Edward M Schaeffer

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Pre-processing Agilent microarray data
    Marianna Zahurak
    Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA
    BMC Bioinformatics 8:142. 2007
  2. doi request reprint Renal medullary carcinoma: molecular, pathological and clinical evidence for treatment with topoisomerase-inhibiting therapy
    Edward M Schaeffer
    The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    BJU Int 106:62-5. 2010
  3. doi request reprint Cystoscopic management of an extruded coil from arteriovenous fistula embolization using arthroscopic instruments
    Edward M Schaeffer
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Endourol 22:1527-9. 2008
  4. ncbi request reprint Duplex ultrasonography detects clinically significant anomalies of penile arterial vasculature affecting surgical approach to penile straightening
    Edward M Schaeffer
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 67:166-9. 2006
  5. ncbi request reprint Incidence of local recurrence and port site metastasis after laparoscopic radical nephroureterectomy
    Michael Muntener
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Urology 70:864-8. 2007
  6. doi request reprint Pathological and oncologic outcomes for men with positive lymph nodes at radical prostatectomy: The Johns Hopkins Hospital 30-year experience
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Prostate 73:1673-80. 2013
  7. doi request reprint Preoperative characteristics of men with unfavorable high-Gleason prostate cancer at radical prostatectomy
    Phillip M Pierorazio
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
    Urol Oncol 31:589-94. 2013
  8. pmc Contemporaneous comparison of open vs minimally-invasive radical prostatectomy for high-risk prostate cancer
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, MD, USA
    BJU Int 112:751-7. 2013
  9. pmc A contemporary analysis of outcomes of adenocarcinoma of the prostate with seminal vesicle invasion (pT3b) after radical prostatectomy
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 185:1691-7. 2011
  10. pmc Is repeat prostate biopsy associated with a greater risk of hospitalization? Data from SEER-Medicare
    Stacy Loeb
    Department of Urology, New York University, New York, New York 10016, USA
    J Urol 189:867-70. 2013

Detail Information

Publications81

  1. pmc Pre-processing Agilent microarray data
    Marianna Zahurak
    Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA
    BMC Bioinformatics 8:142. 2007
    ..The larger goal is to define best study design and pre-processing practices for Agilent arrays, and we offer some suggestions...
  2. doi request reprint Renal medullary carcinoma: molecular, pathological and clinical evidence for treatment with topoisomerase-inhibiting therapy
    Edward M Schaeffer
    The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    BJU Int 106:62-5. 2010
    ..Aetiology (case series) Level of Evidence 4...
  3. doi request reprint Cystoscopic management of an extruded coil from arteriovenous fistula embolization using arthroscopic instruments
    Edward M Schaeffer
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Endourol 22:1527-9. 2008
    ..We describe one potential complication of transcatheter embolization that involves necrosis of the bladder wall with a novel technique for endoscopic management of an extruded coil in the bladder...
  4. ncbi request reprint Duplex ultrasonography detects clinically significant anomalies of penile arterial vasculature affecting surgical approach to penile straightening
    Edward M Schaeffer
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 67:166-9. 2006
    ..To determine the frequency of aberrant penile arterial anatomy in men with Peyronie's disease (PD) and the potential impact on the surgical approach to penile straightening...
  5. ncbi request reprint Incidence of local recurrence and port site metastasis after laparoscopic radical nephroureterectomy
    Michael Muntener
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Urology 70:864-8. 2007
    ..To address the incidence of local recurrence and port site metastasis in patients who underwent laparoscopic radical nephroureterectomy (RNU) for upper tract transitional cell carcinoma (TCC)...
  6. doi request reprint Pathological and oncologic outcomes for men with positive lymph nodes at radical prostatectomy: The Johns Hopkins Hospital 30-year experience
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Prostate 73:1673-80. 2013
    ..We report the 30-year institutional experience of radical prostatectomy (RP) for men with clinically localized prostate cancer (PC) found to have lymph node (LN) metastases at surgery...
  7. doi request reprint Preoperative characteristics of men with unfavorable high-Gleason prostate cancer at radical prostatectomy
    Phillip M Pierorazio
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
    Urol Oncol 31:589-94. 2013
    ..We examine biopsy characteristics of men with high-grade PC at RP to better select those who may benefit from surgery...
