Richard L Wahl

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint The Roles of Fluorodeoxyglucose-PET/Computed Tomography in Ovarian Cancer: Diagnosis, Assessing Response, and Detecting Recurrence
    Richard L Wahl
    Division of Nuclear Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA Division of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Electronic address
    PET Clin 5:447-61. 2010
  2. ncbi request reprint Tositumomab and (131)I therapy in non-Hodgkin's lymphoma
    Richard L Wahl
    Division of Nuclear Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Nucl Med 46:128S-40S. 2005
  3. ncbi request reprint Why nearly all PET of abdominal and pelvic cancers will be performed as PET/CT
    Richard L Wahl
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 45:82S-95S. 2004
  4. ncbi request reprint Prospective multicenter study of axillary nodal staging by positron emission tomography in breast cancer: a report of the staging breast cancer with PET Study Group
    Richard L Wahl
    Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Clin Oncol 22:277-85. 2004
  5. pmc The promise and pitfalls of positron emission tomography and single-photon emission computed tomography molecular imaging-guided radiation therapy
    Richard L Wahl
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Semin Radiat Oncol 21:88-100. 2011
  6. ncbi request reprint Anatomolecular imaging with 2-deoxy-2-[18F]fluoro-D-glucose: bench to outpatient center
    Richard L Wahl
    Department of Nuclear Medicine, Johns Hopkins University, Baltimore, MD, USA
    Mol Imaging Biol 5:49-56. 2003
  7. pmc From RECIST to PERCIST: Evolving Considerations for PET response criteria in solid tumors
    Richard L Wahl
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 50:122S-50S. 2009
  8. ncbi request reprint PET/CT: artifacts caused by bowel motion
    Yuji Nakamoto
    Division of Nuclear Medicine, Johns Hopkins School of Medicine, Baltimore 21287 0817, USA
    Nucl Med Commun 25:221-5. 2004
  9. ncbi request reprint Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients
    Medhat M Osman
    Division of Nuclear Medicine, Department of Internal Medicine, School of Medicine, St Louis University, St Louis, Missouri, USA
    J Nucl Med 44:240-3. 2003
  10. pmc Arterial wall dosimetry for non-Hodgkin lymphoma patients treated with radioimmunotherapy
    Robert F Hobbs
    Johns Hopkins University, Baltimore Maryland 21231, USA
    J Nucl Med 51:368-75. 2010

Collaborators

Detail Information

Publications99

  1. doi request reprint The Roles of Fluorodeoxyglucose-PET/Computed Tomography in Ovarian Cancer: Diagnosis, Assessing Response, and Detecting Recurrence
    Richard L Wahl
    Division of Nuclear Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA Division of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Electronic address
    PET Clin 5:447-61. 2010
    ..This article assesses these roles for predicting and monitoring response to treatment, restaging, and early diagnosis of recurrence. ..
  2. ncbi request reprint Tositumomab and (131)I therapy in non-Hodgkin's lymphoma
    Richard L Wahl
    Division of Nuclear Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Nucl Med 46:128S-40S. 2005
    ..This review outlines the current and evolving status of this therapeutic regimen at nonmyeloablative doses...
  3. ncbi request reprint Why nearly all PET of abdominal and pelvic cancers will be performed as PET/CT
    Richard L Wahl
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 45:82S-95S. 2004
    ..Under the search term "PET/CT," 142 articles were identified under the National Library of Medicine Pub Med database, and a number of general findings are summarized...
  4. ncbi request reprint Prospective multicenter study of axillary nodal staging by positron emission tomography in breast cancer: a report of the staging breast cancer with PET Study Group
    Richard L Wahl
    Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Clin Oncol 22:277-85. 2004
    ..To determine the accuracy of positron emission tomography with fluorine-18-labeled 2-fluoro-2-deoxy-d-glucose (FDG-PET) in detecting axillary nodal metastases in women with primary breast cancer...
  5. pmc The promise and pitfalls of positron emission tomography and single-photon emission computed tomography molecular imaging-guided radiation therapy
    Richard L Wahl
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Semin Radiat Oncol 21:88-100. 2011
    ..As MIGRT evolves, evidence must continue to be gathered to support improved clinical outcomes using MIGRT versus purely anatomic approaches...
  6. ncbi request reprint Anatomolecular imaging with 2-deoxy-2-[18F]fluoro-D-glucose: bench to outpatient center
    Richard L Wahl
    Department of Nuclear Medicine, Johns Hopkins University, Baltimore, MD, USA
    Mol Imaging Biol 5:49-56. 2003
    ..The ability to combine the molecular and anatomic imaging of the entire body into hybrid anatomolecular images using dedicated PET-CT devices very likely represents the future of cancer imaging...
  7. pmc From RECIST to PERCIST: Evolving Considerations for PET response criteria in solid tumors
    Richard L Wahl
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 50:122S-50S. 2009
    ..1. This article also reviews qualitative and quantitative approaches to metabolic tumor response assessment with (18)F-FDG PET and proposes a draft framework for PET Response Criteria in Solid Tumors (PERCIST), version 1.0...
