K K Singh

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells
    Robert Delsite
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Room 143, Baltimore, MD 21231, USA
    Mol Cancer 1:6. 2002
  2. ncbi request reprint The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion
    K K Singh
    Johns Hopkins Oncology Center, Baltimore, MD 21231 1000, USA
    Free Radic Biol Med 29:1043-50. 2000
  3. pmc Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants
    K K Singh
    Johns Hopkins Oncology Center, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    Nucleic Acids Res 29:1381-8. 2001
  4. pmc Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype
    A Chatterjee
    Radiation Research Program, Johns Hopkins Oncology Center, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    Nucleic Acids Res 29:4935-40. 2001
  5. ncbi request reprint Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair
    A Parker
    Department of Biochemistry and Molecular Biology, The University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 276:5547-55. 2001
  6. ncbi request reprint Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiae
    Marija Vujcic
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:9740-9. 2007
  7. ncbi request reprint Mitochondria as determinant of nucleotide pools and chromosomal stability
    Claus Desler
    Department of Science, Systems and Models, Roskilde University, 4000 Roskilde, Denmark
    Mutat Res 625:112-24. 2007
  8. pmc Saccharomyces cerevisiae polymerase zeta functions in mitochondria
    Hengshan Zhang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Genetics 172:2683-8. 2006
  9. pmc Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
    Sushant Kachhap
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans St, Baltimore, MD 21231, USA
    Mol Cancer 3:32. 2004
  10. ncbi request reprint Mitochondria damage checkpoint in apoptosis and genome stability
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Room 247, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    FEMS Yeast Res 5:127-32. 2004

