S H Snyder

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Nitric oxide and carbon monoxide: parallel roles as neural messengers
    S H Snyder
    Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Brain Res Brain Res Rev 26:167-75. 1998
  2. ncbi request reprint Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
    K Ye
    Johns Hopkins University School of Medicine, Department of Neuroscience, North Wolfe Street 21205, Baltimore, MD, USA
    Cell 103:919-30. 2000
  3. ncbi request reprint GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase
    H R Luo
    Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Neuron 31:439-51. 2001
  4. ncbi request reprint Identification and characterization of a novel inositol hexakisphosphate kinase
    A Saiardi
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 276:39179-85. 2001
  5. ncbi request reprint Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2
    A L Burnett
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 4:84-7. 1998
  6. ncbi request reprint Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON
    M Fang
    Department of Neuroscience, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Neuron 28:183-93. 2000
  7. pmc The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1
    L D Walensky
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 141:143-53. 1998
  8. ncbi request reprint Cain, a novel physiologic protein inhibitor of calcineurin
    M M Lai
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:18325-31. 1998
  9. ncbi request reprint FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain
    A M Cameron
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:27582-8. 1997
  10. pmc Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission
    A A Pieper
    Departments of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 97:1845-50. 2000

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Nitric oxide and carbon monoxide: parallel roles as neural messengers
    S H Snyder
    Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Brain Res Brain Res Rev 26:167-75. 1998
    ..The role for CO as neurotransmitter is suggested by the altered intestinal motility in mice harboring a genomic deletion of HO2...
  2. ncbi request reprint Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
    K Ye
    Johns Hopkins University School of Medicine, Department of Neuroscience, North Wolfe Street 21205, Baltimore, MD, USA
    Cell 103:919-30. 2000
    ..Overexpression of 4.1N abolishes PIKE effects on PI3K. Activation of nuclear PI3K by PIKE is inhibited by the NGF-stimulated 4.1N translocation to the nucleus. Thus, PIKE physiologically modulates the activation by NGF of nuclear PI3K...
  3. ncbi request reprint GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase
    H R Luo
    Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Neuron 31:439-51. 2001
    ..The association of InsP6K1 with GRAB fits with a role for InsP7 in vesicle exocytosis...
  4. ncbi request reprint Identification and characterization of a novel inositol hexakisphosphate kinase
    A Saiardi
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 276:39179-85. 2001
    ..Intracellular disposition discriminates the three enzymes with InsP(6)K2 being exclusively nuclear, InsP(6)K3 predominating in the cytoplasm, and InsP(6)K1 displaying comparable nuclear and cytosolic densities...
  5. ncbi request reprint Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2
    A L Burnett
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 4:84-7. 1998
    ..Reflex activity of the bulbospongiosus muscle, which mediates ejaculation and ejaculatory behavior, is markedly diminished in mice with targeted deletion of the gene for HO2 (HO2-)...
  6. ncbi request reprint Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON
    M Fang
    Department of Neuroscience, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Neuron 28:183-93. 2000
    ..These findings identify Dexras1 as a novel physiologic NO effector and suggest that anchoring of nNOS to specific targets is a mechanism by which NO signaling is enhanced...
  7. pmc The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1
    L D Walensky
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 141:143-53. 1998
    ..1 (4.1R) in ghosts, inside-out vesicles, and Triton shell preparations. The identification of FKBP13 in erythrocytes, which lack ER, suggests that FKBP13 may additionally function as a component of membrane cytoskeletal scaffolds...
  8. ncbi request reprint Cain, a novel physiologic protein inhibitor of calcineurin
    M M Lai
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:18325-31. 1998
    ..Like calcineurin, cain has a prominent neuronal expression and a wide tissue distribution. Cain's expression pattern in the brain closely resembles that of calcineurin, indicating a physiologic association between the two proteins...
  9. ncbi request reprint FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain
    A M Cameron
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:27582-8. 1997
    ..We propose that FK506 promotes an FKBP12-calcineurin interaction by mimicking structurally similar dipeptide epitopes present within proteins that use FKBP12 to anchor calcineurin to the appropriate physiologic substrates...
  10. pmc Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission
    A A Pieper
    Departments of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 97:1845-50. 2000
    ..An increase in NAD(+) levels after treatment with NMDA antagonists or NOS inhibitors, as well as in nNOS(-/-) mice, indicates that basal glutamate-PARP activity regulates neuronal energy dynamics...
