Affiliation: Johns Hopkins Bloomberg School of Public Health
- A Virus-based Vaccine May Prevent Cervical CancerPatti E Gravitt
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Curr Infect Dis Rep 7:125-131. 2005..Attempts are being made to prepare vaccines that can be administered more easily to large populations...
- Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, IndiaA Pavani Sowjanya
Centre for DNA Fingerprinting and Diagnostics, Hyderabad, A P India
BMC Infect Dis 5:116. 2005..We investigated the genotype distribution of high-risk HPV types in squamous cell carcinomas and the prevalence of high-risk HPV in cervicovaginal samples in the southern state of Andhra Pradesh (AP), India...
- Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virusCharles G Eberhart
Department of Pathology, Johns Hopkins University School of Medicine, Ross Bldg 558, 720 Rutland Ave, Baltimore, MD 21205, USA
BMC Cancer 5:19. 2005..We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors. The presence of JC virus, which results in p53 protein accumulation, was also examined...
- Investigation of the SV40--human cancer association: look for the full signature of the virusK V Shah
Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Dis Markers 17:159-61. 2001..In view of the rarity of some of the tumors reported to be associated with SV40, a multi-institutional investigation initiated and coordinated by the NIH would be most effective...
- Simian virus 40 (SV40) and human cancer: a review of the serological dataKeerti V Shah
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Rev Med Virol 14:231-9. 2004..Serological data thus do not support the possibility that SV40 is circulating in human communities or that it is associated with human cancer...
- Causality of mesothelioma: SV40 questionKeerti V Shah
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Thorac Surg Clin 14:497-504. 2004..The weaknesses in the evidence linking SV40 with mesothelioma are summarized in Box 11 It seems unlikely that infection with SV40 contributes to the development of human mesothelioma or any other human cancer...
- SV40 and human cancer: a review of recent dataKeerti V Shah
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Int J Cancer 120:215-23. 2007..In summary, the most recent evidence does not support the notion that SV40 contributed to the development of human cancers...
- Genital HPVs in the aerodigestive tract: etiologic association with a subset of oropharyngeal/tonsillar cancers and with recurrent respiratory papillomatosisKeerti V Shah
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Dis Markers 23:235-45. 2007
- Determinants of newly detected human papillomavirus infection in HIV-infected and HIV-uninfected injection drug using womenDarcy F Phelan
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
Sex Transm Dis 36:149-56. 2009..We sought to identify factors associated with newly detected human papillomavirus (HPV) infection in a high-risk cohort of injection drug using women in Baltimore, MD...
- Serum immunoglobulin G response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and risk-matched HIV-negative womenRaphael P Viscidi
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Infect Dis 187:194-205. 2003..Despite the higher prevalence of HPV infection in this group, most HIV-positive women are able to control HPV-16 replication at the cervix, and reactivation, if it occurs, is not very common...
- Human papillomavirus capsid antibody response to natural infection and risk of subsequent HPV infection in HIV-positive and HIV-negative womenRaphael P Viscidi
Johns Hopkins Hospital, Blalock Room 1105, 600 North Wolfe Street, Baltimore, MD 21287, USA
Cancer Epidemiol Biomarkers Prev 14:283-8. 2005..0-2.0). The lack of a protective immune effect from natural infection is most likely due to the low level of antibody elicited by natural HPV infection and/or the potential for reactivation of HPV, especially in HIV-positive women...
- Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, UgandaMahboobeh Safaeian
Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 20852, USA
Sex Transm Dis 34:429-36. 2007..The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda...
- Design and methods of the evaluation of an HPV-based cervical cancer screening strategy in Mexico: The Morelos HPV StudyYvonne Flores
Instituto Mexicano del Seguro Social, Cuernavaca, Morelos, Mexico
Salud Publica Mex 44:335-44. 2002..The main objective of this study is to examine the use of two different methods for obtaining HPV DNA specimens, self-collected vaginal and clinician-collected cervical, to detect pre-invasive cervical lesions and cancer...
- Investigation of pre-diagnostic virological markers for progressive multifocal leukoencephalopathy in human immunodeficiency virus-infected patientsMary K Grabowski
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Med Virol 81:1140-50. 2009..0, 95% CI: 1.2-394.5). The results suggest that persistent JCV viruria and increasing urinary concentration of JCV DNA may be predictive of PML for some patients...
