Eric C Vonderheid
Affiliation: Johns Hopkins University
- On the diagnosis of erythrodermic cutaneous T-cell lymphomaEric C Vonderheid
Department of Dermatology, Johns Hopkins Medical Institutes, Baltimore, MD 21205, USA
J Cutan Pathol 33:27-42. 2006....
- Secondary syphilis presenting as pseudolymphoma of the skinMary E McComb
Department of Dermatology, Lehigh Valley Hospital, 7925 Ridge Avenue, Allentown, PA 19128, USA
J Am Acad Dermatol 49:S174-6. 2003..The papulonodular variant has only been described 11 times in the literature. We describe a case of papulonodular secondary syphilis presenting as an atypical lymphoid hyperplasia suggestive of cutaneous lymphoma...
- Predictors of response to extracorporeal photopheresis in advanced mycosis fungoides and Sézary syndromeLaura Y McGirt
Dermatology, Johns Hopkins Medical Institutes, Baltimore, MD, USA
Photodermatol Photoimmunol Photomed 26:182-91. 2010....
- Lymphomatoid papulosis followed by pityriasis lichenoides: a common pathogenesis?Eric C Vonderheid
Department of Dermatology, Johns Hopkins Medical Institutes, Baltimore, MD, USA
Am J Dermatopathol 33:835-40. 2011..We report a patient who was diagnosed with LyP type B in 1985 followed by PL after 11 years. We hypothesize that LyP followed by PL in the same patient reflects differences in the host immune response to a common antigenic stimulus...
- The Sézary syndrome: hematologic criteriaEric C Vonderheid
Department of Dermatology, Johns Hopkins Medical Institutions, 550 North Broadway, Suite 1002, Baltimore, MD 21205, USA
Hematol Oncol Clin North Am 17:1367-89, viii. 2003..Based on the experience at two institutions, revisions to the definition for Sézary syndrome are proposed...
- Sézary cell counts in erythrodermic cutaneous T-cell lymphoma: implications for prognosis and stagingEric C Vonderheid
Department of Dermatology and Oncology, Johns Hopkins Medical Institutes, 550 N Broadway, Baltimore, MD 21205, USA
Leuk Lymphoma 47:1841-56. 2006..The clinical importance of these variables vis-à-vis the modified TNBM staging system will need to be clarified in future studies...
- Evidence for restricted Vbeta usage in the leukemic phase of cutaneous T cell lymphomaEric C Vonderheid
Department of Dermatology, Johns Hopkins Medical Institutes, Baltimore, Maryland 21205, USA
J Invest Dermatol 124:651-61. 2005..1 usage in CTCL may be the result of depletion of Vbeta2 and other Vbeta-bearing T cells by staphylococcal superantigens prior to neoplastic transformation, resulting in a relative increase in the frequency of Vbeta5.1 usage in CTCL...
- Treatment planning in cutaneous T-cell lymphomaEric C Vonderheid
Johns Hopkins Medical Institutes, Baltimore, Maryland 21205, USA
Dermatol Ther 16:276-82. 2003..The author's approach is provided as a guide for dermatologists in private practice...
- Prognostic factors and risk stratification in early mycosis fungoidesEric C Vonderheid
Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutes, Baltimore, MD, USA
Leuk Lymphoma 55:44-50. 2014..Combination of these factors was used to construct prognostic groupings which, if validated, might be useful to identify patients with clinically early MF at highest risk for disease progression and poor outcome. ..
- Low FAS/CD95 expression by CTCL correlates with reduced sensitivity to apoptosis that can be restored by FAS upregulationJianqiang Wu
Department of Dermatology, University of Wisconsin and VAMC, Madison, Wisconsin 53715, USA
J Invest Dermatol 129:1165-73. 2009....
- High soluble CD30, CD25, and IL-6 may identify patients with worse survival in CD30+ cutaneous lymphomas and early mycosis fungoidesMarshall E Kadin
Department of Dermatology, Boston University, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
J Invest Dermatol 132:703-10. 2012..We conclude that (1) neoplastic cells of some CD30CLPD patients do not resemble Th2 cells, and that (2) high serum sCD30, sCD25, IL-6, and perhaps IL-8 levels may provide prognostic information useful for patient management...
- Simplified flow cytometric assessment in mycosis fungoides and Sézary syndromeAlexandra C Hristov
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Clin Pathol 136:944-53. 2011..Increasing numbers of abnormal T cells were associated with worsening disease. Flow cytometry provides valuable information for diagnosis, prognosis, and therapeutic efficacy in MF/SS...
- Chemokine receptor expression by leukemic T cells of cutaneous T-cell lymphoma: clinical and histopathological correlationsElisabetta Capriotti
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutes, Baltimore, Maryland, USA
J Invest Dermatol 127:2882-92. 2007..The chemokine receptor profile supports the concept that neoplastic T cells are central memory T cells, and that CCR10 and CD62L play a fundamental role respectively in epidermotropism and lymphadenopathy that is observed in SS...
- Multicolor fluorescence in situ hybridization (SKY) in mycosis fungoides and Sézary syndrome: search for recurrent chromosome abnormalitiesDenise A S Batista
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Genes Chromosomes Cancer 45:383-91. 2006..2;p11.2). Two patients with SS reported in the literature seem to have a similar translocation. If confirmed, a psu dic(17;8) could be the first recurring translocation detected in at least three patients with MF/SS...