  11. ncbi request reprint Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling
    D M Sabatini
    The Johns Hopkins University School of Medicine, Department of Neuroscience, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 284:1161-4. 1999
    ..The interaction with gephyrin ascribes a function to the large amino-terminal region of an ATM-related protein and reveals a role in signal transduction for the clustering protein gephyrin...
  12. ncbi request reprint Differential neuronal localizations and dynamics of phosphorylated and unphosphorylated type 1 inositol 1,4,5-trisphosphate receptors
    A A Pieper
    The Johns Hopkins University, School of Medicine, Department of Neuroscience, 725 N. Wolfe Street, Baltimore, MD 21205, USA
    Neuroscience 102:433-44. 2001
    ..Phosphorylation dynamics of type 1 inositol 1,4,5-trisphosphate receptors may modulate intracellular Ca(2+) release and influence the cellular response to neurotoxic insults...
  13. ncbi request reprint Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity
    S Blackshaw
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street 813 WBSB, Baltimore, MD 21205, USA
    Neuroscience 119:979-90. 2003
    ..Moreover, our data suggest that NO produced by eNOS in endothelial cells may play a paracrine role in modulating LTP...
  14. ncbi request reprint The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis
    A Saiardi
    Departments of Neuroscience, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 275:24686-92. 2000
    ..Synthesis of the diphosphorylated inositol phosphates is thus revealed to be more complex and interdependent than previously envisaged...
  15. ncbi request reprint Two novel odorant receptor families expressed in spermatids undergo 5'-splicing
    L D Walensky
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:9378-87. 1998
    ..5'-Splicing of OdRs may regulate the expression of functional chemoreceptors...
  16. ncbi request reprint CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95
    S R Jaffrey
    The Johns Hopkins University School of Medicine, Department of Neuroscience, Pharmacology and Molecular Sciences, Baltimore, Maryland 21205, USA
    Neuron 20:115-24. 1998
    ..CAPON may influence nNOS by regulating its ability to associate with PSD95/NMDA receptor complexes...
  17. ncbi request reprint Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases
    A Saiardi
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, 21205, USA
    Curr Biol 9:1323-6. 1999
    ..We have identified a new family of highly conserved inositol-polyphosphate kinases that contain a newly identified, unique consensus sequence...
  18. ncbi request reprint Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage
    M J Eliasson
    Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 19:5910-8. 1999
    ..Our findings provide a cellular localization for nNOS activation in association with ischemic stroke and establish that NO is not likely a direct neurotoxin, whereas its conversion to peroxynitrite is associated with cell death...
  19. ncbi request reprint Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans
    A L Burnett
    Department of Urology, College of Arts and Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 3:571-4. 1997
    ..The mice possess hypertrophic dilated bladders and dysfunctional urinary outlets which do not relax in response to electrical field stimulation or L-arginine. The mice also display increased urinary frequency...
  20. pmc Odorant receptors and desensitization proteins colocalize in mammalian sperm
    L D Walensky
    Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Med 1:130-41. 1995
    ..We have sought to identify and localize these receptors and their regulatory machinery in rat sperm in order to gain further insight into mammalian sperm chemotaxis and odorant receptor physiology...
  21. ncbi request reprint Atypical neural messengers
    D E BaraƱano
    Johns Hopkins University School of Medicine, Dept of Neuroscience, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Trends Neurosci 24:99-106. 2001
    ....
  22. pmc Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton
    P E Burnett
    Department of Neuroscience, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:8351-6. 1998
    ..Subcellular fractionation of rat brain demonstrates that neurabin and p70(S6k) both localize to the soluble fraction of synaptosomes. By way of its PDZ domain, the neuronal-specific neurabin may target p70(S6k) to nerve terminals...
  23. pmc Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy
    C C Watkins
    Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 106:373-84. 2000
    ..In diabetic animals, delayed gastric emptying can be reversed with a phosphodiesterase inhibitor, sildenafil. These findings have implications for novel therapeutic approaches and may clarify the etiology of diabetic gastropathy...
  24. ncbi request reprint A novel pineal night-specific ATPase encoded by the Wilson disease gene
    J Borjigin
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 19:1018-26. 1999
    ..These studies suggest a potential role of rhythmic copper metabolism in pineal and/or retina circadian function...
  25. ncbi request reprint Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia
    S Dore
    Department of Neuroscience, The Johns Hopkins University, School of Medicine, 725 N Wolfe Street, MD, Baltimore 21205, USA
    Neuroscience 99:587-92. 2000
    ..In intact mice, we show an increased incidence of apoptotic morphology in the penumbra area surrounding the infarct core in HO2(-/-) mice undergoing transient focal ischemia...
