Machiko Shirahata

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Carotid chemoreceptor development in mice
    Machiko Shirahata
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 185:20-9. 2013
  2. ncbi request reprint Role of acetylcholine in neurotransmission of the carotid body
    Machiko Shirahata
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 157:93-105. 2007
  3. ncbi request reprint Identification of M1 and M2 muscarinic acetylcholine receptors in the cat carotid body chemosensory system
    M Shirahata
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Neuroscience 128:635-44. 2004
  4. ncbi request reprint Genetic influence on carotid body structure in DBA/2J and A/J strains of mice
    Shigeki Yamaguchi
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 580:105-9; discussion 351-9. 2006
  5. pmc The impact of adenosine and an A2A adenosine receptor agonist on the ACh-induced increase in intracellular calcium of the glomus cells of the cat carotid body
    Robert S Fitzgerald
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, MD, USA
    Brain Res 1301:20-33. 2009
  6. pmc Behavioral and respiratory characteristics during sleep in neonatal DBA/2J and A/J mice
    Alexander Balbir
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, E7610, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Brain Res 1241:84-91. 2008
  7. ncbi request reprint Differential expression of oxygen sensitivity in voltage-dependent K channels in inbred strains of mice
    Toshiki Otsubo
    Department of Environmental Health Science, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 580:209-14; discussion 351-9. 2006
  8. ncbi request reprint Genetic regulation of chemoreceptor development in DBA/2J and A/J strains of mice
    Alexander Balbir
    Department of Environmental Health Sciences, Division of Physiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Adv Exp Med Biol 580:99-104; discussion 351-9. 2006
  9. pmc The impact of hydrogen sulfide (H₂S) on neurotransmitter release from the cat carotid body
    Robert S Fitzgerald
    Department of Environmental Health Sciences Division of Physiology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 176:80-9. 2011
  10. ncbi request reprint The impact of adenosine on the release of acetylcholine, dopamine, and norepinephrine from the cat carotid body
    Robert S Fitzgerald
    Department of Environmental Health Sciences, Division of Physiology, Bloomberg School of Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Neurosci Lett 367:304-8. 2004

Research Grants

  1. CAROTID BODY EXCITATION--NEW CONCEPT
    Machiko Shirahata; Fiscal Year: 2002
  2. Modulation of Voltage-gated K Channels in Glomus Cells
    Machiko Shirahata; Fiscal Year: 2006