  8. pmc Contemporaneous comparison of open vs minimally-invasive radical prostatectomy for high-risk prostate cancer
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, MD, USA
    BJU Int 112:751-7. 2013
    ....
  9. pmc A contemporary analysis of outcomes of adenocarcinoma of the prostate with seminal vesicle invasion (pT3b) after radical prostatectomy
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 185:1691-7. 2011
    ..We investigated outcomes in men with pT3b disease in the contemporary era...
  10. pmc Is repeat prostate biopsy associated with a greater risk of hospitalization? Data from SEER-Medicare
    Stacy Loeb
    Department of Urology, New York University, New York, New York 10016, USA
    J Urol 189:867-70. 2013
    ..We determined whether repeat biopsies are associated with an increased risk of hospitalization compared to the initial biopsy...
  11. pmc Trends in immediate perioperative morbidity and delay in discharge after open and minimally invasive radical prostatectomy (RP): a 20-year institutional experience
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
    BJU Int 112:45-53. 2013
    ..Specifically, it addresses approach-specific morbidities and indicates that MIRP is associated with higher rates of 'off-pathway' discharge, most often due to ileus...
  12. doi request reprint Effect of treatment with 5-α reductase inhibitors on progression in monitored men with favourable-risk prostate cancer
    Ashley E Ross
    James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medicinal Institutions, Baltimore, MD, USA
    BJU Int 110:651-7. 2012
    ....
  13. pmc Preoperative characteristics of high-Gleason disease predictive of favourable pathological and clinical outcomes at radical prostatectomy
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA
    BJU Int 110:1122-8. 2012
    ....
  14. pmc Pathological examination of radical prostatectomy specimens in men with very low risk disease at biopsy reveals distinct zonal distribution of cancer in black American men
    Debasish Sundi
    The Brady Institute of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Urol 191:60-7. 2014
    ..We studied radical prostatectomy specimens from black and white men at very low risk to determine whether there are systematic pathological differences...
  15. pmc Wnt signaling though beta-catenin is required for prostate lineage specification
    Brian W Simons
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 371:246-55. 2012
    ..Deletion of beta-catenin in the adult prostate did not significantly affect organ homeostasis. Collectively, these data establish that beta-catenin and Wnt signaling play key roles in prostate lineage specification and bud outgrowth...
  16. ncbi request reprint Oncologic outcomes of extravesical stapling of distal ureter in laparoscopic nephroureterectomy
    Frederico R Romero
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Endourol 21:1025-7. 2007
    ..To evaluate the safety and oncologic efficacy of extravesical laparoscopic stapling of the distal ureter and bladder cuff during nephroureterectomy for pelvicaliceal transitional-cell carcinoma (TCC)...
  17. doi request reprint The accuracy of multidetector computerized tomography for evaluating tumor thrombus in patients with renal cell carcinoma
    Thomas J Guzzo
    The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 181:486-90; discussion 491. 2009
    ..We assessed the accuracy of multidetector computerized tomography for predicting tumor thrombus and the level of venous involvement in patients with renal cell carcinoma...
  18. doi request reprint SPINK1 Defines a Molecular Subtype of Prostate Cancer in Men with More Rapid Progression in an at Risk, Natural History Radical Prostatectomy Cohort
    Michael H Johnson
    James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland
    J Urol 196:1436-1444. 2016
    ..Prostate cancer is clinically and molecularly heterogeneous. We determined the prognosis of men with ERG-ETS fusions and SPINK1 over expression...
  19. doi request reprint Utility of Risk Models in Decision Making After Radical Prostatectomy: Lessons from a Natural History Cohort of Intermediate- and High-Risk Men
    Ashley E Ross
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Electronic address
    Eur Urol 69:496-504. 2016
    ..Current guidelines suggest adjuvant radiation therapy for men with adverse pathologic features (APFs) at radical prostatectomy (RP). We examine at-risk men treated only with RP until the time of metastasis...
  20. pmc Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
    Paula J Hurley
    Brady Urological Institute, Department of Urology, Johns Hopkins University, Baltimore, Maryland Department of Oncology, Johns Hopkins University, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Institute, Johns Hopkins University, Baltimore, Maryland
    Clin Cancer Res 22:448-58. 2016
    ..Associations of germline ASPN D polymorphisms with risk of prostate cancer progression to metastatic disease have not been assessed...
