Genomes and Genes
Janis M Taube
Affiliation: Johns Hopkins University
- Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapyJanis M Taube
Departments of Dermatology, Pathology, Oncology, and
Clin Cancer Res 20:5064-74. 2014..Immunomodulatory drugs differ in mechanism-of-action from directly cytotoxic cancer therapies. Identifying factors predicting clinical response could guide patient selection and therapeutic optimization...
- Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escapeJanis M Taube
Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Sci Transl Med 4:127ra37. 2012..These observations suggest that therapies that block this pathway may benefit patients with B7-H1(+) tumors...
- Langerhans cell density and high-grade vulvar intraepithelial neoplasia in women with human immunodeficiency virus infectionJanis M Taube
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Cutan Pathol 34:565-70. 2007..The objective of this study was to compare the S100+ LC density in high-grade vulvar intraepithelial neoplasia (VIN) in HIV-positive and HIV-negative women...
- Human papillomavirus prevalence and cytopathology correlation in young Ugandan women using a low-cost liquid-based Pap preparationJanis M Taube
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Diagn Cytopathol 38:555-63. 2010..Notably, the manual low-cost liquid-based Pap preparation is practical in this setting and offers an alternate method for local studies of HPV vaccine efficacy...
- Differentiated (simplex) vulvar intraepithelial neoplasia: a case report and review of the literatureJanis M Taube
Departments of Dermatology and Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Dermatopathol 33:e27-30. 2011....
- Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibodyEvan J Lipson
Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA
Clin Cancer Res 19:462-8. 2013..Here, we provide long-term follow-up on three patients from that trial who sustained objective tumor regressions off therapy, and test the hypothesis that reinduction therapy for late tumor recurrence can be effective...
- Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinomaSofia Lyford-Pike
Department of Otolaryngology Head and Neck Surgery, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
Cancer Res 73:1733-41. 2013....
- PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutationNemanja Rodic
Department of Pathology, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Cancer Immunol Res 3:110-5. 2015..PD-L1 expression in melanocytic lesions does not correlate with the BRAFmut. Thus, distinct populations of melanoma patients will likely benefit from BRAF inhibitors versus PD-1 pathway blockade...
- Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization methodJustin A Bishop
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
Am J Surg Pathol 36:1874-82. 2012....
- Safety, activity, and immune correlates of anti-PD-1 antibody in cancerSuzanne L Topalian
Department of Surgery, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA
N Engl J Med 366:2443-54. 2012..Blockade of programmed death 1 (PD-1), an inhibitory receptor expressed by T cells, can overcome immune resistance. We assessed the antitumor activity and safety of BMS-936558, an antibody that specifically blocks PD-1...
- PD-1, PD-L1, PD-L2 expression in the chordoma microenvironmentDimitrios Mathios
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neurooncol 121:251-9. 2015..Future studies are needed to evaluate the contribution of the PD-1 pathway to the immunosuppressive microenvironment of chordomas. ..
- Locally invasive dermal squamomelanocytic tumor with matrical differentiation: a peculiar case with review of the literatureNemanja Rodic
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21205, USA
Am J Dermatopathol 35:e72-6. 2013..Most notable feature of this case is focal matrical differentiation and locally invasive tumor growth, characterized by multifocal perineural invasion...
- Neural crest transcription factor Sox10 is preferentially expressed in triple-negative and metaplastic breast carcinomasAshley Cimino-Mathews
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Hum Pathol 44:959-65. 2013..Sox10 expression in the basal-like, unclassified triple-negative, and metaplastic carcinomas types supports the concept that these neoplasms show myoepithelial differentiation...
- Benign nodal nevi frequently harbor the activating V600E BRAF mutationJanis M Taube
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 33:568-71. 2009..Indeed, these nodal nevi, like melanoma, frequently harbor activating mutations of the BRAF oncogene underscoring the potentially confounding impact of these inclusions on melanoma detection...
- Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neckWilliam H Westra
Department of Pathology and Otolaryngology, Head and Neck Surgery Division of Head and Neck Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Clin Cancer Res 14:366-9. 2008..The purpose of this study was to discern whether HNSCCs differ in the type of p53 mutations as a function of HPV16 status...
