Affiliation: Johns Hopkins University
- Morphometry of the human substantia nigra in ageing and Parkinson's diseaseGay Rudow
Neuropathology, Johns Hopkins School of Medicine, Ross Research Building 555, 720 Rutland Avenue, Baltimore, MD 21205, USA
Acta Neuropathol 115:461-70. 2008..Presumably, this compensatory mechanism breaks down or is overwhelmed by the pathological events of PD leading to the onset of the characteristic motor disturbances...
- Neuronal hypertrophy in asymptomatic Alzheimer diseaseDiego Iacono
Division of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neuropathol Exp Neurol 67:578-89. 2008....
- Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA)RICHARD J O'BRIEN
Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Alzheimers Dis 18:665-75. 2009..e., neuronal hypertrophy and synaptic plasticity) whereas a failure of compensation may culminate in disease...
- Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaquesIra Driscoll
National Institute on Aging, Baltimore, MD, USA
Acta Neuropathol 124:823-31. 2012..The strong associations of PiB retention with region-matched, quantitative analyses of Aβ in postmortem tissue offer support for the validity of (11)C-PiB-PET imaging as a method for evaluation of plaque burden in vivo...
- Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's diseaseJing Jin
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Neurochem 125:410-9. 2013..Our results suggest that modifying the PPAR-γ pathway plays a beneficial role in rescuing motor function as well as glucose metabolic abnormalities in HD...
- Striatal neuronal loss correlates with clinical motor impairment in Huntington's diseaseZhihong Guo
Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mov Disord 27:1379-86. 2012..Our findings suggest that neuronal loss and atrophy in striatum and neuronal loss in subthalamic nuclei contribute specifically to the motor impairment of HD, but not to chorea...
- APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun StudyDiego Iacono
Neuropathology Division, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
Oncotarget 6:14082-91. 2015....
- Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neuronsMiguel Angel Riudavets
Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neurobiol Aging 28:1484-92. 2007..This nuclear hypertrophy may represent an early neuronal reaction to Abeta or Tau, or a compensatory mechanism which forestalls the progression of AD and allows the brain to resist the development of dementia...