  26. ncbi request reprint Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae
    A Saiardi
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEBS Lett 468:28-32. 2000
    ..Transcriptional control by ipmk reflects that it is a pivotal regulator of nuclear mRNA export via inositol phosphate metabolism...
  27. ncbi request reprint Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux
    A M Cameron
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 83:463-72. 1995
    ..Calcineurin anchored to the IP3R via FKBP12 regulates the phosphorylation status of the receptor, resulting in a dynamic Ca(2+)-sensitive regulation of IP3-mediated Ca2+ flux...
  28. ncbi request reprint Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
    D S Bredt
    Department of Neuroscience, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205
    Nature 351:714-8. 1991
    ..The only known mammalian enzyme with close homology is cytochrome P-450 reductase...
  29. ncbi request reprint Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
    S R Jaffrey
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Cell Biol 3:193-7. 2001
    ..Targets of NO include metabolic, structural and signalling proteins that may be effectors for neuronally generated NO. These findings establish protein S-nitrosylation as a physiological signalling mechanism for nNOS...
  30. ncbi request reprint A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1
    L D Walensky
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA
    J Neurosci 19:6457-67. 1999
    ....
  31. pmc Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion
    T M Ma
    The Solomon H Snyder Department of Neuroscience, Baltimore, MD, USA
    Mol Psychiatry 18:557-67. 2013
    ....
  32. ncbi request reprint Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain
    A H Sharp
    Laboratory of Cellular Neurobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Comp Neurol 406:207-20. 1999
    ..The IP3R3 may be involved in regulation of neurotransmitter or neuropeptide release in terminals within specific nuclei of the basal forebrain and limbic system...
  33. ncbi request reprint Nocturnal motor coordination deficits in neuronal nitric oxide synthase knock-out mice
    L J Kriegsfeld
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroscience 89:311-5. 1999
    ..These previous studies were all conducted during the day (between 1400 and 1600, lights on at 0700). We now report striking, discrete abnormalities in balance and motor coordination in nNOS-mice reflected selectively at night...
  34. ncbi request reprint Haem oxygenase-1 prevents cell death by regulating cellular iron
    C D Ferris
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Cell Biol 1:152-7. 1999
    ..Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability...
  35. pmc RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
    P E Burnett
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:1432-7. 1998
    ..This raises the possibility that, in vivo, an unidentified kinase analogous to p70(S6k) is activated by RAFT1 phosphorylation and acts at the rapamycin-sensitive phosphorylation sites of 4E-BP1...
  36. ncbi request reprint Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation
    N A Cohen
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 17:759-67. 1996
    ..Stimulation of PKA in intact cells causes rapid dissociation of the channel from PSD-95. This work identifies a physiological mechanism for regulating ion channel interactions with the postsynaptic density...
  37. ncbi request reprint Aggressive behavior in male mice lacking the gene for neuronal nitric oxide synthase requires testosterone
    L J Kriegsfeld
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Brain Res 769:66-70. 1997
    ..Testosterone replacement restored aggression to precastration levels in both genotypes. These data provide evidence that increased aggressive behavior of nNOS - /- mice, like aggression in WT mice, is testosterone-dependent...
  38. ncbi request reprint Parapinopsin, a novel catfish opsin localized to the parapineal organ, defines a new gene family
    S Blackshaw
    Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, Maryland 21205, USA
    J Neurosci 17:8083-92. 1997
    ..These data imply that phototransduction in these sites of extraretinal photoreception must be mediated by novel opsins...
  39. ncbi request reprint Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor
    K Ye
    Departments of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 19:10747-56. 1999
    ..1N. Thus, nuclear 4.1N appears to mediate the antiproliferative actions of NGF by antagonizing the role of NuMA in mitosis...
  40. pmc Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate
    A Saiardi
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:2306-11. 2001
    ..mIPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-InsP(4)) from InsP(5). Additionally, mIPMK forms InsP(4) from Ins(1,4,5)P(3) and InsP(5) from Ins(1,3,4,5)P(4)...
  41. ncbi request reprint Autoradiographic imaging of phosphoinositide turnover in the brain
    P M Hwang
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Science 249:802-4. 1990
    ....
  42. ncbi request reprint Characterization of a neutral, divalent cation-sensitive endopeptidase: a possible role in neuropeptide processing
    S Supattapone
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Brain Res 427:173-81. 1988
    ..The endopeptidase has a neutral pH optimum, is sensitive to divalent cations and thiol reagents, and can cleave on either the amino or carboxyl side of some but not all internal basic amino acids...