- Erythrodermic cutaneous T cell lymphoma with hypereosinophilic syndrome: Treatment with interferon alfa and extracorporeal photopheresisCatherine H Lee
Department of Dermatology, Johns Hopkins University, Baltimore, MD 21205, USA
Int J Dermatol 46:1198-204. 2007..Eosinophilia is also recognized as a poor prognostic factor in cutaneous T-cell lymphoma (CTCL) in which neoplastic T cells may produce eosinophilopoietic cytokines...
- Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease: review and speculations about pathogenesisMaryam Haque
Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA 19107, USA
Clin Lymphoma Myeloma Leuk 11:453-61. 2011....
- Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphomaMadeleine Duvic
Department of Dermatology, The University of Texas M D Anderson Cancer Center, Box 1492, 1515 Holcombe Blvd, Houston, TX 77030, USA
Clin Lymphoma Myeloma 9:412-6. 2009....
- Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgarisSimon S Yoo
Department of Dermatology, Johns Hopkins Medical Institutes, Baltimore, Maryland 21287, USA
J Dermatol 30:405-10. 2003..This case provides an opportunity to discuss the difficulty of managing two potentially mortal conditions in which the treatment of pemphigus vulgaris may exacerbate the disseminated cryptococcal infection...
- Photopheresis: current and future perspectivesEric C Vonderheid
Department of Dermatology, Johns Hopkins Medical Institutes, Baltimore, MD, USA
J Cutan Med Surg 7:1-2. 2003
- CD158k/KIR3DL2 is a useful marker for identifying neoplastic T-cells in Sézary syndrome by flow cytometryDavid W Bahler
Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA
Cytometry B Clin Cytom 74:156-62. 2008..Moreover, our observation that CD4 positive, CD7 negative T-cells are mostly CD158k negative further suggests that CD158k may be able to help identify and enumerate neoplastic T-cells in SS even when present at low levels...
- Papular mycosis fungoides: a variant of mycosis fungoides or lymphomatoid papulosis?Eric C Vonderheid
J Am Acad Dermatol 55:177-80. 2006
- Infrequent Fas mutations but no Bax or p53 mutations in early mycosis fungoides: a possible mechanism for the accumulation of malignant T lymphocytes in the skinOlivier Dereure
Department of Pathology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts 02215, USA
J Invest Dermatol 118:949-56. 2002..These results support the hypothesis that Fas defects may play a role in the pathogenesis of MF...
- Heterogeneous abnormalities of CCND1 and RB1 in primary cutaneous T-Cell lymphomas suggesting impaired cell cycle control in disease pathogenesisXin Mao
Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, King s College, London, UK
J Invest Dermatol 126:1388-95. 2006..These findings suggest heterogeneous abnormalities of CCND and RB in CTCL, in which dysregulated CCND and RB1 may lead to impaired cell cycle control...
- Quantitative PCR on 5 genes reliably identifies CTCL patients with 5% to 99% circulating tumor cells with 90% accuracyMichael Nebozhyn
The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
Blood 107:3189-96. 2006..These results are the first to demonstrate that gene expression profiling by quantitative PCR on a selected number of critical genes can be employed to molecularly diagnosis SS...
- Improved sensitivity of T-cell clonality detection in mycosis fungoides by hand microdissection and heteroduplex analysisOlivier Dereure
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Arch Dermatol 139:1571-5. 2003..Procedures based on polymerase chain reaction (PCR) are the most sensitive to detect clonality, but heteroduplex analysis is less sensitive than other methods such as denaturing gradient gel electrophoresis...
- Treatment of cutaneous T cell lymphoma: 2001Eric C Vonderheid
MCP Hahnemann University, Philadelphia, PA 19102, USA
Recent Results Cancer Res 160:309-20. 2002..Overall the future of therapy for CTCL seems quite optimistic...
- Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeriQian Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Arch Immunol Ther Exp (Warsz) 50:421-9. 2002....
- Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphomaLaszlo Kari
Molecular Oncology Program, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
J Exp Med 197:1477-88. 2003..Finally, we show that using 10 genes, we can identify a class of patients who will succumb within six months of sampling regardless of their tumor burden...
- Do neoplastic stem cells underlie the pathogenesis of cutaneous lymphomas?Eric C Vonderheid
Arch Dermatol 141:641-2; author reply 642-3. 2005
- Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphomaElisabetta Capriotti
Department of Dermatology, University of Rome, Tor Vergata, Italy
Leuk Lymphoma 49:1190-201. 2008..Although the underlying mechanisms accounting for this correlation remain unclear, the expression of the Foxp3 and CTLA-4 regulatory elements indicates that a subset of leukemic cases displays a regulatory T-cell phenotype...
- Durable complete remission of mycosis fungoides following erythroderma induced by denileukin diftitoxRebecca Kazin
J Am Acad Dermatol 58:S31-2. 2008
- Sézary syndrome coexisting with B-cell chronic lymphocytic leukemia: case report and review of the literatureSyrus Karsai
Laserklinik Karlsruhe, Karlsruhe, Germany
Dermatology 216:68-75. 2008..The simultaneous presentation of chronic B-cell lymphocytic leukemia (B-CLL) and cutaneous T-cell lymphoma (CTCL) is extremely rare...
- Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous LymphomasEric C Vonderheid
MCP Hahnemann University, Philadelphia, Pennsylvannia 19102, USA
J Am Acad Dermatol 46:95-106. 2002..For staging purposes, it is proposed that these criteria define the B2 blood rating and that the B2 rating be considered equivalent to nodal involvement...