LINDA M RESAR

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Bloodless medicine: current strategies and emerging treatment paradigms
    Linda M S Resar
    Department of Medicine Hematology, The, Baltimore, Maryland
    Transfusion 56:2637-2647. 2016
  2. ncbi request reprint The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development
    T F Sumter
    Department of Medicine, Faculty of the Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Room 1025, Baltimore, MD 21205 2109, USA
    Curr Mol Med 16:353-93. 2016
  3. pmc HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma
    Alexandra C Hristov
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mod Pathol 23:98-104. 2010
  4. pmc HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells
    Sandeep N Shah
    Hematology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e63419. 2013
  5. pmc HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks
    Sandeep N Shah
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 7:e48533. 2012
  6. pmc HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells
    Amy Belton
    Hematology Division, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e30034. 2012
  7. pmc The high mobility group A1 gene: transforming inflammatory signals into cancer?
    Linda M S Resar
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2109, USA
    Cancer Res 70:436-9. 2010
  8. ncbi request reprint Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapy
    Linda M S Resar
    Department of Pediatrics, Johns Hopkins University School of Medicine, Ross Research Building, Room 1125, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Pediatr Hematol Oncol 24:737-41. 2002
  9. pmc HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis
    Andrew Schuldenfrei
    Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    BMC Genomics 12:549. 2011
  10. ncbi request reprint Concentrations of B vitamins and homocysteine in children with sickle cell anemia
    Jodi B Segal
    Department of Medicine and Pediatrics, The Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine and Medical Institutions, Baltimore, MD 21205, USA
    South Med J 97:149-55. 2004

Research Grants

  1. HMG-1/Y AND NEOPLASTIC TRANSFORMATION
    Linda Resar; Fiscal Year: 2002
  2. Mechanisms of Neoplastic Transformation by HMG-I/Y
    Linda Resar; Fiscal Year: 2006
  3. The Role of HMG-I/Y in Uterine Cancer
    Linda Resar; Fiscal Year: 2007

Collaborators

  • Lisa Wood
  • J B Segal
  • Anirban Maitra
  • Saraswati Sukumar
  • Andrew Schuldenfrei
  • Francescopaolo Di Cello
  • Young Kyung Bae
  • Charles M Rudin
  • EDGAR RAYMOND MILLER
  • J Turkson
  • Christine A Iacobuzio-Donahue
  • Amy Belton
  • Joelle Hillion
  • David L Huso
  • Sandeep N Shah
  • Leslie Cope
  • Surajit Dhara
  • T F Sumter
  • Raka Bhattacharya
  • Mita Mukherjee
  • Abeba Tesfaye
  • Alexandra C Hristov
  • Ray Reeves
  • Biju Joseph
  • Jeanne Kowalski
  • Patrick Hines
  • Ossama Elbahloul
  • Takita Felder Sumter
  • Natsuki Takaha
  • Yi Xu
  • D Reid
  • T Huso
  • L Chia
  • L Xian
  • Y T Chang
  • C Inglis
  • M Koo
  • T N Almasri
  • Christine E Dolde
  • C Conover Talbot
  • Sujayita Roy
  • Weijie Poh
  • Candace Kerr
  • Elias Zambidis
  • Alexander Gabrovsky
  • Cyndi Liu
  • Mansher Singh
  • Marcelo Delos Reyes
  • Joelle A Hillion
  • Stanley Zucker
  • John Poirier
  • Souyma Jaganathan
  • Peter Aplan
  • Linzhao Cheng
  • Kelsey Wertzler
  • George J Dover
  • Ossama Elbahlouh
  • Richard Jove
  • Ying Wei Lin
  • Zhaohui Ye
  • Brigitte M Ronnett
  • Lora Hedrick Ellenson
  • Raymond Reeves
  • Kathryn Tworkoski
  • Raheela Ashfaq
  • Richard Roden
  • Edward Prochownik
  • Donald S Coffey
  • Ephraim J Fuchs
  • Don Vindivich
  • Chung Cho