- Suitability of self-collected vaginal samples for cervical cancer screening in periurban villages in Andhra Pradesh, IndiaA Pavani Sowjanya
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 18:1373-8. 2009....
- Risk factors for cervical cancer among HPV positive women in MexicoYvonne N Flores
Unidad de Investigación Epidemiológica y en Servicios de, Instituto Mexicano del Seguro Social, Morelos, Mexico
Salud Publica Mex 50:49-58. 2008..To identify factors that are associated with an increased risk of developing high-grade cervical intraepithelial neoplasia (CIN) or cancer among human papillomavirus (HPV)-positive women in Mexico...
- Determinants of incidence and clearance of high-risk human papillomavirus infections in rural Rakai, UgandaMahboobeh Safaeian
Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Cancer Epidemiol Biomarkers Prev 17:1300-7. 2008..We used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (HPV) infections in rural Rakai, Uganda...
- Investigation of human brain tumors for the presence of polyomavirus genome sequences by two independent laboratoriesDana E M Rollison
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Int J Cancer 113:769-74. 2005..Results for masked quality control tissues were concordant between laboratories. Nucleotide sequences for JCV, BKV and SV40 are rarely present in a large series of adult and pediatric brain tumors...
- HPV testing for cervical cancer screening appears more cost-effective than Papanicolau cytology in MexicoYvonne N Flores
Instituto Mexicano del Seguro Social, Cuernavaca, Morelos, Mexico
Cancer Causes Control 22:261-72. 2011..To determine the incremental costs and effects of different HPV testing strategies, when compared to Papanicolau cytology (Pap), for cervical cancer screening in Mexico...
- Clinical course of recurrent respiratory papillomatosis in Danish childrenMichael J Silverberg
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Arch Otolaryngol Head Neck Surg 130:711-6. 2004..To evaluate the clinical course of juvenile-onset recurrent respiratory papillomatosis (RP) with respect to age, disease duration, and maternal condylomas...
- Effectiveness of VIA, Pap, and HPV DNA testing in a cervical cancer screening program in a peri-urban community in Andhra Pradesh, IndiaPatti E Gravitt
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
PLoS ONE 5:e13711. 2010....
- Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatusAimee R Kreimer
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
J Infect Dis 189:686-98. 2004..8; 95% confidence interval, 3.1-52.7) among HIV-seropositive individuals. HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection...
- Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosisMichael J Silverberg
Department of Epidemiology, Baltimore, Maryland 21205 2179, USA
Obstet Gynecol 101:645-52. 2003....
- Serum antibodies to JC virus, BK virus, simian virus 40, and the risk of incident adult astrocytic brain tumorsDana E M Rollison
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Cancer Epidemiol Biomarkers Prev 12:460-3. 2003..00 for SV40 (95% CI, 0.30-3.32). Given the high prevalence of JCV and BKV infections and the millions who were potentially exposed to SV40 through contaminated polio vaccines, future studies should attempt to replicate these findings...
- Accuracy of Papanicolaou test among HIV-infected womenJean R Anderson
Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Clin Infect Dis 42:562-8. 2006..We examined the accuracy of the Papanicolaou (Pap) test among women with and women at high risk for human immunodeficiency virus (HIV) infection...
- Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotypeCornelia L Trimble
Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Clin Cancer Res 11:4717-23. 2005..We carried out a prospective observational cohort study evaluating known, quantifiable prognostic variables of clinical behavior in women with high-grade cervical lesions...
- Detection of human papillomavirus in cervical lymph nodes: a highly effective strategy for localizing site of tumor originShahnaz Begum
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Clin Cancer Res 9:6469-75. 2003..Detection of HPV-16 or a surrogate marker may be useful in localizing tumor origin in patients who present with metastatic HNSCC...
- Reproducibility of HPV 16 and HPV 18 viral load quantitation using TaqMan real-time PCR assaysPatti E Gravitt
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room E6014 Baltimore, MD 21205, USA
J Virol Methods 112:23-33. 2003..87, respectively). These HPV 16 and HPV 18 quantitative PCR assays with GAPDH normalization are reproducibly quantitative over a broad linear dynamic range allowing for application in epidemiologic studies for measurement of viral load...
