Genomes and Genes
Affiliation: Johns Hopkins University
- The Ca-activated Cl channel and its control in rat olfactory receptor neuronsJohannes Reisert
Institut für Biologische Informationsverarbeitung, Frorschungszentrum Jülich, 52425 Julich, Germany
J Gen Physiol 122:349-63. 2003..These densities, together with the Ca2+ diffusion coefficient, demonstrate that a given Cl channel is activated by Ca2+ originating from multiple CNG channels, thus allowing low-noise amplification of the olfactory receptor current...
- Mechanism of the excitatory Cl- response in mouse olfactory receptor neuronsJohannes Reisert
Department of Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Neuron 45:553-61. 2005..Thus, a single functional architecture serves two entirely different purposes, probably underscoring the epithelial origin of the ORNs...
- Olfactory marker protein modulates the cAMP kinetics of the odour-induced response in cilia of mouse olfactory receptor neuronsJohannes Reisert
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
J Physiol 585:731-40. 2007..These observations also help explain the deficits in odour detection threshold and odour quality discrimination seen in the OMP(-/-) mice...
- ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplificationAaron B Stephan
Department of Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
Proc Natl Acad Sci U S A 106:11776-81. 2009..Considering these findings together, we propose that ANO2 constitutes the olfactory calcium-activated chloride channel...
- Olfactory CNG channel desensitization by Ca2+/CaM via the B1b subunit affects response termination but not sensitivity to recurring stimulationYijun Song
Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA
Neuron 58:374-86. 2008....
- The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory responseAaron B Stephan
Department of Biology, The Johns Hopkins University, Baltimore, Maryland, USA
Nat Neurosci 15:131-7. 2012..These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception...
- Signaling by olfactory receptor neurons near thresholdVikas Bhandawat
Solomon H Snyder Department of Neuroscience and Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 107:18682-7. 2010..2 pA. Thus, it takes about 35 odorant-binding events successfully triggering transduction during a brief odorant pulse in order for an ORN to signal to the brain...
- Activation of olfactory cyclic-nucleotide gated channels revisitedJohannes Reisert
Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 20205, USA
J Physiol 569:4-5. 2005
- Regulation of cyclic nucleotide-gated channelsJonathan Bradley
Department of Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Curr Opin Neurobiol 15:343-9. 2005....
- Elementary response of olfactory receptor neurons to odorantsVikas Bhandawat
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 308:1931-4. 2005..Thus, signal amplification in olfactory transduction appears fundamentally different from that of phototransduction...
- Calcium, the two-faced messenger of olfactory transduction and adaptationHugh R Matthews
Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Curr Opin Neurobiol 13:469-75. 2003..The feedback actions of Ca(2+) on different elements of the transduction cascade seem to occur on different timescales, and are therefore responsible for shaping different parts of the receptor current response to odour stimulation...
- Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trappingStylianos Michalakis
Department Pharmazie, Zentrum für Pharmaforschung, Ludwig Maximilians Universitüt München, D 81377 Munchen, Germany
J Biol Chem 281:35156-66. 2006..Second, together with the CNGA4 subunit, CNGB1 is needed for ciliary targeting of the olfactory CNG channel...