Ashley E Ross

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Prostate-specific antigen kinetics during follow-up are an unreliable trigger for intervention in a prostate cancer surveillance program
    Ashley E Ross
    Departments of Urology and Pathology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 28:2810-6. 2010
  2. doi request reprint Gene expression pathways of high grade localized prostate cancer
    Ashley E Ross
    Department of Urology, School of Medicine, Johns Hopkins University, Baltimore, Maryland
    Prostate 71:1568-77. 2011
  3. doi request reprint Pathological and oncologic outcomes for men with positive lymph nodes at radical prostatectomy: The Johns Hopkins Hospital 30-year experience
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Prostate 73:1673-80. 2013
  4. doi request reprint Effect of treatment with 5-α reductase inhibitors on progression in monitored men with favourable-risk prostate cancer
    Ashley E Ross
    James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medicinal Institutions, Baltimore, MD, USA
    BJU Int 110:651-7. 2012
  5. pmc Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity
    Ashley E Ross
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    BJU Int 108:447-54. 2011
  6. pmc Pathological examination of radical prostatectomy specimens in men with very low risk disease at biopsy reveals distinct zonal distribution of cancer in black American men
    Debasish Sundi
    The Brady Institute of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Urol 191:60-7. 2014
  7. pmc Trends in immediate perioperative morbidity and delay in discharge after open and minimally invasive radical prostatectomy (RP): a 20-year institutional experience
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
    BJU Int 112:45-53. 2013
  8. doi request reprint Utility of Risk Models in Decision Making After Radical Prostatectomy: Lessons from a Natural History Cohort of Intermediate- and High-Risk Men
    Ashley E Ross
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Electronic address
    Eur Urol 69:496-504. 2016
  9. pmc Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
    Paula J Hurley
    Brady Urological Institute, Department of Urology, Johns Hopkins University, Baltimore, Maryland Department of Oncology, Johns Hopkins University, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Institute, Johns Hopkins University, Baltimore, Maryland
    Clin Cancer Res 22:448-58. 2016
  10. pmc Outcomes of men with an elevated prostate-specific antigen (PSA) level as their sole preoperative intermediate- or high-risk feature
    Farzana A Faisal
    Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
    BJU Int 114:E120-9. 2014