Collaborators

Detail Information

Publications33

  1. pmc Carotid chemoreceptor development in mice
    Machiko Shirahata
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 185:20-9. 2013
    ..Various inbred strains with well-designed experiments will provide useful information regarding genetic mechanisms of the postnatal carotid chemoreceptor development. Also, targeted gene deletion is a critical approach...
  2. ncbi request reprint Role of acetylcholine in neurotransmission of the carotid body
    Machiko Shirahata
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 157:93-105. 2007
    ..Development and environment influence cholinergic biology. We discuss these issues in light of current knowledge of neuroscience...
  3. ncbi request reprint Identification of M1 and M2 muscarinic acetylcholine receptors in the cat carotid body chemosensory system
    M Shirahata
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Neuroscience 128:635-44. 2004
    ..Thus, activation of M1 mAChRs on afferent nerve endings may be linked to the increase in neural output during hypoxia. Further, M1 and M2 mAChRs on glomus cells modulate the release of neurotransmitters...
  4. ncbi request reprint Genetic influence on carotid body structure in DBA/2J and A/J strains of mice
    Shigeki Yamaguchi
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 580:105-9; discussion 351-9. 2006
  5. pmc The impact of adenosine and an A2A adenosine receptor agonist on the ACh-induced increase in intracellular calcium of the glomus cells of the cat carotid body
    Robert S Fitzgerald
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, MD, USA
    Brain Res 1301:20-33. 2009
    ..This suggested the possible involvement of a new path in the action. Potential mechanisms to explain the phenomena are discussed...
  6. pmc Behavioral and respiratory characteristics during sleep in neonatal DBA/2J and A/J mice
    Alexander Balbir
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, E7610, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Brain Res 1241:84-91. 2008
    ..Carotid body-mediated respiratory responses (decreased ventilation upon hyperoxia and increased ventilation upon mild hypoxia) during sleep were clearly observed in these neonatal mice with or without EMG instrumentation...
  7. ncbi request reprint Differential expression of oxygen sensitivity in voltage-dependent K channels in inbred strains of mice
    Toshiki Otsubo
    Department of Environmental Health Science, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 580:209-14; discussion 351-9. 2006
  8. ncbi request reprint Genetic regulation of chemoreceptor development in DBA/2J and A/J strains of mice
    Alexander Balbir
    Department of Environmental Health Sciences, Division of Physiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Adv Exp Med Biol 580:99-104; discussion 351-9. 2006
  9. pmc The impact of hydrogen sulfide (H₂S) on neurotransmitter release from the cat carotid body
    Robert S Fitzgerald
    Department of Environmental Health Sciences Division of Physiology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 176:80-9. 2011
    ..Since during hypoxia H(2)S levels rise, the glomus cells responding very actively to hypoxia may be protected from over-exertion by the H(2)S opening of the K(ATP) channels...
  10. ncbi request reprint The impact of adenosine on the release of acetylcholine, dopamine, and norepinephrine from the cat carotid body
    Robert S Fitzgerald
    Department of Environmental Health Sciences, Division of Physiology, Bloomberg School of Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Neurosci Lett 367:304-8. 2004
    ..Adenosine significantly increased the release of ACh, but significantly decreased the hypoxia-induced release of DA. Potential mechanisms for these changes are reviewed...
  11. ncbi request reprint Nicotinic acetylcholine receptor channels in cat chemoreceptor cells
    Tomoko Higashi
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 536:285-90. 2003
  12. ncbi request reprint A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice
    Alexander Balbir
    Division of Physiology, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, E7610, 615 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Lung Cell Mol Physiol 292:L704-15. 2007
    ..Particularly, Gdnf, Bmp2, Kcnmb2, Tph1, Hif1a, and Arnt2 may contribute to the functional differences in the CB between the two strains. Bmp2, Phox2b, Dlx2, and Msx2 may be important for the morphological differences...
  13. ncbi request reprint The effect of a nitric oxide donor, sodium nitroprusside, on the release of acetylcholine from the in vitro cat carotid body
    Robert S Fitzgerald
    Division of Physiology, Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Neurosci Lett 385:148-52. 2005
    ..The results are consistent with a previous report in which l-arginine, an NO precursor, had the same reducing effect. Possible mechanisms are discussed...
  14. ncbi request reprint Hypoxic augmentation of neuronal nicotinic acetylcholine receptors and carotid body function
    Machiko Shirahata
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 536:269-75. 2003
  15. ncbi request reprint Diverse cholinergic receptors in the cat carotid chemosensory unit
    Serabi Hirasawa
    Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, USA
    Adv Exp Med Biol 536:313-9. 2003
  16. ncbi request reprint Voltage-dependent K channels in mouse glomus cells are modulated by acetylcholine
    Toshiki Otsubo
    Departments of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 580:319-24; discussion 351-9. 2006
  17. ncbi request reprint Hypoxic modulation of the cholinergic system in the cat carotid glomus cell
    Jeffrey A Mendoza
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 580:275-80; discussion 351-9. 2006
  18. ncbi request reprint ACh differentially modulates voltage-gated K channels in glomus cells between DBA/2J and A/J strains of mice
    Shigeki Yamaguchi
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 536:263-8. 2003