Collaborators

Detail Information

Publications28

  1. pmc Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells
    Robert Delsite
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Room 143, Baltimore, MD 21231, USA
    Mol Cancer 1:6. 2002
    ..Mutations in mitochondrial genes encoding the 13 subunits have been reported in a variety of cancers. However, little is known about the nuclear response to impairment of mitochondrial function in human cells...
  2. ncbi request reprint The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion
    K K Singh
    Johns Hopkins Oncology Center, Baltimore, MD 21231 1000, USA
    Free Radic Biol Med 29:1043-50. 2000
    ..These results suggest that Sln1p-Ssk1p and Sho1p signal transduction pathways participate in oxidative stress response. However, this response to oxidative stress is limited to specific oxidants...
  3. pmc Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants
    K K Singh
    Johns Hopkins Oncology Center, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    Nucleic Acids Res 29:1381-8. 2001
    ..Together, these studies provide in vivo evidence for the repair of oxidative lesions in the mitochondrial genome by human and yeast Ogg1 proteins. Our study also identifies Ogg2 as a suppressor of oxidative mutagenesis in mitochondria...
  4. pmc Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype
    A Chatterjee
    Radiation Research Program, Johns Hopkins Oncology Center, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    Nucleic Acids Res 29:4935-40. 2001
    ..Our study suggests that deamination of cytosine is a frequent event in S.cerevisiae mitochondria and both yeast and human Ung1p repairs deaminated cytosine in mitochondria...
  5. ncbi request reprint Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair
    A Parker
    Department of Biochemistry and Molecular Biology, The University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 276:5547-55. 2001
    ..The PCNA- and RPA-binding sites of hMYH are further confirmed by peptide and antibody titration. These results suggest that hMYH repair is a long patch base excision repair pathway...
  6. ncbi request reprint Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiae
    Marija Vujcic
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:9740-9. 2007
    ..cerevisiae from arsenic-induced toxicity. Together, our studies suggest that evolutionary conserved mitochondrial networks identified in yeast S. cerevisiae must play an important role in arsenic-induced carcinogenesis in humans...
  7. ncbi request reprint Mitochondria as determinant of nucleotide pools and chromosomal stability
    Claus Desler
    Department of Science, Systems and Models, Roskilde University, 4000 Roskilde, Denmark
    Mutat Res 625:112-24. 2007
    ..Our results suggest that mitochondria are central players in maintaining genomic stability and in controlling essential nuclear processes such as upholding a balanced supply of nucleotides...
  8. pmc Saccharomyces cerevisiae polymerase zeta functions in mitochondria
    Hengshan Zhang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Genetics 172:2683-8. 2006
    ..Supporting this evidence, both polymerase zeta and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase zeta and Rev1 proteins function in the mitochondria...
  9. pmc Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
    Sushant Kachhap
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans St, Baltimore, MD 21231, USA
    Mol Cancer 3:32. 2004
    ..UDG in human cells is present in both the nucleus and mitochondrial compartments. Although, UDG's role in the nucleus is well established its role in mitochondria is less clear...
  10. ncbi request reprint Mitochondria damage checkpoint in apoptosis and genome stability
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Room 247, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    FEMS Yeast Res 5:127-32. 2004
    ..This study reveals molecular genetic mechanisms underlying a role for mitochondria in carcinogenesis in humans...
  11. ncbi request reprint Mitochondrial dysfunction is a common phenotype in aging and cancer
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Ann N Y Acad Sci 1019:260-4. 2004
    ..These observations suggest that the mitochondrial dysfunction that accompanies aging may exert a major influence on carcinogenesis...
  12. ncbi request reprint Genome-wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiae
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Ann N Y Acad Sci 1011:284-98. 2004
    ..Together, our data suggest that gene(s) involved in mitochondria-to-nucleus communication play a role in mutagenesis and may be implicated in carcinogenesis...
  13. ncbi request reprint A colony color method identifies the vulnerability of mitochondria to oxidative damage
    Grace Kim
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street Room 143, Baltimore, MD 21231, USA
    Mutagenesis 17:375-81. 2002
    ....
  14. pmc Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae
    Anne Karin Rasmussen
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
    Nucleic Acids Res 31:3909-17. 2003
    ..Together, our data suggest that mitochondrial dysfunction is mutagenic and multiple pathways are involved in this nuclear mutator phenotype...
  15. ncbi request reprint Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus
    Robert L Delsite
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 212312, USA
    Mutagenesis 18:497-503. 2003
    ..It also provides insights into the development of mitochondrial disease as a consequence of cancer therapy...
  16. ncbi request reprint Xenogenic transfer of isolated murine mitochondria into human rho0 cells can improve respiratory function
    Eyad Katrangi
    Bouve College of Health Sciences, School of Pharmacy, Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Rejuvenation Res 10:561-70. 2007
    ....
  17. ncbi request reprint Mitochondria as targets for detection and treatment of cancer
    Josephine S Modica-Napolitano
    Department of Biology, Merrimack College, North Andover, MA 01845, USA
    Expert Rev Mol Med 4:1-19. 2002
    ....
  18. ncbi request reprint Mitochondrial impairment in p53-deficient human cancer cells
    Shaoyu Zhou
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Room 143, Baltimore, MD 21231, USA
    Mutagenesis 18:287-92. 2003
    ..Together, our study suggests that p53 is involved in regulation of COXII at the protein level but not at the mRNA level. p53 does not affect mtDNA mutation or mitochondrial ultrastructure...
  19. ncbi request reprint Mitochondria and human cancer
    Josephine S Modica-Napolitano
    Department of Cancer Genetics, BLSC Room L3 316, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Curr Mol Med 7:121-31. 2007
    ..The potential use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents is also discussed...
  20. ncbi request reprint Meeting report: mitochondrial DNA and cancer epidemiology
    Mukesh Verma
    Analytic Epidemiology Research Branch, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Res 67:437-9. 2007
  21. ncbi request reprint Mitochondria damage checkpoint, aging, and cancer
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Ann N Y Acad Sci 1067:182-90. 2006
    ..Alternatively, mutations occur in the mitochondrial and/or nuclear DNA, resulting in tumorigenesis...
  22. ncbi request reprint Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer
    Mariola Kulawiec
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Biol Ther 5:967-75. 2006
    ..Our study opens an avenue for identification of retrograde proteins as potential tumor suppressors or oncogenes involved in carcinogenesis...
  23. pmc Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer 5:14. 2006
    ..To address this issue, the in situ level of m-aconitase enzyme was determined by immunohistochemical analysis of prostate cancer tissue sections and malignant prostate cell lines...
  24. ncbi request reprint Cellular aging of mitochondrial DNA-depleted cells
    Sun Young Park
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Republic of Korea
    Biochem Biophys Res Commun 325:1399-405. 2004
    ..Features simulating aged cells were also observed in MDA-MB-435 rho(0) cells. These results support the mitochondrial theory of aging, and suggest that rho(0) cells could serve as an in vitro model for aged cells...
  25. ncbi request reprint Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors
    Mohamed Mokhtar Desouki
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Biol Ther 4:1367-73. 2005
    ..Furthermore, our studies suggest that mitochondria control Nox1 redox signaling and the loss of control of this signaling contributes to breast and ovarian tumorigenesis...
  26. ncbi request reprint Mitochondrial correlation microscopy and nanolaser spectroscopy - new tools for biophotonic detection of cancer in single cells
    Paul L Gourley
    Biomolecular Interfaces and Systems, Sandia National Laboratories, Albuquerque, NM 87185, USA
    Technol Cancer Res Treat 4:585-92. 2005
    ..These optical methods represent powerful new tools that hold promise for detecting cancer at an early stage and may help to limit delays in diagnosis and treatment...
  27. ncbi request reprint Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Room 247, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Gene 354:140-6. 2005
    ..Taken together, these studies suggest that inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis and that APE1 mediates this process...
  28. ncbi request reprint Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 65:1105-11. 2005
    ..33; 95% confidence interval, 0.13-0.80; P = 0.01). These data indicate that gene variants that impact oxidative stress modify prognosis after treatment for breast cancer...