Detail Information

Publications21

  1. doi request reprint Bloodless medicine: current strategies and emerging treatment paradigms
    Linda M S Resar
    Department of Medicine Hematology, The, Baltimore, Maryland
    Transfusion 56:2637-2647. 2016
    ....
  2. ncbi request reprint The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development
    T F Sumter
    Department of Medicine, Faculty of the Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Room 1025, Baltimore, MD 21205 2109, USA
    Curr Mol Med 16:353-93. 2016
    ..In this review, we summarize the list of putative downstream transcriptional targets regulated by HMGA1. We also briefly discuss studies linking HMGA1 to Alzheimer's disease and type-2 diabetes...
  3. pmc HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma
    Alexandra C Hristov
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mod Pathol 23:98-104. 2010
    ..These results suggest that HMGA1 promotes tumor progression in pancreatic ductal adenocarcinoma and could be a useful biomarker and rational therapeutic target in advanced disease...
  4. pmc HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells
    Sandeep N Shah
    Hematology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e63419. 2013
    ..Future studies are needed to determine how to target HMGA1 in therapy...
  5. pmc HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks
    Sandeep N Shah
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 7:e48533. 2012
    ..The high mobility group A1 (HMGA1) gene is highly expressed in hESCs and poorly differentiated, stem-like cancers; however, its role in these settings has been unclear...
  6. pmc HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells
    Amy Belton
    Hematology Division, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e30034. 2012
    ..Previous studies identified HMGA1 as a key transcription factor enriched in ES cells, colon cancer, and other aggressive tumors, although its role in these settings is poorly understood...
  7. pmc The high mobility group A1 gene: transforming inflammatory signals into cancer?
    Linda M S Resar
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2109, USA
    Cancer Res 70:436-9. 2010
    ..Further elucidation of HMGA1 function in transformation promises to have a major impact on our war on cancer...
  8. ncbi request reprint Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapy
    Linda M S Resar
    Department of Pediatrics, Johns Hopkins University School of Medicine, Ross Research Building, Room 1125, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Pediatr Hematol Oncol 24:737-41. 2002
    ..We conclude that lower dose SPB is effective in inducing HbF synthesis in some children with HbSS. Further trials are warranted to determine the optimal treatment regimen...
  9. pmc HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis
    Andrew Schuldenfrei
    Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    BMC Genomics 12:549. 2011
    ..To define the HMGA1 transcriptome, we analyzed gene expression profiles in lymphoid cells from HMGA1a transgenic mice at different stages in tumorigenesis...
  10. ncbi request reprint Concentrations of B vitamins and homocysteine in children with sickle cell anemia
    Jodi B Segal
    Department of Medicine and Pediatrics, The Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine and Medical Institutions, Baltimore, MD 21205, USA
    South Med J 97:149-55. 2004
    ..We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover...
  11. ncbi request reprint Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia
    Patrick Hines
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatr Blood Cancer 50:357-9. 2008
    ..This patient developed a modest, but sustained elevation in HbF over the course of therapy without side effects. Although larger studies are needed, this case demonstrates that pulsed-dosing with OSPB enhances HbF synthesis...
  12. ncbi request reprint HMG-I/Y in human breast cancer cell lines
    Christine E Dolde
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Breast Cancer Res Treat 71:181-91. 2002
    ....
  13. pmc Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer
    Joelle Hillion
    Hematology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Res 7:1803-12. 2009
    ..Our findings suggest an important role for MMP-2 in transformation mediated by HMGA1 in large-cell, undifferentiated lung carcinoma and support the development of strategies to target this pathway in selected tumors...
  14. pmc The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?
    Joelle Hillion
    Departments of Medicine, Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 68:10121-7. 2008
    ..Our results show that the HMGA1a-STAT3 axis is a potential Achilles heel that could be exploited therapeutically in hematopoietic and other malignancies overexpressing HMGA1a...
  15. ncbi request reprint The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis
    Abeba Tesfaye
    Hematology Division, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 67:3998-4004. 2007
    ..Although a larger study is needed to confirm these results, HMGA1a may be a useful marker for aggressive human uterine cancers...
  16. ncbi request reprint The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia
    Yi Xu
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 64:3371-5. 2004
    ..Our results show that HMG-I functions as an oncogene and suggest that it contributes to the pathogenesis of leukemia and other cancers with increased HMG-I expression...
  17. pmc Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts
    Francescopaolo Di Cello
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Ther 7:2090-5. 2008
    ..Importantly, these drugs have lower toxicity than chemotherapeutic agents used to treat advanced-stage uterine cancers...
  18. pmc HMGA2 participates in transformation in human lung cancer
    Francescopaolo Di Cello
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Res 6:743-50. 2008
    ..Although additional studies with animal models are needed, these findings suggest that targeting HMGA2 could be therapeutically beneficial in lung cancer and other cancers characterized by increased HMGA2 expression...
  19. ncbi request reprint High mobility group protein HMGI(Y) enhances tumor cell growth, invasion, and matrix metalloproteinase-2 expression in prostate cancer cells
    Natsuki Takaha
    Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Prostate 60:160-7. 2004
    ..The high mobility group protein HMGI(Y) has oncogenic properties and correlates with an aggressive phenotype in prostate cancer. The molecular mechanisms involved in transformation associated with HMGI(Y) overexpression remain unknown...

Research Grants3

  1. HMG-1/Y AND NEOPLASTIC TRANSFORMATION
    Linda Resar; Fiscal Year: 2002
    ..Insight gained from these studies should advance our understanding of malignancies associated with increased c-myc and or HMG-I/Y expression and may lead to new treatment strategies. ..
  2. Mechanisms of Neoplastic Transformation by HMG-I/Y
    Linda Resar; Fiscal Year: 2006
    ..This proposal is significant because the results will enhance our understanding of human malignancies with increased HMG-I/Y proteins and may lead to new treatment strategies. ..
  3. The Role of HMG-I/Y in Uterine Cancer
    Linda Resar; Fiscal Year: 2007
    ..There is no effective therapy for this cancer after it has spread outside the uterus. Thus, research is urgently needed to determine how these cancers develop in order to design better therapies. [unreadable] [unreadable] [unreadable]..