcomes among men with Gleason score 7 adenocarcinoma of the prostate
    Mark L Gonzalgo
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 67:115-9. 2006
    ..To examine the relationship among needle biopsy primary grade, prostatectomy grade, and postprostatectomy biochemical recurrence among men with Gleason score 7 disease...
  52. ncbi Expectant management of nonpalpable prostate cancer with curative intent: preliminary results
    H Ballentine Carter
    Department of Urology and Pathology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Urol 167:1231-4. 2002
    ..We evaluate a strategy of expectant management for men with stage T1c prostate cancer...
  53. pmc Progression after radical prostatectomy for men in their thirties compared to older men
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    BJU Int 101:1503-6. 2008
    ..To assess the biochemical outcome after radical prostatectomy (RP) specifically for men aged 30-39 years, as previous studies suggest that prostate cancer in young men might be more aggressive...
  54. ncbi Radical retropubic prostatectomy. How often do experienced surgeons have positive surgical margins when there is extraprostatic extension in the region of the neurovascular bundle?
    David J Hernandez
    James Buchanan Brady Urological Institute and The Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 173:446-9. 2005
    ..We determined the frequency of positive surgical margins (PSMs) in patients with extraprostatic extension (EPE) in the region of the neurovascular bundle (NVB) who underwent open radical retropubic prostatectomy by 2 experienced surgeons...
  55. ncbi Effect of methylprednisolone on return of sexual function after nerve-sparing radical retropubic prostatectomy
    J Kellogg Parsons
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 64:987-90. 2004
    ..To determine whether postoperative methylprednisolone improves the recovery of sexual function after nerve-sparing radical retropubic prostatectomy...
  56. ncbi Hypermethylation of CpG islands in primary and metastatic human prostate cancer
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    Cancer Res 64:1975-86. 2004
    ..Furthermore, CpG island hypermethylation patterns in prostate cancer metastases were very similar to the primary prostate cancers and tended to show greater differences between cases than between anatomical sites of metastasis...
  57. ncbi An evaluation of the decreasing incidence of positive surgical margins in a large retropubic prostatectomy series
    Misop Han
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 171:23-6. 2004
    ....
  58. pmc Prostate volume changes over time: results from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 182:1458-62. 2009
    ..Although there is an abundance of literature describing prostatic enlargement in association with benign prostatic hyperplasia, less is known about the phenomenon of prostate atrophy...
  59. pmc What are the outcomes of radical prostatectomy for high-risk prostate cancer?
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Urology 76:710-4. 2010
    ..These patients are often treated with combined radiation and androgen deprivation therapy, and less is known about the long-term survival in this population after radical prostatectomy (RP)...
  60. ncbi Black race does not independently predict adverse outcome following radical retropubic prostatectomy at a tertiary referral center
    Matthew E Nielsen
    Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 176:515-9. 2006
    ..To address this issue we examined the outcomes of a cohort of black and white men treated by multiple surgeons at our institution...
  61. pmc Long-term survival after radical prostatectomy for men with high Gleason sum in pathologic specimen
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 76:715-21. 2010
    ..To evaluate the long-term outcomes of patients with high Gleason sum 8-10 at radical prostatectomy (RP) and to identify the predictors of prostate cancer-specific survival (CSS) in this cohort...
  62. pmc Trefoil factor 3 overexpression in prostatic carcinoma: prognostic importance using tissue microarrays
    Dennis A Faith
    Brady Urological Institute, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
    Prostate 61:215-27. 2004
    ..Human intestinal trefoil factor 3 (TFF3) is a member of a family of polypeptides encoded by a cluster of genes on chromosome 21. Through gene expression profiling studies TFF3 mRNA has been found to be overexpressed in prostate cancer...
  63. ncbi Quantitative GSTP1 methylation and the detection of prostate adenocarcinoma in sextant biopsies
    Susan V Harden
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    J Natl Cancer Inst 95:1634-7. 2003
    ..Further studies should determine whether detection of GSTP1 hypermethylation in a biopsy sample with normal histology indicates the need for an early repeat biopsy at the same site...
  64. ncbi Association of cigarette smoking with extraprostatic prostate cancer in young men
    William W Roberts
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, The Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Urol 169:512-6; discussion 516. 2003
    ..We evaluate the association of cigarette smoking with extraprostatic and/or Gleason sum 7 or greater prostate cancer in young men...
  65. ncbi Impact of surgical delay on long-term cancer control for clinically localized prostate cancer
    Masood A Khan
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2101, USA
    J Urol 172:1835-9. 2004
    ..Therefore, in a contemporary series we determined long-term cancer control in men who underwent RRP for clinically localized prostate cancer with some treated early and others treated after a longer delay...
  66. ncbi Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma
    Jun Luo
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Prostate 57:134-9. 2003
    ..The therapeutic influence of SRD5A2 inhibitor finasteride on prostate cancer is currently unknown. The direction and extent of changes in SRD5A2 expression in disease tissues is a relevant issue in this regard...
  67. ncbi Intussusception of the reconstructed bladder neck leads to earlier continence after radical prostatectomy
    Patrick C Walsh
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Urology 59:934-8. 2002
    ....