  21. pmc Outcomes of men with an elevated prostate-specific antigen (PSA) level as their sole preoperative intermediate- or high-risk feature
    Farzana A Faisal
    Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
    BJU Int 114:E120-9. 2014
    ....
  22. pmc African American men with very low-risk prostate cancer exhibit adverse oncologic outcomes after radical prostatectomy: should active surveillance still be an option for them?
    Debasish Sundi
    Johns Hopkins University, Baltimore, MD, USA
    J Clin Oncol 31:2991-7. 2013
    ..To explore whether race-based health disparities exist among men with very low-risk PCa, we evaluated oncologic outcomes of AA men with very low-risk PCa who were candidates for AS but elected to undergo radical prostatectomy (RP)...
  23. pmc Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome
    Paula J Hurley
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 109:14977-82. 2012
    ..Thus, SPARCL1 is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence...
  24. pmc Should prostate specific antigen be adjusted for body mass index? Data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:2646-51. 2009
    ..We examined the relationship between body mass index and prostate specific antigen by age in men without prostate cancer in a longitudinal aging study to determine whether prostate specific antigen must be adjusted for body mass index...
  25. doi request reprint Laparoscopic radical nephrectomy for patients with pathologic T3b renal-cell carcinoma: the Johns Hopkins experience
    Thomas J Guzzo
    The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    J Endourol 23:63-7. 2009
    ..The goal of our study was to evaluate the safety and short-tem oncologic efficacy of laparoscopic radical nephrectomy in patients with renal vein involvement...
  26. doi request reprint Perioperative outcomes of elderly patients undergoing laparoscopic renal procedures
    Thomas J Guzzo
    James Buchanan Brady Urologic Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 73:572-6. 2009
    ..S. population. The outcomes of elderly patients undergoing laparoscopic renal procedures are less well defined than those of younger patients...
  27. pmc Long-term survival after radical prostatectomy for men with high Gleason sum in pathologic specimen
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 76:715-21. 2010
    ..To evaluate the long-term outcomes of patients with high Gleason sum 8-10 at radical prostatectomy (RP) and to identify the predictors of prostate cancer-specific survival (CSS) in this cohort...
  28. pmc Bone mineral content and prostate cancer risk: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, and the National Institute on Ageing, National Institutes of Health Clinical Research Branch, Baltimore, MD, USA
    BJU Int 106:28-31. 2010
    ..Aetiology (inception cohort) Level of Evidence 2b...
  29. pmc Sox9 is required for prostate development and prostate cancer initiation
    Zhenhua Huang
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Oncotarget 3:651-63. 2012
    ..Due to its essential role in cancer initiation, manipulation of Sox9 targets in at-risk men may prove useful in the chemoprevention of prostate cancer...
  30. pmc Evolution of the clinical presentation of men undergoing radical prostatectomy for high-risk prostate cancer
    Phillip M Pierorazio
    Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA
    BJU Int 109:988-93. 2012
    ....
  31. pmc What are the outcomes of radical prostatectomy for high-risk prostate cancer?
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Urology 76:710-4. 2010
    ..These patients are often treated with combined radiation and androgen deprivation therapy, and less is known about the long-term survival in this population after radical prostatectomy (RP)...
  32. doi request reprint Prostate specific antigen at the initial diagnosis of metastasis to bone in patients after radical prostatectomy
    Stacy Loeb
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 184:157-61. 2010
    ..This information would be useful in determining when to initiate androgen deprivation therapy...
  33. doi request reprint The Role of Multiparametric Magnetic Resonance Imaging/Ultrasound Fusion Biopsy in Active Surveillance
    Ting Martin Ma
    The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Eur Urol . 2016
    ..Multiparametric magnetic resonance imaging (mpMRI)/ultrasound fusion biopsy (targeted biopsy or TB) may improve detection of high-grade cancers when compared to systematic biopsy (SB)...
  34. pmc Elevated Prostate Health Index (phi) and Biopsy Reclassification During Active Surveillance of Prostate Cancer
    Darian Andreas
    The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Urol Case Rep 7:64-6. 2016
    ..Here we describe a case in which an elevated phi encouraged biopsy of a gentleman undergoing active surveillance leading to reclassification of his disease as high risk prostate cancer. ..
  35. pmc Prevalence and Prognostic Significance of PTEN Loss in African-American and European-American Men Undergoing Radical Prostatectomy
    Jeffrey J Tosoian
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Eur Urol . 2016
    ..25, 95% confidence interval [CI] 1.33-3.82) and metastasis (HR 3.90, 95% CI 1.46-10.4) in multivariable models...