- The acceptability of self-collected samples for HPV testing vs. the pap test as alternatives in cervical cancer screeningIlana G Dzuba
The Johns Hopkins University School of Public Health, Baltimore, Maryland, USA
J Womens Health Gend Based Med 11:265-75. 2002..To explore the acceptability of the self-collection of samples for human papillomavirus (HPV) testing in comparison with that of the Pap test...
- The impact of HIV infection and immunodeficiency on human papillomavirus type 6 or 11 infection and on genital wartsMichael J Silverberg
Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
Sex Transm Dis 29:427-35. 2002..HIV infection and associated immunodeficiency are known to alter the course of human papillomavirus (HPV) infections and of associated diseases...
- Distinction of endocervical and endometrial adenocarcinomas: immunohistochemical p16 expression correlated with human papillomavirus (HPV) DNA detectionM Ali Ansari-Lari
Department of Pathology Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Surg Pathol 28:160-7. 2004....
- Smoking and time to clearance of human papillomavirus infection in HIV-seropositive and HIV-seronegative womenJill Koshiol
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, USA
Am J Epidemiol 164:176-83. 2006..93, 95% CI: 0.68, 1.26) women. HPV clearance did not appear to vary by amount or duration of smoking. Smoking did not modify overall clearance but was associated with lower high-risk HPV clearance in HIV-seronegative women...
- Cancer. A skin cancer virus?Raphael P Viscidi
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Science 319:1049-50. 2008
- Human papillomavirus genotype prevalence in high-grade squamous intraepithelial lesions and colposcopically normal women from ZimbabwePatti E Gravitt
Int J Cancer 100:729-32. 2002
- Male circumcision, penile human papillomavirus infection, and cervical cancer in female partnersXavier Castellsague
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Hospitalet de Llobregat, Barcelona, Spain
N Engl J Med 346:1105-12. 2002..It is uncertain whether male circumcision reduces the risks of penile human papillomavirus (HPV) infection in the man and of cervical cancer in his female partner...
- Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control studyNubia Munoz
Unit of Field and Intervention Studies, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372, Cedex 08, Lyon, France
Lancet 359:1093-101. 2002..To assess the role of reproductive factors in the progression from HPV infection to cancer, we did a pooled analysis including only HPV-positive women...
- Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control studyVictor Moreno
Epidemiology and Cancer Registry Service, Catalan Institute of Oncology, Hospital Duran i Reynals, L Hospitalet de Llobregat, Barcelona, Spain
Lancet 359:1085-92. 2002..We aimed to assess how use of oral contraceptives affected risk of cervical cancer in women who tested positive for HPV DNA...
- Lack of BK virus DNA sequences in most transitional-cell carcinomas of the bladderDana E Rollison
Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC CANCONT, Tampa, FL 33612, USA
Int J Cancer 120:1248-51. 2007..The 6 BKV-positive tissues by QPCR were also positive by conventional PCR, but all stained negative for BKV T-Ag by immunohistochemistry. BKV is unlikely to be involved in the etiology of most bladder tumors...
- Epidemiologic classification of human papillomavirus types associated with cervical cancerNubia Munoz
International Agency for Research on Cancer, Lyons, France
N Engl J Med 348:518-27. 2003..Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed...
- Serological cross-reactivities between antibodies to simian virus 40, BK virus, and JC virus assessed by virus-like-particle-based enzyme immunoassaysRaphael P Viscidi
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore Maryland, USA
Clin Diagn Lab Immunol 10:278-85. 2003..With their greater versatility and their suitability for large-scale testing, the VLP-based EIAs for SV40, BKV, and JCV are likely to contribute to a better understanding of the biology of these viruses...
- Chapter 4: Burden and management of non-cancerous HPV-related conditions: HPV-6/11 diseaseCharles J N Lacey
Hull York Medical School, University of York, Heslington, York, UK
Vaccine 24:S3/35-41. 2006..Cost-effectiveness analyses are needed to assess the benefits of the HPV-6/11 virus-like particle (VLP) components of the quadrivalent vaccine in population-based vaccination programmes...
- Cyclin D1, p53, MIB1, intratumoral microvessel density, and human papillomavirus in advanced laryngeal carcinoma: association with nodal metastasisRekha V Kumar
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India
Otolaryngol Head Neck Surg 131:509-13. 2004..We sought to study various parameters in laryngeal squamous cell carcinoma (LSCC) that might predict nodal metastasis...