- BRAF pyrosequencing analysis aided by a lookup tableMatthew T Olson
The Sol Goldman Pancreatic Cancer Research Center, Professor of Pathology and Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231
Am J Clin Pathol 141:639-47. 2014..Therefore, we introduce a pyrosequencing lookup table based on Pyromaker that assists the user in generating hypotheses for solving complex pyrosequencing results...
- Sox10 is expressed in primary melanocytic neoplasms of various histologies but not in fibrohistiocytic proliferations and histiocytosesJeonghyun Shin
Department of Dermatology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Am Acad Dermatol 67:717-26. 2012..Sox10 is a transcription factor associated with neural crest development. Its expression has been reported in melanocytes and peripheral nerve sheath cells and their associated tumors...
- Quantitative comparison of MiTF, Melan-A, HMB-45 and Mel-5 in solar lentigines and melanoma in situJinah Kim
Department of Pathology, Stanford University, Stanford, CA 94305, USA
J Cutan Pathol 38:775-9. 2011..Therefore, dermatopathologists routinely use immunostains to help differentiate melanocytes from surrounding keratinocytes...
- Tumor cellularity as a quality assurance measure for accurate clinical detection of BRAF mutations in melanomaJonathan C Dudley
Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Park SB202, 600 North Wolfe St, Baltimore, MD, 21287, USA
Mol Diagn Ther 18:409-18. 2014..Molecular assays should be designed to detect not only the most common p.V600E mutation, but also p.V600K and other non-p.V600E mutations...
- Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlatesJulie R Brahmer
Johns Hopkins University School of Medicine, and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
J Clin Oncol 28:3167-75. 2010..This phase I study sought to determine the safety and tolerability of anti-PD-1 blockade in patients with treatment-refractory solid tumors and to preliminarily assess antitumor activity, pharmacodynamics, and immunologic correlates...
- Merkel cell carcinoma: update and reviewTimothy S Wang
Division of Cutaneous Surgery and Oncology, Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Semin Cutan Med Surg 30:48-56. 2011..Recent effort has broadened our breadth of knowledge regarding MCC and developed instruments to improve data collection and future study. This article provides an update on current thinking about the Merkel cell and MCC...
- Characterization of human mesenchymal stem cell-engineered cartilage: analysis of its ultrastructure, cell density and chondrocyte phenotype compared to native adult and fetal cartilageAlexander T Hillel
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
Cells Tissues Organs 191:12-20. 2010....
- Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancerSuhail K Mithani
Division of Plastic and Reconstructive Surgery, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0910, USA
Clin Cancer Res 13:4331-5. 2007..To determine the timing of mitochondrial mutations in the progression of head and neck squamous cell carcinoma...
- Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypesChristopher M Heaphy
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Pathol 179:1608-15. 2011..These findings may have therapeutic consequences, because ALT-positive cancers are predicted to be resistant to anti-telomerase therapies...
- Photoactivated composite biomaterial for soft tissue restoration in rodents and in humansAlexander T Hillel
Department of Otolaryngology, Johns Hopkins University, Baltimore, MD 21287, USA
Sci Transl Med 3:93ra67. 2011..Pilot clinical testing in human patients confirmed the feasibility of the transdermal photocrosslinking approach for implantation in abdomen soft tissue, although an inflammatory response was observed surrounding some of the materials...
- Multifocal ischemic necroses of varying age (MINOVA): A distinctive form of atherosclerotic heart diseaseJanis M Taube
Department of Pathology, The Johns Hopkins Medical Institutions, Room 400, 600 N Wolfe Street, Baltimore, MD 21287, USA
Pathol Res Pract 204:113-20. 2008..Review of patient histories showed that the clinical suspicion for the degree of ischemic heart disease did not correlate well with the severity of the pathological findings...
- Combined use of PCR-based TCRG and TCRB clonality tests on paraffin-embedded skin tissue in the differential diagnosis of mycosis fungoides and inflammatory dermatosesBing Zhang
Department of Pathology, L235, Stanford University Medical Center, Stanford, CA 94305, USA
J Mol Diagn 12:320-7. 2010..Combined use of the two tests in patients with intermediate pretest probabilities as proposed in the algorithm could improve test utility...