  36. pmc Reclassification rates are higher among African American men than Caucasians on active surveillance
    Debasish Sundi
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD
    Urology 85:155-60. 2015
    ..To evaluate the risk of reclassification on serial biopsy for Caucasian and African American (AA) men with very low-risk (VLR) prostate cancer enrolled in a large prospective active surveillance (AS) registry...
  37. pmc Distribution of PSA velocity by total PSA levels: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Urology 77:143-7. 2011
    ..35 and >2.0 ng/mL/y have been associated with an increased risk of prostate cancer (CaP) death more than 10 years and 1 year before diagnosis, respectively. It is unknown how frequently PSAVs of this magnitude occur in community men...
  38. doi request reprint Xanthogranulomatous pyelonephritis: presentation and management in the era of laparoscopy
    Thomas J Guzzo
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    BJU Int 104:1265-8. 2009
    ....
  39. pmc Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity
    Ashley E Ross
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    BJU Int 108:447-54. 2011
    ..To evaluate the cytotoxicity of dimeric naphthoquinones (BiQs) in prostate cancer cells. • To assess the interaction of dimeric naphthoquinones with common therapies including radiation and docetaxel...
  40. pmc A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy
    Jeffrey J Tosoian
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Urol Case Rep 6:45-6. 2016
    ..We herein describe our experience with this technique. ..
  41. doi request reprint Pathologic Outcomes in Favorable-risk Prostate Cancer: Comparative Analysis of Men Electing Active Surveillance and Immediate Surgery
    Jeffrey J Tosoian
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Eur Urol 69:576-81. 2016
    ..It remains unclear whether men selecting active surveillance (AS) are at increased risk of unfavorable longer term outcomes as compared with men who undergo immediate treatment...
  42. ncbi request reprint Long-term oncologic outcome after laparoscopic radical nephroureterectomy for upper tract transitional cell carcinoma
    Michael Muntener
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
    Eur Urol 51:1639-44. 2007
    ..To assess the long-term oncologic efficacy of laparoscopic radical nephroureterectomy (RNU)...
  43. doi request reprint Intraperitoneal effects of extraperitoneal laparoscopic radical prostatectomy
    Trinity J Bivalacqua
    The Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    Urology 72:273-7. 2008
    ..To compare routine radiologic and laboratory findings after extraperitoneal and transperitoneal laparoscopic radical prostatectomy (eLRP, tLRP) and assess relevant clinical correlations...
  44. doi request reprint Laparoscopic radical nephroureterectomy with en-bloc distal ureteral and bladder cuff excision using a single position pneumovesicum method
    Thomas J Guzzo
    The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 72:850-2. 2008
    ..This technique is efficient, technically feasible and adheres to the oncologic principles of radical nephroureterectomy...
  45. pmc Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy
    Roula Albadine
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    J Urol 182:735-40. 2009
    ....
  46. doi request reprint Oligometastatic prostate cancer: definitions, clinical outcomes, and treatment considerations
    Jeffrey J Tosoian
    The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Marburg 134, Baltimore, MD 21287, USA
    Nat Rev Urol . 2016
    ..Thus, a protocol for clinicians to manage the patient presenting with oligometastatic prostate cancer would be a useful clinical tool...
  47. ncbi request reprint Association of quantitative magnetic resonance imaging parameters with histological findings from MRI/ultrasound fusion prostate biopsy
    Seyed Saeid Dianat
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Can J Urol 22:7965-72. 2015
    ....
  48. pmc Clinical Validation of the 2005 ISUP Gleason Grading System in a Cohort of Intermediate and High Risk Men Undergoing Radical Prostatectomy
    Sheila F Faraj
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
    PLoS ONE 11:e0146189. 2016
    ....
  49. doi request reprint Prostate Health Index (PHI) Predicts High-stage Pathology in African American Men
    Zeyad R Schwen
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Md Electronic address
    Urology 90:136-40. 2016
    ..To evaluate the association between the Prostate Health Index (PHI) and adverse pathology in a cohort of African American (AA) men undergoing radical prostatectomy...
  50. doi request reprint Instrument Life for Robot-assisted Laparoscopic Radical Prostatectomy and Partial Nephrectomy: Are Ten Lives for Most Instruments Justified?