  8. ncbi request reprint PET/CT: artifacts caused by bowel motion
    Yuji Nakamoto
    Division of Nuclear Medicine, Johns Hopkins School of Medicine, Baltimore 21287 0817, USA
    Nucl Med Commun 25:221-5. 2004
    ..The purpose of this study was to investigate potential differences in PET/CT caused by attenuation differences in bowel due to motion...
  9. ncbi request reprint Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients
    Medhat M Osman
    Division of Nuclear Medicine, Department of Internal Medicine, School of Medicine, St Louis University, St Louis, Missouri, USA
    J Nucl Med 44:240-3. 2003
    ..This study evaluated lesion mislocalization between PET and CT on PET/CT studies when CT instead of germanium is used for attenuation correction (AC)...
  10. pmc Arterial wall dosimetry for non-Hodgkin lymphoma patients treated with radioimmunotherapy
    Robert F Hobbs
    Johns Hopkins University, Baltimore Maryland 21231, USA
    J Nucl Med 51:368-75. 2010
    ..Therefore, we present a model of aortic wall toxicity based on data from 4 patients treated with (131)I-tositumomab...
  11. pmc Therapeutic potential of 90Y- and 131I-labeled anti-CD20 monoclonal antibody in treating non-Hodgkin's lymphoma with pulmonary involvement: a Monte Carlo-based dosimetric analysis
    Hong Song
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 48:150-7. 2007
    ..In this work, we used Monte Carlo-based dosimetry to compare the potential of (90)Y and (131)I, based purely on their emission properties, in targeted therapy for NHL lung metastases of various nodule sizes and tumor burdens...
  12. pmc A treatment planning method for sequentially combining radiopharmaceutical therapy and external radiation therapy
    Robert F Hobbs
    Johns Hopkins University, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 80:1256-62. 2011
    ..We have developed and tested a treatment planning method, using the patient-specific three-dimensional dosimetry package 3D-RD, for sequentially combined RPT/XRT therapy designed to limit toxicity to organs at risk...
  13. pmc Radiobiologic optimization of combination radiopharmaceutical therapy applied to myeloablative treatment of non-Hodgkin lymphoma
    Robert F Hobbs
    Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231, USA
    J Nucl Med 54:1535-42. 2013
    ..We have developed such a methodology and applied it to hypothetical myeloablative treatment of non-Hodgkin lymphoma (NHL) patients using (131)I-tositumomab and (90)Y-ibritumomab tiuxetan...
  14. pmc Assessment of tumoricidal efficacy and response to treatment with 18F-FDG PET/CT after intraarterial infusion with the antiglycolytic agent 3-bromopyruvate in the VX2 model of liver tumor
    Eleni Liapi
    Division of Interventional Radiology, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 52:225-30. 2011
    ....
  15. pmc Tumor dosimetry and response for 153Sm-ethylenediamine tetramethylene phosphonic acid therapy of high-risk osteosarcoma
    Srinivasan Senthamizhchelvan
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    J Nucl Med 53:215-24. 2012
    ..We also studied the biologic implication of the nonuniform tumor AD distribution using radiobiologic modeling and examined the relationship between tumor AD and response...
  16. ncbi request reprint Accuracy of image fusion of normal upper abdominal organs visualized with PET/CT
    Yuji Nakamoto
    Division of Nuclear Medicine, Rm 3223A, Johns Hopkins University, 601 N Caroline St, Baltimore, MD 21287 0817, USA
    Eur J Nucl Med Mol Imaging 30:597-602. 2003
    ..Although these differences could potentially affect the quality of the image registrations, they were generally of a modest nature...
  17. ncbi request reprint Clinically significant incidental findings on the unenhanced CT portion of PET/CT studies: frequency in 250 patients
    Medhat M Osman
    Division of Nuclear Medicine, Department of Internal Medicine, St Louis University, St Louis, Missouri, USA
    J Nucl Med 46:1352-5. 2005
    ....
  18. ncbi request reprint Lymphadenopathy resulting from acute hepatitis C infection mimicking metastatic breast carcinoma on FDG PET/CT
    Heather A Jacene
    Division of Nuclear Medicine, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Nucl Med 31:379-81. 2006
    ..This case highlights the importance of clinical history and laboratory correlation for the proper interpretation of FDG PET scans...
  19. pmc Lung dosimetry for radioiodine treatment planning in the case of diffuse lung metastases
    Hong Song
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    J Nucl Med 47:1985-94. 2006
    ..In this work we demonstrated the use of MCNP, a Monte Carlo electron and photon transport code, in a 3-dimensional (3D) imaging-based absorbed dose calculation for tumor and normal lungs...
  20. pmc Three-dimensional radiobiologic dosimetry: application of radiobiologic modeling to patient-specific 3-dimensional imaging-based internal dosimetry
    Andrew R Prideaux
    Russell H Morgan Department of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 48:1008-16. 2007
    ..The methodology is illustrated using data from a thyroid cancer patient treated with radioiodine...
