Clarke Tankersley

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Circadian rhythm variation in activity, body temperature, and heart rate between C3H/HeJ and C57BL/6J inbred strains
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 92:870-7. 2002
  2. ncbi request reprint Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice
    Matthew J Campen
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, USA
    Physiol Genomics 20:15-20. 2004
  3. pmc Interstrain variation in cardiac and respiratory adaptation to repeated ozone and particulate matter exposures
    Ali K Hamade
    Department of Environmental Health Sciences, John Hopkins University, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1202-15. 2009
  4. ncbi request reprint Strain-specific differences in sensitivity to ischemia-reperfusion lung injury in mice
    Jeffrey M Dodd-o
    Department of Anesthesia and Critical Care, School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 9106, USA
    J Appl Physiol (1985) 100:1590-5. 2006
  5. ncbi request reprint Impact of interrupted leptin pathways on ventilatory control
    Vsevolod Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 96:991-8. 2004
  6. ncbi request reprint Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains
    Arnon E Rubin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 168:1520-7. 2003
  7. pmc Adverse cardiovascular effects with acute particulate matter and ozone exposures: interstrain variation in mice
    Ali K Hamade
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Environ Health Perspect 116:1033-9. 2008
  8. pmc Exposure to inhaled particulate matter impairs cardiac function in senescent mice
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health and School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 295:R252-63. 2008
  9. ncbi request reprint Differences in alveolar size in inbred mouse strains
    Shawn E Soutiere
    Department of Environmental Health Sciences, Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 140:283-91. 2004
  10. ncbi request reprint Variation in heart rate regulation and the effects of particle exposure in inbred mice
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Inhal Toxicol 19:621-9. 2007

