Eric H Raabe
Affiliation: Johns Hopkins University
- Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine gliomaSama Ahsan
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 1800 Orleans St, 21287 Baltimore, MD, USA
Acta Neuropathol Commun 2:59. 2014..An H-score was derived by multiplying intensity (0-2) by percentage of positive tumor nuclei (0-100%)...
- Methylome alterations "mark" new therapeutic opportunities in glioblastomaEric H Raabe
Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Division of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Electronic address
Cancer Cell 22:417-8. 2012..These findings suggest novel opportunities for therapeutics for this dreaded disease...
- Subtotal splenic embolization is a safe and effective treatment for isolated splenic vascular tumors associated with consumptive coagulopathyEric H Raabe
Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Pediatr Hematol Oncol 33:383-6. 2011..One child was successfully treated by subtotal embolization of the spleen, whereas the second child required splenectomy after an initial embolization improved--but did not fully control--his consumptive coagulopathy...
- BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma modelEric H Raabe
Division of Pediatric Oncology and Departments of Pathology and Pediatrics and Adolescent Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Clin Cancer Res 17:3590-9. 2011..We investigated the functional effect of constitutive BRAF activation in normal human neural stem and progenitor cells to determine its role in tumor induction in the brain...
- Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic targetMelanie F Weingart
Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA
Oncotarget 6:3165-77. 2015..These data implicate LIN28/RAS/MAP kinase as key drivers of AT/RT tumorigenesis and indicate that targeting this pathway may be a therapeutic option in this aggressive pediatric malignancy. ..
- Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic targetMarianne Hütt-Cabezas
Corresponding Authors Fausto J Rodriguez, MD, Division of Neuropathology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21231 Eric H Raabe, MD, PhD, Division of Neuropathology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21231
Neuro Oncol 15:1604-14. 2013..Here we further evaluate the role of the mTORC1/mTORC2 pathway in order to better direct pharmacologic blockade in these common childhood tumors...
- LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic programXing gang Mao
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Oncotarget 4:1050-64. 2013..Taken together, these data suggest a role for LIN28A in high grade gliomas and illustrate an HMGA2-associated, pro-invasive program that can be activated in GBM by LIN28A-mediated suppression of let-7 microRNAs. ..
- The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicityHarpreet Kaur
From the Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center HK, MH C, MFW, CGE, EHR, Division of Pediatric Oncology EHR, Johns Hopkins University School of Medicine, Bloomberg Children s Hospital, Baltimore, Maryland Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina YK, BEW and Division of Hematology, Oncology, and Blood and Bone Marrow Transplant, Children s Hospital Los Angeles JX, AE E and the University of Southern California AE E, Los Angeles, California
J Neuropathol Exp Neurol 74:177-85. 2015..Our results indicate a role for HMGA2 in AT/RT in vitro and in vivo and demonstrate that HMGA2 is a potential therapeutic target in these lethal pediatric tumors. ..