  21. pmc 124I PET-based 3D-RD dosimetry for a pediatric thyroid cancer patient: real-time treatment planning and methodologic comparison
    Robert F Hobbs
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 50:1844-7. 2009
    ..A retrospective analysis of the conventional methodologies with appropriate corrections yielded absorbed dose estimates consistent with 3D-RD...
  22. ncbi request reprint Initial experience with oral contrast in PET/CT: phantom and clinical studies
    Christian Cohade
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 44:412-6. 2003
    ..The aims of the study were to evaluate the effects of oral contrast on apparent tracer activity measured with PET/CT when using CT attenuation correction and to report our initial experience in the use of oral contrast with PET/CT...
  23. ncbi request reprint Applications of positron emission tomography/computed tomography image fusion in clinical positron emission tomography-clinical use, interpretation methods, diagnostic improvements
    Christian Cohade
    Division of Nuclear Medicine, The Johns Hopkins Hospital, The Russell H Morgan Department of Radiology and Radiological Sciences, Baltimore, MD 21287, USA
    Semin Nucl Med 33:228-37. 2003
    ..More studies are warranted to clearly define the clinical impact of PET/CT over PET; however, it is clear this dedicated fusion technology will be very important for patient imaging in the coming years...
  24. ncbi request reprint Normal FDG distribution patterns in the head and neck: PET/CT evaluation
    Yuji Nakamoto
    Division of Nuclear Medicine, Johns Hopkins University, 601 N Caroline St, Rm 3223A, Baltimore, MD 21287 0817, USA
    Radiology 234:879-85. 2005
    ..To retrospectively evaluate the distribution of fluorine 18 fluorodeoxyglucose (FDG) in the head and neck region with combined positron emission tomography-computed tomography (PET/CT) in patients with no known abnormality in this region...
  25. pmc Comparison of organ residence time estimation methods for radioimmunotherapy dosimetry and treatment planning--patient studies
    Bin He
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Med Phys 36:1595-601. 2009
    ..More sophisticated methods, such as the hybrid SPECT/planar method investigated here, are likely to be better predictors of organ dose and, as a result, organ toxicities...
  26. ncbi request reprint Direct comparison of FDG PET and CT findings in patients with lymphoma: initial experience
    Mitsuaki Tatsumi
    Division of Nuclear Medicine, Johns Hopkins Medical Institutions, 601 N Caroline St, Rm 3223A, Baltimore, MD 21287 0817, USA
    Radiology 237:1038-45. 2005
    ....
  27. ncbi request reprint Stunning and its effect on 3H-FDG uptake and key gene expression in breast cancer cells undergoing chemotherapy
    James M Engles
    Russell H Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Nucl Med 47:603-8. 2006
    ..Glucose transporter-1 (Glut-1) and hexokinase II (HKII) proteins are highly expressed in many breast carcinomas, but their status while undergoing DOX or 5FU chemotherapy has not been systematically evaluated...
  28. ncbi request reprint Efficacy of preoperative combined 18-fluorodeoxyglucose positron emission tomography and computed tomography for assessing primary rectal cancer response to neoadjuvant therapy
    Genevieve B Melton
    Department of Surgery, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 11:961-9; discussion 969. 2007
    ..We sought to evaluate serial FDG-PET/CT for assessing tumor down-staging, percentage residual tumor, and complete response or microscopic disease with rectal cancer neoadjuvant therapy...
  29. pmc Targeting of VX2 rabbit liver tumor by selective delivery of 3-bromopyruvate: a biodistribution and survival study
    Mustafa Vali
    Russell H Morgan Department of Radiology and Radiological Sciences, Division of Vascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Pharmacol Exp Ther 327:32-7. 2008
    ..The local control of the liver tumor by 3-BrPA resulted in a significant survival benefit...
  30. pmc Comparison and effectiveness of regadenoson versus dipyridamole on stress electrocardiographic changes during positron emission tomography evaluation of patients with hypertrophic cardiomyopathy
    Paco E Bravo
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Cardiol 110:1033-9. 2012
    ..Regadenoson is tolerated better than dipyridamole and is easier to administer. Vasodilator-induced ST-segment depression is a specific but nonsensitive marker for the prediction of abnormal rMP in patients with HC...
  31. pmc Three-dimensional radiobiological dosimetry (3D-RD) with 124I PET for 131I therapy of thyroid cancer
    George Sgouros
    The Russell H Morgan Department of Radiology, Division of Nuclear Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Eur J Nucl Med Mol Imaging 38:S41-7. 2011
    ..We highlight specific examples of such calculations and discuss the potential impact of (124)I PET/CT on thyroid cancer therapy...
  32. ncbi request reprint Effects of pegfilgrastim on normal biodistribution of 18F-FDG: preclinical and clinical studies
    Heather A Jacene
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA
    J Nucl Med 47:950-6. 2006
    ..The purpose of this study was to evaluate the effects of pegfilgrastim, a long-acting granulocyte colony-stimulating factor, on the normal biodistribution of (18)F-FDG in an animal model and in humans...