  19. doi request reprint The impact of hypoxia and low glucose on the release of acetylcholine and ATP from the incubated cat carotid body
    Robert S Fitzgerald
    Department of Environmental Health Sciences, Division of Physiology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Brain Res 1270:39-44. 2009
    ..The data suggested the possibility that in the cat the increased CB neural output in response to low glucose might be due primarily to ACh...
  20. ncbi request reprint Neurotransmitter relationships in the hypoxia-challenged cat carotid body
    Robert S Fitzgerald
    Department of Environmental Health Sciences Division of Physiology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Adv Exp Med Biol 536:255-61. 2003
  21. ncbi request reprint Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains
    Arnon E Rubin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 168:1520-7. 2003
    ..Our data imply that individuals with low hypoxic sensitivity may be at a greater risk for hypoxia-related complications of obstructive sleep apnea...
  22. pmc Divergent postnatal development of the carotid body in DBA/2J and A/J strains of mice
    Eric W Kostuk
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 112:490-500. 2012
    ..The current study indicates the critical postnatal period for developing distinctive morphology of the carotid body in these mice. Further studies are required to further elucidate a role of Msx2 and other uninvestigated genes...
  23. ncbi request reprint L-arginine's effect on the hypoxia-induced release of acetylcholine from the in vitro cat carotid body
    Robert S Fitzgerald
    Division of Physiology, Department of Environ Health Sciences, Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, 615 N Wolfe St, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 147:11-7. 2005
    ..The data are consistent with those reports showing that NO donors and precursors reduce the hypoxia-induced increase in CBNA, and further support a role for ACh in the hypoxia-induced increase in CBNA...
  24. doi request reprint ATP release from the carotid bodies of DBA/2J and A/J inbred mouse strains
    Pejmon Pashai
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Adv Exp Med Biol 758:279-85. 2012
    ....
  25. ncbi request reprint The impact of PCO2 and H+ on the release of acetylcholine from the cat carotid body
    Robert S Fitzgerald
    Division of Physiology, Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Neurosci Lett 397:205-9. 2006
    ..In five of the six animals the responses to RAC and MtAC were compared to the responses to hypoxia. The latter were statistically indistinguishable from the former two...
  26. ncbi request reprint Patch clamp study of mouse glomus cells using a whole carotid body
    Shigeki Yamaguchi
    Division of Physiology, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Neurosci Lett 357:155-7. 2004
    ..The results suggest electrophysiological similarities of glomus cells among the cat, the rat, and the DBA/2J mouse. The method appears useful for physiological experiments...
  27. doi request reprint Inflammation in the carotid body during development and its contribution to apnea of prematurity
    Estelle B Gauda
    Department of Pediatrics, Division of Neonatology, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Respir Physiol Neurobiol 185:120-31. 2013
    ....
  28. ncbi request reprint Oxygen sensing in the carotid body and its relation to heart failure
    Robert S Fitzgerald
    Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 9:745-9. 2007
    ..Finally, a brief glance at the operation of the CB in chronic heart failure patients is presented. Specifically, the role of nitric oxide, NO, is discussed...
  29. ncbi request reprint Characterization of nicotinic acetylcholine receptors in cultured arterial chemoreceptor cells of the cat
    Tomoko Higashi
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Brain Res 974:167-75. 2003
    ..These results indicate that cultured cat glomus cells possess functional nAChRs, and that their characteristics are consistent with those of alpha3, alpha4 and beta2 containing nAChRs...
  30. pmc Differential Expression of Large-Conductance Ca-Activated K Channels in the Carotid Body between DBA/2J and A/J Strains of Mice
    Toshiki Otsubo
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University Baltimore, MD, USA
    Front Cell Neurosci 5:19. 2011
    ..Differential expression of BK channel β subunits in the CBs may, at least in part, explain the different hypoxic sensitivity in these mouse strains...
  31. ncbi request reprint Structural and functional differences of the carotid body between DBA/2J and A/J strains of mice
    Shigeki Yamaguchi
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Appl Physiol 94:1536-42. 2003
    ..These data suggest that genetic determinants account for the strain differences in the structure and function of the carotid body...
  32. pmc A Short-Term Fasting in Neonates Induces Breathing Instability and Epigenetic Modification in the Carotid Body
    Machiko Shirahata
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD, USA
    Adv Exp Med Biol 860:187-93. 2015
    ..Epigenetic effect on CB function/activity may be related to the prolonged effect of fasting on ventilation. ..
  33. ncbi request reprint Vecuronium directly inhibits hypoxic neurotransmission of the rat carotid body
    Ayuko Igarashi
    Department of Anesthesiology, Shinjo Prefectural Hospital, Yamagata, Japan
    Anesth Analg 94:117-22, table of contents. 2002
    ..These results indicate that vecuronium directly inhibits the carotid body neural response to hypoxia, possibly because of the inhibition of neuronal nicotinic receptors in the carotid body...

Research Grants2

  1. CAROTID BODY EXCITATION--NEW CONCEPT
    Machiko Shirahata; Fiscal Year: 2002
    ....
  2. Modulation of Voltage-gated K Channels in Glomus Cells
    Machiko Shirahata; Fiscal Year: 2006
    ..These diseases are known to have a genetic basis. ..