Affiliation: Johns Hopkins University
- Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypesA E Pulver
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Mol Psychiatry 5:650-3. 2000..008). The identification of multiple susceptibility loci for schizophrenia may be enhanced by stratification of families using psychiatric diagnoses of the non-schizophrenic relatives...
- An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophreniaAnn E Pulver
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
Am J Med Genet B Neuropsychiatr Genet 124:6-9. 2004..The failure to support the paternal age hypothesis may be a function of heterogeneous samples, but calls for further research in the context of family studies...
- Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish womenYaping Liu
Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Psychiatr Genet 20:184-6. 2010..Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype--phenotype correlations...
- Functional consequences of PRODH missense mutationsHans Ulrich Bender
Howard Hughes Medical Institute, and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Hum Genet 76:409-20. 2005..These observations plus the high degree of polymorphism at the PRODH locus are consistent with the hypothesis that reduction in POX function is a risk factor for schizophrenia...
- Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot studyHeather C Strasser
Division of Psychiatric Neuroimaging, Johns Hopkins University, Baltimore, Catonsville, Maryland
Biol Psychiatry 57:633-9. 2005..One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests that psychotic (PBP) and nonpsychotic (NPBP) forms of BP are two subtypes that might differ in pathophysiology...
- Neuropsychological functioning in bipolar disorder and schizophreniaDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, and Olin Neuropsychiatric Research Center, Hartford Hospital Institute of Living, CT, USA
Biol Psychiatry 62:179-86. 2007..Some patients with bipolar disorder (BD) demonstrate neuropsychological deficits even when stable. However, it remains unclear whether these differ qualitatively from those seen in schizophrenia (SZ)...
- Five latent factors underlying schizophrenia: analysis and relationship to illnesses in relativesJohn A McGrath
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Schizophr Bull 30:855-73. 2004..Increased early onset/developmental signs in the proband were also associated with increased risk for depression in relatives. These findings suggest a possible endophenotypic role for the factor scores in future studies...
- Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish familiesM Daniele Fallin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Am J Hum Genet 75:204-19. 2004....
- No major schizophrenia locus detected on chromosome 1q in a large multicenter sampleDouglas F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 296:739-41. 2002..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
- Multipoint affected sibpair linkage methods for localizing susceptibility genes of complex diseasesDavid V Glidden
Department of Epidemiology and Biostatistics, Box 560, University of California, San Francisco, CA 94143 0560, USA
Genet Epidemiol 24:107-17. 2003....
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8qMatthew B McQueen
Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
Am J Hum Genet 77:582-95. 2005..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
- Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent triosM Daniele Fallin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
Am J Hum Genet 77:918-36. 2005..They provide further support for shared genetic susceptibility between these two disorders that involve glutamate-signaling pathways...
- Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22M Daniele Fallin
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21231, USA
Am J Hum Genet 73:601-11. 2003..2 Mb for the location of the trait locus (D10S1677 to D10S1753). We find these results encouraging for the study of schizophrenia among Ashkenazi families and suggest further linkage and association studies in this chromosome 10q region...
- Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B geneDimitrios Avramopoulos
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
Genet Med 9:745-51. 2007..This study is a second stage follow-up focusing on regions that showed positive linkage scores in our previous scan but were not fine-mapped at that time...
- Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnessesAtsushi Kamiya
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Arch Gen Psychiatry 65:996-1006. 2008..A role for the centrosome has been suggested in the pathology of major mental illnesses, especially schizophrenia (SZ)...
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: SchizophreniaCathryn M Lewis
Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
Am J Hum Genet 73:34-48. 2003..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
- MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIAAnn Pulver; Fiscal Year: 2007..abstract_text> ..
- HETEROGENEITY OF SCHIZOPHRENIAAnn Pulver; Fiscal Year: 2001....
- HETEROGENEITY OF BIPOLAR DISORDERAnn Pulver; Fiscal Year: 2003....
- Schizophrenia Susceptibility GenesAnn Pulver; Fiscal Year: 2004..abstract_text> ..
- A Genome Wide SNP Association Study: SchizophreniaAnn Pulver; Fiscal Year: 2007..We will make all SNP genotyping data publicly available and deposit dnas and clinical data into the national repository at the NIMH Center for Genetic Studies. ..