Collaborators

Detail Information

Publications36

  1. doi request reprint Prostate-specific antigen kinetics during follow-up are an unreliable trigger for intervention in a prostate cancer surveillance program
    Ashley E Ross
    Departments of Urology and Pathology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 28:2810-6. 2010
    ....
  2. doi request reprint Gene expression pathways of high grade localized prostate cancer
    Ashley E Ross
    Department of Urology, School of Medicine, Johns Hopkins University, Baltimore, Maryland
    Prostate 71:1568-77. 2011
    ..Here we identify the genes and cellular pathways that distinguish high grade from low grade pathologically localized prostate cancer...
  3. doi request reprint Pathological and oncologic outcomes for men with positive lymph nodes at radical prostatectomy: The Johns Hopkins Hospital 30-year experience
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Prostate 73:1673-80. 2013
    ..We report the 30-year institutional experience of radical prostatectomy (RP) for men with clinically localized prostate cancer (PC) found to have lymph node (LN) metastases at surgery...
  4. doi request reprint Effect of treatment with 5-α reductase inhibitors on progression in monitored men with favourable-risk prostate cancer
    Ashley E Ross
    James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medicinal Institutions, Baltimore, MD, USA
    BJU Int 110:651-7. 2012
    ....
  5. pmc Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity
    Ashley E Ross
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    BJU Int 108:447-54. 2011
    ..To evaluate the cytotoxicity of dimeric naphthoquinones (BiQs) in prostate cancer cells. • To assess the interaction of dimeric naphthoquinones with common therapies including radiation and docetaxel...
  6. pmc Pathological examination of radical prostatectomy specimens in men with very low risk disease at biopsy reveals distinct zonal distribution of cancer in black American men
    Debasish Sundi
    The Brady Institute of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Urol 191:60-7. 2014
    ..We studied radical prostatectomy specimens from black and white men at very low risk to determine whether there are systematic pathological differences...
  7. pmc Trends in immediate perioperative morbidity and delay in discharge after open and minimally invasive radical prostatectomy (RP): a 20-year institutional experience
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
    BJU Int 112:45-53. 2013
    ..Specifically, it addresses approach-specific morbidities and indicates that MIRP is associated with higher rates of 'off-pathway' discharge, most often due to ileus...
  8. doi request reprint Utility of Risk Models in Decision Making After Radical Prostatectomy: Lessons from a Natural History Cohort of Intermediate- and High-Risk Men
    Ashley E Ross
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Electronic address
    Eur Urol 69:496-504. 2016
    ..Current guidelines suggest adjuvant radiation therapy for men with adverse pathologic features (APFs) at radical prostatectomy (RP). We examine at-risk men treated only with RP until the time of metastasis...
  9. pmc Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
    Paula J Hurley
    Brady Urological Institute, Department of Urology, Johns Hopkins University, Baltimore, Maryland Department of Oncology, Johns Hopkins University, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Institute, Johns Hopkins University, Baltimore, Maryland
    Clin Cancer Res 22:448-58. 2016
    ..Associations of germline ASPN D polymorphisms with risk of prostate cancer progression to metastatic disease have not been assessed...
  10. pmc Outcomes of men with an elevated prostate-specific antigen (PSA) level as their sole preoperative intermediate- or high-risk feature
    Farzana A Faisal
    Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
    BJU Int 114:E120-9. 2014
    ....
  11. pmc African American men with very low-risk prostate cancer exhibit adverse oncologic outcomes after radical prostatectomy: should active surveillance still be an option for them?
    Debasish Sundi
    Johns Hopkins University, Baltimore, MD, USA
    J Clin Oncol 31:2991-7. 2013
    ..To explore whether race-based health disparities exist among men with very low-risk PCa, we evaluated oncologic outcomes of AA men with very low-risk PCa who were candidates for AS but elected to undergo radical prostatectomy (RP)...
  12. pmc Wnt signaling though beta-catenin is required for prostate lineage specification
    Brian W Simons
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 371:246-55. 2012
    ..Deletion of beta-catenin in the adult prostate did not significantly affect organ homeostasis. Collectively, these data establish that beta-catenin and Wnt signaling play key roles in prostate lineage specification and bud outgrowth...
  13. pmc Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome
    Paula J Hurley
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 109:14977-82. 2012
    ..Thus, SPARCL1 is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence...
  14. pmc Preoperative characteristics of high-Gleason disease predictive of favourable pathological and clinical outcomes at radical prostatectomy
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA
    BJU Int 110:1122-8. 2012
    ....
  15. pmc Sox9 is required for prostate development and prostate cancer initiation
    Zhenhua Huang
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Oncotarget 3:651-63. 2012
    ..Due to its essential role in cancer initiation, manipulation of Sox9 targets in at-risk men may prove useful in the chemoprevention of prostate cancer...
  16. pmc Identification of men with the highest risk of early disease recurrence after radical prostatectomy
    Debasish Sundi
    Brady Institute of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Prostate 74:628-36. 2014
    ..Men destined to have early biochemical recurrence (BCR) following radical prostatectomy (RP) may be optimal candidates for multimodal treatment. Here we identified pre-operative predictors of early BCR within a surgical cohort who recurred...
  17. pmc A contemporary analysis of outcomes of adenocarcinoma of the prostate with seminal vesicle invasion (pT3b) after radical prostatectomy
    Phillip M Pierorazio
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 185:1691-7. 2011
    ..We investigated outcomes in men with pT3b disease in the contemporary era...
  18. pmc Evolution of the clinical presentation of men undergoing radical prostatectomy for high-risk prostate cancer
    Phillip M Pierorazio
    Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA
    BJU Int 109:988-93. 2012
    ....
  19. pmc Reclassification rates are higher among African American men than Caucasians on active surveillance
    Debasish Sundi
