Farhad Vesuna

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Genomic pathways modulated by Twist in breast cancer
    Farhad Vesuna
    Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    BMC Cancer 17:52. 2017
  2. pmc Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α
    F Vesuna
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21250, USA
    Oncogene 31:3223-34. 2012
  3. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
  4. pmc Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression
    Farhad Vesuna
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Traylor 338, Baltimore, MD 21205, USA
    Neoplasia 11:1318-28. 2009
  5. pmc Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells
    Mahendran Botlagunta
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e17563. 2011
  6. pmc NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3
    Min Xie
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 6:29901-13. 2015
  7. pmc Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    Farhad Vesuna
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:235-41. 2008
  8. pmc Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts
    Jacob E Koskimaki
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neoplasia 11:1285-91. 2009
  9. pmc HOXA5 regulates hMLH1 expression in breast cancer cells
    Sai Duriseti
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neoplasia 8:250-8. 2006
  10. doi request reprint Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model
    Kristine Glunde
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 68:172-80. 2008

Collaborators

  • Venu Raman
  • Yoshinori Kato
  • Phuoc T Tran
  • Yehudit Bergman
  • Kristine Glunde
  • Onno Kranenburg
  • Petra van der Groep
  • Paul J van Diest
  • Michelle A Rudek
  • Ming Zhao
  • Jacob E Koskimaki
  • Emmanouil D Karagiannis
  • Chi Zhang
  • Arvind P Pathak
  • Brian M Polster
  • Zaver Bhujwalla
  • Elena V Rosca
  • Maria D Cao
  • Marise R Heerma van Voss
  • Paul T Winnard
  • Min Xie
  • Guus M Bol
  • Elsken van der Wall
  • Mahendran Botlagunta
  • Kathleen Gabrielson
  • Saritha Tantravedi
  • Ashley Irving
  • Ramachandra S Hosmane
  • Yelena Mironchik
  • Dimas Yusuf
  • Horst Burger
  • Sai Duriseti
  • RAMACHANDRA RAO DASARI
  • Jeon Woong Kang
  • Ishan Barman
  • Justin D Brilliant
  • Jonah Garry
  • Katriana Nugent
  • Reem Malek
  • Cynthia Berlinicke
  • Anne Levine
  • Leslie Cope
  • Evan A Bordt
  • Justin Brilliant
  • Kari Trumpi
  • Khaled Aziz
  • Wendy de Leng
  • Jing Zeng
  • Nishant Gandhi
  • Guus Martinus Bol
  • G Johan Offerhaus
  • Dorian Korz
  • Atul Kondaskar
  • Daniel J Peet
  • Jason P Debruyne
  • Dominique Leprince
  • Michal Mikula
  • Rachel D Mullen
  • Marieke Rozendaal
  • Elizabeth Wederell
  • Peggy J Farnham
  • Eugene Bolotin
  • Jan J Brosens
  • Xiao Yu Cindy Zhang
  • Mireille Vasseur-Cognet
  • Yuriko Mishima
  • Sylvie Mader
  • M Michela Mancarelli
  • Stefanie L Butland
  • Astrid Eijkelenboom
  • Henriette O'Geen
  • Helma D C Schwenen
  • Amy Ticoll
  • Elizabeth M Simpson
  • Christopher T D Dickman
  • Jerzy Ostrowski
  • Padma Sheela Jayaraman
  • Marrit Putker
  • Bérénice A Benayoun
  • Jake M Schnabl
  • David Laperriere
  • Bianca Blom
  • Rebecca L Cullum
  • Harini Chakravarthy
  • Eric W F Lam
  • Philip J Brown
  • Rumela Chakrabarti
  • Jason Park
  • Mary B Breslin
  • Stephanie C Colvin