- Simian virus 40 and human diseaseKeerti V Shah
J Infect Dis 190:2061-4. 2004
- Comparison of HPV-based assays with Papanicolaou smears for cervical cancer screening in Morelos State, MexicoJorge Salmeron
Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Morelos, Mexico
Cancer Causes Control 14:505-12. 2003..To compare the performance of human papillomavirus (HPV) assays with conventional Pap cytology for cervical cancer (CC) screening in Mexico...
- Human papillomavirus type 16 and immune status in human immunodeficiency virus-seropositive womenHoward D Strickler
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Natl Cancer Inst 95:1062-71. 2003..To address this issue, we examined HPV test results from repeated study visits in the WIHS and from an independent study, the HIV Epidemiology Research Study (HERS)...
- Absence of simian virus 40 in human brain tumors from northern IndiaEric A Engels
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Int J Cancer 101:348-52. 2002..Our findings do not support a role for SV40 in choroid plexus tumors or ependymomas from northern India...
- Markers of past infection with simian virus 40 (SV40) and risk of incident non-Hodgkin lymphoma in a Maryland cohortDana E Rollison
Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
Cancer Epidemiol Biomarkers Prev 14:1448-52. 2005..8% of cases and 1.6% of controls (OR, 1.51; 95% CI, 0.41-5.52). Our findings suggest that past infection with SV40 is not associated with an increased risk of developing NHL...
- Prediagnostic circulating antibodies to JC and BK human polyomaviruses and risk of non-Hodgkin lymphomaDana E Rollison
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Cancer Epidemiol Biomarkers Prev 15:543-50. 2006....
- Against which human papillomavirus types shall we vaccinate and screen? The international perspectiveNubia Munoz
International Agency for Research on Cancer, Lyon, France
Int J Cancer 111:278-85. 2004..The impact of modifying the number of types in the screening cocktail tests would be small and probably irrelevant for screening programs...
- Human papillomavirus type distribution in cervical cancer in Delhi, IndiaNeerja Bhatla
Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India
Int J Gynecol Pathol 25:398-402. 2006..Increasing the genotype spectrum (e.g. valency) if the existing vaccines would be expected to have only a modest impact on the potential for cervical protection...
- Human papillomavirus-type distribution in women with and without cervical neoplasia in north IndiaNeerja Bhatla
Department of Obstetrics, All India Institute of Medical Sciences, New Delhi, India
Int J Gynecol Pathol 27:426-30. 2008..A wide spectrum of HPV types is seen in north Indian women, with the majority being HPV-16 in all grades of histology. A vaccine against HPV-16 and HPV-18 could prevent two thirds of cases of high-grade cervical neoplasia...
- Correlates of IL-10 and IL-12 concentrations in cervical secretionsPatti E Gravitt
Interdisciplinary Studies Section, Environmental Epidemiology Branch, DCEG, National Cancer Institute, 6120 Executive Blvd, EPS 7059, Bethesda, Maryland 20852, USA
J Clin Immunol 23:175-83. 2003..Future analyses of cervical cytokine levels and HPV infection should control for the inherent variation of local cytokine levels due to hormonal influences, hemoglobin contamination, pH, and cervical secretion volume differences...
- Polyomaviruses and human diseasesNasimul Ahsan
Mayo Clinic, College of Medicine, Mayo Clinic Transplant Center, Jacksonville, Florida, USA
Adv Exp Med Biol 577:1-18. 2006..In this chapter, we provide an overview of polyomaviruses and briefly introduce its association with human diseases, which will be covered extensively in other chapters by experts in the field...
- Time to clearance of human papillomavirus infection by type and human immunodeficiency virus serostatusJill E Koshiol
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Int J Cancer 119:1623-9. 2006..57 (95% CI: 0.22-1.45) for HIV-positive and -negative women, respectively. HPV types within the high-risk category had low estimated clearance rates relative to low-risk types, but HRs were not substantially modified by HIV serostatus...
- Lack of serological evidence for an association between simian virus 40 and lymphomaSilvia de Sanjose
Institut Catala d Oncologia, Barcelona, Spain
Int J Cancer 104:522-4. 2003..VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain...
- HPV ETIOLOGY OF A SUBSET OF HEAD AND NECK CANCERSKeerti Shah; Fiscal Year: 2004..If HPV etiology is established for a subset of HNSCC, patients with these tumors may benefit from HPV-specific immunotherapies which are being evaluated for the treatment of invasive cervical cancer. ..