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD
    Urology 85:155-60. 2015
    ..To evaluate the risk of reclassification on serial biopsy for Caucasian and African American (AA) men with very low-risk (VLR) prostate cancer enrolled in a large prospective active surveillance (AS) registry...
  20. doi request reprint Prostate Health Index (PHI) Predicts High-stage Pathology in African American Men
    Zeyad R Schwen
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Md Electronic address
    Urology 90:136-40. 2016
    ..To evaluate the association between the Prostate Health Index (PHI) and adverse pathology in a cohort of African American (AA) men undergoing radical prostatectomy...
  21. pmc Racial disparities in oncologic outcomes after radical prostatectomy: long-term follow-up
    Farzana A Faisal
    Brady Urological Institute, Johns Hopkins University, Baltimore, Md Electronic address
    Urology 84:1434-41. 2014
    ..To report race-based outcomes after radical prostatectomy (RP) in a cohort stratified by National Comprehensive Cancer Network (NCCN) risk category with updated follow-up...
  22. doi request reprint Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men
    Ashley E Ross
    James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA Department of Oncology, Johns Hopkins Hospital, Baltimore, MD, USA
    Eur Urol 69:157-65. 2016
    ..It has been shown that the Decipher test predicts metastatic progression in cohorts that received adjuvant and salvage therapy following RP...
  23. pmc Clinical Validation of the 2005 ISUP Gleason Grading System in a Cohort of Intermediate and High Risk Men Undergoing Radical Prostatectomy
    Sheila F Faraj
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
    PLoS ONE 11:e0146189. 2016
    ....
  24. pmc A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression
    Brian W Simons
    The Brady Urological Institute, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pathol 235:478-89. 2015
    ..This study provides direct evidence that prostate inflammation accelerates prostate cancer progression and gives insight into the microenvironment changes induced by inflammation that may accelerate tumour initiation or progression...
  25. pmc Metabolic and electrochemical mechanisms of dimeric naphthoquinones cytotoxicity in breast cancer cells
    Ashkan Emadi
    Johns Hopkins University, School of Medicine, Department of Internal Medicine, Division of Hematology, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Bioorg Med Chem 19:7057-62. 2011
    ..These results also suggest that dimeric naphthoquinones may be used to selectively target cancer cells that depend on oxidative phosphorylation for energy production and macromolecular synthesis...
  26. pmc Attenuated RhoA/Rho-kinase signaling in penis of transgenic sickle cell mice
    Trinity J Bivalacqua
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 76:510.e7-12. 2010
    ..Therefore, the objective of the present study was to evaluate the molecular changes in RhoA and ROCK in an established transgenic sickle cell mouse model of priapism...
  27. pmc Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression
    Paula J Hurley
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins University, Baltimore, Maryland The Department of Oncology, Johns Hopkins University, Baltimore, Maryland The Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, Maryland
    Cancer Res 75:4322-34. 2015
    ....
  28. pmc HES6 promotes prostate cancer aggressiveness independently of Notch signalling
    Filipe L F Carvalho
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Cell Mol Med 19:1624-36. 2015
    ..Our results did not reveal any cell-autonomous roles for canonical Notch signalling in prostate cancer. However, the results do implicate HES6 as a promoter of prostate cancer progression. ..
  29. pmc Establishment of a new prostate cancer multidisciplinary clinic: Format and initial experience
    Debasish Sundi
    Brady Institute of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Prostate 75:191-9. 2015
    ....
  30. doi request reprint Urinary Biomarkers for Prostate Cancer
    Jeffrey J Tosoian
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA Electronic address
    Urol Clin North Am 43:17-38. 2016
    ....
  31. doi request reprint Molecular effects of genistein on male urethral development
    Ashley E Ross
    Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 185:1894-8. 2011
    ..We investigated the effects of genistein, the primary phytoestrogen in soy, on the molecular program of male urethral development...
  32. doi request reprint Benign prostate glands at the bladder neck margin in robotic vs open radical prostatectomy
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 105:1446-9. 2010
    ....
  33. pmc Novel Biomarker Signature That May Predict Aggressive Disease in African American Men With Prostate Cancer
    Kosj Yamoah
    Kosj Yamoah, Robert Den, and Adam P Dicker, Thomas Jefferson University Hospital Priti Lal, Michael Feldman, and Timothy R Rebbeck, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Kosj Yamoah, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL Michael H Johnson, Farzana A Faisal, Ashley E Ross, and Edward M Schaeffer, Johns Hopkins University, Baltimore, MD Voleak Choeurng, Kasra Yousefi, Zaid Haddad, Mohammed Alshalafa, and Elai Davicioni, GenomeDx Biosciences, Vancouver, British Columbia, Canada and Eric A Klein, The Cleveland Clinic Foundation, Cleveland, OH
    J Clin Oncol 33:2789-96. 2015
    ..We studied the ethnicity-specific expression of prostate cancer (PC) -associated biomarkers to evaluate whether genetic/biologic factors affect ethnic disparities in PC pathogenesis and disease progression...
  34. pmc A chemical genetic screen for modulators of asymmetrical 2,2'-dimeric naphthoquinones cytotoxicity in yeast
    Ashkan Emadi
    Department of Internal Medicine and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 5:e10846. 2010
    ..In order to gain insight into the mode of action of binaphthoquinones we performed a systematic high-throughput screen in a yeast isogenic deletion mutant array for enhanced or suppressed growth in the presence of binaphthoquinones...
  35. pmc Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk
    Theresa Tretter
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 198:1863-73. 2003
    ..Thus, sustained activation of Blk induces responses normally associated with the pre-BCR...
  36. pmc Posttranslational modification of constitutive nitric oxide synthase in the penis
    Biljana Musicki
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, 600 N Wolfe Avenue, Marburg 143, Baltimore, MD 21287, USA
    J Androl 30:352-62. 2009
    ..This communication reviews the role of eNOS and nNOS in erectile physiology and discusses the alterations in eNOS and nNOS via posttranslation modification in various vascular diseases of the penis...