Detail Information

Publications19

  1. pmc Genomic pathways modulated by Twist in breast cancer
    Farhad Vesuna
    Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    BMC Cancer 17:52. 2017
    ..Moreover, many of the genes and pathways dysregulated by Twist in cell lines and mouse models have not been validated against data obtained from larger, independant datasets of breast cancer patients...
  2. pmc Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α
    F Vesuna
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21250, USA
    Oncogene 31:3223-34. 2012
    ..In summary, the regulation of ER by Twist could be an underlying mechanism for the loss of ER activity observed in breast tumors, and may contribute to the generation of hormone-resistant, ER-negative breast cancer...
  3. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
    ..TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe...
  4. pmc Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression
    Farhad Vesuna
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Traylor 338, Baltimore, MD 21205, USA
    Neoplasia 11:1318-28. 2009
    ..Taken together, our data demonstrate the direct involvement of Twist in generating a breast cancer stem cell phenotype through down-regulation of CD24 expression and independent of an epithelial-mesenchymal transition...
  5. pmc Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells
    Mahendran Botlagunta
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e17563. 2011
    ....
  6. pmc NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3
    Min Xie
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 6:29901-13. 2015
    ..Further studies are needed to optimize drug formulation, dose and delivery. Continuing work will determine the in vitro-in vivo correlation of NZ51 activity and its utility in a clinical setting. ..
  7. pmc Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    Farhad Vesuna
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:235-41. 2008
    ..Finally, the functional relevance of this regulation was verified by quantitative real-time PCR and immunohistochemistry on a cohort of breast cancer samples...
  8. pmc Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts
    Jacob E Koskimaki
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neoplasia 11:1285-91. 2009
    ..We have demonstrated significant suppression of tumor growth in vivo and subsequent reductions in microvascular density, indicating the potential of these peptides as therapeutic agents for breast cancer...
  9. pmc HOXA5 regulates hMLH1 expression in breast cancer cells
    Sai Duriseti
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neoplasia 8:250-8. 2006
    ..Furthermore, we demonstrate that, in the presence of HOXA5, there is an increase in in vivo repair activity in MCF-7 cells. Taken together, our results indicate that HOXA5 is a transcriptional regulator of hMLH1 in breast cancer cells...
  10. doi request reprint Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model
    Kristine Glunde
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 68:172-80. 2008
    ..These data suggest that HIF-1 activation of HREs within the putative chk-alpha promoter region can increase Chk-alpha expression within hypoxic environments, consequently increasing cellular PC and tCho levels within these environments...
  11. pmc Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer
    Maria D Cao
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 25:1033-42. 2012
    ..Our study identified GDPD5 as a GPC-PDE that probably participates in the regulation of choline phospholipid metabolism in breast cancer, which possibly occurs in cooperation with CHKA and PLD1...
  12. pmc Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models
    Yoshinori Kato
    Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 6:891-7. 2007
    ..The absence of these molecular responses to TMZ treatment in MCF-7 tumors in vivo supports the possibility that the onset of cancer drug resistance is associated with reduced PS, which can decrease delivery of the drug to cancer cells...
  13. doi request reprint Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer
    Marise R Heerma van Voss
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA
    Med Oncol 34:33. 2017
    ..62. Overall, we conclude that BRCA pro- and deficient breast cancers have a similar dependency upon DDX3. DDX3 inhibition by RK-33 synergizes with PARP inhibitor treatment, especially in breast cancers with a BRCA1-proficient background...
  14. ncbi request reprint RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3
    Min Xie
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Cancer Res 76:6340-6350. 2016
    ..Taken together, these results indicate that blocking DDX3 by RK-33 in combination with radiation treatment is a viable option for treating locally advanced prostate cancer. Cancer Res; 76(21); 6340-50. ©2016 AACR...
  15. pmc Histamine: a potential therapeutic agent for breast cancer treatment?
    Farhad Vesuna
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore Maryland, USA
    Cancer Biol Ther 5:1472-3. 2006
  16. ncbi request reprint Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
    Yelena Mironchik
    Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 65:10801-9. 2005
    ....
  17. doi request reprint Organ-specific isogenic metastatic breast cancer cell lines exhibit distinct Raman spectral signatures and metabolomes
    Paul T Winnard
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncotarget . 2017
    ..Our findings provide evidence that metastatic spread generates tissue-specific adaptations at the molecular level within cancer cells, which can be differentiated with Raman spectroscopy...
  18. pmc Targeting DDX3 with a small molecule inhibitor for lung cancer therapy
    Guus M Bol
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    EMBO Mol Med 7:648-69. 2015
    ..Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. ..
  19. pmc Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer
    Marise R Heerma van Voss
    Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Oncotarget 6:28312-26. 2015
    ..Inhibition of DDX3 with the small molecule inhibitor RK-33 causes inhibition of Wnt signaling and may therefore be a promising future treatment strategy for a subset of colorectal cancers. ..