  33. pmc Evaluation of quantitative imaging methods for organ activity and residence time estimation using a population of phantoms having realistic variations in anatomy and uptake
    Bin He
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0859, USA
    Med Phys 36:612-9. 2009
    ..The QPlanar or hybrid QPlanar/QSPECT methods had mean errors and standard deviations of errors that approached those of pure QSPECT while providing simplified image acquisition protocols, and thus may be more clinically practical...
  34. ncbi request reprint CT appearance of bone metastases detected with FDG PET as part of the same PET/CT examination
    Yuji Nakamoto
    Division of Nuclear Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287 0817, USA
    Radiology 237:627-34. 2005
    ....
  35. doi request reprint CT Hounsfield units of brown adipose tissue increase with activation: preclinical and clinical studies
    Shingo Baba
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 51:246-50. 2010
    ..Brown adipose tissue (BAT) densities assessed as CT Hounsfield units (HUs) were evaluated in a rodent model and in patients to determine whether HUs changed in relation to BAT activity...
  36. pmc Extension of the biological effective dose to the MIRD schema and possible implications in radionuclide therapy dosimetry
    S├ębastien Baechler
    Russell H Morgan Department of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Med Phys 35:1123-34. 2008
    ..The MIRD-based BED formalism is expected to be useful for patient-specific adjustments of activity and to facilitate the investigation of dose-toxicity correlations with respect to dose-rate and tissue repair mechanism...
  37. ncbi request reprint Effects of nonionic intravenous contrast agents at PET/CT imaging: phantom and canine studies
    Yuji Nakamoto
    Department of Radiology, Division of Nuclear Medicine, Johns Hopkins University Hospital, 601 N Caroline St, Rm 3223, Baltimore, MD 21287 0817, USA
    Radiology 227:817-24. 2003
    ..To investigate the effects of intravenous contrast agents on quantitative values obtained with a combined positron emission tomographic (PET) and computed tomographic (CT) scanner by using several phantoms and a dog...
  38. ncbi request reprint "USA-Fat": prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT
    Christian Cohade
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins Outpatient Center, Johns Hopkins Medical Institutions, 601 N Caroline Street, Baltimore, MD 21287 0817, USA
    J Nucl Med 44:1267-70. 2003
    ..Such tissue might be expected to have varying metabolic activity depending on the ambient temperature. The purpose of this study was to evaluate the frequency of USA-Fat and its relationship to the outdoor temperature...
  39. ncbi request reprint PET-CT in recurrent ovarian cancer: initial observations
    Harpreet K Pannu
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21287, USA
    Radiographics 24:209-23. 2004
    ..Combined functional-anatomic imaging can also increase diagnostic confidence at CT. Further study is needed to determine the possible benefits of lesion conspicuity at PET and anatomic localization at CT on fused PET-CT scans...
  40. ncbi request reprint Comparison of uptake of multiple clinical radiotracers into brown adipose tissue under cold-stimulated and nonstimulated conditions
    Shingo Baba
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nucl Med 48:1715-23. 2007
    ..Our objective was to determine whether multiple clinically useful radiotracers accumulate in brown adipose tissue (BAT) and to assess their uptake in rats kept at room temperature or exposed to a cold environment...
  41. pmc Simultaneous measurement of noise and spatial resolution in PET phantom images
    Martin A Lodge
    The Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Phys Med Biol 55:1069-81. 2010
    ..The proposed method of simultaneously measuring image noise and spatial resolution is useful for evaluating reconstruction algorithms and may aid standardization of data collection between centers...
  42. ncbi request reprint Scalene muscle uptake: a potential pitfall in head and neck PET/CT
    Heather A Jacene
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 601 N Caroline Street, JHOC 3235, Baltimore, MD 21287, USA
    Eur J Nucl Med Mol Imaging 35:89-94. 2008
    ..To describe increased 2-deoxy-2-[(18)F] fluoro-D-glucose (FDG) uptake in the scalene muscles in a large population of patients referred for evaluation with FDG positron emission tomography/computed tomography (PET/CT) imaging...
  43. ncbi request reprint Effect of nicotine and ephedrine on the accumulation of 18F-FDG in brown adipose tissue
    Shingo Baba
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore Maryland 21287, USA
    J Nucl Med 48:981-6. 2007
    ..This study evaluated the effect of various beta-adrenergic agonists on (18)F-FDG uptake in brown adipose tissue (BAT) in rats using ex vivo biodistribution studies...
  44. ncbi request reprint In vitro evaluation of adenosine 5'-monophosphate as an imaging agent of tumor metabolism
    Steve Y Cho
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Nucl Med 47:837-45. 2006
    ..Adenosine appears to play an important role in tumor growth and metastasis. Synthesized (11)C-adenosine 5'-monophosphate (AMP) has recently been reported as a potential tumor-imaging radiotracer...