  43. pmc Cloning and expression of two brain-specific inwardly rectifying potassium channels
    D S Bredt
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 92:6753-7. 1995
    ..BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation...
  44. pmc A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX
    X Li
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:1876-81. 1998
    ..These data suggest that Crx may play a crucial role in regulating pineal gene expression through interactions with PIRE...
  45. pmc Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor
    S M Voglmaier
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:4305-10. 1996
    ..The purified enzyme transfers a phosphate from PP-IP5 to ADP to form ATP. This ATP synthase activity indicates the high phosphate group transfer potential of PP-IP5 and may represent a physiological role for PP-IP5...
  46. ncbi request reprint PIN: an associated protein inhibitor of neuronal nitric oxide synthase
    S R Jaffrey
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 274:774-7. 1996
    ..Binding of PIN destabilizes the nNOS dimer, a conformation necessary for activity. These results suggest that PIN may regulate numerous biological processes through its effects on nitric oxide synthase activity...
  47. pmc Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase
    A L Burnett
    Department of Urology, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Mol Med 2:288-96. 1996
    ..To clarify the source of NO in penile function, we have examined mice with targeted deletion of the nNOS gene (nNOS- mice)...
  48. pmc Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide
    R Zakhary
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:14848-53. 1997
    ..In nNOSDelta/Delta animals, NOS inhibitors selectively lost their efficacy, and HO inhibitors were inactive in HO-2(Delta)/Delta animals...
  49. ncbi request reprint The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis
    M M Lai
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 275:34017-20. 2000
    ....
  50. pmc Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide
    C J Lowenstein
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 90:9730-4. 1993
    ..Delineation of these two cooperative regions explains at the level of transcription how IFN-gamma and LPS act in concert to induce maximally the mac-NOS gene and, furthermore, how IFN-gamma augments the inflammatory response to LPS...
  51. ncbi request reprint Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain
    A H Sharp
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Neurosci 13:3051-63. 1993
    ..These results suggest that the IP3- and ryanodine-sensitive Ca2+ pools have largely distinct roles in controlling intracellular Ca2+ levels, though in some sites they may interact to varying degrees...
  52. ncbi request reprint Novel neurotransmitters and their neuropsychiatric relevance
    S H Snyder
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Am J Psychiatry 157:1738-51. 2000
    ..The purpose of this review is to integrate insights regarding novel neurotransmitters or neuromodulators of neuropsychiatric significance...
  53. pmc Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation
    S K Danoff
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 88:2951-5. 1991
    ..The phosphorylation kinetics by cAMP-dependent protein kinase and the phosphopeptide maps differ for inositol 1,4,5-trisphosphate receptors purified from tissues predominantly expressing different forms of the transcript...
  54. pmc Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission
    H Wolosker
    Departments of Neuroscience, The Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 96:13409-14. 1999
    ..Occurrence of serine racemase in the brain demonstrates the conservation of D-amino acid metabolism in mammals with implications for the regulation of N-methyl-D-aspartate neurotransmission through glia-neuronal interactions...
  55. ncbi request reprint Differential interaction of guanabenz with receptor binding sites in rat brain and kidney
    R J Gould
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Res Commun Chem Pathol Pharmacol 66:3-19. 1989
    ..The remainder of the binding resembles the non-adrenergic binding in kidney. The relationship of this unique binding site to the pharmacologic actions of guanabenz is currently not known...
  56. pmc Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals
    M Ruat
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 92:3161-5. 1995
    ..Cerebral arteries display an intense network of CaSR immunoreactive fibers associated with vessel innervation. CaSR on nerve terminal membranes may regulate neurotransmitter disposition in response to Ca2+ levels in the synaptic space...
  57. ncbi request reprint Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain
    S Blackshaw
    The Johns Hopkins University, School of Medicine, Departments of Neuroscience, Pharmacology and Molecular Sciences, and Psychiatry, Baltimore, Maryland 21205, USA
    J Neurosci 19:3681-90. 1999
    ..Encephalopsin is the first putative extraocular opsin identified in mammals and may play a role in encephalic photoreception...
  58. pmc FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle
    B Aghdasi
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:2425-30. 2001
    ..Thus, FKBP12 is a physiologic regulator of cell cycle acting by normally down-regulating TGF-beta receptor signaling...
  59. ncbi request reprint Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily
    P M Hwang
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Neurosci 13:1569-76. 1993
    ..These localizations may reflect specialized delayed rectifier functions and targeting properties manifested differentially by K+ channel subfamily members...
