Andrew D Redd

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Liver stiffness is associated with monocyte activation in HIV-infected Ugandans without viral hepatitis
    Andrew D Redd
    Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 29:1026-30. 2013
  2. pmc The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, Uganda
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    J Infect Dis 206:267-74. 2012
  3. pmc T-cell enumeration from dried blood spots by quantifying rearranged T-cell receptor-beta genes
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Immunol Methods 354:40-4. 2010
  4. pmc Efficiency of CCR5 coreceptor utilization by the HIV quasispecies increases over time, but is not associated with disease progression
    Andrew D Redd
    Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, USA
    AIDS Res Hum Retroviruses 28:289-94. 2012
  5. pmc Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Infect Dis 205:486-90. 2012
  6. pmc Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research DIR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    J Infect Dis 206:1433-42. 2012
  7. pmc Geographic HIV type 1 subtype distribution in Rakai district, Uganda
    Aleisha N Collinson-Streng
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 25:1045-8. 2009
  8. pmc Human papillomavirus clearance among males is associated with HIV acquisition and increased dendritic cell density in the foreskin
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Carnegie 437, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Infect Dis 207:1713-22. 2013
  9. pmc C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 54:556-9. 2010
  10. pmc Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates
    Oon Tek Ng
    Johns Hopkins School of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, USA
    AIDS Res Hum Retroviruses 28:527-30. 2012