  45. ncbi request reprint Initial experience with FDG-PET/CT in the evaluation of breast cancer
    Mitsuaki Tatsumi
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins Medical Institutions, 601 N Caroline St, Rm 3223A, Baltimore, MD 21287 0817, USA
    Eur J Nucl Med Mol Imaging 33:254-62. 2006
    ....
  46. ncbi request reprint Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes
    Robert E Bristow
    The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 281, Baltimore, MD 21287, USA
    Gynecol Oncol 99:294-300. 2005
    ..To evaluate the utility of combined positron emission tomography/computed tomography (PET/CT) for detecting recurrent epithelial ovarian cancer limited to retroperitoneal adenopathy...
  47. ncbi request reprint Imaging of pelvic malignancies with in-line FDG PET-CT: case examples and common pitfalls of FDG PET
    Naveen Subhas
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 601 N Caroline St, Rm 3223, Baltimore, MD 21287 0817, USA
    Radiographics 25:1031-43. 2005
    ..The use of an in-line FDG PET-CT system, with special attention given to proper patient preparation and scanning protocol, often provides valuable information to help localize and define disease and avoid potential diagnostic pitfalls...
  48. doi request reprint Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer
    Manon Buijs
    Russell H Morgan Department of Radiology, and Radiological Sciences, Division of Vascular and Interventional Radiology, 600 North Wolfe Street, Blalock 545, Baltimore, MD 21287, USA
    Invest New Drugs 27:120-3. 2009
    ..To evaluate the anti-glycolytic effects of 3-BrPA on rats bearing RMT mammary tumors, by determining FDG uptake after intravenous administration of the therapeutic dose...
  49. pmc Myocardial substrate and route of administration determine acute cardiac retention and lung bio-distribution of cardiosphere-derived cells
    Michael Bonios
    Johns Hopkins University, 720 Rutland Ave, Ross 871, Baltimore, MD 21210, USA
    J Nucl Cardiol 18:443-50. 2011
    ..Quantification of acute myocardial retention and lung bio-distribution of cardiosphere-derived cells (CDCs) following transplantation is important to improve engraftment...
  50. pmc Relationship of delayed enhancement by magnetic resonance to myocardial perfusion by positron emission tomography in hypertrophic cardiomyopathy
    Paco E Bravo
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Circ Cardiovasc Imaging 6:210-7. 2013
    ..We investigated the relationship between DE on CMR and myocardial ischemia in hypertrophic cardiomyopathy...
  51. doi request reprint Systemic administration of 3-bromopyruvate in treating disseminated aggressive lymphoma
    Niklaus G Schaefer
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0817, USA
    Transl Res 159:51-7. 2012
    ..This, to our knowledge, is the first report of the use of 3-BrPA in a systemic tumor model. Based on these data, 3-BrPA holds promise for treatment of systemic metastatic cancers...
  52. ncbi request reprint Combined FDG-positron emission tomography and computed tomography for the detection of ovarian cancer recurrence in an inguinal hernia sac
    Teresa P Diaz-Montes
    The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 281, Baltimore, MD 21287, USA
    Gynecol Oncol 98:510-2. 2005
    ..Combined positron emission tomography (PET) and computed tomography (CT) may have a potential role in the early detection and anatomical localization of recurrent ovarian cancer...
  53. ncbi request reprint F-18 FDG PET/CT in acute respiratory distress syndrome: a case report
    Heather A Jacene
    Johns Hopkins Medical Institutions, Russell H Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, 601 North Caroline Street, Rm 3223, Baltimore, MD 21287 0817, USA
    Clin Nucl Med 29:786-8. 2004
    ..In the proper clinical setting, ARDS should be considered in the differential diagnosis of patients with diffusely increased F-18 FDG activity in the lungs...
  54. pmc Radioimmunotherapy in non-Hodgkin lymphoma: opinions of nuclear medicine physicians and radiation oncologists
    Niklaus G Schaefer
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 52:830-8. 2011
    ....
  55. pmc Reproducibility of tumor blood flow quantification with 15O-water PET
    Martin A Lodge
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Nucl Med 49:1620-7. 2008
    ..Assessing the significance of changes in TBF requires knowledge of the reproducibility of the technique. This article quantifies the reproducibility of the (15)O-water technique for TBF applications...
  56. ncbi request reprint Integrating PET and PET/CT into the risk-adapted therapy of lymphoma
    Yvette L Kasamon
    Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nucl Med 48:19S-27S. 2007
    ..We selected aggressive lymphomas as a platform for the discussion of these imaging modalities in oncology patients and the resulting management questions...
  57. doi request reprint 18F-FDG PET/CT for monitoring the response of lymphoma to radioimmunotherapy
    Heather A Jacene
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Nucl Med 50:8-17. 2009
    ..We retrospectively evaluated 18F-FDG PET/CT for monitoring the response of non-Hodgkin's lymphoma to radioimmunotherapy...