  60. ncbi request reprint Developmental regulation of adenosine A1 receptors, uptake sites and endogenous adenosine in the chick retina
    R P de Carvalho
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Brain Res Dev Brain Res 70:87-95. 1992
    ..The results indicate that elements of a putative purinergic system differentiate at specific localizations early in retinal development...
  61. ncbi request reprint Identification and purification of diphosphoinositol pentakisphosphate kinase, which synthesizes the inositol pyrophosphate bis(diphospho)inositol tetrakisphosphate
    C F Huang
    Department of Neuroscience, Pharmacology and Molecular Sciences, and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 37:14998-5004. 1998
    ..This ATP synthase activity is an indication of the high phosphoryl group transfer potential of bis-PP-IP4 and may represent a physiological role for PP-IP5 and bis-PP-IP4...
  62. ncbi request reprint Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
    M J Eliasson
    Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 3:1089-95. 1997
    ....
  63. pmc Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes
    A A Pieper
    Departments of Neuroscience, Pharmacology and Molecular Sciences, and Psychiatry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 96:3059-64. 1999
    ..Partial protection occurs in PARP +/- animals. Thus, PARP activation may participate in the pathophysiology of type I diabetes, for which PARP inhibitors might afford therapeutic benefit...
  64. ncbi request reprint Molecular cloning of Ebnerin, a von Ebner's gland protein associated with taste buds
    X J Li
    Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, Maryland 21205, USA
    J Biol Chem 270:17674-9. 1995
    ..The unique structure and localization of Ebnerin suggest that it may function as a binding protein in saliva for the regulation of taste sensation...
  65. ncbi request reprint Molecular rhythms in the pineal gland
    X Li
    Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, Maryland 21205, USA
    Curr Opin Neurobiol 8:648-51. 1998
    ..This regulatory element is present in promoters of pineal-selective enzymes, such as N-acetyltransferase, hydroxyindole-O-methyl transferase, and pineal night-specific ATPase...
  66. ncbi request reprint The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition
    M A Bianchet
    Department of Biophysics and Biophysical Chemistry, University of Pisa, Italy
    Nat Struct Biol 3:934-9. 1996
    ....
  67. ncbi request reprint Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family
    H Attramadal
    Howard Hughes Medical Research Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 267:17882-90. 1992
    ..Furthermore, immunoelectron microscopy shows that the beta-arrestins are appropriately situated at postsynaptic sites to act in concert with beta ARK to regulate G protein-coupled neurotransmitter receptors...
  68. pmc Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules
    L D Fricker
    Proc Natl Acad Sci U S A 79:3886-90. 1982
    ..Enkephalin convertase appears to be associated selectively and physiologically with biosynthesis of the enkephalins...
  69. ncbi request reprint Molecular cloning of odorant-binding protein: member of a ligand carrier family
    J Pevsner
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Science 241:336-9. 1988
    ..Other members of an alpha 2-microglobulin superfamily bind and transport hydrophobic ligands. Thus, OBP probably binds and carries odorants within the nasal epithelium to putative olfactory receptors...
  70. ncbi request reprint Structure of the PIN/LC8 dimer with a bound peptide
    J Liang
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 1301, USA
    Nat Struct Biol 6:735-40. 1999
    ..A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein...
  71. pmc Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor
    R Simantov
    Proc Natl Acad Sci U S A 73:2515-9. 1976
    ..Sodium and manganese effects on opiate receptor interactions show that both peptides are agonists, whereas leucine enkephalin may be a "purer" agonist than methionine enkephalin...
  72. pmc Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier
    M W McEnery
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185
    Proc Natl Acad Sci U S A 89:3170-4. 1992
    ..VDAC and ADC, outer and inner mitochondrial membrane channel proteins, respectively, together with the 18-kDa subunit, may comprise mBzR at functionally important transport sites at the junction of two mitochondrial membranes...
  73. ncbi request reprint Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2
    S M Voglmaier
    Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205
    Biochem Biophys Res Commun 187:158-63. 1992
    ..The IP6 receptor protein analyzed by SDS-PAGE contains a series of subunits which are the same as those of AP-2. Antibodies to AP-2 react with the IP6 receptor protein in immunoblot analysis...
  74. ncbi request reprint Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites
    D S Bredt
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 267:10976-81. 1992
    ..We demonstrate that purified NOS is labeled by a photoaffinity derivative of calmodulin. These recognition sites on NOS provide multiple means for regulation of NO levels and "cross-talk" between second messenger systems...