Collaborators

Detail Information

Publications33

  1. pmc Liver stiffness is associated with monocyte activation in HIV-infected Ugandans without viral hepatitis
    Andrew D Redd
    Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 29:1026-30. 2013
    ..Liver stiffness in HIV-infected Ugandans is associated with increased sCD14 indicative of monocyte activation in the absence of viral hepatitis or microbial translocation, and suggests that HIV may be directly involved in liver disease...
  2. pmc The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, Uganda
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    J Infect Dis 206:267-74. 2012
    ..Human immunodeficiency virus (HIV) superinfection has been documented in high-risk individuals; however, the rate of superinfection among HIV-infected individuals within a general population remains unknown...
  3. pmc T-cell enumeration from dried blood spots by quantifying rearranged T-cell receptor-beta genes
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Immunol Methods 354:40-4. 2010
    ..This technique as well as other dried blood spot based technologies could increase the diagnostic and monitoring capabilities in resource-limited settings...
  4. pmc Efficiency of CCR5 coreceptor utilization by the HIV quasispecies increases over time, but is not associated with disease progression
    Andrew D Redd
    Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, USA
    AIDS Res Hum Retroviruses 28:289-94. 2012
    ..These data demonstrate that the R5-UE of the viral quasispecies early in HIV infection is not associated with disease progression, and that R5-UE levels increase in HIV-infected individuals over time...
  5. pmc Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Infect Dis 205:486-90. 2012
    ..17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI, .44-1.67]; P = .62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners...
  6. pmc Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research DIR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    J Infect Dis 206:1433-42. 2012
    ..A genetic bottleneck is known to exist for human immunodeficiency virus (HIV) at the point of sexual transmission. However, the nature of this bottleneck and its effect on viral diversity over time is unclear...
  7. pmc Geographic HIV type 1 subtype distribution in Rakai district, Uganda
    Aleisha N Collinson-Streng
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 25:1045-8. 2009
    ..001) and more subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design...
  8. pmc Human papillomavirus clearance among males is associated with HIV acquisition and increased dendritic cell density in the foreskin
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Carnegie 437, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Infect Dis 207:1713-22. 2013
    ..The association between human papillomavirus (HPV) infection and the risk of human immunodeficiency virus (HIV) seroconversion is unclear, and the genital cellular immunology has not been evaluated...
  9. pmc C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 54:556-9. 2010
    ..However, the role of general immune activation in HIV disease progression in this population was not fully examined...
  10. pmc Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates
    Oon Tek Ng
    Johns Hopkins School of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, USA
    AIDS Res Hum Retroviruses 28:527-30. 2012
    ..As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore...
  11. pmc Identification of HIV superinfection in seroconcordant couples in Rakai, Uganda, by use of next-generation deep sequencing
    Andrew D Redd
    Johns Hopkins University School of Medicine, Rangos Building, Room 530, 855 N Wolfe St, Baltimore, MD 21205, USA
    J Clin Microbiol 49:2859-67. 2011
    ..Our results indicate that NGS can be used for detection of HIV superinfection within large cohorts, which could assist in determining the incidence and the epidemiologic, virologic, and immunological correlates of this phenomenon...
  12. doi request reprint Use of injectable hormonal contraception and women's risk of herpes simplex virus type 2 acquisition: a prospective study of couples in Rakai, Uganda
    Mary K Grabowski
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Lancet Glob Health 3:e478-86. 2015
    ..Whether DMPA increases the risk of other sexually transmitted viral infections is unknown. We assessed the association between DMPA use and incident herpes simplex virus type 2 (HSV2) infection in women...
  13. pmc Changes in the distribution of HIV type 1 subtypes D and A in Rakai District, Uganda between 1994 and 2002
    Samantha A Conroy
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA
    AIDS Res Hum Retroviruses 26:1087-91. 2010
    ..Over this 8-year period, the overall viral population in this region evolved toward the less virulent HIV-1A strain, most likely as a consequence of the faster disease progression and lower transmissibility of HIV-1D...
  14. pmc Frequency of long-term nonprogressors in HIV-1 seroconverters From Rakai Uganda
    Oliver Laeyendecker
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 52:316-9. 2009
    ..Studies on long-term nonprogressors (LTNP) have been conducted in the USA and Europe. This study examined the frequency of LTNPs and HIV controllers among 637 HIV-1 seroconverters in rural Uganda...
  15. doi request reprint Penile Immune Activation and Risk of HIV Shedding: A Prospective Cohort Study
    Eshan U Patel
    1 Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Baltimore, Maryland, USA
    Clin Infect Dis . 2016
    ..Genital immune activation is suspected to modulate local HIV RNA levels and the risk of sexual HIV transmission...
  16. pmc Frequency and implications of HIV superinfection
    Andrew D Redd
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Lancet Infect Dis 13:622-8. 2013
    ..Additional collaborative research could benefit care of patients and inform future vaccine design. ..
  17. pmc Comparison of a high-resolution melting assay to next-generation sequencing for analysis of HIV diversity
    Matthew M Cousins
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 50:3054-9. 2012
    ..The HRM diversity assay is faster and less expensive than NGS, facilitating rapid analysis of large studies of HIV diversity and evolution...
  18. doi request reprint Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation
    Eshan U Patel
    aDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, Baltimore, MD, USA bDepartment of Medicine, University of California San Diego, San Diego, CA, USA cResearch Data and Communication Technologies, Inc, Garrett Park, MD, USA dDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA eDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA fRakai Health Sciences Program, Kalisizo, Uganda gInstitute of Public Health, Makerere University, Kampala, Uganda hDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    AIDS . 2017
    ..To assess the association between CMV IgG antibody levels, HIV disease progression, and immune activation in sub-Saharan Africa...
  19. pmc HIV subtype is not associated with dementia among individuals with moderate and advanced immunosuppression in Kampala, Uganda
    Ned Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, 301 Building, Suite 2100, 4940 Eastern Ave, Baltimore, MD, 21224, USA
    Metab Brain Dis 29:261-8. 2014
    ..There was no association between HIV subtype and dementia among HIV+ individuals with moderate and advanced immunosuppression. Future studies should be performed to confirm these results...
  20. pmc Effects of HIV-1 and herpes simplex virus type 2 infection on lymphocyte and dendritic cell density in adult foreskins from Rakai, Uganda
    Kristine E Johnson
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Infect Dis 203:602-9. 2011
    ..To assess the cellular basis for these associations, we estimated immunologic cellular densities in foreskin tissue...
  21. pmc Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01_AE/B recombinant forms
    Oon Tek Ng
    Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 27:1135-7. 2011
    ..However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01_AE and 62% infected with subtype B (p = 0.001)...
  22. pmc Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial
    Susan H Eshleman
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC Vaccine and Infectious Disease Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, DIR, NIAID, NIH, Hamilton, MT Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD Science Facilitation Department, FHI360, Washington, DC Science Facilitation Department, FHI360, Durham, NC College of Medicine Johns Hopkins Project, Blantyre, Malawi UNC Project, Lilongwe, Malawi Department of Medicine, University of Zimbabwe, Harare, Zimbabwe HIV Research Branch, Center for Global Health, Kenya Medical Research Institute KEMRI Centers for Disease Control CDC, Kisumu, Missouri
    J Acquir Immune Defic Syndr 74:112-116. 2017
    ..Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART...
  23. doi request reprint Decreased monocyte activation with daily acyclovir use in HIV-1/HSV-2 coinfected women
    Andrew D Redd
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Sex Transm Infect 91:485-8. 2015
    ..This study examines if this slowing in clinical progression is a direct cause of the decrease in viral load or an indirect effect of lower immune activation due to lower levels of herpetic reactivation...
  24. pmc Limited HIV-1 superinfection in seroconverters from the CAPRISA 004 Microbicide Trial
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, Maryland, USA
    J Clin Microbiol 52:844-8. 2014
    ..A better understanding of the rate of HIV superinfection could have important implications for ongoing HIV vaccine research...
  25. ncbi request reprint CD4 immunodiagnostics for HIV in the developing world
    Andrew D Redd
    Division of Intramural Research, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 6:S1. 2008
    ..Here, Andrew Redd and Thomas Quinn introduce the supplement...
  26. pmc Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial
    Susan H Eshleman
    Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Infect Dis 204:1918-26. 2011
    ..We analyzed HIV from 38 index-partner pairs and 80 unrelated index participants (controls) to assess the linkage of seroconversion events...
  27. pmc Use of Hepatitis C Virus (HCV) Immunoglobulin G Antibody Avidity as a Biomarker to Estimate the Population-Level Incidence of HCV Infection
    Eshan U Patel
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
    J Infect Dis 214:344-52. 2016
    ..Sensitive methods are needed to estimate the population-level incidence of hepatitis C virus (HCV) infection...
  28. pmc Evaluation of postpartum HIV superinfection and mother-to-child transmission
    Andrew D Redd
    aLaboratory of Immunoregulation, NIAID, NIH bJohns Hopkins School of Medicine, Johns Hopkins University cJohns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland dGenomics Unit, Division of Intramural Research, Research Technologies Branch, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA
    AIDS 29:1567-73. 2015
    ..This study examined HIV superinfection in HIV-infected women postpartum, and its association with mother-to-child transmission (MTCT)...
  29. pmc Rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda
    Andrew D Redd
    aLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda bDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA cMedical Research Council Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda dLondon School of Hygiene and Tropical Medicine, London, UK eGenomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH, Hamilton, Montana, USA Andrew D Redd and Deogratius Ssemwanga contributed equally to the writing of this article
    AIDS 28:2147-52. 2014
    ..To determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers (FSWs) in Kampala, Uganda...
  30. pmc Short communication: Colony-forming hematopoietic progenitor cells are not preferentially infected by HIV type 1 subtypes A and D in vivo
    Caroline E Mullis
    Johns Hopkins Medical Institute, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS Res Hum Retroviruses 28:1119-23. 2012
    ..Our findings suggest that HIV-1 subtypes A and D do not preferentially infect colony-forming HPCs over mature HIV target cells in vivo...
  31. pmc Molecular tools for studying HIV transmission in sexual networks
    Mary K Grabowski
    aBloomberg School of Public Health, Johns Hopkins University bLaboratory of Immunoregulation, NIAID, NIH, Baltimore, Maryland, USA
    Curr Opin HIV AIDS 9:126-33. 2014
    ..The purpose of this review is to highlight the current utilities and limitations of phylogenetics in HIV epidemiological research from sample collection through to data analysis...
  32. pmc Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa
    Andrew D Redd
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:6718-23. 2009
    ..These data suggest that microbial translocation and its subsequent inflammatory immune response do not have a causal relationship with HIV-1 disease progression in Africa...
  33. pmc Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected blood donors or individuals in Africa
    Shixing Tang
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Transfusion 51:463-8. 2011
    ....