  58. pmc Phase II study of risk-adapted therapy of newly diagnosed, aggressive non-Hodgkin lymphoma based on midtreatment FDG-PET scanning
    Yvette L Kasamon
    Johns Hopkins University, Baltimore, Maryland, USA
    Biol Blood Marrow Transplant 15:242-8. 2009
    ..The favorable outcome achieved here in historically poor-risk patients warrants further, more definitive investigation of treatment modification based on early PET scanning...
  59. ncbi request reprint Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/CT
    Christian Cohade
    Division of Nuclear Medicine, The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 44:170-6. 2003
    ..PET/CT offers the unique opportunity to correlate PET findings with CT anatomy in the supraclavicular region...
  60. doi request reprint Imaging uterine cervical cancer with FDG-PET/CT: direct comparison with PET
    Mitsuaki Tatsumi
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins Medical Institutions, 601 North Caroline Street, Baltimore, MD 21287 0817, USA
    Mol Imaging Biol 11:229-35. 2009
    ....
  61. ncbi request reprint Clinical use of positron emission tomography in the management of cutaneous melanoma
    Kent P Friedman
    Department of Radiology, Johns Hopkins University Hospital, Baltimore, MD 21287 0817, USA
    Semin Nucl Med 34:242-53. 2004
    ....
  62. doi request reprint Assessment of interobserver reproducibility in quantitative 18F-FDG PET and CT measurements of tumor response to therapy
    Heather A Jacene
    Division of Nuclear Medicine and Body CT, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA
    J Nucl Med 50:1760-9. 2009
    ....
  63. ncbi request reprint Initial experience in small animal tumor imaging with a clinical positron emission tomography/computed tomography scanner using 2-[F-18]fluoro-2-deoxy-D-glucose
    Mitsuaki Tatsumi
    Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins Medical Institutions, 601 North Caroline Street, Baltimore, MD 21287 0817, USA
    Cancer Res 63:6252-7. 2003
    ....
  64. doi request reprint Characterization of a perirectal artifact in 18F-FDG PET/CT
    Martin A Lodge
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Nucl Med 51:1501-6. 2010
    ..The aim of this study was to describe this artifact, which-as far as we are aware-has not been previously reported, and to investigate its cause...
  65. ncbi request reprint PET/CT: comparison of quantitative tracer uptake between germanium and CT transmission attenuation-corrected images
    Yuji Nakamoto
    Division of Nuclear Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 43:1137-43. 2002
    ..The purpose of this study was to assess the quantitative differences between CT-based and germanium-based attenuation-corrected PET images...
  66. ncbi request reprint Respiratory motion artifacts on PET emission images obtained using CT attenuation correction on PET-CT
    Medhat M Osman
    Department of Internal Medicine, Division of Nuclear Medicine, Saint Louis University, 3635 Vista at Grand FOT2, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:603-6. 2003
    ..In conclusion, RMA of varying magnitude were noted in most of our patients as a curvilinear cold area at the lung/diaphragm interface, but were not diagnostically problematic in these patients...
  67. ncbi request reprint Clinically occult recurrent ovarian cancer: patient selection for secondary cytoreductive surgery using combined PET/CT
    Robert E Bristow
    The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Gynecol Oncol 90:519-28. 2003
    ....
  68. doi request reprint Diagnosis and differentiation of bronchioloalveolar carcinoma from adenocarcinoma with bronchioloalveolar components with metabolic and anatomic characteristics using PET/CT
    Behnaz Goudarzi
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21287 0817, USA
    J Nucl Med 49:1585-92. 2008
    ..Also, the correlation between tumor size and (18)F-FDG uptake or Hounsfield unit (HU) value was determined in these 2 groups...
  69. ncbi request reprint The clinical importance of dosimetry in radioimmunotherapy with tositumomab and iodine I 131 tositumomab
    Richard L Wahl
    Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Department of Radiology, Baltimore, MD 21287 0817, USA
    Semin Oncol 30:31-8. 2003
    ....
  70. pmc A practical, automated quality assurance method for measuring spatial resolution in PET
    Martin A Lodge
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 50:1307-14. 2009
    ..The aim of this project was to aid standardization of data collection by developing a quality assurance method for measuring the spatial resolution achieved with clinical imaging protocols...
  71. ncbi request reprint Update on hybrid conjugate-view SPECT tumor dosimetry and response in 131I-tositumomab therapy of previously untreated lymphoma patients
    Kenneth F Koral
    Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0028, USA
    J Nucl Med 44:457-64. 2003
    ..In this article, the patient's average tumor dose, estimated by a hybrid method using that SPECT, is compared with the same statistic estimated by pretherapy conjugate views...
  72. ncbi request reprint Comparison of mutual information-based warping accuracy for fusing body CT and PET by 2 methods: CT mapped onto PET emission scan versus CT mapped onto PET transmission scan
    Joseph Skalski
    Department of Nuclear Medicine and Radiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Nucl Med 43:1184-7. 2002
    ..In the direct, fusion method, the CT is warped directly onto the attenuation-corrected emission dataset...