    Wesley W Ludwig
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Md Electronic address
    Urology 86:942-5. 2015
    ..The majority of robotic instruments have a predetermined lifespan of 10 uses; however, it is unknown if instruments are routinely exchanged before 10 uses in clinical practice...
  51. doi request reprint Gene expression pathways of high grade localized prostate cancer
    Ashley E Ross
    Department of Urology, School of Medicine, Johns Hopkins University, Baltimore, Maryland
    Prostate 71:1568-77. 2011
    ..Here we identify the genes and cellular pathways that distinguish high grade from low grade pathologically localized prostate cancer...
  52. doi request reprint Magnetic resonance-invisible versus magnetic resonance-visible prostate cancer in active surveillance: a preliminary report on disease outcomes
    Seyed Saeid Dianat
    Russell H Morgan Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD
    Urology 85:147-53. 2015
    ....
  53. pmc A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression
    Brian W Simons
    The Brady Urological Institute, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pathol 235:478-89. 2015
    ..This study provides direct evidence that prostate inflammation accelerates prostate cancer progression and gives insight into the microenvironment changes induced by inflammation that may accelerate tumour initiation or progression...
  54. doi request reprint Complications after prostate biopsy: data from SEER-Medicare
    Stacy Loeb
    Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 186:1830-4. 2011
    ..We determined the risk of serious complications requiring hospitalization. We hypothesized that with emerging multidrug resistant organisms there may be an increasing risk of infectious complications...
  55. doi request reprint Application of Evicel to cavernous nerves of the rat does not influence erectile function in vivo
    Trinity J Bivalacqua
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 72:1169-73. 2008
    ..To evaluate the effect of the fibrin sealant, Evicel, on the neuroregulatory control of penile erections in an experimental rat model...
  56. doi request reprint The case for open radical prostatectomy
    Edward M Schaeffer
    Johns Hopkins Medical Institution, Brady Urological Institute, 600 North Wolfe Street, Marburg 145, Baltimore, MD 21287, USA
    Urol Clin North Am 37:49-55, Table of Contents. 2010
    ..Although there are many differences between the 2 approaches, the common goal is to optimize oncologic and functional outcomes. This article highlights the background, techniques, and outcomes of open and robotic prostatectomy...
  57. pmc Urothelial carcinoma: stem cells on the edge
    William D Brandt
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Cancer Metastasis Rev 28:291-304. 2009
    ..In this review, we discuss the implications of these findings in understanding CSCs and in better understanding how UroCas form, progress, and should be treated...
  58. ncbi request reprint Amyloidosis of the seminal vesicle and hematospermia
    Edward M Schaeffer
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    J Urol 171:2382. 2004
  59. ncbi request reprint Urinary markers in the detection of bladder cancer: what's new?
    Matthew E Nielsen
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2101, USA
    Curr Opin Urol 16:350-5. 2006
    ..In the context of relative limitations of the current standard of cystoscopy and cytology, there has been burgeoning activity in the development of novel molecular urine-based markers for bladder cancer detection...
  60. ncbi request reprint Prophylactic use of antimicrobials in commonly performed outpatient urologic procedures
    Edward M Schaeffer
    James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
    Nat Clin Pract Urol 3:24-31. 2006
    ..Special consideration for the type and duration of prophylaxis should be given to patients with moderate to severe cardiac valvular conditions and recently inserted prosthetic joints...
  61. pmc Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression
    Paula J Hurley
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins University, Baltimore, Maryland The Department of Oncology, Johns Hopkins University, Baltimore, Maryland The Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, Maryland
    Cancer Res 75:4322-34. 2015
    ....
  62. pmc HES6 promotes prostate cancer aggressiveness independently of Notch signalling
    Filipe L F Carvalho
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Cell Mol Med 19:1624-36. 2015
    ..Our results did not reveal any cell-autonomous roles for canonical Notch signalling in prostate cancer. However, the results do implicate HES6 as a promoter of prostate cancer progression. ..
  63. doi request reprint A critical analysis of the long-term impact of radical prostatectomy on cancer control and function outcomes
    Stephen A Boorjian
    Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, MN 55905, USA
    Eur Urol 61:664-75. 2012
    ..Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP)...
  64. doi request reprint Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury
    Giulia Calenda
    Albert Einstein College of Medicine, Bronx, NY, USA
    BJU Int 109:1552-64. 2012
    ....