Research Grants

  1. Particle-Induced Cardiac Effects in Senescent Mice
    Clarke Tankersley; Fiscal Year: 2008

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Circadian rhythm variation in activity, body temperature, and heart rate between C3H/HeJ and C57BL/6J inbred strains
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 92:870-7. 2002
    ..Furthermore, phenotypic differences between C3 and B6 strains can be used to explore the genetic basis for differential circadian regulation of body temperature and HR...
  2. ncbi request reprint Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice
    Matthew J Campen
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, USA
    Physiol Genomics 20:15-20. 2004
    ..These results suggest that genetic background affects the cardiovascular response to hypoxia, but not hypercapnia...
  3. pmc Interstrain variation in cardiac and respiratory adaptation to repeated ozone and particulate matter exposures
    Ali K Hamade
    Department of Environmental Health Sciences, John Hopkins University, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1202-15. 2009
    ..During O(3)CB exposure, adaptation of cardiac and respiratory systems is markedly synchronized, which may explain a potential mechanism for adverse effects of PM on heart function...
  4. ncbi request reprint Strain-specific differences in sensitivity to ischemia-reperfusion lung injury in mice
    Jeffrey M Dodd-o
    Department of Anesthesia and Critical Care, School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 9106, USA
    J Appl Physiol (1985) 100:1590-5. 2006
    ..Although neutrophil-derived ROS production is also modulated by genetic factors, the pattern did not explain the genetic sensitivity to lung I/R injury...
  5. ncbi request reprint Impact of interrupted leptin pathways on ventilatory control
    Vsevolod Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 96:991-8. 2004
    ..We conclude that interruption of leptin pathways does not affect hypoxic sensitivity during sleep and wakefulness but that melanocortin 4 blockade is associated with depressed hypercapnic sensitivity in non-rapid eye movement sleep...
  6. ncbi request reprint Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains
    Arnon E Rubin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 168:1520-7. 2003
    ..Our data imply that individuals with low hypoxic sensitivity may be at a greater risk for hypoxia-related complications of obstructive sleep apnea...
  7. pmc Adverse cardiovascular effects with acute particulate matter and ozone exposures: interstrain variation in mice
    Ali K Hamade
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Environ Health Perspect 116:1033-9. 2008
    ..Furthermore, the mechanisms by which PM affects cardiac function remain uncertain. We hypothesized that PM and O(3) induce adverse cardiovascular effects in mice and that these effects are strain dependent...
  8. pmc Exposure to inhaled particulate matter impairs cardiac function in senescent mice
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health and School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 295:R252-63. 2008
    ..These results demonstrate that acute PM exposure reduces cardiac contractility in senescent mice, and this decline in function is associated with increased ROS production linked to NOS uncoupling...
  9. ncbi request reprint Differences in alveolar size in inbred mouse strains
    Shawn E Soutiere
    Department of Environmental Health Sciences, Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 140:283-91. 2004
    ..We speculate that these structural differences might have significant influence on several mouse models of lung disease, especially those involving the development of emphysema...
  10. ncbi request reprint Variation in heart rate regulation and the effects of particle exposure in inbred mice
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Inhal Toxicol 19:621-9. 2007
    ..Finally, strain variation in HR between B6 and C3 mice in responding to acute PM exposure implies that robust genetic determinants modulate altered autonomic regulation in susceptible individuals...
  11. ncbi request reprint Heritable and pharmacological influences on pauses and apneas in inbred mice during anesthesia and emergence
    Harald Groeben
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Exp Lung Res 31:839-53. 2005
    ..This response seems to be independent from the inherited response to hypercapnia...
  12. ncbi request reprint Variation in senescent-dependent lung changes in inbred mouse strains
    Kewu Huang
    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, Maryland 21205, USA
    J Appl Physiol 102:1632-9. 2007
    ..However, changes in D2 mice are accelerated relative to B6 mice. Moreover, gene expression differences appear to be involved in the strain-specific changes of lung mechanic properties...
  13. ncbi request reprint PEEP-induced changes in epithelial permeability in inbred mouse strains
    John M Bishai
    Johns Hopkins Asthma and Allergy Center, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Physiol Neurobiol 156:340-4. 2007
    ..001). Thus, when lung volume is increased, the susceptible C57Bl/6J strain shows a greater change in epithelial barrier than the resistant C3H/HeJ strain. These results may reflect fundamental differences in lung architecture...
  14. ncbi request reprint The effect of leptin on the ventilatory responseto hyperoxia
    Harald Groeben
    Department of Anesthesiology and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Exp Lung Res 30:559-70. 2004
    ..Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function...
  15. ncbi request reprint Interactions in hypoxic and hypercapnic breathing are genetically linked to mouse chromosomes 1 and 5
    Clarke G Tankersley
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Appl Physiol 97:77-84. 2004
    ..7) in a region between 7 and 29 cM (i.e., centered at D5Mit66). In conclusion, these results support the hypothesis that a minimum of two significant genes modulate the interactive effects of hypoxia and hypercapnia in this genetic model...
  16. pmc Air pollution and daily mortality: a hypothesis concerning the role of impaired homeostasis
    Robert Frank
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Health Perspect 110:61-5. 2002
    ....
  17. doi request reprint Ambient air pollution alters heart rate regulation in aged mice
    Juan P Ramos-Bonilla
    Department of Environmental Health Sciences, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Inhal Toxicol 22:330-9. 2010
    ..Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear...
  18. ncbi request reprint Genetic aspects of breathing: on interactions between hypercapnia and hypoxia
    Clarke G Tankersley
    Division of Physiology, Department of Environment Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 135:167-78. 2003
    ....
  19. ncbi request reprint Differential CO(2)-induced c-fos gene expression in the nucleus tractus solitarii of inbred mouse strains
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 92:1277-84. 2002
    ....
  20. ncbi request reprint Unstable heart rate and temperature regulation predict mortality in AKR/J mice
    Clarke G Tankersley
    The Johns Hopkins University, Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 284:R742-50. 2003
    ..The results further suggested that multiple predictors of cardiac and thermal instability in AK mice, including significant bradycardia, hypothermia, and a loss of circadian periodicity, forecast life span 5-6 wk before expiration...
  21. doi request reprint Variation in echocardiographic and cardiac hemodynamic effects of PM and ozone inhalation exposure in strains related to Nppa and Npr1 gene knock-out mice
    Clarke G Tankersley
    Department of Environmental Health Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Inhal Toxicol 22:695-707. 2010
    ..These results suggest that PM and O3 exposures, alone and combined, lead to different cardiac functional changes, and these unique changes are age-specific and dependent on Nppa and Npr1 genes...
  22. ncbi request reprint Structural and functional differences of the carotid body between DBA/2J and A/J strains of mice
    Shigeki Yamaguchi
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Appl Physiol 94:1536-42. 2003
    ..These data suggest that genetic determinants account for the strain differences in the structure and function of the carotid body...
  23. pmc Effects of leptin deficiency on postnatal lung development in mice
    Kewu Huang
    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD 21205, USA
    J Appl Physiol (1985) 105:249-59. 2008
    ..These data support the hypothesis that leptin is critical to postnatal lung remodeling, particularly related to increased V(40) and enlarged alveolar surface area...
  24. ncbi request reprint Age-dependent changes of airway and lung parenchyma in C57BL/6J mice
    Kewu Huang
    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, Maryland, USA
    J Appl Physiol (1985) 102:200-6. 2007
    ..Moreover, the reduction in elastic fiber content with age is an early lung remodeling event, and the increased collagen content in the lung parenchyma occurs later in senescence...
  25. ncbi request reprint Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes
    Vikas Misra
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Physiol Genomics 31:429-40. 2007
    ....
  26. ncbi request reprint Particle effects on heart-rate regulation in senescent mice
    Clarke G Tankersley
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, 21205 USA
    Inhal Toxicol 16:381-90. 2004
    ..The significance of the current results suggest that PM-induced HR regulatory changes may ultimately depend on the degree of physiological aging...
  27. ncbi request reprint Genetic influence on carotid body structure in DBA/2J and A/J strains of mice
    Shigeki Yamaguchi
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 580:105-9; discussion 351-9. 2006
  28. ncbi request reprint Respiratory impairment in a mouse model of amyotrophic lateral sclerosis
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Appl Physiol (1985) 102:926-32. 2007
    ..The present results outline the magnitude and time course of respiratory complications in SOD1(G93A) mutant mice as the progression of disease occurs in this mouse model of ALS...
  29. ncbi request reprint Genetic regulation of chemoreceptor development in DBA/2J and A/J strains of mice
    Alexander Balbir
    Department of Environmental Health Sciences, Division of Physiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Adv Exp Med Biol 580:99-104; discussion 351-9. 2006

Research Grants1

  1. Particle-Induced Cardiac Effects in Senescent Mice
    Clarke Tankersley; Fiscal Year: 2008
    ..summary, the proposed studies are significant because they represent a multidisciplinary approach that will advance our understanding of the adverse cardiac health effects of air pollution exposure in the elderly [unreadable] [unreadable]..