  73. doi request reprint The added diagnostic value of liquid gastric emptying compared with solid emptying alone
    Harvey A Ziessman
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Nucl Med 50:726-31. 2009
    ..The purpose of this investigation was to determine whether a study of clear liquid gastric emptying has added value for the diagnosis of gastroparesis over a study of solid emptying alone...
  74. ncbi request reprint Increased 18F-FDG uptake in degenerative disease of the spine: Characterization with 18F-FDG PET/CT
    Ron S Rosen
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Nucl Med 47:1274-80. 2006
    ..We determined the prevalence of abnormal spinal 18F-FDG uptake and assessed the relationship between the severity of findings on 18F-FDG PET and the severity of degenerative spinal disease (DSD) on CT...
  75. pmc 18F-FDG PET/CT for image-guided and intensity-modulated radiotherapy
    Eric C Ford
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 50:1655-65. 2009
    ..We also briefly consider novel radiopharmaceuticals that are beginning to be used in the context of radiotherapy planning...
  76. pmc Lung toxicity in radioiodine therapy of thyroid carcinoma: development of a dose-rate method and dosimetric implications of the 80-mCi rule
    George Sgouros
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    J Nucl Med 47:1977-84. 2006
    ..This is particularly important, for example, in pediatric patients exhibiting diffuse lung metastases. The approach also highlights the impact of altered radioiodine kinetics as seen with recombinant human thyroid-stimulating hormone...
  77. pmc FDG PET and risk-adapted therapy in Hodgkin's and non-Hodgkin's lymphoma
    Yvette L Kasamon
    Department of Oncology, Johns Hopkins University, Baltimore, Maryland, USA
    Curr Opin Oncol 20:206-19. 2008
    ..Outcomes based on midtreatment FDG PET performed during primary and salvage therapy are reviewed and management strategies considered, with a focus on treatment intensification for poor-risk disease as identified by metabolic imaging...
  78. ncbi request reprint FDG metabolism and uptake versus blood flow in women with untreated primary breast cancers
    Kenneth R Zasadny
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins Medical Institutions, 601 N Caroline St, Rm 3223, Baltimore, MD 21287 0817, USA
    Eur J Nucl Med Mol Imaging 30:274-80. 2003
    ..The slope of FDG uptake versus blood flow appears higher at low flow rates, suggesting the possible presence of areas of tumor hypoxia...
  79. ncbi request reprint Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
    J Infect Dis 195:703-10. 2007
    ..To inform the development of rectal microbicide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa...
  80. ncbi request reprint 18F-FDG PET/CT in evaluating non-CNS pediatric malignancies
    Mitsuaki Tatsumi
    Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 48:1923-31. 2007
    ....
  81. doi request reprint Comparison of FDG-PET/CT and CT for delineation of lumpectomy cavity for partial breast irradiation
    Eric C Ford
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 71:595-602. 2008
    ..We examined the use of fluorodeoxyglucose-positron emission tomography (FDG-PET)/computed tomography (CT) for improved lumpectomy cavity (LC) delineation and treatment planning...
  82. ncbi request reprint FDG PET and high-dose therapy for aggressive lymphomas: toward a risk-adapted strategy
    Yvette L Kasamon
    Divisions of Hematologic Malignancies and Nuclear Medicine, Johns Hopkins Medical Institutions, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Room 207, Baltimore, MD 21231, USA
    Curr Opin Oncol 16:100-5. 2004
    ..This review summarizes the developments in risk assessment through positron emission tomography in patients with lymphoma and the implications for management...
  83. ncbi request reprint PET scanning and measuring the impact of treatment
    Christian Cohade
    Division of Nuclear Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21287 0817, USA
    Cancer J 8:119-34. 2002
    ..Disease specific applications of PET imaging are then reviewed. While FDG is the most commonly used radiotracer for PET, many other radioligands could be applied in the future...
  84. ncbi request reprint Impact of body habitus on quantitative and qualitative image quality in whole-body FDG-PET
    Mitsuaki Tatsumi
    Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins Medical Institutions, 601 N Caroline St, Rm 3223, Baltimore, MD 21287 0817, USA
    Eur J Nucl Med Mol Imaging 30:40-5. 2003
    ..Adjusting injected FDG dose in each patient on the basis of body weight may be more appropriate to achieve consistent PET image quality than giving a fixed injected FDG dose...
  85. ncbi request reprint Comparison of 90Y-ibritumomab tiuxetan and 131I-tositumomab in clinical practice
    Heather A Jacene
    Russell H Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Nucl Med 48:1767-76. 2007
    ..We evaluated the hypothesis that the patient-specific dosing regimen used with (131)I-tositumomab results in less bone marrow toxicity than does the weight-based dosing regimen used with (90)Y-ibritumomab tiuxetan...
  86. ncbi request reprint Overcorrection of iodinated contrast attenuation in SPECT-CT: phantom studies
    Dacian V Bonta
    Department of Nuclear Medicine, VAMC, Atlanta, Georgia, USA
    Med Phys 37:4897-901. 2010
    ..The authors investigated the effects of iodinated contrast agents on the quantification of radioactivity obtained using a combined single photon emission tomography (SPECT) and high resolution 16 slice computed tomography (CT) scanner...