  65. ncbi request reprint Oncologic efficacy of laparoscopic RPLND in treatment of clinical stage I nonseminomatous germ cell testicular cancer
    Matthew E Nielsen
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Urology 70:1168-72. 2007
    ..LRPLND is emerging as a less-invasive alternative in the adjuvant surgical treatment of patients with testicular cancer...
  66. doi request reprint Can ischemic preconditioning ameliorate renal ischemia-reperfusion injury in a single-kidney porcine model?
    David J Hernandez
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Endourol 22:2531-6. 2008
    ..We sought to determine the effect of a specific preconditioning regimen on ischemia-reperfusion renal injury in a single-kidney porcine model...
  67. ncbi request reprint Pyeloduodenal fistula due to advanced upper tract malignancy
    David J Hernandez
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 69:1206-7. 2007
  68. pmc Prostate specific antigen testing among the elderly--when to stop?
    Edward M Schaeffer
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Urol 181:1606-14; discussion 1613-4. 2009
    ..We evaluated the relationship between prostate specific antigen and the risk of aggressive prostate cancer developing in men of various ages...
  69. pmc Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP)-Induced Cancer at Multiple Sites
    Karen S Sfanos
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Cancer Prev Res (Phila) 8:683-92. 2015
    ..These results suggest that bacterial infections and dietary carcinogens, two conceivably preventable cancer risk factors, may synergistically promote tumorigenesis...
  70. pmc Establishment of a new prostate cancer multidisciplinary clinic: Format and initial experience
    Debasish Sundi
    Brady Institute of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Prostate 75:191-9. 2015
    ....
  71. pmc Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells
    Nishant Gandhi
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Biol Ther 14:347-56. 2013
    ..0001). Our data suggest that combined RT-AUY922 therapy exhibits promising activity against prostate cancer cells, which should be investigated in clinical studies...
  72. doi request reprint High anterior release of the levator fascia improves sexual function following open radical retropubic prostatectomy
    Matthew E Nielsen
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    J Urol 180:2557-64; discussion 2564. 2008
    ..We prospectively evaluated the effect of high anterior release on oncological and sexual function outcomes following open radical retropubic prostatectomy...
  73. ncbi request reprint Clinical sequelae of radiographic iceball involvement of collecting system during computed tomography-guided percutaneous renal tumor cryoablation
    Christopher A Warlick
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 67:918-22. 2006
    ....
  74. ncbi request reprint Laparoscopic retroperitoneal lymph node dissection: duplication of open technique
    Mohamad E Allaf
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21237, USA
    Urology 65:575-7. 2005
    ..A modified template dissection that fully duplicates the open technique is now routinely performed at our institution. We describe and show in the accompanying video segments a laparoscopic modified template dissection...
  75. doi request reprint Molecular effects of genistein on male urethral development
    Ashley E Ross
    Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 185:1894-8. 2011
    ..We investigated the effects of genistein, the primary phytoestrogen in soy, on the molecular program of male urethral development...
  76. doi request reprint Risk factors, prevention and early detection of prostate cancer
    Stacy Loeb
    Brady Urological Institute, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Marburg 1, Baltimore, MD 21287, USA
    Prim Care 36:603-21. 2009
    ..The current screening strategies using prostate-specific antigen and digital rectal examination are also discussed, as well as the limitations of these protocols and potential methods for improving early detection...
  77. ncbi request reprint Paraneoplastic polyarthritis from non-small-cell lung cancer metastatic to the bladder
    Trinity J Bivalacqua
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 25:2621-3. 2007
  78. pmc Genetic regulation of prostate development
    Joshua J Meeks
    Department of Urology, Northwestern University School of Medicine, Chicago, Illinois, USA
    J Androl 32:210-7. 2011
    ..These molecules and pathways are critical for prostate development with both known and postulated roles in prostatic pathology...
  79. ncbi request reprint Urological radiographic manifestations of the Ehlers-Danlos syndrome
    Jonathan Berger
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 178:1490. 2007
  80. ncbi request reprint Adrenal myelolipoma
    Edward M Schaeffer
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Urol 173:1760. 2005
  81. ncbi request reprint Rebuttal from authors re: Peter Albers. Quality criteria of laparoscopic nephroureterectomy. Eur Urol. 2007;51:1481-2
    Michael Muntener
    Eur Urol 51:1482-4. 2007