  87. ncbi request reprint Expression of hexokinase II and Glut-1 in untreated human breast cancer
    Raya S Brown
    Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical Center, Ann Arbor, MI, USA
    Nucl Med Biol 29:443-53. 2002
    ..6).FDG uptake in breast cancer tissue appears to be associated with the extent of immunodetectable expression of Glut-1, but not that of HKII, and FDG uptake may differ between individual tumors depending on tumor stage and histology...
  88. ncbi request reprint Volume reduction versus radiation dose for tumors in previously untreated lymphoma patients who received iodine-131 tositumomab therapy. Conjugate views compared with a hybrid method
    Kenneth F Koral
    University of Michigan Medical Center, Ann Arbor, Michigan 48109 0552, USA
    Cancer 94:1258-63. 2002
    ..The responses of these patients have been characterized, and for some of them tumor dosimetry during therapy has been estimated not only by pretherapy tracer conjugate views but also by a hybrid method...
  89. ncbi request reprint Choosing an optimal radioimmunotherapy dose for clinical response
    Sally J DeNardo
    Department of Internal Medicine, Division of Hematology and Oncology, Section of Radiodiagnosis and Therapy, University of California, Davis Medical Center, Sacramento, California 95816, USA
    Cancer 94:1275-86. 2002
    ..Future clinical trial designs, the sophistication of dosimetry, treatment planning, and clinical treatment decisions should all be focused on achieving the best benefit-risk relationship for each patient...
  90. ncbi request reprint FDG positron emission tomography detection of pelvic nodal metastases in gynecologic cancer
    Barry A Siegel
    AJR Am J Roentgenol 178:762-4. 2002
  91. ncbi request reprint A practical methodology for patient release after tositumomab and (131)I-tositumomab therapy
    Jeffry A Siegel
    Nuclear Physics Enterprises, Cherry Hill, New Jersey 08003, USA
    J Nucl Med 43:354-63. 2002
    ..A methodology was developed determining patient releasability after radioimmunotherapy with tositumomab and (131)I-tositumomab for the treatment of non-Hodgkin's lymphoma...
  92. ncbi request reprint Prognostic value of positron emission tomography using F-18-fluorodeoxyglucose in patients with cervical cancer undergoing radiotherapy
    Yuji Nakamoto
    Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland 21287 0817, USA
    Gynecol Oncol 84:289-95. 2002
    ..The purpose of this study was to determine whether positron emission tomography (PET) using F-18-fluorodeoxyglucose (FDG) before and after radiotherapy would predict whether local control of cervical cancer had been achieved...
  93. ncbi request reprint Re-treatment with I-131 tositumomab in patients with non-Hodgkin's lymphoma who had previously responded to I-131 tositumomab
    Mark S Kaminski
    University of Michigan Comprehensive Cancer Center, Ann Arbor, USA
    J Clin Oncol 23:7985-93. 2005
    ..To study efficacy and safety of re-treatment with I-131 tositumomab in patients with low-grade, follicular, or transformed low-grade B-cell lymphoma who relapsed following a response to I-131 tositumomab...
  94. ncbi request reprint Correlation of tumor radiation-absorbed dose with response is easier to find in previously untreated patients
    Kenneth F Koral
    J Nucl Med 44:1541-3; author reply 1543. 2003
  95. ncbi request reprint A positron-emitting internal marker for identification of normal tissue by positron emission tomography: phantom studies and validation in patients
    Cherry T Thomas
    Division of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Mol Imaging Biol 5:79-85. 2003
    ....
  96. ncbi request reprint The radioisotope contributes significantly to the activity of radioimmunotherapy
    Thomas A Davis
    Stanford University, Stanford, California, USA
    Clin Cancer Res 10:7792-8. 2004
    ....
  97. ncbi request reprint Fluorodeoxyglucose uptake in the aortic wall at PET/CT: possible finding for active atherosclerosis
    Mitsuaki Tatsumi
    Russell H Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, Johns Hopkins Medical Institutions, 601 N Caroline St, Rm 3223A, Baltimore, MD 21287 0817, USA
    Radiology 229:831-7. 2003
    ..To evaluate fluorine 18 fluorodeoxyglucose (FDG) uptake in the thoracic aortic wall at combined positron emission tomography (PET)/computed tomography (CT) and compare uptake with aortic wall calcification...
  98. ncbi request reprint Bias reduction in correlation of radiation-absorbed dose with response
    Kenneth F Koral
    J Nucl Med 45:1271; author reply 1271-2. 2004
  99. ncbi request reprint Tositumomab and iodine-131 tositumomab produces durable complete remissions in a subset of heavily pretreated patients with low-grade and transformed non-Hodgkin's lymphomas
    Richard I Fisher
    University of Rochester School of Medicine, James P Wilmot Cancer Center, 601 Elmwood Ave, Box 704, Rochester, NY 14642, USA
    J Clin Oncol 23:7565-73. 2005
    ....